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Strain Name:
C57BL/6J-MtgxR7946Btlr/Mmmh
Stock Number:
045991-MU
Citation ID:
RRID:MMRRC_045991-MU
Other Names:
R7946 (G1)
Major Collection:

Strain Information

Bahcc1
Name: BAH domain and coiled-coil containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268515
Homologene: 129585
Rai14
Name: retinoic acid induced 14
Synonyms: 1700020L11Rik, Ankycorbin, Norpeg, 1700008J19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75646
VEGA: 15
Homologene: 9199
Phf21a
Name: PHD finger protein 21A
Synonyms: 80kDa, Braf35/HDAC complex (Bhc), PFTF1, Bhc80, D030065N23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192285
Homologene: 9597
Dido1
Name: death inducer-obliterator 1
Synonyms: DIO-1, 6720461J16Rik, D130048F08Rik, Datf1, dido, C130092D22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Aspscr1
Name: ASPSCR1 tether for SLC2A4, UBX domain containing
Synonyms: ASPCR1, RCC17, ASPC, 1190006K01Rik, TUG, ASPL
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68938
Homologene: 41550
Tars2
Name: threonyl-tRNA synthetase 2, mitochondrial (putative)
Synonyms: 2610024N01Rik, Tarsl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71807
Homologene: 23520
Ctbp1
Name: C-terminal binding protein 1
Synonyms: D4S115h, D5H4S115, BARS, D5H4S115E, CtBP1-S, CtBP1-L, CtBP3/BARS
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13016
HGNC: HGNC:2494
Homologene: 1015
Caprin1
Name: cell cycle associated protein 1
Synonyms: MMGPIP137, caprin-1, Gpiap1, RNG105
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53872
HGNC: HGNC:6743
Homologene: 4310
Cntrob
Name: centrobin, centrosomal BRCA2 interacting protein
Synonyms: Lip8, 9830165K03Rik, Nip2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216846
Homologene: 14205
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Afap1
Name: actin filament associated protein 1
Synonyms: 9630044L16Rik, 2600003E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70292
Homologene: 11009
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, A130030D10Rik, 1110059H15Rik, Zfp650
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Vegfa
Name: vascular endothelial growth factor A
Synonyms: VPF, VEGF-A, VEGF120, Vegf, VEGF188, VEGF164
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22339
Homologene: 2534
Klrb1c
Name: killer cell lectin-like receptor subfamily B member 1C
Synonyms: Nkrp1-c, NK-RP1, Nk1.1, CD161, NK-1.1, Ly-59, Nk-1, Ly55c, Nk-1.2, NKR-P1, Nk1, Ly59, NKR-P1C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17059
HGNC: HGNC:6373
Homologene: 84369
Inka2
Name: inka box actin regulator 2
Synonyms: 6530418L21Rik, Inka2, Fam212b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109050
Homologene: 10421
Gpr107
Name: G protein-coupled receptor 107
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277463
Homologene: 81077
Rfx7
Name: regulatory factor X, 7
Synonyms: 2510005N23Rik, 9930116O05Rik, D130086K05Rik, Rfxdc2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319758
Homologene: 11275
Abca16
Name: ATP-binding cassette, sub-family A member 16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233810
Homologene: 132942
Atp2b4
Name: ATPase, Ca++ transporting, plasma membrane 4
Synonyms: PMCA4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381290
HGNC: HGNC:817
Homologene: 48034
Aqp9
Name: aquaporin 9
Synonyms: 1700020I22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64008
HGNC: HGNC:643
Homologene: 41405
Or4k51
Name: olfactory receptor family 4 subfamily K member 51
Synonyms: GA_x6K02T2Q125-72805651-72806589, MOR248-5, Olfr1301
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258889
Homologene: 74057
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Ampd3
Name: adenosine monophosphate deaminase 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11717
HGNC: HGNC:470
Homologene: 408
Cdc16
Name: CDC16 cell division cycle 16
Synonyms: 2810431D22Rik, 2700071J12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69957
HGNC: HGNC:1720
Homologene: 2899
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209590
Homologene: 16930
Ggt7
Name: gamma-glutamyltransferase 7
Synonyms: 6330563L03Rik, 1110017C11Rik, Ggtl3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 207182
HGNC: HGNC:4259
Homologene: 70866
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80797
HGNC: HGNC:2017
Homologene: 77224
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Kif2b
Name: kinesin family member 2B
Synonyms: 1700063D03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73470
Homologene: 23775
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Iqsec1
Name: IQ motif and Sec7 domain 1
Synonyms: cI-43, D6Ertd349e, BRAG2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232227
Homologene: 82429
Palm2
Name: paralemmin 2
Synonyms: 53-H12, pEN70
Type: Gene
Species: Mouse
Chromosome: 4
Fndc7
Name: fibronectin type III domain containing 7
Synonyms: E230011A21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320181
Homologene: 18551
Adprhl1
Name: ADP-ribosylhydrolase like 1
Synonyms: Arh2, D330008N11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234072
Homologene: 16311
Tor1a
Name: torsin family 1, member A (torsin A)
Synonyms: DQ2, Tor1a, torsinA, Dyt1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 30931
HGNC: HGNC:3098
Homologene: 37263
Mgst2
Name: microsomal glutathione S-transferase 2
Synonyms: MGST-II, GST2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 211666
HGNC: HGNC:7063
Homologene: 1811
Cela2a
Name: chymotrypsin-like elastase family, member 2A
Synonyms: Ela-2, Ela2, Ela2a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13706
Homologene: 40598
Anks4b
Name: ankyrin repeat and sterile alpha motif domain containing 4B
Synonyms: Harp, 2010013E14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72074
Homologene: 49898
Vmn1r172
Name: vomeronasal 1 receptor 172
Synonyms: V3R9, V1rd9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81010
Homologene: 79577
Obox1
Name: oocyte specific homeobox 1
Synonyms: 7420700M11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71468
Homologene: 44937
Or7e174
Name: olfactory receptor family 7 subfamily E member 174
Synonyms: GA_x6K02T2PVTD-13841888-13842802, MOR145-4, Olfr868
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258552
HGNC: HGNC:8396
Homologene: 74168
Vmn1r29
Name: vomeronasal 1 receptor 29
Synonyms: V1rc2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113859
Homologene: 123821
Gm17324
Name: predicted gene, 17324
Type: Gene
Species: Mouse
Chromosome: 9
Ccdc7a
Name: coiled-coil domain containing 7A
Synonyms: 4930540C21Rik, 4930517G15Rik, Ccdc7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74703
Homologene: 134760
Kcnc3
Name: potassium voltage gated channel, Shaw-related subfamily, member 3
Synonyms: Kv3.3, KShIIID, Kcr2-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16504
HGNC: HGNC:6235
Homologene: 3650
Or5p59
Name: olfactory receptor family 5 subfamily P member 59
Synonyms: GA_x6K02T2PBJ9-10432095-10433042, MOR204-12, Olfr483
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258730
Homologene: 133602
Ccdc9b
Name: coiled-coil domain containing 9B
Synonyms: A430105I19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214239
Homologene: 128188
Tomm5
Name: translocase of outer mitochondrial membrane 5
Synonyms: 1110019J04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68512
Homologene: 104342
Stra8
Name: stimulated by retinoic acid gene 8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20899
Homologene: 49197
Spata31d1d
Name: spermatogenesis associated 31 subfamily D, member 1D
Synonyms: Fam75d1d, 4932411G14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238663
Homologene: 129932
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 46,233,579 bp
  • C to A, chromosome 1 at 133,730,582 bp
  • A to G, chromosome 2 at 30,963,692 bp
  • A to G, chromosome 2 at 31,188,704 bp
  • T to C, chromosome 2 at 52,212,734 bp
  • T to C, chromosome 2 at 69,951,395 bp
  • A to T, chromosome 2 at 92,359,167 bp
  • A to T, chromosome 2 at 103,772,748 bp
  • A to T, chromosome 2 at 111,754,818 bp
  • G to T, chromosome 2 at 118,759,665 bp
  • G to T, chromosome 2 at 155,505,972 bp
  • A to T, chromosome 2 at 175,131,480 bp
  • G to T, chromosome 2 at 180,661,708 bp
  • A to G, chromosome 3 at 51,677,570 bp
  • C to A, chromosome 3 at 59,319,704 bp
  • A to T, chromosome 3 at 95,750,381 bp
  • T to A, chromosome 3 at 105,716,445 bp
  • T to A, chromosome 3 at 108,872,136 bp
  • A to G, chromosome 3 at 144,807,314 bp
  • T to C, chromosome 4 at 45,107,969 bp
  • A to T, chromosome 4 at 57,710,045 bp
  • T to C, chromosome 4 at 128,520,265 bp
  • A to G, chromosome 4 at 141,822,306 bp
  • A to T, chromosome 5 at 33,250,344 bp
  • A to G, chromosome 5 at 35,935,651 bp
  • G to A, chromosome 5 at 35,984,052 bp
  • A to G, chromosome 6 at 34,930,881 bp
  • G to T, chromosome 6 at 58,307,849 bp
  • T to A, chromosome 6 at 67,434,664 bp
  • A to T, chromosome 6 at 90,690,270 bp
  • T to A, chromosome 6 at 128,789,109 bp
  • G to T, chromosome 7 at 15,555,531 bp
  • T to G, chromosome 7 at 23,659,432 bp
  • A to T, chromosome 7 at 44,596,145 bp
  • A to G, chromosome 7 at 108,103,846 bp
  • A to G, chromosome 7 at 110,777,940 bp
  • A to G, chromosome 7 at 120,182,484 bp
  • A to G, chromosome 7 at 120,527,175 bp
  • C to T, chromosome 8 at 13,248,682 bp
  • A to G, chromosome 8 at 13,762,882 bp
  • T to A, chromosome 8 at 128,917,146 bp
  • T to C, chromosome 9 at 20,101,484 bp
  • C to T, chromosome 9 at 71,123,008 bp
  • T to C, chromosome 9 at 72,616,814 bp
  • T to C, chromosome 9 at 78,448,512 bp
  • A to G, chromosome 9 at 89,091,485 bp
  • A to G, chromosome 10 at 5,250,919 bp
  • T to C, chromosome 11 at 69,315,221 bp
  • T to C, chromosome 11 at 91,575,745 bp
  • T to C, chromosome 11 at 120,272,499 bp
  • T to G, chromosome 11 at 120,708,617 bp
  • G to T, chromosome 13 at 59,730,792 bp
  • T to C, chromosome 14 at 33,070,748 bp
  • G to A, chromosome 14 at 33,104,115 bp
  • T to C, chromosome 15 at 10,574,201 bp
  • A to T, chromosome 17 at 46,025,451 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7946 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045991-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.