Strain Name:
C57BL/6J-MtgxR7882Btlr/Mmmh
Stock Number:
045934-MU
Citation ID:
RRID:MMRRC_045934-MU
Other Names:
R7882 (G1)
Major Collection:

Strain Information

Nrp2
Name: neuropilin 2
Synonyms: Npn2, NP-2, 1110048P06Rik, NP2, Npn-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Acadm
Name: acyl-Coenzyme A dehydrogenase, medium chain
Synonyms: MCAD
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11364
HGNC: HGNC:89
Homologene: 3
Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: PTPzeta, DSD-1-PG, phosphacan, RPTPz, Ptprz, Ptpz, Rptpbeta, PTPbeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Cxcl12
Name: C-X-C motif chemokine ligand 12
Synonyms: PBSF, TLSF-a, Sdf1a, TLSF-b, TPAR1, Sdf1b, Sdf1, SDF-1, Scyb12, PBSF/SDF-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20315
Homologene: 128606
Stk11ip
Name: serine/threonine kinase 11 interacting protein
Synonyms: 1200014D22Rik, LKB1IP, LIP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71728
Homologene: 12406
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: Rpo2-1, 220kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Zfp532
Name: zinc finger protein 532
Synonyms: C530030I18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328977
Homologene: 138627
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Kctd3
Name: potassium channel tetramerisation domain containing 3
Synonyms: NY-REN-45, 4930438A20Rik, E330032J19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226823
Homologene: 9395
Nrf1
Name: nuclear respiratory factor 1
Synonyms: D6Ertd415e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18181
HGNC: HGNC:7996
Homologene: 3674
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Xpot
Name: exportin, tRNA (nuclear export receptor for tRNAs)
Synonyms: C79645, 1110004L07Rik, EXPORTIN-T
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73192
VEGA: 10
Homologene: 38291
Vdac3
Name: voltage-dependent anion channel 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22335
Homologene: 36115
Cntrl
Name: centriolin
Synonyms: Cep110, b2b1468Clo, IB3/5, Ma2a8, 6720467O09Rik, Cep1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Arid3b
Name: AT-rich interaction domain 3B
Synonyms: Bdp, Dri2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56380
Homologene: 4721
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: C730036B14Rik, D12Ertd364e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Cachd1
Name: cache domain containing 1
Synonyms: Vwcd1, 1190007F10Rik, B430218L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320508
Homologene: 10854
Tnfsf13b
Name: tumor necrosis factor (ligand) superfamily, member 13b
Synonyms: BLyS, D8Ertd387e, TALL-1, BAFF, zTNF4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 24099
Homologene: 48443
Cyp2r1
Name: cytochrome P450, family 2, subfamily r, polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244209
Homologene: 75210
Tarbp1
Name: TAR RNA binding protein 1
Synonyms: Gm17296
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212728
Homologene: 38082
Pld1
Name: phospholipase D1
Synonyms: Pld1b, Pld1a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241589
Homologene: 115928
Fgd5
Name: FYVE, RhoGEF and PH domain containing 5
Synonyms: ZFYVE23, C330025N11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232237
Homologene: 27798
Nr1h5
Name: nuclear receptor subfamily 1, group H, member 5
Synonyms: FXRB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381463
Homologene: 131277
Adad1
Name: adenosine deaminase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21744
Homologene: 7569
Cadm2
Name: cell adhesion molecule 2
Synonyms: Igsf4d, 2900078E11Rik, A830029E02Rik, Necl3, SynCAM2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239857
Homologene: 17705
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r13, V2r3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 669149
Homologene: 129606
Cgn
Name: cingulin
Synonyms: 6330408J11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70737
Homologene: 41394
Cntn4
Name: contactin 4
Synonyms: BIG-2A, Axcam
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269784
HGNC: HGNC:2174
Homologene: 14257
Ina
Name: internexin neuronal intermediate filament protein, alpha
Synonyms: NF66, NF-66
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226180
HGNC: HGNC:6057
Homologene: 10433
Vmn2r18
Name: vomeronasal 2, receptor 18
Synonyms: EG632671
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 632671
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Krt84
Name: keratin 84
Synonyms: HRb-1, Krt2-16, Krt2-3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16680
VEGA: 15
HGNC: HGNC:6461
Homologene: 22473
Kif14
Name: kinesin family member 14
Synonyms: N-3 kinesin, D1Ertd367e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381293
Homologene: 8916
Ces1c
Name: carboxylesterase 1C
Synonyms: Es-1, Es-N, Es-4, Ee-1, Ces-N, Es1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13884
HGNC: HGNC:1863
Homologene: 117484
Axdnd1
Name: axonemal dynein light chain domain containing 1
Synonyms: LOC381304, 9430070O13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77352
Homologene: 52328
Plxnc1
Name: plexin C1
Synonyms: 2510048K12Rik, CD232, vespr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Mast1
Name: microtubule associated serine/threonine kinase 1
Synonyms: 9430008B02Rik, SAST170, SAST
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56527
Homologene: 10543
Or5b116
Name: olfactory receptor family 5 subfamily B member 116
Synonyms: Olfr1471, GA_x6K02T2RE5P-3777626-3778570, MOR202-47_p, MOR202-38
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258231
Homologene: 79417
Stat5b
Name: signal transducer and activator of transcription 5B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20851
Homologene: 55718
Vmn2r45
Name: vomeronasal 2, receptor 45
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042810
Homologene: 113703
Mmp28
Name: matrix metallopeptidase 28 (epilysin)
Synonyms: epilysin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 118453
Homologene: 41559
Zfp526
Name: zinc finger protein 526
Synonyms: D030024H03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210172
Homologene: 18447
Tmem19
Name: transmembrane protein 19
Synonyms: 2810428F02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67226
VEGA: 10
Homologene: 10107
Ccpg1
Name: cell cycle progression 1
Synonyms: 1700030B06Rik, 9430028F23Rik, 1810073J13Rik, D9Ertd392e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72278
Homologene: 3487
Adgra2
Name: adhesion G protein-coupled receptor A2
Synonyms: Gpr124, 8430414O08Rik, Tem5, 9530074E10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78560
Homologene: 13112
Rspo4
Name: R-spondin 4
Synonyms: A930029K19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228770
Homologene: 65290
Pcdhga4
Name: protocadherin gamma subfamily A, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93712
HGNC: HGNC:8702
Homologene: 81866
Lyrm9
Name: LYR motif containing 9
Synonyms: 1810012P15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66274
Homologene: 47720
Krtap9-1
Name: keratin associated protein 9-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16705
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 62,783,521 bp
  • C to A, chromosome 1 at 75,529,464 bp
  • T to C, chromosome 1 at 136,471,576 bp
  • T to C, chromosome 1 at 136,516,025 bp
  • A to G, chromosome 1 at 156,397,453 bp
  • C to A, chromosome 1 at 188,983,046 bp
  • A to G, chromosome 2 at 35,170,580 bp
  • C to T, chromosome 2 at 104,257,629 bp
  • C to A, chromosome 2 at 151,869,826 bp
  • T to C, chromosome 3 at 28,045,009 bp
  • G to T, chromosome 3 at 37,079,802 bp
  • T to G, chromosome 3 at 94,762,634 bp
  • T to C, chromosome 3 at 102,949,615 bp
  • C to A, chromosome 3 at 153,938,613 bp
  • T to A, chromosome 4 at 100,967,047 bp
  • A to C, chromosome 5 at 151,561,864 bp
  • A to G, chromosome 6 at 23,002,257 bp
  • A to G, chromosome 6 at 30,090,300 bp
  • T to A, chromosome 6 at 92,068,478 bp
  • A to G, chromosome 6 at 106,353,723 bp
  • A to G, chromosome 6 at 117,171,503 bp
  • A to G, chromosome 7 at 8,483,410 bp
  • G to A, chromosome 7 at 25,221,435 bp
  • A to T, chromosome 7 at 114,554,589 bp
  • A to G, chromosome 8 at 10,007,078 bp
  • C to A, chromosome 8 at 22,579,057 bp
  • A to G, chromosome 8 at 27,117,412 bp
  • A to G, chromosome 8 at 84,913,318 bp
  • T to C, chromosome 8 at 93,106,603 bp
  • G to A, chromosome 8 at 126,456,493 bp
  • T to C, chromosome 9 at 57,796,497 bp
  • T to C, chromosome 9 at 73,015,505 bp
  • A to T, chromosome 10 at 94,843,836 bp
  • A to G, chromosome 10 at 115,343,703 bp
  • A to G, chromosome 10 at 121,619,091 bp
  • A to G, chromosome 11 at 69,736,174 bp
  • A to T, chromosome 11 at 78,838,141 bp
  • T to C, chromosome 11 at 83,443,926 bp
  • A to C, chromosome 11 at 99,873,530 bp
  • A to C, chromosome 11 at 100,783,775 bp
  • A to G, chromosome 12 at 65,126,794 bp
  • G to A, chromosome 13 at 38,184,018 bp
  • C to G, chromosome 14 at 51,413,046 bp
  • A to G, chromosome 14 at 61,207,071 bp
  • T to C, chromosome 15 at 101,528,391 bp
  • A to T, chromosome 16 at 66,731,471 bp
  • A to T, chromosome 17 at 84,429,196 bp
  • A to G, chromosome 18 at 37,686,628 bp
  • A to G, chromosome 18 at 65,623,490 bp
  • A to T, chromosome 19 at 13,445,587 bp
  • G to A, chromosome 19 at 47,015,661 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7882 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045934-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.