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Strain Name:
C57BL/6J-MtgxR7942Btlr/Mmmh
Stock Number:
045988-MU
Citation ID:
RRID:MMRRC_045988-MU
Other Names:
R7942 (G1)
Major Collection:

Strain Information

Ptch2
Name: patched 2
Synonyms: ptc2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19207
HGNC: HGNC:9586
Homologene: 37842
Lgals8
Name: lectin, galactose binding, soluble 8
Synonyms: Lgals-8, 1200015E08Rik, D13Ertd524e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56048
HGNC: HGNC:6569
Homologene: 31386
Eps8
Name: epidermal growth factor receptor pathway substrate 8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13860
HGNC: HGNC:3420
Homologene: 3272
Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms: Autotaxin, Npps2, PD-Ialpha, Pdnp2, ATX
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18606
HGNC: HGNC:3357
Homologene: 4526
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: 6230412P20Rik, Elys
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226747
Homologene: 9142
Akap13
Name: A kinase anchor protein 13
Synonyms: AKAP-Lbc, PROTO-LBC, PROTO-LB, Ht31, 5730522G15Rik, 1700026G02Rik, 5830460E08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Mms19
Name: MMS19 cytosolic iron-sulfur assembly component
Synonyms: Mms19, 2610042O15Rik, C86341, Mms19l
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72199
Homologene: 41480
Zfp407
Name: zinc finger protein 407
Synonyms: LOC240469, LOC381139, 6430585N13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240476
Homologene: 86402
Atp13a1
Name: ATPase type 13A1
Synonyms: catp, Cgi152, Atp13a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170759
VEGA: 8
Homologene: 5791
Glyr1
Name: glyoxylate reductase 1 homolog (Arabidopsis)
Synonyms: Npac, 2810419J22Rik, 3930401K13Rik, NDF
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74022
VEGA: 16
Homologene: 12525
Unc5b
Name: unc-5 netrin receptor B
Synonyms: 6330415E02Rik, Unc5h2, D10Bwg0792e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 107449
VEGA: 10
Homologene: 32538
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12032
Homologene: 7244
Ampd2
Name: adenosine monophosphate deaminase 2
Synonyms: Ampd-2, 1200014F01Rik, m4521Dajl
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109674
HGNC: HGNC:469
Homologene: 2979
Gna15
Name: guanine nucleotide binding protein, alpha 15
Synonyms: Galpha15, G[a]15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14676
HGNC: HGNC:4383
Homologene: 1563
Zfp57
Name: zinc finger protein 57
Synonyms: G19
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22715
Homologene: 7603
Tpcn2
Name: two pore segment channel 2
Synonyms: D830047E22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233979
Homologene: 16375
Marchf11
Name: membrane associated ring-CH-type finger 11
Synonyms: March11
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211147
Homologene: 45584
Tspan18
Name: tetraspanin 18
Synonyms: 2610042G18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241556
Homologene: 24122
Tek
Name: TEK receptor tyrosine kinase
Synonyms: Hyk, Tie2, Cd202b, tie-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21687
Homologene: 397
Slc35d1
Name: solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
Synonyms: UGTREL7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242585
Homologene: 22870
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Tet3
Name: tet methylcytosine dioxygenase 3
Synonyms: D230004J03Rik, B430006D22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194388
Homologene: 35360
Fam184b
Name: family with sequence similarity 184, member B
Synonyms: 9630031F12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58227
Homologene: 137353
Cldnd1
Name: claudin domain containing 1
Synonyms: 1110019C08Rik, Cldn25
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224250
HGNC: HGNC:1322
Homologene: 10534
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213043
Homologene: 84622
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Marlin-1, 5830437M04Rik, C330021K24Rik, Gababrbp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76071
Homologene: 90789
Krt71
Name: keratin 71
Synonyms: mK6irs, Cu, mK6irs1, Ca, Krt2-6g, Cal4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56735
Homologene: 88864
Fsip1
Name: fibrous sheath-interacting protein 1
Synonyms: 4933432K11Rik, 1700012M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71313
Homologene: 12390
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Tdpoz1
Name: TD and POZ domain containing 1
Synonyms: 2cpoz56, Spopl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 207213
Homologene: 128308
Spag16
Name: sperm associated antigen 16
Synonyms: Pf20, 4930524F24Rik, 4930585K05Rik, Wdr29, 4921511D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66722
Homologene: 11572
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: LOC268884, 5530401I02Rik, 9530025L16Rik, 4632417D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77446
Homologene: 35276
Abcg3
Name: ATP binding cassette subfamily G member 3
Synonyms: Mxr2, Abcp2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27405
HGNC: HGNC:74
Homologene: 86845
Ano9
Name: anoctamin 9
Synonyms: 5430425C04Rik, Tp53i5, Trp53i5, Tmem16j
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71345
Homologene: 67083
Wdsub1
Name: WD repeat, SAM and U-box domain containing 1
Synonyms: 1700048E19Rik, 2610014F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72137
Homologene: 17609
Mctp1
Name: multiple C2 domains, transmembrane 1
Synonyms: 2810465F10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78771
Homologene: 75211
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Synonyms: small heterodimer partner, SHP-1, SHP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 23957
HGNC: HGNC:7961
Homologene: 8030
Slc41a1
Name: solute carrier family 41, member 1
Synonyms: B230315F01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98396
Homologene: 14871
Slc5a7
Name: solute carrier family 5 (choline transporter), member 7
Synonyms: CHT1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 63993
VEGA: 17
Homologene: 32516
Vmn2r95
Name: vomeronasal 2, receptor 95
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328759
Homologene: 115024
Spaca7b
Name: sperm acrosome associated 7B
Synonyms: GC14, 1700016D06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76413
Trcg1
Name: taste receptor cell gene 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 541610
Homologene: 134171
Adamts8
Name: ADAM metallopeptidase with thrombospondin type 1 motif 8
Synonyms: METH2, METH-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30806
HGNC: HGNC:224
Homologene: 5108
Polr3gl
Name: polymerase (RNA) III (DNA directed) polypeptide G like
Synonyms: 2010003I19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69870
Homologene: 41712
Speer4f2
Name: spermatogenesis associated glutamate (E)-rich protein 4f2
Synonyms: Gm3535, Gm3495
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041749
Or3a4
Name: olfactory receptor family 3 subfamily A member 4
Synonyms: GA_x6K02T2P1NL-4211516-4210581, MOR255-1, Olfr399
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259006
Homologene: 27325
Or8k32
Name: olfactory receptor family 8 subfamily K member 32
Synonyms: GA_x6K02T2Q125-48024195-48023254, MOR189-1, Olfr1079
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258402
Homologene: 74090
Hoxd1
Name: homeobox D1
Synonyms: Hox-4.9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15429
HGNC: HGNC:5132
Homologene: 7772
Nudt16l1
Name: nudix hydrolase 16 like 1
Synonyms: 5330437I08Rik, 1110001K21Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1, syndesmos
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66911
VEGA: 16
Homologene: 12053
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,337,431 bp
  • G to T, chromosome 1 at 69,827,088 bp
  • G to A, chromosome 1 at 131,840,897 bp
  • A to C, chromosome 1 at 179,786,095 bp
  • G to A, chromosome 2 at 59,876,717 bp
  • A to G, chromosome 2 at 74,764,160 bp
  • T to C, chromosome 2 at 86,538,222 bp
  • A to G, chromosome 2 at 93,210,858 bp
  • G to A, chromosome 2 at 118,136,611 bp
  • A to C, chromosome 2 at 125,412,786 bp
  • A to G, chromosome 3 at 87,993,075 bp
  • T to C, chromosome 3 at 93,671,210 bp
  • A to T, chromosome 3 at 96,582,236 bp
  • C to A, chromosome 3 at 108,080,116 bp
  • C to T, chromosome 4 at 94,851,874 bp
  • A to G, chromosome 4 at 103,213,163 bp
  • T to A, chromosome 4 at 117,106,001 bp
  • C to T, chromosome 4 at 118,614,931 bp
  • T to C, chromosome 4 at 133,553,536 bp
  • T to A, chromosome 5 at 17,377,632 bp
  • C to A, chromosome 5 at 37,173,838 bp
  • T to C, chromosome 5 at 45,584,253 bp
  • A to G, chromosome 5 at 104,939,161 bp
  • A to G, chromosome 6 at 48,488,500 bp
  • C to T, chromosome 6 at 83,376,974 bp
  • G to T, chromosome 6 at 113,466,150 bp
  • T to A, chromosome 6 at 137,530,577 bp
  • A to G, chromosome 7 at 75,611,470 bp
  • T to C, chromosome 7 at 141,104,076 bp
  • C to T, chromosome 7 at 145,257,191 bp
  • A to G, chromosome 8 at 11,655,615 bp
  • G to A, chromosome 8 at 35,771,786 bp
  • A to G, chromosome 8 at 69,807,220 bp
  • G to A, chromosome 9 at 30,953,482 bp
  • G to A, chromosome 9 at 30,958,913 bp
  • T to C, chromosome 9 at 57,242,216 bp
  • A to T, chromosome 10 at 60,777,543 bp
  • G to A, chromosome 10 at 81,523,911 bp
  • A to G, chromosome 11 at 74,054,228 bp
  • A to G, chromosome 13 at 12,453,256 bp
  • A to T, chromosome 13 at 76,641,710 bp
  • A to T, chromosome 14 at 103,155,238 bp
  • A to G, chromosome 15 at 26,409,419 bp
  • A to T, chromosome 15 at 54,845,879 bp
  • T to C, chromosome 15 at 101,735,459 bp
  • T to A, chromosome 16 at 4,939,379 bp
  • T to C, chromosome 16 at 5,018,921 bp
  • T to C, chromosome 16 at 33,751,200 bp
  • A to T, chromosome 16 at 58,729,715 bp
  • T to A, chromosome 17 at 18,440,267 bp
  • T to C, chromosome 17 at 37,009,674 bp
  • T to C, chromosome 17 at 54,276,681 bp
  • A to T, chromosome 18 at 32,013,369 bp
  • A to G, chromosome 18 at 84,559,629 bp
  • C to A, chromosome 19 at 41,955,961 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7942 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045988-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.