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Strain Name:
C57BL/6J-MtgxR7938Btlr/Mmmh
Stock Number:
045984-MU
Citation ID:
RRID:MMRRC_045984-MU
Other Names:
R7938 (G1)
Major Collection:

Strain Information

Hapln1
Name: hyaluronan and proteoglycan link protein 1
Synonyms: link protein, cartilage linking protein 1, Crtl1l, Crtl1, CLP, LP-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12950
VEGA: 13
HGNC: HGNC:2380
Homologene: 1420
Bmp7
Name: bone morphogenetic protein 7
Synonyms: osteogenic protein 1, OP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12162
HGNC: HGNC:1074
Homologene: 20410
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94187
Homologene: 9010
Rpa1
Name: replication protein A1
Synonyms: Rpa, RF-A, RP-A, 5031405K23Rik, 70kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68275
Homologene: 2208
Katna1
Name: katanin p60 (ATPase-containing) subunit A1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23924
HGNC: HGNC:6216
Homologene: 56014
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: 4930502N04Rik, A630020C16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74996
Homologene: 9929
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: nonmuscle myosin heavy chain II-B, NMHC-B, SMemb, nonmuscle myosin heavy chain IIB, 9330167F11Rik, 5730504C04Rik, NMHC II-B, Myhn2, Myosin IIB, Myhn-2, myosin IIB, Fltn, Fltn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 84,695,497 bp
  • A to G, chromosome 1 at 132,605,531 bp
  • A to T, chromosome 1 at 133,680,158 bp
  • T to G, chromosome 1 at 184,731,928 bp
  • A to T, chromosome 2 at 36,057,070 bp
  • A to T, chromosome 2 at 48,910,191 bp
  • A to T, chromosome 2 at 90,118,829 bp
  • G to T, chromosome 2 at 91,965,472 bp
  • A to C, chromosome 2 at 104,788,967 bp
  • A to G, chromosome 2 at 146,045,456 bp
  • A to T, chromosome 2 at 164,255,647 bp
  • A to C, chromosome 2 at 172,879,490 bp
  • C to A, chromosome 3 at 108,080,116 bp
  • A to G, chromosome 4 at 42,850,765 bp
  • A to G, chromosome 4 at 119,470,613 bp
  • G to A, chromosome 4 at 148,944,486 bp
  • A to C, chromosome 5 at 21,950,872 bp
  • A to G, chromosome 5 at 38,230,951 bp
  • T to C, chromosome 5 at 72,604,254 bp
  • T to A, chromosome 5 at 145,452,856 bp
  • T to A, chromosome 5 at 146,583,284 bp
  • G to T, chromosome 6 at 41,698,376 bp
  • T to C, chromosome 6 at 96,164,885 bp
  • T to C, chromosome 7 at 10,159,373 bp
  • T to G, chromosome 7 at 19,756,813 bp
  • T to C, chromosome 7 at 36,769,158 bp
  • T to C, chromosome 7 at 48,482,492 bp
  • T to A, chromosome 7 at 112,087,925 bp
  • T to A, chromosome 8 at 27,581,962 bp
  • A to G, chromosome 8 at 33,621,684 bp
  • G to T, chromosome 8 at 75,577,968 bp
  • T to C, chromosome 8 at 87,895,676 bp
  • T to C, chromosome 8 at 112,012,085 bp
  • T to A, chromosome 9 at 49,071,633 bp
  • T to G, chromosome 9 at 57,701,790 bp
  • A to G, chromosome 9 at 65,594,791 bp
  • C to T, chromosome 9 at 92,490,790 bp
  • A to C, chromosome 9 at 105,780,684 bp
  • A to G, chromosome 9 at 110,851,432 bp
  • A to G, chromosome 9 at 111,365,028 bp
  • G to T, chromosome 10 at 7,761,311 bp
  • C to T, chromosome 10 at 45,686,696 bp
  • T to A, chromosome 10 at 105,841,594 bp
  • A to G, chromosome 10 at 106,474,787 bp
  • T to C, chromosome 11 at 55,273,096 bp
  • T to A, chromosome 11 at 68,692,501 bp
  • CA to C, chromosome 11 at 75,307,224 bp
  • T to C, chromosome 11 at 75,448,002 bp
  • A to G, chromosome 11 at 87,147,037 bp
  • T to A, chromosome 12 at 51,596,583 bp
  • A to T, chromosome 12 at 76,438,406 bp
  • A to T, chromosome 12 at 112,031,215 bp
  • A to G, chromosome 13 at 30,231,976 bp
  • G to T, chromosome 13 at 46,689,379 bp
  • G to A, chromosome 13 at 89,605,228 bp
  • T to C, chromosome 14 at 33,538,289 bp
  • T to G, chromosome 14 at 53,470,231 bp
  • T to C, chromosome 14 at 99,299,008 bp
  • T to A, chromosome 14 at 119,059,107 bp
  • C to A, chromosome 15 at 59,324,466 bp
  • T to A, chromosome 15 at 82,172,815 bp
  • A to T, chromosome 16 at 59,035,962 bp
  • G to T, chromosome 17 at 7,946,218 bp
  • T to A, chromosome 17 at 37,280,100 bp
  • T to A, chromosome 17 at 48,351,749 bp
  • T to A, chromosome 19 at 17,466,185 bp
  • A to T, chromosome 19 at 45,794,290 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7938 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045984-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.