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Strain Name:
C57BL/6J-MtgxR7915Btlr/Mmmh
Stock Number:
045963-MU
Citation ID:
RRID:MMRRC_045963-MU
Other Names:
R7915 (G1)
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Drd1
Name: dopamine receptor D1
Synonyms: D1 receptor, Gpcr15, Drd-1, C030036C15Rik, Drd1a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13488
VEGA: 13
HGNC: HGNC:3020
Homologene: 30992
Plxnd1
Name: plexin D1
Synonyms: 6230425C21Rik, b2b553Clo, b2b1863Clo
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67784
HGNC: HGNC:9107
Homologene: 22866
Ptpn12
Name: protein tyrosine phosphatase, non-receptor type 12
Synonyms: P19-PTP, PTP-PEST, PTP-P19
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19248
HGNC: HGNC:9645
Homologene: 37691
Mapk14
Name: mitogen-activated protein kinase 14
Synonyms: p38-alpha, p38, p38 MAP Kinase, Mxi2, CSBP2, Crk1, Csbp1, p38MAPK, p38a, p38 alpha, p38alpha, p38 MAP kinase alpha, p38 MAPK
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26416
HGNC: HGNC:6876
Homologene: 31777
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 52,151,281 bp
  • T to C, chromosome 1 at 93,213,641 bp
  • T to A, chromosome 1 at 104,934,173 bp
  • A to C, chromosome 1 at 162,692,408 bp
  • T to A, chromosome 2 at 76,737,195 bp
  • T to A, chromosome 2 at 86,638,766 bp
  • T to A, chromosome 2 at 114,050,486 bp
  • G to A, chromosome 2 at 129,207,837 bp
  • A to G, chromosome 2 at 166,621,192 bp
  • A to G, chromosome 3 at 57,575,599 bp
  • A to C, chromosome 3 at 72,921,138 bp
  • A to T, chromosome 3 at 90,432,825 bp
  • T to A, chromosome 4 at 6,822,949 bp
  • T to A, chromosome 4 at 96,591,384 bp
  • A to C, chromosome 4 at 108,848,246 bp
  • G to T, chromosome 4 at 108,848,247 bp
  • T to A, chromosome 4 at 120,097,765 bp
  • T to C, chromosome 4 at 143,655,745 bp
  • T to C, chromosome 4 at 145,086,819 bp
  • A to G, chromosome 5 at 16,827,014 bp
  • A to G, chromosome 5 at 21,009,451 bp
  • T to C, chromosome 5 at 37,386,862 bp
  • T to A, chromosome 5 at 38,266,531 bp
  • A to T, chromosome 5 at 44,004,935 bp
  • A to G, chromosome 5 at 140,741,435 bp
  • T to TCCA, chromosome 6 at 4,756,451 bp
  • A to T, chromosome 6 at 57,323,395 bp
  • C to A, chromosome 6 at 94,630,101 bp
  • T to C, chromosome 6 at 115,966,918 bp
  • T to C, chromosome 7 at 15,988,522 bp
  • T to C, chromosome 7 at 24,333,688 bp
  • G to A, chromosome 7 at 30,523,223 bp
  • G to A, chromosome 7 at 90,244,082 bp
  • T to A, chromosome 7 at 128,265,794 bp
  • C to A, chromosome 7 at 128,667,709 bp
  • T to C, chromosome 8 at 11,678,645 bp
  • C to A, chromosome 8 at 45,341,243 bp
  • A to C, chromosome 8 at 81,001,083 bp
  • T to C, chromosome 8 at 104,447,216 bp
  • A to G, chromosome 8 at 105,842,781 bp
  • T to C, chromosome 8 at 124,741,156 bp
  • A to T, chromosome 9 at 38,581,673 bp
  • G to A, chromosome 9 at 58,823,935 bp
  • A to T, chromosome 9 at 58,930,981 bp
  • G to T, chromosome 9 at 70,587,149 bp
  • A to G, chromosome 9 at 114,516,055 bp
  • A to T, chromosome 10 at 12,465,212 bp
  • A to G, chromosome 10 at 60,307,889 bp
  • A to G, chromosome 10 at 79,017,430 bp
  • A to T, chromosome 11 at 84,276,588 bp
  • A to G, chromosome 12 at 110,280,039 bp
  • T to C, chromosome 13 at 19,752,559 bp
  • G to T, chromosome 13 at 54,053,815 bp
  • T to C, chromosome 13 at 59,784,814 bp
  • A to G, chromosome 14 at 12,705,544 bp
  • T to C, chromosome 14 at 55,700,426 bp
  • C to T, chromosome 15 at 82,404,427 bp
  • A to T, chromosome 15 at 101,558,403 bp
  • A to G, chromosome 16 at 17,859,402 bp
  • C to A, chromosome 17 at 15,368,428 bp
  • A to T, chromosome 17 at 19,067,231 bp
  • T to G, chromosome 17 at 24,265,533 bp
  • T to A, chromosome 17 at 24,592,656 bp
  • A to G, chromosome 17 at 28,728,954 bp
  • T to C, chromosome 17 at 35,664,839 bp
  • A to T, chromosome 18 at 57,240,735 bp
  • A to G, chromosome 19 at 7,457,500 bp
  • G to A, chromosome 19 at 8,707,818 bp
  • A to G, chromosome 19 at 29,812,673 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7915 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045963-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.