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Strain Name:
C57BL/6J-MtgxR7924Btlr/Mmmh
Stock Number:
045971-MU
Citation ID:
RRID:MMRRC_045971-MU
Other Names:
R7924 (G1)
Major Collection:

Strain Information

Adipor1
Name: adiponectin receptor 1
Synonyms: 2810031L11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72674
Homologene: 69199
Dlc1
Name: deleted in liver cancer 1
Synonyms: p122-RhoGAP, STARD12, Arhgap7, A730069N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Mtmr7
Name: myotubularin related protein 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54384
HGNC: HGNC:7454
Homologene: 99732
Cilk1
Name: ciliogenesis associated kinase 1
Synonyms: 2210420N10Rik, Ick
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56542
Homologene: 69218
Bbx
Name: bobby sox HMG box containing
Synonyms: 5730403O13Rik, 5530401J07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70508
Homologene: 10634
Pard3
Name: par-3 family cell polarity regulator
Synonyms: ASIP, D8Ertd580e, PAR-3, Par3, Pard3a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93742
Homologene: 10489
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 2410104C19Rik, 9530048I21Rik, 3010027A04Rik, Yod
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77087
Homologene: 69134
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 46,219,430 bp
  • C to G, chromosome 1 at 85,577,214 bp
  • A to G, chromosome 1 at 107,273,174 bp
  • T to A, chromosome 1 at 134,425,993 bp
  • T to C, chromosome 1 at 160,196,989 bp
  • T to C, chromosome 2 at 76,809,850 bp
  • T to C, chromosome 2 at 85,414,219 bp
  • T to C, chromosome 2 at 120,289,164 bp
  • T to C, chromosome 2 at 129,015,480 bp
  • A to T, chromosome 2 at 135,359,693 bp
  • C to T, chromosome 2 at 152,962,487 bp
  • G to A, chromosome 2 at 173,113,656 bp
  • T to C, chromosome 3 at 87,259,533 bp
  • T to A, chromosome 4 at 34,728,833 bp
  • C to T, chromosome 4 at 73,740,929 bp
  • T to C, chromosome 4 at 119,282,279 bp
  • T to G, chromosome 4 at 139,467,276 bp
  • T to C, chromosome 5 at 33,410,951 bp
  • T to C, chromosome 5 at 44,029,769 bp
  • A to G, chromosome 5 at 84,084,846 bp
  • A to G, chromosome 5 at 106,457,649 bp
  • A to T, chromosome 5 at 109,286,388 bp
  • A to G, chromosome 5 at 114,245,220 bp
  • A to G, chromosome 5 at 137,768,011 bp
  • A to G, chromosome 5 at 143,174,486 bp
  • T to A, chromosome 6 at 25,753,310 bp
  • A to T, chromosome 6 at 136,763,055 bp
  • C to T, chromosome 7 at 24,542,125 bp
  • G to A, chromosome 7 at 73,966,952 bp
  • A to T, chromosome 7 at 83,943,715 bp
  • A to G, chromosome 7 at 86,394,730 bp
  • G to T, chromosome 7 at 87,374,381 bp
  • G to GACGGCCGCC, chromosome 7 at 97,579,909 bp
  • T to A, chromosome 7 at 105,407,821 bp
  • G to T, chromosome 7 at 141,695,388 bp
  • T to C, chromosome 7 at 143,569,871 bp
  • T to C, chromosome 8 at 25,809,855 bp
  • T to C, chromosome 8 at 36,571,416 bp
  • G to A, chromosome 8 at 40,606,884 bp
  • C to T, chromosome 8 at 45,795,470 bp
  • G to A, chromosome 8 at 83,729,400 bp
  • ACG to A, chromosome 8 at 95,745,647 bp
  • T to G, chromosome 8 at 110,418,471 bp
  • T to C, chromosome 8 at 122,569,352 bp
  • T to C, chromosome 8 at 122,895,902 bp
  • T to A, chromosome 8 at 124,663,312 bp
  • A to G, chromosome 8 at 127,410,750 bp
  • T to C, chromosome 9 at 15,999,297 bp
  • A to G, chromosome 9 at 54,922,240 bp
  • A to T, chromosome 9 at 62,273,451 bp
  • A to T, chromosome 9 at 73,734,408 bp
  • T to C, chromosome 9 at 78,155,464 bp
  • T to C, chromosome 10 at 115,833,324 bp
  • G to A, chromosome 11 at 54,055,222 bp
  • G to A, chromosome 11 at 55,262,787 bp
  • C to G, chromosome 11 at 59,112,555 bp
  • A to G, chromosome 11 at 87,794,840 bp
  • T to C, chromosome 11 at 115,615,550 bp
  • T to C, chromosome 12 at 87,270,456 bp
  • T to A, chromosome 12 at 101,520,565 bp
  • A to G, chromosome 12 at 116,841,264 bp
  • A to T, chromosome 13 at 3,594,331 bp
  • C to A, chromosome 13 at 14,322,528 bp
  • A to T, chromosome 13 at 22,008,664 bp
  • G to A, chromosome 13 at 34,993,070 bp
  • A to T, chromosome 13 at 40,918,564 bp
  • A to T, chromosome 13 at 119,386,645 bp
  • A to T, chromosome 15 at 55,082,176 bp
  • C to A, chromosome 15 at 81,649,502 bp
  • A to G, chromosome 15 at 102,118,327 bp
  • A to G, chromosome 16 at 18,823,285 bp
  • G to A, chromosome 16 at 38,812,464 bp
  • A to T, chromosome 16 at 50,224,308 bp
  • T to A, chromosome 17 at 43,627,806 bp
  • T to C, chromosome 17 at 47,378,283 bp
  • G to T, chromosome 17 at 50,047,380 bp
  • G to A, chromosome 18 at 22,525,545 bp
  • A to T, chromosome 19 at 53,677,585 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7924 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045971-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.