Strain Name:
C57BL/6J-MtgxR7955Btlr/Mmmh
Stock Number:
045999-MU
Citation ID:
RRID:MMRRC_045999-MU
Other Names:
R7955 (G1)
Major Collection:

Strain Information

Chrna7
Name: cholinergic receptor, nicotinic, alpha polypeptide 7
Synonyms: alpha7, alpha7 nicotinic receptor, Acra7, alpha7-nAChR
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11441
Homologene: 593
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: C030017F07Rik, C130076O07Rik, Bravo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Gpm6a
Name: glycoprotein m6a
Synonyms: Gpm6, M6A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234267
HGNC: HGNC:4460
Homologene: 3864
Dnmbp
Name: dynamin binding protein
Synonyms: 2410003M15Rik, Tuba, 2410003L07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71972
Homologene: 9061
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: p53BP1, 53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Rabep1
Name: rabaptin, RAB GTPase binding effector protein 1
Synonyms: neurocrescin, rabaptin-5, RAB5 effector protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54189
Homologene: 3451
Larp4b
Name: La ribonucleoprotein 4B
Synonyms: Larp5, D13Wsu64e, A130023E24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217980
Homologene: 18195
Zfp407
Name: zinc finger protein 407
Synonyms: 6430585N13Rik, LOC240469, LOC381139
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240476
Homologene: 86402
Trpm4
Name: transient receptor potential cation channel, subfamily M, member 4
Synonyms: 1110030C19Rik, TRPM4B, LTRPC4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68667
Homologene: 23033
Adgrg5
Name: adhesion G protein-coupled receptor G5
Synonyms: LOC382045, PGR27, Gpr114
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382045
Homologene: 17828
Map2
Name: microtubule-associated protein 2
Synonyms: G1-397-34, Mtap2, repro4, MAP-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Slc12a9
Name: solute carrier family 12 (potassium/chloride transporters), member 9
Synonyms: CIP1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83704
Homologene: 5429
Tspan18
Name: tetraspanin 18
Synonyms: 2610042G18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241556
Homologene: 24122
Clvs2
Name: clavesin 2
Synonyms: Rlbp1l2, A330019N05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215890
Homologene: 27894
Tgm3
Name: transglutaminase 3, E polypeptide
Synonyms: we, TG E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21818
Homologene: 20690
Ndst3
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
Synonyms: 4921531K01Rik, 4930511P15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83398
HGNC: HGNC:7682
Homologene: 3513
Mocos
Name: molybdenum cofactor sulfurase
Synonyms: 1110018O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68591
VEGA: 18
Homologene: 9931
Ano4
Name: anoctamin 4
Synonyms: A330096O15Rik, Tmem16d
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320091
Homologene: 66599
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64580
Homologene: 11208
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: Acvrinp1, Magi-2, S-SCAM
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50791
Homologene: 8189
Mybpc3
Name: myosin binding protein C, cardiac
Synonyms: cardiac C-protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17868
HGNC: HGNC:7551
Homologene: 215
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: RIM1alpha, RIM1a, C030033M19Rik, RIM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116837
Homologene: 128399
Ttc39d
Name: tetratricopeptide repeat domain 39D
Synonyms: 4930560E09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67737
Homologene: 65053
Sh2d4a
Name: SH2 domain containing 4A
Synonyms: 2210402M20Rik, SH2A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72281
Homologene: 11117
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329421
Homologene: 51393
Tmprss11f
Name: transmembrane protease, serine 11f
Synonyms: 4732406D01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243083
Homologene: 65356
Adamts10
Name: ADAM metallopeptidase with thrombospondin type 1 motif 10
Synonyms: ZnMP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224697
Homologene: 81940
Hps1
Name: HPS1, biogenesis of lysosomal organelles complex 3 subunit 1
Synonyms: 6030422N11Rik, Hermansky-Pudlak syndrome 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 192236
HGNC: HGNC:5163
Homologene: 163
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244810
HGNC: HGNC:6658
Daxx
Name: Fas death domain-associated protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13163
HGNC: HGNC:2681
Homologene: 1033
Flot2
Name: flotillin 2
Synonyms: reggie-2, Esa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14252
HGNC: HGNC:3758
Homologene: 3293
Slc30a1
Name: solute carrier family 30 (zinc transporter), member 1
Synonyms: Znt1, C130040I11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22782
Homologene: 6681
Ankrd53
Name: ankyrin repeat domain 53
Synonyms: 4930564N15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75305
Homologene: 49810
Ganc
Name: glucosidase, alpha; neutral C
Synonyms: 5830445O15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76051
HGNC: HGNC:4139
Homologene: 25627
Msl2
Name: MSL complex subunit 2
Synonyms: Rnf184, Msl2l1, E130103E02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77853
Homologene: 10021
Cox10
Name: heme A:farnesyltransferase cytochrome c oxidase assembly factor 10
Synonyms: 2410004F01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70383
HGNC: HGNC:2260
Homologene: 80170
Zswim2
Name: zinc finger SWIM-type containing 2
Synonyms: 1700025P14Rik, 4933437F18Rik, MEX
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71861
Homologene: 32689
Erich3
Name: glutamate rich 3
Synonyms: 5031409G23Rik, 4922501L14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 209601
Homologene: 27877
Tmem17
Name: transmembrane protein 17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103765
Homologene: 17795
Crygs
Name: crystallin, gamma S
Synonyms: Opj
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12970
VEGA: 16
HGNC: HGNC:2417
Homologene: 40695
Or6z1
Name: olfactory receptor family 6 subfamily Z member 1
Synonyms: GA_x6K02T2QGBW-3232059-3231121, Olfr1348, MOR103-9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258915
Homologene: 17435
Cldnd2
Name: claudin domain containing 2
Synonyms: 1700071E18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74276
Homologene: 17559
Zdhhc4
Name: zinc finger, DHHC domain containing 4
Synonyms: 2900029I10Rik, 1810021D01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72881
Homologene: 10006
Tex35
Name: testis expressed 35
Synonyms: 1700057K13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73435
Homologene: 49980
Krtap10-34
Name: keratin associated protein 10-34
Synonyms: Gm19668
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100503388
Homologene: 115744
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 22,468,241 bp
  • T to A, chromosome 1 at 66,413,716 bp
  • C to T, chromosome 1 at 157,100,172 bp
  • T to C, chromosome 1 at 191,907,283 bp
  • A to T, chromosome 2 at 70,095,279 bp
  • A to C, chromosome 2 at 83,916,883 bp
  • A to G, chromosome 2 at 91,126,056 bp
  • A to G, chromosome 2 at 93,209,960 bp
  • A to G, chromosome 2 at 120,430,700 bp
  • G to A, chromosome 2 at 121,235,744 bp
  • A to T, chromosome 2 at 130,038,480 bp
  • T to G, chromosome 3 at 123,606,937 bp
  • T to A, chromosome 3 at 125,438,182 bp
  • C to T, chromosome 3 at 154,739,314 bp
  • A to G, chromosome 5 at 20,389,072 bp
  • A to C, chromosome 5 at 86,544,823 bp
  • A to C, chromosome 5 at 137,325,546 bp
  • A to T, chromosome 5 at 143,321,864 bp
  • A to G, chromosome 6 at 83,767,863 bp
  • A to G, chromosome 7 at 6,502,079 bp
  • G to T, chromosome 7 at 43,441,696 bp
  • C to A, chromosome 7 at 45,319,259 bp
  • T to G, chromosome 7 at 63,103,793 bp
  • A to G, chromosome 8 at 55,058,805 bp
  • A to G, chromosome 8 at 68,329,255 bp
  • G to A, chromosome 8 at 94,937,697 bp
  • A to G, chromosome 9 at 39,596,664 bp
  • A to G, chromosome 9 at 101,102,155 bp
  • T to C, chromosome 10 at 33,595,812 bp
  • G to A, chromosome 10 at 77,798,796 bp
  • T to A, chromosome 10 at 88,995,226 bp
  • T to A, chromosome 11 at 22,518,490 bp
  • A to T, chromosome 11 at 63,993,924 bp
  • A to G, chromosome 11 at 70,917,441 bp
  • A to G, chromosome 11 at 78,058,943 bp
  • G to A, chromosome 12 at 44,584,954 bp
  • T to C, chromosome 13 at 9,136,780 bp
  • C to T, chromosome 16 at 22,805,332 bp
  • T to A, chromosome 17 at 33,545,639 bp
  • T to A, chromosome 17 at 33,912,255 bp
  • T to C, chromosome 17 at 80,215,923 bp
  • A to G, chromosome 18 at 24,666,159 bp
  • A to T, chromosome 18 at 84,559,291 bp
  • A to T, chromosome 19 at 18,854,290 bp
  • T to C, chromosome 19 at 42,770,782 bp
  • T to C, chromosome 19 at 43,902,323 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7955 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045999-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.