Strain Name:
C57BL/6J-MtgxR7950Btlr/Mmmh
Stock Number:
045995-MU
Citation ID:
RRID:MMRRC_045995-MU
Other Names:
R7950 (G1)
Major Collection:

Strain Information

Epha4
Name: Eph receptor A4
Synonyms: Hek8, Sek1, Cek8, Tyro1, Sek, rb, 2900005C20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13838
HGNC: HGNC:3388
Homologene: 20933
Strn
Name: striatin, calmodulin binding protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268980
Homologene: 2380
Galnt10
Name: polypeptide N-acetylgalactosaminyltransferase 10
Synonyms: Galnt9, C330012K04Rik, GalNAc-T10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171212
Homologene: 14924
Nap1l1
Name: nucleosome assembly protein 1-like 1
Synonyms: D10Ertd68e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 53605
VEGA: 10
HGNC: HGNC:7637
Homologene: 129218
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: A430040A19Rik, D630005A10Rik, apollon, A430032G04Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Orc2
Name: origin recognition complex, subunit 2
Synonyms: Orc2l
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18393
HGNC: HGNC:8488
Homologene: 4512
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: SRm300, 5033413A03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75956
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: D630048A14Rik, Ki67, Ki-67
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Pdcd11
Name: programmed cell death 11
Synonyms: ALG-4, 1110021I22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231214
Homologene: 18159
Hsf1
Name: heat shock factor 1
Synonyms: heat shock transcription factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15499
VEGA: 15
HGNC: HGNC:5224
Homologene: 74556
Ecel1
Name: endothelin converting enzyme-like 1
Synonyms: XCE, DINE
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13599
HGNC: HGNC:3147
Homologene: 3549
Arhgap17
Name: Rho GTPase activating protein 17
Synonyms: Rich1, WBP15, Nadrin2, 5730403H17Rik, Nadrin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70497
Homologene: 9984
Alb
Name: albumin
Synonyms: Alb1, Alb-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11657
HGNC: HGNC:399
Homologene: 405
Osbp
Name: oxysterol binding protein
Synonyms: 1110018F06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76303
VEGA: 19
HGNC: HGNC:8503
Homologene: 97668
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99470
Homologene: 26431
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Nkx6-1
Name: NK6 homeobox 1
Synonyms: NKX6A, Nkx6.1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18096
HGNC: HGNC:7839
Homologene: 4495
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: Gpr116, 8430401C09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Nlrc4
Name: NLR family, CARD domain containing 4
Synonyms: 9530011P19Rik, Ipaf, Card12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268973
VEGA: 17
Homologene: 10924
C130074G19Rik
Name: RIKEN cDNA C130074G19 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226777
Homologene: 11669
Slc1a1
Name: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Synonyms: EAAT3, MEAAC1, D130048G10Rik, EAAC1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20510
Homologene: 20881
Ccl1
Name: C-C motif chemokine ligand 1
Synonyms: CCR8 ligand, Tca-3, I-309, Scya1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20290
Homologene: 55541
Scube3
Name: signal peptide, CUB domain, EGF-like 3
Synonyms: D030038I21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268935
Homologene: 65059
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: muscle dysgenesis, mdg, Cchl1a3, Cav1.1, DHPR alpha1s, fmd, sj
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Arhgef5
Name: Rho guanine nucleotide exchange factor 5
Synonyms: 2210412D05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54324
Homologene: 66300
Golgb1
Name: golgin B1
Synonyms: Giantin, Gm6840, C130074L01Rik, 6330407A06Rik, F730017E11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Kcnh2
Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Synonyms: ether a go-go related, LQT, ERG1, merg1a, Lqt2, merg1b, M-erg
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16511
HGNC: HGNC:6251
Homologene: 201
Bnc1
Name: basonuclin zinc finger protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12173
HGNC: HGNC:1081
Homologene: 31048
Atp13a4
Name: ATPase type 13A4
Synonyms: 4631413J11Rik, 9330174J19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224079
Homologene: 75330
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, actin binding protein 280, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Iho1
Name: interactor of HORMAD1 1
Synonyms: Iho1, Ccdc36
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434438
Homologene: 52256
Cfap410
Name: cilia and flagella associated protein 410
Synonyms: 1810043G02Rik, D10Jhu13e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67884
HGNC: HGNC:1260
Homologene: 3619
Arl6
Name: ADP-ribosylation factor-like 6
Synonyms: BBS3, 1110018H24Rik, 2210411E14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56297
Homologene: 12960
Kbtbd3
Name: kelch repeat and BTB (POZ) domain containing 3
Synonyms: 2200003A07Rik, Bklhd3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69149
Homologene: 12300
Napsa
Name: napsin A aspartic peptidase
Synonyms: pronapsin, napsin, NAP1, Kdap
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16541
Homologene: 68418
Scrn2
Name: secernin 2
Synonyms: SES2, D11Moh48
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217140
Homologene: 26698
Filip1l
Name: filamin A interacting protein 1-like
Synonyms: 4631422O05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78749
Homologene: 37121
C1ql4
Name: complement component 1, q subcomponent-like 4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239659
VEGA: 15
Homologene: 19354
Ppdpf
Name: pancreatic progenitor cell differentiation and proliferation factor
Synonyms: 3110053G12Rik, 0610012G23Rik, 2610317A05Rik, 2700038C09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66496
Homologene: 11511
Malrd1
Name: MAM and LDL receptor class A domain containing 1
Synonyms: Gm13318, Gm13364, Diet1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 102635496
Homologene: 136214
Pcdha6
Name: protocadherin alpha 6
Synonyms: Crnr2, Cnr2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12937
Homologene: 75098
Ighv2-2
Name: immunoglobulin heavy variable 2-2
Synonyms: Gm16970
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 777686
Or5b114-ps1
Name: olfactory receptor family 5 subfamily B member 114, pseudogene 1
Synonyms: GA_x6K02T2RE5P-3706029-3706953, MOR202-21, Olfr1468-ps1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258192
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,467,668 bp
  • T to A, chromosome 1 at 77,507,196 bp
  • A to T, chromosome 1 at 87,148,269 bp
  • A to G, chromosome 1 at 136,100,625 bp
  • T to C, chromosome 1 at 184,874,374 bp
  • T to A, chromosome 2 at 16,128,068 bp
  • A to G, chromosome 2 at 181,187,857 bp
  • A to C, chromosome 3 at 104,016,689 bp
  • C to T, chromosome 5 at 24,333,036 bp
  • T to C, chromosome 5 at 43,695,296 bp
  • A to G, chromosome 5 at 89,058,278 bp
  • T to C, chromosome 5 at 90,472,464 bp
  • A to T, chromosome 5 at 101,663,599 bp
  • A to G, chromosome 6 at 29,456,382 bp
  • A to G, chromosome 6 at 43,273,925 bp
  • A to G, chromosome 7 at 44,585,334 bp
  • A to G, chromosome 7 at 81,973,502 bp
  • A to G, chromosome 7 at 123,286,816 bp
  • G to A, chromosome 7 at 135,699,724 bp
  • C to T, chromosome 9 at 4,316,878 bp
  • T to C, chromosome 9 at 108,405,671 bp
  • C to T, chromosome 10 at 77,979,767 bp
  • T to C, chromosome 10 at 111,492,908 bp
  • C to G, chromosome 11 at 57,783,723 bp
  • T to A, chromosome 11 at 82,179,693 bp
  • T to A, chromosome 11 at 97,030,929 bp
  • T to C, chromosome 12 at 113,588,294 bp
  • A to G, chromosome 14 at 44,560,733 bp
  • T to C, chromosome 15 at 76,498,193 bp
  • T to A, chromosome 15 at 99,084,812 bp
  • A to T, chromosome 16 at 29,449,917 bp
  • A to C, chromosome 16 at 36,915,424 bp
  • A to G, chromosome 16 at 57,569,711 bp
  • A to T, chromosome 16 at 59,618,731 bp
  • T to C, chromosome 17 at 23,808,110 bp
  • G to A, chromosome 17 at 28,171,226 bp
  • G to A, chromosome 17 at 43,451,157 bp
  • A to T, chromosome 17 at 74,445,615 bp
  • A to T, chromosome 17 at 74,593,100 bp
  • A to T, chromosome 17 at 78,670,423 bp
  • T to G, chromosome 18 at 36,969,426 bp
  • T to A, chromosome 19 at 11,978,248 bp
  • T to C, chromosome 19 at 13,375,067 bp
  • T to C, chromosome 19 at 28,911,761 bp
  • AGAGGAGGAGGAGGAGGAGGAGGAG to AGAGGAGGAGGAGGAGGAGGAG, chromosome 19 at 47,113,437 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7950 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045995-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.