Strain Name:
C57BL/6J-MtgxR7944Btlr/Mmmh
Stock Number:
045990-MU
Citation ID:
RRID:MMRRC_045990-MU
Other Names:
R7944 (G1)
Major Collection:

Strain Information

Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Cltc
Name: clathrin heavy chain
Synonyms: CHC
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Dlgap4
Name: DLG associated protein 4
Synonyms: WBP16, SAP90/PSD-95-associated protein 4, PSD-95/SAP90 binding protein 4, Sapap4, DAP4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228836
Homologene: 8935
Ano6
Name: anoctamin 6
Synonyms: 2900059G15Rik, F730003B03Rik, Tmem16f
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107182
Homologene: 31978
Wapl
Name: WAPL cohesin release factor
Synonyms: A530089A20Rik, Wapal
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218914
Homologene: 41002
Fbxo21
Name: F-box protein 21
Synonyms: 2810425J22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231670
Homologene: 14145
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109135
Homologene: 10377
Hmx3
Name: H6 homeobox 3
Synonyms: Nkx5-1, Nkx5.1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15373
HGNC: HGNC:5019
Homologene: 40612
Panx1
Name: pannexin 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 55991
HGNC: HGNC:8599
Homologene: 49416
Trappc3
Name: trafficking protein particle complex 3
Synonyms: 1110058K12Rik, Bet3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27096
Homologene: 6399
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Clec1a
Name: C-type lectin domain family 1, member a
Synonyms: 5930406N14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243653
Homologene: 9549
Casp8ap2
Name: caspase 8 associated protein 2
Synonyms: D4Ertd659e, FLASH
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26885
HGNC: HGNC:1510
Homologene: 8066
Mtmr4
Name: myotubularin related protein 4
Synonyms: ESTM44, FYVE-DSP2, FYVE zinc finger phosphatase, ZFYVE11
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170749
HGNC: HGNC:7452
Homologene: 3440
Armh4
Name: armadillo-like helical domain containing 4
Synonyms: 3632451O06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67419
Homologene: 12127
Pkd2l2
Name: polycystic kidney disease 2-like 2
Synonyms: Polycystin - L2, TRPP5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53871
VEGA: 18
HGNC: HGNC:9012
Homologene: 22812
Ttn
Name: titin
Synonyms: connectin, L56, 1100001C23Rik, mdm, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: DRAG1, E030006K04Rik, Centd3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106952
VEGA: 18
Homologene: 11199
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Slc1a5
Name: solute carrier family 1 (neutral amino acid transporter), member 5
Synonyms: ASCT2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20514
Homologene: 21155
Pdzph1
Name: PDZ and pleckstrin homology domains 1
Synonyms: 2610034M16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69239
Homologene: 130756
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, 9430031G15Rik, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Serpinb6e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6e
Synonyms: ovalbumin, SPI3B, Gm11396
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 435350
HGNC: HGNC:8950
Homologene: 50933
Mrgprx2
Name: MAS-related GPR, member X2
Synonyms: MrgB10, Mrgprb10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243978
Homologene: 24986
Ephb3
Name: Eph receptor B3
Synonyms: Sek4, MDK5, HEK2, Etk2, Tyro6, Cek10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13845
HGNC: HGNC:3394
Homologene: 20938
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Treh
Name: trehalase (brush-border membrane glycoprotein)
Synonyms: 2210412M19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 58866
Homologene: 5198
Serpinb1a
Name: serine (or cysteine) peptidase inhibitor, clade B, member 1a
Synonyms: LEI, 1190005M04Rik, ovalbumin, ELANH2, M/NEI, MNEI, EIA
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66222
HGNC: HGNC:3311
Homologene: 133768
Slc7a6
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
Synonyms: LAT-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330836
Homologene: 62496
Rtn2
Name: reticulon 2 (Z-band associated protein)
Synonyms: Nspl1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20167
Homologene: 32180
Golgb1
Name: golgin B1
Synonyms: Giantin, C130074L01Rik, F730017E11Rik, 6330407A06Rik, Gm6840
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Mrto4
Name: mRNA turnover 4, ribosome maturation factor
Synonyms: 2610012O22Rik, Mrt4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69902
Homologene: 6379
Nup210
Name: nucleoporin 210
Synonyms: gp210, gp190, Pom210
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54563
Homologene: 41286
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627805
Homologene: 129678
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Ccna1
Name: cyclin A1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12427
HGNC: HGNC:1577
Homologene: 31203
Or8i2
Name: olfactory receptor family 8 subfamily I member 2
Synonyms: GA_x6K02T2Q125-48508763-48507833, MOR207-1, Olfr1104
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258763
Homologene: 64916
Chil3
Name: chitinase-like 3
Synonyms: Ym1, Chi3l3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12655
Homologene: 74931
Hpse2
Name: heparanase 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 545291
VEGA: 19
Homologene: 19680
Meiosin
Name: meiosis initiator
Synonyms: Bhmg1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243866
Homologene: 131804
Spsb1
Name: splA/ryanodine receptor domain and SOCS box containing 1
Synonyms: 1110014L01Rik, SSB1, 4930422J18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74646
Homologene: 11832
Zmat4
Name: zinc finger, matrin type 4
Synonyms: 9630048M01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320158
Homologene: 81899
Adprhl1
Name: ADP-ribosylhydrolase like 1
Synonyms: Arh2, D330008N11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234072
Homologene: 16311
Sgip1
Name: SH3-domain GRB2-like (endophilin) interacting protein 1
Synonyms: 3110007P09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73094
Homologene: 13001
Ifit1bl1
Name: interferon induced protein with tetratricpeptide repeats 1B like 1
Synonyms: Gm14446
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667373
Homologene: 78213
Zp3r
Name: zona pellucida 3 receptor
Synonyms: SP56
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22789
HGNC: HGNC:1325
Homologene: 7609
Slc23a3
Name: solute carrier family 23 (nucleobase transporters), member 3
Synonyms: SVCT3, Yspl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22626
Homologene: 65865
Rhbg
Name: Rhesus blood group-associated B glycoprotein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 58176
Homologene: 9469
Zfp78
Name: zinc finger protein 78
Synonyms: KRAB12, Zfp77
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330463
Homologene: 128524
Mylk4
Name: myosin light chain kinase family, member 4
Synonyms: EG238564
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238564
Homologene: 66243
Hsf2bp
Name: heat shock transcription factor 2 binding protein
Synonyms: 4932437G14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74377
HGNC: HGNC:5226
Homologene: 38263
Asb13
Name: ankyrin repeat and SOCS box-containing 13
Synonyms: 6430573K02Rik, 2210015B19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 142688
Homologene: 11666
Aig1
Name: androgen-induced 1
Synonyms: CGI-103, 1500031O19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66253
Homologene: 32297
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: PC3, prohormone convertase 1/3, Nec-1, Nec1, PC1, SPC3, Phpp-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
Lypd6b
Name: LY6/PLAUR domain containing 6B
Synonyms: 2310010M24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71897
Homologene: 12419
Krtap27-1
Name: keratin associated protein 27-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239933
Homologene: 90787
Cdc42ep1
Name: CDC42 effector protein 1
Synonyms: MSE55, CEP1, 1810058K22Rik, Borg5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 104445
VEGA: 15
Homologene: 5128
Tuft1
Name: tuftelin 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22156
Homologene: 7985
Ttc6
Name: tetratricopeptide repeat domain 6
Synonyms: LOC217602, EG639426, Gm9813, 4921506M07Rik, AU024163
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70846
Homologene: 78002
Pcdha6
Name: protocadherin alpha 6
Synonyms: Cnr2, Crnr2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12937
Homologene: 75098
Gale
Name: galactose-4-epimerase, UDP
Synonyms: 2310002A12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74246
HGNC: HGNC:4116
Homologene: 347
Hdgfl3
Name: HDGF like 3
Synonyms: HRP-3, 2700022B06Rik, Hdgfrp3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29877
Homologene: 32196
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 46,227,003 bp
  • A to G, chromosome 1 at 75,129,396 bp
  • G to T, chromosome 1 at 130,596,823 bp
  • A to G, chromosome 2 at 49,943,600 bp
  • T to C, chromosome 2 at 52,271,348 bp
  • G to T, chromosome 2 at 76,884,965 bp
  • A to G, chromosome 2 at 87,022,313 bp
  • T to A, chromosome 2 at 156,749,134 bp
  • G to T, chromosome 3 at 55,050,589 bp
  • A to G, chromosome 3 at 88,247,700 bp
  • G to A, chromosome 3 at 94,632,602 bp
  • A to C, chromosome 3 at 106,150,148 bp
  • A to G, chromosome 4 at 32,645,909 bp
  • T to G, chromosome 4 at 102,915,101 bp
  • T to C, chromosome 4 at 126,275,206 bp
  • T to C, chromosome 4 at 135,965,671 bp
  • T to C, chromosome 4 at 139,349,689 bp
  • T to C, chromosome 4 at 149,906,446 bp
  • T to C, chromosome 5 at 118,008,147 bp
  • A to T, chromosome 6 at 85,641,380 bp
  • T to G, chromosome 6 at 91,073,197 bp
  • T to C, chromosome 6 at 129,432,187 bp
  • T to A, chromosome 6 at 140,580,475 bp
  • C to T, chromosome 7 at 6,378,590 bp
  • C to A, chromosome 7 at 16,789,882 bp
  • T to A, chromosome 7 at 19,100,086 bp
  • T to A, chromosome 7 at 19,287,062 bp
  • T to C, chromosome 7 at 48,483,005 bp
  • T to C, chromosome 7 at 81,933,958 bp
  • T to G, chromosome 7 at 131,544,382 bp
  • T to A, chromosome 8 at 13,221,929 bp
  • T to A, chromosome 8 at 23,748,420 bp
  • C to T, chromosome 8 at 106,179,607 bp
  • A to G, chromosome 9 at 15,007,829 bp
  • T to C, chromosome 9 at 44,681,287 bp
  • A to T, chromosome 10 at 13,868,673 bp
  • T to A, chromosome 11 at 59,093,409 bp
  • A to T, chromosome 11 at 86,737,141 bp
  • T to C, chromosome 11 at 87,604,428 bp
  • T to G, chromosome 12 at 57,660,443 bp
  • A to T, chromosome 12 at 75,904,305 bp
  • T to A, chromosome 13 at 3,649,413 bp
  • T to C, chromosome 13 at 32,727,113 bp
  • C to A, chromosome 13 at 32,850,256 bp
  • T to A, chromosome 13 at 33,832,605 bp
  • G to A, chromosome 13 at 75,132,092 bp
  • T to C, chromosome 14 at 34,677,148 bp
  • T to A, chromosome 14 at 49,773,213 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • T to A, chromosome 15 at 78,847,773 bp
  • A to G, chromosome 15 at 95,941,309 bp
  • A to G, chromosome 16 at 21,221,684 bp
  • T to C, chromosome 16 at 36,914,104 bp
  • T to C, chromosome 16 at 88,671,452 bp
  • T to C, chromosome 17 at 20,471,628 bp
  • C to T, chromosome 17 at 32,007,769 bp
  • T to C, chromosome 17 at 58,932,460 bp
  • T to G, chromosome 17 at 75,390,551 bp
  • T to A, chromosome 18 at 34,427,428 bp
  • C to A, chromosome 18 at 36,968,912 bp
  • T to C, chromosome 18 at 37,989,179 bp
  • T to A, chromosome 19 at 34,593,824 bp
  • T to C, chromosome 19 at 36,949,165 bp
  • T to C, chromosome 19 at 43,384,809 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7944 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045990-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.