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Strain Name:
C57BL/6J-MtgxR7846Btlr/Mmmh
Stock Number:
045900-MU
Citation ID:
RRID:MMRRC_045900-MU
Other Names:
R7846 (G1)
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, spectrin G, brain spectrin, elf3, elf1, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Chrna5
Name: cholinergic receptor, nicotinic, alpha polypeptide 5
Synonyms: Acra-5, Acra5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110835
VEGA: 9
HGNC: HGNC:1959
Homologene: 55485
Tert
Name: telomerase reverse transcriptase
Synonyms: TR
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21752
VEGA: 13
Homologene: 31141
Kcna6
Name: potassium voltage-gated channel, shaker-related, subfamily, member 6
Synonyms: Kv1.6, MK1.6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16494
HGNC: HGNC:6225
Homologene: 1684
Kdm5b
Name: lysine demethylase 5B
Synonyms: PLU-1, 2010009J12Rik, Plu1, Rb-Bp2, 2210016I17Rik, D1Ertd202e, Jarid1b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
Synonyms: Frabin-gamma, Frabin-beta, Frabin-alpha, Frabin, 9330209B17Rik, ZFYVE6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224014
Homologene: 26727
Lpp
Name: LIM domain containing preferred translocation partner in lipoma
Synonyms: B130055L10Rik, 9430020K16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 210126
VEGA: 16
HGNC: HGNC:6679
Homologene: 4075
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 60,082,066 bp
  • G to A, chromosome 1 at 134,617,840 bp
  • A to T, chromosome 1 at 153,826,037 bp
  • A to G, chromosome 1 at 179,531,361 bp
  • A to T, chromosome 1 at 179,787,073 bp
  • G to T, chromosome 2 at 18,219,893 bp
  • A to T, chromosome 2 at 122,785,088 bp
  • A to T, chromosome 2 at 155,561,033 bp
  • C to A, chromosome 3 at 36,165,589 bp
  • T to C, chromosome 3 at 59,264,934 bp
  • A to G, chromosome 3 at 97,715,174 bp
  • T to C, chromosome 4 at 49,538,858 bp
  • C to T, chromosome 4 at 114,244,879 bp
  • A to T, chromosome 4 at 143,793,993 bp
  • C to T, chromosome 5 at 21,675,723 bp
  • G to T, chromosome 5 at 34,636,112 bp
  • A to G, chromosome 5 at 100,806,832 bp
  • G to A, chromosome 5 at 113,819,420 bp
  • A to G, chromosome 6 at 55,978,335 bp
  • G to T, chromosome 6 at 122,333,370 bp
  • A to T, chromosome 6 at 126,739,020 bp
  • A to T, chromosome 7 at 6,710,651 bp
  • A to G, chromosome 7 at 22,843,271 bp
  • A to G, chromosome 7 at 35,794,538 bp
  • C to A, chromosome 7 at 45,810,954 bp
  • A to G, chromosome 7 at 103,683,200 bp
  • A to G, chromosome 7 at 104,021,529 bp
  • A to G, chromosome 7 at 108,031,992 bp
  • C to T, chromosome 7 at 140,652,461 bp
  • G to T, chromosome 8 at 45,358,641 bp
  • A to G, chromosome 8 at 83,541,897 bp
  • C to A, chromosome 9 at 3,477,889 bp
  • A to G, chromosome 9 at 38,524,379 bp
  • G to A, chromosome 9 at 43,222,780 bp
  • A to T, chromosome 9 at 55,005,107 bp
  • T to C, chromosome 9 at 83,843,679 bp
  • A to C, chromosome 10 at 62,659,526 bp
  • G to A, chromosome 10 at 79,787,379 bp
  • A to T, chromosome 10 at 116,283,548 bp
  • A to G, chromosome 10 at 121,785,492 bp
  • T to C, chromosome 11 at 29,693,274 bp
  • C to A, chromosome 11 at 30,142,153 bp
  • T to C, chromosome 11 at 31,365,413 bp
  • A to T, chromosome 11 at 54,361,075 bp
  • C to A, chromosome 11 at 97,526,100 bp
  • T to A, chromosome 11 at 104,714,745 bp
  • T to A, chromosome 12 at 76,608,526 bp
  • A to G, chromosome 12 at 85,057,268 bp
  • A to T, chromosome 12 at 116,000,317 bp
  • G to T, chromosome 13 at 24,818,150 bp
  • G to A, chromosome 13 at 27,272,459 bp
  • T to A, chromosome 13 at 73,628,195 bp
  • A to G, chromosome 14 at 56,231,560 bp
  • A to T, chromosome 14 at 65,075,732 bp
  • C to A, chromosome 14 at 78,618,586 bp
  • T to C, chromosome 14 at 105,298,014 bp
  • A to G, chromosome 15 at 50,831,877 bp
  • T to C, chromosome 16 at 4,670,536 bp
  • T to G, chromosome 16 at 16,422,726 bp
  • C to A, chromosome 16 at 21,532,320 bp
  • T to A, chromosome 16 at 24,608,126 bp
  • C to A, chromosome 17 at 26,935,317 bp
  • A to G, chromosome 17 at 35,380,158 bp
  • G to T, chromosome 18 at 34,809,240 bp
  • A to T, chromosome 18 at 37,692,220 bp
  • A to G, chromosome 18 at 53,948,105 bp
  • A to G, chromosome 18 at 61,198,704 bp
  • A to G, chromosome 18 at 67,629,905 bp
  • G to A, chromosome 18 at 77,781,315 bp
  • T to A, chromosome 19 at 8,193,487 bp
  • C to T, chromosome 19 at 36,116,818 bp
  • T to A, chromosome 19 at 41,847,776 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7846 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045900-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.