Strain Name:
C57BL/6J-MtgxR7954Btlr/Mmmh
Stock Number:
045998-MU
Citation ID:
RRID:MMRRC_045998-MU
Other Names:
R7954 (G1)
Major Collection:

Strain Information

Ep400
Name: E1A binding protein p400
Synonyms: mDomino, p400, 1700020J09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: Tmem2, 3110012M15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Gp330, Megalin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Dnmbp
Name: dynamin binding protein
Synonyms: 2410003L07Rik, 2410003M15Rik, Tuba
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71972
Homologene: 9061
Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: RA-GEF-1, Pdzgef1, 5830453M24Rik, nRapGEP, CNRasGEF
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76089
Homologene: 35477
Htr1b
Name: 5-hydroxytryptamine (serotonin) receptor 1B
Synonyms: 5-HT1B receptor, 5HT1B receptor, 5-HT1B receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15551
HGNC: HGNC:5287
Homologene: 669
Ano6
Name: anoctamin 6
Synonyms: 2900059G15Rik, F730003B03Rik, Tmem16f
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Anapc2
Name: anaphase promoting complex subunit 2
Synonyms: APC2, expressed during mesenchymal induction 4, Emi4, Imi4, 9230107K09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99152
Homologene: 8359
Tasor
Name: transcription activation suppressor
Synonyms: 4933409E02Rik, MommeD6, Fam208a, D14Abb1e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218850
VEGA: 14
Homologene: 9062
Nop14
Name: NOP14 nucleolar protein
Synonyms: 2610033H07Rik, Nol14
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75416
Homologene: 41773
Vars1
Name: valyl-tRNA synthetase 1
Synonyms: Bat-6, G7a, D17H6S56E, Vars, Bat6, Vars2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22321
Homologene: 4587
Fbxo9
Name: f-box protein 9
Synonyms: 9030401P18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71538
Homologene: 8217
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Prss58
Name: serine protease 58
Synonyms: BC048599
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232717
Homologene: 65285
Apc
Name: APC, WNT signaling pathway regulator
Synonyms: adenomatosis polyposis coli, Min, CC1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11789
HGNC: HGNC:583
Homologene: 30950
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: C030002J06Rik, 4930429G18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 78787
Homologene: 90902
Styxl2
Name: serine/threonine/tyrosine interacting like 2
Synonyms: Dusp27, C130085G02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240892
Homologene: 18949
Nr2f1
Name: nuclear receptor subfamily 2, group F, member 1
Synonyms: Tcfcoup1, COUP-TFI, COUP-TF1, Erbal3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13865
HGNC: HGNC:7975
Homologene: 21158
St3gal1
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms: ST3GalI, Siat4, Siat4a, CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20442
VEGA: 15
Homologene: 7540
Cfi
Name: complement component factor i
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12630
HGNC: HGNC:5394
Homologene: 171
Adam20
Name: a disintegrin and metallopeptidase domain 20
Synonyms: 4930529F22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384806
HGNC: HGNC:199
Homologene: 128364
Epb41l4b
Name: erythrocyte membrane protein band 4.1 like 4b
Synonyms: D4Ertd346e, Ehm2, 6430543G08Rik, Lulu2, Epb4.1l4b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54357
Homologene: 69270
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: nmf355, Clc1, SMCC1, NMF355, Clc-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, D430038H04Rik, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Vmn1r78
Name: vomeronasal 1 receptor 78
Synonyms: V1rg7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171242
Homologene: 74316
Krtcap3
Name: keratinocyte associated protein 3
Synonyms: 2010001C09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69815
Homologene: 12332
Fbxl13
Name: F-box and leucine-rich repeat protein 13
Synonyms: 4921539K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320118
Homologene: 27057
Umodl1
Name: uromodulin-like 1
Synonyms: D17Ertd488e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52020
VEGA: 17
Homologene: 45466
Or5p51
Name: olfactory receptor family 5 subfamily P member 51
Synonyms: MOR204-22, Olfr470, GA_x6K02T2PBJ9-10175273-10174329
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258417
Aatk
Name: apoptosis-associated tyrosine kinase
Synonyms: AATYK1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11302
HGNC: HGNC:21
Homologene: 74861
Kif26b
Name: kinesin family member 26B
Synonyms: D230039L06Rik, N-11 kinesin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269152
Homologene: 18623
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Hs6st3
Name: heparan sulfate 6-O-sulfotransferase 3
Synonyms: 6OST3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50787
VEGA: 14
Homologene: 89201
Eno3
Name: enolase 3, beta muscle
Synonyms: Eno-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13808
HGNC: HGNC:3354
Homologene: 68215
Rgs22
Name: regulator of G-protein signalling 22
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 626596
Homologene: 75047
Or5al7
Name: olfactory receptor family 5 subfamily AL member 7
Synonyms: MOR185-7, GA_x6K02T2Q125-47631900-47630956, Olfr1043
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258570
Homologene: 88364
Mocs1
Name: molybdenum cofactor synthesis 1
Synonyms: 3110045D15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56738
HGNC: HGNC:7190
Homologene: 4343
Acsm2
Name: acyl-CoA synthetase medium-chain family member 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233799
Homologene: 70404
Spata2
Name: spermatogenesis associated 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 263876
Homologene: 4407
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: G6pd1, Gpd-1, Gpd1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Dok5
Name: docking protein 5
Synonyms: 2700055C10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76829
Homologene: 10195
Lmod1
Name: leiomodin 1 (smooth muscle)
Synonyms: 1D, D1, SM-Lmod, 9530015K06Rik, 64kD D1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 93689
HGNC: HGNC:6647
Homologene: 8118
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21892
Homologene: 49202
Glis1
Name: GLIS family zinc finger 1
Synonyms: GliH1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230587
Homologene: 77390
Vmn1r202
Name: vomeronasal 1 receptor 202
Synonyms: V1ri7
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171258
Homologene: 110880
Pkd2l1
Name: polycystic kidney disease 2-like 1
Synonyms: TRPP3, polycystin-L, PCL, PKD2L, Pkdl
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 329064
HGNC: HGNC:9011
Homologene: 22946
Gpr156
Name: G protein-coupled receptor 156
Synonyms: Gababl
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239845
VEGA: 16
Homologene: 17683
Paqr9
Name: progestin and adipoQ receptor family member IX
Synonyms: 1700020G04Rik, C730029A08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75552
Homologene: 18882
Gpr15
Name: G protein-coupled receptor 15
Synonyms: 4933439K08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71223
VEGA: 16
HGNC: HGNC:4469
Homologene: 3869
Crygs
Name: crystallin, gamma S
Synonyms: Opj
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12970
VEGA: 16
HGNC: HGNC:2417
Homologene: 40695
Tex35
Name: testis expressed 35
Synonyms: 1700057K13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73435
Homologene: 49980
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 135,325,056 bp
  • C to T, chromosome 1 at 157,100,172 bp
  • C to T, chromosome 1 at 166,099,280 bp
  • A to T, chromosome 1 at 178,869,379 bp
  • T to A, chromosome 2 at 25,274,700 bp
  • T to G, chromosome 2 at 69,503,523 bp
  • A to G, chromosome 2 at 86,162,868 bp
  • T to C, chromosome 2 at 167,483,937 bp
  • T to A, chromosome 2 at 170,833,073 bp
  • G to A, chromosome 3 at 79,070,147 bp
  • G to A, chromosome 3 at 129,868,585 bp
  • A to G, chromosome 4 at 57,088,034 bp
  • G to A, chromosome 4 at 107,619,657 bp
  • T to C, chromosome 4 at 149,982,826 bp
  • T to C, chromosome 5 at 21,543,769 bp
  • T to C, chromosome 5 at 31,252,671 bp
  • G to A, chromosome 5 at 34,650,385 bp
  • T to C, chromosome 5 at 110,668,733 bp
  • T to C, chromosome 6 at 40,895,609 bp
  • A to T, chromosome 6 at 42,286,691 bp
  • T to C, chromosome 6 at 85,621,162 bp
  • T to A, chromosome 7 at 12,153,300 bp
  • T to C, chromosome 7 at 107,844,912 bp
  • C to T, chromosome 7 at 119,580,729 bp
  • T to C, chromosome 8 at 40,796,544 bp
  • G to A, chromosome 8 at 64,118,534 bp
  • A to G, chromosome 9 at 15,998,412 bp
  • A to G, chromosome 9 at 78,101,544 bp
  • A to G, chromosome 9 at 81,631,945 bp
  • G to A, chromosome 9 at 95,560,628 bp
  • T to C, chromosome 11 at 70,661,180 bp
  • C to T, chromosome 11 at 120,012,343 bp
  • A to T, chromosome 13 at 22,501,701 bp
  • A to C, chromosome 13 at 78,189,994 bp
  • A to G, chromosome 14 at 20,561,913 bp
  • T to C, chromosome 14 at 27,447,524 bp
  • T to C, chromosome 14 at 119,869,110 bp
  • A to C, chromosome 15 at 36,082,002 bp
  • A to T, chromosome 15 at 67,112,573 bp
  • G to T, chromosome 15 at 95,965,821 bp
  • A to G, chromosome 15 at 98,596,892 bp
  • C to T, chromosome 16 at 22,805,332 bp
  • T to C, chromosome 16 at 37,987,558 bp
  • T to G, chromosome 16 at 58,718,684 bp
  • A to T, chromosome 17 at 30,986,387 bp
  • A to G, chromosome 17 at 35,015,984 bp
  • G to A, chromosome 17 at 49,454,771 bp
  • A to G, chromosome 18 at 34,314,268 bp
  • T to A, chromosome 19 at 21,792,900 bp
  • A to T, chromosome 19 at 43,902,303 bp
  • T to C, chromosome 19 at 44,154,212 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7954 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045998-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.