Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7943Btlr/Mmmh
Stock Number:
045989-MU
Citation ID:
RRID:MMRRC_045989-MU
Other Names:
R7943 (G1)
Major Collection:

Strain Information

Cd4
Name: CD4 antigen
Synonyms: L3T4, Ly-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12504
HGNC: HGNC:1678
Homologene: 513
Zfp143
Name: zinc finger protein 143
Synonyms: D7Ertd805e, pHZ-1, KRAB14, Zfp79, Zfp80-rs1, Staf
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20841
Homologene: 56444
Ptpa
Name: protein phosphatase 2 protein activator
Synonyms: 2610042B21Rik, Ppp2r4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110854
HGNC: HGNC:9308
Homologene: 6149
Anks1
Name: ankyrin repeat and SAM domain containing 1
Synonyms: Odin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224650
Homologene: 9068
Prkd2
Name: protein kinase D2
Synonyms: PKD2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101540
Homologene: 9516
Cry1
Name: cryptochrome circadian regulator 1
Synonyms: Phll1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12952
VEGA: 10
HGNC: HGNC:2384
Homologene: 7042
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 80,648,289 bp
  • A to T, chromosome 1 at 157,554,757 bp
  • T to A, chromosome 2 at 30,432,044 bp
  • A to G, chromosome 2 at 85,951,998 bp
  • A to G, chromosome 2 at 118,119,617 bp
  • C to T, chromosome 3 at 32,876,940 bp
  • A to G, chromosome 3 at 62,530,711 bp
  • T to C, chromosome 3 at 65,956,905 bp
  • A to C, chromosome 3 at 89,141,507 bp
  • A to T, chromosome 3 at 93,692,763 bp
  • C to T, chromosome 4 at 63,318,283 bp
  • C to T, chromosome 4 at 96,659,612 bp
  • T to C, chromosome 4 at 120,132,357 bp
  • T to G, chromosome 4 at 134,072,984 bp
  • T to A, chromosome 4 at 156,218,534 bp
  • C to T, chromosome 5 at 8,686,222 bp
  • A to T, chromosome 5 at 77,010,548 bp
  • A to T, chromosome 5 at 88,488,551 bp
  • G to A, chromosome 6 at 17,844,912 bp
  • T to C, chromosome 6 at 57,524,828 bp
  • C to T, chromosome 6 at 124,870,244 bp
  • G to A, chromosome 7 at 16,850,319 bp
  • A to T, chromosome 7 at 17,745,566 bp
  • A to T, chromosome 7 at 45,308,681 bp
  • G to A, chromosome 7 at 102,194,822 bp
  • G to A, chromosome 7 at 103,097,946 bp
  • T to A, chromosome 7 at 110,072,474 bp
  • A to T, chromosome 8 at 4,748,812 bp
  • C to A, chromosome 8 at 22,175,074 bp
  • G to T, chromosome 8 at 71,890,089 bp
  • A to G, chromosome 8 at 109,575,555 bp
  • A to G, chromosome 9 at 44,849,140 bp
  • A to T, chromosome 9 at 49,470,320 bp
  • T to C, chromosome 9 at 54,622,737 bp
  • C to T, chromosome 9 at 88,582,185 bp
  • A to G, chromosome 9 at 121,799,130 bp
  • T to C, chromosome 10 at 7,457,053 bp
  • C to A, chromosome 10 at 53,633,706 bp
  • C to T, chromosome 10 at 53,647,041 bp
  • A to G, chromosome 10 at 79,396,245 bp
  • T to A, chromosome 10 at 80,675,867 bp
  • A to T, chromosome 10 at 85,143,120 bp
  • T to A, chromosome 10 at 129,012,065 bp
  • T to C, chromosome 11 at 4,166,537 bp
  • A to G, chromosome 11 at 54,502,388 bp
  • A to T, chromosome 11 at 62,850,661 bp
  • A to G, chromosome 11 at 86,278,526 bp
  • A to T, chromosome 11 at 98,390,401 bp
  • T to A, chromosome 11 at 121,147,160 bp
  • C to T, chromosome 12 at 87,517,003 bp
  • T to A, chromosome 12 at 103,693,690 bp
  • G to T, chromosome 12 at 113,330,337 bp
  • A to G, chromosome 13 at 55,669,722 bp
  • T to A, chromosome 14 at 26,945,568 bp
  • T to C, chromosome 14 at 118,861,859 bp
  • A to G, chromosome 15 at 9,601,085 bp
  • A to C, chromosome 15 at 89,474,089 bp
  • C to T, chromosome 16 at 5,088,861 bp
  • A to G, chromosome 16 at 17,650,552 bp
  • A to G, chromosome 16 at 21,477,872 bp
  • T to A, chromosome 16 at 32,630,221 bp
  • A to G, chromosome 17 at 17,712,304 bp
  • T to A, chromosome 17 at 27,985,204 bp
  • A to G, chromosome 17 at 34,872,378 bp
  • G to T, chromosome 17 at 50,047,380 bp
  • A to G, chromosome 18 at 4,672,700 bp
  • T to C, chromosome 18 at 10,112,357 bp
  • C to T, chromosome 18 at 37,722,010 bp
  • A to T, chromosome 19 at 13,815,236 bp
  • C to A, chromosome 19 at 46,324,730 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7943 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045989-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.