Strain Name:
C57BL/6J-MtgxR7971Btlr/Mmmh
Stock Number:
046014-MU
Citation ID:
RRID:MMRRC_046014-MU
Other Names:
R7971 (G1)
Major Collection:

Strain Information

Npy2r
Name: neuropeptide Y receptor Y2
Synonyms: NPY-Y2 receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18167
HGNC: HGNC:7957
Homologene: 701
Cd80
Name: CD80 antigen
Synonyms: B7.1, Ly-53, B7-1, Ly53, Cd28l
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12519
VEGA: 16
HGNC: HGNC:1700
Homologene: 3804
Omd
Name: osteomodulin
Synonyms: OSAD, osteoadherin, SLRR2C
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27047
VEGA: 13
HGNC: HGNC:8134
Homologene: 3677
Slc35a1
Name: solute carrier family 35 (CMP-sialic acid transporter), member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 24060
Homologene: 38181
Lars1
Name: leucyl-tRNA synthetase 1
Synonyms: 3110009L02Rik, Lars, 2310045K21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107045
VEGA: 18
HGNC: HGNC:6512
Homologene: 7083
Clasp1
Name: CLIP associating protein 1
Synonyms: mCLASP1, 5730583A19Rik, 1700030C23Rik, B130045P17Rik, CLASP1alpha, CLASP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76707
Homologene: 41024
Pmpca
Name: peptidase (mitochondrial processing) alpha
Synonyms: INPP5E, 4933435E07Rik, Alpha-MPP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66865
Homologene: 6078
Shroom3
Name: shroom family member 3
Synonyms: Shrm3, Shrm, D5Ertd287e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27428
Homologene: 9263
Tmem87b
Name: transmembrane protein 87B
Synonyms: 2810431I02Rik, 2610301K12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72477
Homologene: 69513
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Sh3d19
Name: SH3 domain protein D19
Synonyms: Kryn
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 27059
Homologene: 19064
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Triml2
Name: tripartite motif family-like 2
Synonyms: EG622117
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 622117
Homologene: 18316
Creld1
Name: cysteine-rich with EGF-like domains 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171508
Homologene: 32265
Olfm4
Name: olfactomedin 4
Synonyms: LOC239192, LOC380924, pPD4, GW112, OlfD, GC1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380924
VEGA: 14
Homologene: 4684
Slc12a4
Name: solute carrier family 12, member 4
Synonyms: K-Cl Co-transporter-1, KCC1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20498
Homologene: 21056
Pigk
Name: phosphatidylinositol glycan anchor biosynthesis, class K
Synonyms: 3000001O05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329777
HGNC: HGNC:8965
Homologene: 4002
Amotl2
Name: angiomotin-like 2
Synonyms: MASCOT, Lccp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56332
Homologene: 9420
Rufy1
Name: RUN and FYVE domain containing 1
Synonyms: 3000002E04Rik, ZFYVE12, Rabip4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216724
Homologene: 23522
Tnfrsf25
Name: tumor necrosis factor receptor superfamily, member 25
Synonyms: Tnfrsf12, APO-3, DR3, DDR3, TRAMP, LARD, Wsl, WSL-1, WSL-LR, TR3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 85030
Homologene: 13202
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: Ttc40, 9330101J02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212124
Akap6
Name: A kinase anchor protein 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Csk
Name: c-src tyrosine kinase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12988
VEGA: 9
HGNC: HGNC:2444
Homologene: 55818
Tatdn2
Name: TatD DNase domain containing 2
Synonyms: mKIAA0218
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381801
Homologene: 8848
Prkg2
Name: protein kinase, cGMP-dependent, type II
Synonyms: cGK-II, Prkgr2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19092
HGNC: HGNC:9416
Homologene: 4556
Scaf1
Name: SR-related CTD-associated factor 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233208
Dgkg
Name: diacylglycerol kinase, gamma
Synonyms: 2900055E17Rik, E430001K23Rik, Dagk3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110197
HGNC: HGNC:2853
Homologene: 1029
Synm
Name: synemin, intermediate filament protein
Synonyms: Synemin, Dmn, 4930412K21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233335
Homologene: 9081
Slc13a4
Name: solute carrier family 13 (sodium/sulfate symporters), member 4
Synonyms: 9630060C05Rik, SUT-1, SUT1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243755
Homologene: 69125
Adamts2
Name: ADAM metallopeptidase with thrombospondin type 1 motif 2
Synonyms: hPCPNI, a disintegrin and metalloproteinase with thrombospondin repeats, procollagen N-proteinase, ADAM-TS2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216725
HGNC: HGNC:218
Homologene: 8597
Ifi206
Name: interferon activated gene 206
Synonyms: Gm4955, Pyblhin-C
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102639543
HGNC: HGNC:5395
Homologene: 115929
Kcnh6
Name: potassium voltage-gated channel, subfamily H (eag-related), member 6
Synonyms: m-erg2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192775
Homologene: 32740
Cacnb2
Name: calcium channel, voltage-dependent, beta 2 subunit
Synonyms: Cavbeta2, Cchb2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12296
HGNC: HGNC:1402
Homologene: 75191
Mest
Name: mesoderm specific transcript
Synonyms: Peg1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17294
HGNC: HGNC:7028
Homologene: 1800
Trim34a
Name: tripartite motif-containing 34A
Synonyms: Trim34, Trim34-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 94094
Homologene: 128238
Dao
Name: D-amino acid oxidase
Synonyms: DAO, Dao1, Dao-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13142
HGNC: HGNC:2671
Homologene: 37553
Ifi44
Name: interferon-induced protein 44
Synonyms: MTAP44, p44, A430056A10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99899
Homologene: 4683
Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms: P-REX1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277360
Homologene: 10821
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: Mdrap, MRP, Mrp1, Abcc1a, Abcc1b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Dnaaf2
Name: dynein, axonemal assembly factor 2
Synonyms: 2810020C19Rik, kintoun, Ktu, 1110034A24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109065
Homologene: 10026
Or8c16
Name: olfactory receptor family 8 subfamily C member 16
Synonyms: Olfr894, GA_x6K02T2PVTD-31898993-31899934, MOR170-5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258868
Gm4353
Name: predicted gene 4353
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043313
VEGA: 7
Fastkd1
Name: FAST kinase domains 1
Synonyms: 5330408N05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320720
Homologene: 36420
Olfml2a
Name: olfactomedin-like 2A
Synonyms: 4932431K08Rik, photomedin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241327
Homologene: 35248
Rcc1l
Name: reculator of chromosome condensation 1 like
Synonyms: Wbscr16, 5730496C04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 94254
Homologene: 36477
Tubg1
Name: tubulin, gamma 1
Synonyms: 1500010O08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103733
Homologene: 833
Hmgb2
Name: high mobility group box 2
Synonyms: HMG-2, Hmg2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 97165
HGNC: HGNC:5000
Homologene: 37582
Hoxa4
Name: homeobox A4
Synonyms: Hox-1.4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15401
HGNC: HGNC:5105
Homologene: 37583
5530401A14Rik
Name: RIKEN cDNA 5530401A14 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71388
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 118,521,829 bp
  • A to T, chromosome 1 at 173,471,410 bp
  • A to T, chromosome 2 at 14,971,598 bp
  • G to A, chromosome 2 at 26,393,152 bp
  • A to T, chromosome 2 at 38,941,782 bp
  • A to G, chromosome 2 at 69,707,359 bp
  • A to G, chromosome 2 at 128,850,330 bp
  • C to T, chromosome 2 at 166,581,939 bp
  • A to T, chromosome 3 at 82,540,868 bp
  • A to G, chromosome 3 at 86,114,796 bp
  • T to A, chromosome 3 at 151,749,220 bp
  • C to A, chromosome 3 at 152,744,539 bp
  • T to C, chromosome 4 at 34,664,161 bp
  • A to C, chromosome 4 at 152,119,736 bp
  • C to T, chromosome 5 at 92,951,074 bp
  • A to T, chromosome 5 at 98,932,014 bp
  • AGG to AG, chromosome 5 at 114,015,209 bp
  • A to G, chromosome 5 at 134,165,369 bp
  • T to A, chromosome 6 at 30,740,735 bp
  • A to G, chromosome 6 at 35,271,760 bp
  • G to A, chromosome 6 at 52,191,731 bp
  • T to C, chromosome 6 at 85,628,679 bp
  • T to C, chromosome 6 at 113,491,972 bp
  • A to G, chromosome 6 at 113,710,274 bp
  • T to A, chromosome 7 at 45,003,541 bp
  • T to C, chromosome 7 at 67,735,235 bp
  • T to C, chromosome 7 at 104,247,818 bp
  • C to A, chromosome 7 at 116,083,512 bp
  • A to G, chromosome 7 at 139,635,127 bp
  • T to C, chromosome 8 at 43,190,276 bp
  • A to G, chromosome 8 at 57,513,134 bp
  • G to A, chromosome 8 at 105,951,605 bp
  • G to T, chromosome 9 at 38,219,547 bp
  • C to A, chromosome 9 at 57,628,687 bp
  • C to T, chromosome 9 at 102,723,769 bp
  • A to T, chromosome 11 at 50,421,671 bp
  • G to A, chromosome 11 at 50,756,696 bp
  • G to A, chromosome 11 at 81,863,700 bp
  • G to T, chromosome 11 at 101,124,028 bp
  • A to G, chromosome 11 at 106,017,527 bp
  • T to C, chromosome 12 at 53,139,795 bp
  • T to C, chromosome 12 at 69,197,345 bp
  • T to A, chromosome 13 at 38,192,523 bp
  • A to T, chromosome 13 at 49,590,254 bp
  • T to A, chromosome 14 at 80,021,800 bp
  • T to A, chromosome 16 at 14,448,579 bp
  • G to A, chromosome 16 at 22,570,216 bp
  • T to A, chromosome 16 at 38,474,029 bp
  • T to A, chromosome 17 at 84,272,769 bp
  • T to C, chromosome 18 at 42,218,566 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7971 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046014-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.