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Strain Name:
C57BL/6J-MtgxR7891Btlr/Mmmh
Stock Number:
045943-MU
Citation ID:
RRID:MMRRC_045943-MU
Other Names:
R7891 (G1)
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Zfp934
Name: zinc finger protein 934
Synonyms: 6720457D02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77117
VEGA: 13
Psmb1
Name: proteasome (prosome, macropain) subunit, beta type 1
Synonyms: Lmpc5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19170
VEGA: 17
HGNC: HGNC:9537
Homologene: 2087
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
R3hdm2
Name: R3H domain containing 2
Synonyms: 1300003K24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71750
Homologene: 8954
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, dynein heavy chain, retrograde transport, Dnec1, Loa, 9930018I23Rik, Dnchc1, Swl
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730455C01Rik, 9130215G10Rik, 5730555F13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Gprin3
Name: GPRIN family member 3
Synonyms: C030038J10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243385
Homologene: 52334
Mxi1
Name: MAX interactor 1, dimerization protein
Synonyms: Mad2, bHLHc11
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17859
VEGA: 19
HGNC: HGNC:7534
Homologene: 4351
Adam12
Name: ADAM metallopeptidase domain 12
Synonyms: Mltna, ADAM12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11489
HGNC: HGNC:190
Homologene: 74862
Cckbr
Name: cholecystokinin B receptor
Synonyms: CCK-B/gastrin receptor, CCK2/gastrin, CCK2R, CCKR-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12426
HGNC: HGNC:1571
Homologene: 7258
Susd1
Name: sushi domain containing 1
Synonyms: Gm12528
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 634731
Homologene: 11204
Chpf
Name: chondroitin polymerizing factor
Synonyms: 1700028N03Rik, D1Bwg1363e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74241
Homologene: 11574
Gask1b
Name: golgi associated kinase 1B
Synonyms: 2210419I08Rik, Ened, 1110032E23Rik, Fam198b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68659
Homologene: 9590
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Acsl3
Name: acyl-CoA synthetase long-chain family member 3
Synonyms: 2610510B12Rik, C85929, Facl3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74205
HGNC: HGNC:3570
Homologene: 3278
Arid3b
Name: AT-rich interaction domain 3B
Synonyms: Bdp, Dri2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56380
Homologene: 4721
Mphosph9
Name: M-phase phosphoprotein 9
Synonyms: 4930548D04Rik, MPP-9, MPP9, B930097C17Rik, 9630025B04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269702
HGNC: HGNC:7215
Homologene: 11256
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, ALS2CR17, A530083I02Rik, 2310076G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Fgfr4
Name: fibroblast growth factor receptor 4
Synonyms: Fgfr-4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14186
HGNC: HGNC:3691
Homologene: 20461
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: 3110001A05Rik, 1810064L21Rik, 3110027P15Rik, A230065J02Rik, Ugcgl2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66435
Homologene: 56875
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Rasef
Name: RAS and EF hand domain containing
Synonyms: RAB45
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242505
Homologene: 28424
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Miox
Name: myo-inositol oxygenase
Synonyms: RSOR, 0610009I10Rik, C85427, Aldrl6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56727
Homologene: 9732
Tnfrsf1b
Name: tumor necrosis factor receptor superfamily, member 1b
Synonyms: CD120b, TNF-R2, p75, p75 TNFR, Tnfr2, TNF-R75, TNF-R-II, TNFR80, TNFBR, TNFRII, TNF-alphaR2, TNFalpha-R2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21938
Homologene: 829
Ushbp1
Name: USH1 protein network component harmonin binding protein 1
Synonyms: MCC2, 2210404N08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234395
Homologene: 12914
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Vmn1r73
Name: vomeronasal 1 receptor 73
Synonyms: V1rg2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171237
Homologene: 103842
Abca9
Name: ATP-binding cassette, sub-family A member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Or4c100
Name: olfactory receptor family 4 subfamily C member 100
Synonyms: GA_x6K02T2Q125-50012960-50013871, MOR230-5, Olfr1186
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258523
Homologene: 110555
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Frmpd1
Name: FERM and PDZ domain containing 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666060
Homologene: 8939
Ccdc7b
Name: coiled-coil domain containing 7B
Synonyms: 1700008F21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75453
Homologene: 49919
Or13c25
Name: olfactory receptor family 13 subfamily C member 25
Synonyms: GA_x6K02T2N78B-7084885-7085844, MOR262-7, Olfr272
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258836
Homologene: 17409
Onecut2
Name: one cut domain, family member 2
Synonyms: OC-2, Oc2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225631
HGNC: HGNC:8139
Homologene: 113592
Slc39a10
Name: solute carrier family 39 (zinc transporter), member 10
Synonyms: 2900042E17Rik, Zip10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227059
Homologene: 34076
Gpx5
Name: glutathione peroxidase 5
Synonyms: Arep
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14780
HGNC: HGNC:4557
Homologene: 1155
Ttbk2
Name: tau tubulin kinase 2
Synonyms: TTK, B930008N24Rik, 2610507N02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140810
Homologene: 62795
Polrmt
Name: polymerase (RNA) mitochondrial (DNA directed)
Synonyms: 1110018N15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216151
HGNC: HGNC:9200
Homologene: 37996
Ptgis
Name: prostaglandin I2 (prostacyclin) synthase
Synonyms: Pgi2, Pgis, Cyp8a1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19223
HGNC: HGNC:9603
Homologene: 37374
Aif1
Name: allograft inflammatory factor 1
Synonyms: G1, Iba1, D17H6S50E
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11629
HGNC: HGNC:352
Homologene: 1226
Sema4c
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Synonyms: M-Sema F, Semaf, Semacl1, Semai, Semacl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20353
Homologene: 23047
Pou3f1
Name: POU domain, class 3, transcription factor 1
Synonyms: Scip, Tst-1, Test1, Otf6, Oct-6, Tst1, Oct6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18991
HGNC: HGNC:9214
Homologene: 20590
Ehd3
Name: EH-domain containing 3
Synonyms: Ehd2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57440
HGNC: HGNC:3244
Homologene: 81837
Acnat1
Name: acyl-coenzyme A amino acid N-acyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230161
Homologene: 28287
Adam3
Name: ADAM metallopeptidase domain 3
Synonyms: Taz83, tMDC, Cyrn1, ADAM3, Taz83
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Trhr2
Name: thyrotropin releasing hormone receptor 2
Synonyms: TRH-R2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170732
Homologene: 44052
Foxe1
Name: forkhead box E1
Synonyms: Titf2, thyroid transcription factor 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110805
HGNC: HGNC:3806
Homologene: 3291
Pou2af1
Name: POU domain, class 2, associating factor 1
Synonyms: OBF.1, BOB.1, OBF-1, Bob1, OCA-B, OCAB, Bob-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18985
VEGA: 9
HGNC: HGNC:9211
Homologene: 4543
Or7g22
Name: olfactory receptor family 7 subfamily G member 22
Synonyms: GA_x6K02T2PVTD-12873838-12874776, MOR152-2, Olfr837
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258558
HGNC: HGNC:8466
Homologene: 115507
Spata31d1a
Name: spermatogenesis associated 31 subfamily D, member 1A
Synonyms: 1700013B16Rik, Fam75d1a, Fam75d3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72219
VEGA: 13
Homologene: 122131
Or10ag54
Name: olfactory receptor family 10 subfamily AG member 54
Synonyms: MOR264-8P, GA_x6K02T2Q125-48753766-48754734, MOR264-21P, Olfr1116, Olfr1116-ps, Olfr1521-ps1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257875
Homologene: 134077
Gm21886
Name: predicted gene, 21886
Type: Gene
Species: Mouse
Chromosome: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 36,549,914 bp
  • C to T, chromosome 1 at 46,812,168 bp
  • T to C, chromosome 1 at 60,260,432 bp
  • T to C, chromosome 1 at 75,475,295 bp
  • C to T, chromosome 1 at 78,703,588 bp
  • T to C, chromosome 1 at 150,593,189 bp
  • A to T, chromosome 2 at 87,269,077 bp
  • G to A, chromosome 2 at 88,525,945 bp
  • A to G, chromosome 2 at 120,786,029 bp
  • T to G, chromosome 2 at 165,078,944 bp
  • T to C, chromosome 2 at 167,227,514 bp
  • G to A, chromosome 3 at 59,328,411 bp
  • G to A, chromosome 3 at 79,886,284 bp
  • A to G, chromosome 4 at 45,284,478 bp
  • G to A, chromosome 4 at 46,344,599 bp
  • G to A, chromosome 4 at 49,449,181 bp
  • C to T, chromosome 4 at 52,911,663 bp
  • T to C, chromosome 4 at 59,349,915 bp
  • G to A, chromosome 4 at 73,759,698 bp
  • T to C, chromosome 4 at 73,790,964 bp
  • G to A, chromosome 4 at 124,658,439 bp
  • T to C, chromosome 4 at 145,229,090 bp
  • G to A, chromosome 5 at 25,300,111 bp
  • T to C, chromosome 5 at 124,290,904 bp
  • T to C, chromosome 6 at 59,353,711 bp
  • G to A, chromosome 7 at 11,757,109 bp
  • T to A, chromosome 7 at 105,435,350 bp
  • A to T, chromosome 7 at 133,998,232 bp
  • T to A, chromosome 8 at 24,707,497 bp
  • T to G, chromosome 8 at 71,388,778 bp
  • C to A, chromosome 8 at 122,357,344 bp
  • T to A, chromosome 8 at 129,072,665 bp
  • T to C, chromosome 9 at 19,137,845 bp
  • G to T, chromosome 9 at 51,232,997 bp
  • A to G, chromosome 9 at 57,810,159 bp
  • C to G, chromosome 9 at 70,586,673 bp
  • A to G, chromosome 9 at 118,556,366 bp
  • A to G, chromosome 10 at 69,988,309 bp
  • A to T, chromosome 10 at 79,741,880 bp
  • A to G, chromosome 10 at 127,498,574 bp
  • T to C, chromosome 11 at 49,019,716 bp
  • A to G, chromosome 11 at 110,163,272 bp
  • A to G, chromosome 12 at 110,643,156 bp
  • C to A, chromosome 13 at 21,288,748 bp
  • A to G, chromosome 13 at 55,159,151 bp
  • A to G, chromosome 13 at 59,700,325 bp
  • A to C, chromosome 13 at 62,520,189 bp
  • T to A, chromosome 14 at 119,042,647 bp
  • A to C, chromosome 15 at 89,336,539 bp
  • G to A, chromosome 15 at 90,956,314 bp
  • A to G, chromosome 16 at 37,027,882 bp
  • C to T, chromosome 17 at 15,494,486 bp
  • A to G, chromosome 17 at 30,712,289 bp
  • G to A, chromosome 17 at 35,172,624 bp
  • A to G, chromosome 17 at 73,816,392 bp
  • T to A, chromosome 18 at 64,340,975 bp
  • T to G, chromosome 18 at 80,089,757 bp
  • A to T, chromosome 19 at 18,776,710 bp
  • T to A, chromosome 19 at 53,310,761 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7891 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045943-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.