Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7869Btlr/Mmmh
Stock Number:
045921-MU
Citation ID:
RRID:MMRRC_045921-MU
Other Names:
R7869 (G1)
Major Collection:

Strain Information

Kif5a
Name: kinesin family member 5A
Synonyms: Kns, Kif5, D10Bwg0738e, Khc
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16572
VEGA: 10
HGNC: HGNC:6323
Homologene: 55861
Gabra6
Name: gamma-aminobutyric acid type A receptor subunit alpha 6
Synonyms: Gabra-6, alpha6, GABA-ARalpha6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14399
HGNC: HGNC:4080
Homologene: 20220
Dspp
Name: dentin sialophosphoprotein
Synonyms: Dmp3, Dpp, Dsp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666279
HGNC: HGNC:3054
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, beta-MHC, B-MHC, MYH-beta/slow, MyHC-I, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Srd5a3
Name: steroid 5 alpha-reductase 3
Synonyms: D730040M03Rik, 1110025P14Rik, Srd5a2l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57357
Homologene: 41385
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd1, Edd
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Arfgef2
Name: ARF guanine nucleotide exchange factor 2
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99371
Homologene: 111880
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 39,974,044 bp
  • A to G, chromosome 1 at 65,071,855 bp
  • T to C, chromosome 1 at 84,383,881 bp
  • C to T, chromosome 1 at 132,939,378 bp
  • T to G, chromosome 1 at 166,309,292 bp
  • G to A, chromosome 2 at 37,487,130 bp
  • T to C, chromosome 2 at 88,897,064 bp
  • T to C, chromosome 2 at 120,339,394 bp
  • C to T, chromosome 2 at 166,873,703 bp
  • T to C, chromosome 3 at 69,726,417 bp
  • A to T, chromosome 3 at 104,804,678 bp
  • G to A, chromosome 3 at 106,733,143 bp
  • A to G, chromosome 4 at 134,132,298 bp
  • A to G, chromosome 4 at 149,184,376 bp
  • T to C, chromosome 5 at 76,147,736 bp
  • T to C, chromosome 5 at 76,640,956 bp
  • A to C, chromosome 5 at 104,175,665 bp
  • A to T, chromosome 5 at 107,370,179 bp
  • A to G, chromosome 5 at 109,052,120 bp
  • G to A, chromosome 5 at 113,184,135 bp
  • C to T, chromosome 5 at 137,473,601 bp
  • A to T, chromosome 6 at 12,471,124 bp
  • G to T, chromosome 6 at 48,597,345 bp
  • T to C, chromosome 6 at 115,250,394 bp
  • A to G, chromosome 7 at 3,630,860 bp
  • A to G, chromosome 7 at 14,254,812 bp
  • G to T, chromosome 7 at 25,476,529 bp
  • T to A, chromosome 7 at 100,469,491 bp
  • T to A, chromosome 7 at 104,925,104 bp
  • T to C, chromosome 7 at 114,494,687 bp
  • T to C, chromosome 7 at 126,410,526 bp
  • C to A, chromosome 7 at 127,539,194 bp
  • T to A, chromosome 7 at 141,749,734 bp
  • T to G, chromosome 8 at 45,051,222 bp
  • A to T, chromosome 9 at 3,359,503 bp
  • T to G, chromosome 9 at 73,694,877 bp
  • C to T, chromosome 9 at 76,492,144 bp
  • G to T, chromosome 9 at 90,093,791 bp
  • C to T, chromosome 9 at 110,550,014 bp
  • T to A, chromosome 10 at 34,298,100 bp
  • T to C, chromosome 10 at 75,773,226 bp
  • T to C, chromosome 10 at 88,921,705 bp
  • G to A, chromosome 10 at 127,243,474 bp
  • G to A, chromosome 11 at 42,316,495 bp
  • A to G, chromosome 11 at 64,999,387 bp
  • T to A, chromosome 11 at 73,313,552 bp
  • T to A, chromosome 11 at 79,418,588 bp
  • T to C, chromosome 11 at 81,967,998 bp
  • A to T, chromosome 11 at 83,421,990 bp
  • T to C, chromosome 11 at 86,797,706 bp
  • A to T, chromosome 11 at 103,360,304 bp
  • T to A, chromosome 11 at 106,459,019 bp
  • A to G, chromosome 12 at 8,713,595 bp
  • G to T, chromosome 12 at 17,358,238 bp
  • C to T, chromosome 12 at 100,879,238 bp
  • A to G, chromosome 12 at 104,240,251 bp
  • C to T, chromosome 13 at 24,803,399 bp
  • G to T, chromosome 13 at 54,503,900 bp
  • G to A, chromosome 13 at 91,771,725 bp
  • G to A, chromosome 13 at 92,357,963 bp
  • T to C, chromosome 13 at 95,701,011 bp
  • G to T, chromosome 14 at 18,269,017 bp
  • T to C, chromosome 14 at 31,154,472 bp
  • A to G, chromosome 14 at 54,989,073 bp
  • A to T, chromosome 14 at 60,802,936 bp
  • A to G, chromosome 14 at 103,076,065 bp
  • G to A, chromosome 15 at 37,979,832 bp
  • G to T, chromosome 15 at 39,793,386 bp
  • T to C, chromosome 16 at 30,564,722 bp
  • A to G, chromosome 16 at 33,988,847 bp
  • T to C, chromosome 17 at 38,175,939 bp
  • C to T, chromosome 17 at 46,244,891 bp
  • T to C, chromosome 17 at 46,991,008 bp
  • T to C, chromosome 18 at 21,299,700 bp
  • T to C, chromosome 18 at 61,692,409 bp
  • G to A, chromosome 19 at 6,118,426 bp
  • A to G, chromosome 19 at 12,919,547 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7869 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045921-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.