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Strain Name:
C57BL/6J-MtgxR7994Btlr/Mmmh
Stock Number:
046035-MU
Citation ID:
RRID:MMRRC_046035-MU
Other Names:
R7994 (G1)
Major Collection:

Strain Information

Tert
Name: telomerase reverse transcriptase
Synonyms: TR
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21752
VEGA: 13
Homologene: 31141
Cort
Name: cortistatin
Synonyms: PCST, CST
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12854
HGNC: HGNC:2257
Homologene: 997
Ilrun
Name: inflammation and lipid regulator with UBA-like and NBR1-like domains
Synonyms: D17Wsu92e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224647
Homologene: 32575
Fam3c
Name: FAM3 metabolism regulating signaling molecule C
Synonyms: Fam3c, D6Wsu176e, Ilei
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27999
Homologene: 8926
Madcam1
Name: mucosal vascular addressin cell adhesion molecule 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17123
VEGA: 10
HGNC: HGNC:6765
Homologene: 8413
Ppp1r13b
Name: protein phosphatase 1, regulatory subunit 13B
Synonyms: ASPP1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21981
VEGA: 12
Homologene: 9090
Scrib
Name: scribbled planar cell polarity
Synonyms: Scrb1, Crc
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 39,328,337 bp
  • T to C, chromosome 1 at 44,178,334 bp
  • T to A, chromosome 1 at 74,747,255 bp
  • G to A, chromosome 1 at 82,662,906 bp
  • A to T, chromosome 1 at 134,747,592 bp
  • G to T, chromosome 1 at 174,136,707 bp
  • C to A, chromosome 1 at 192,101,645 bp
  • T to C, chromosome 2 at 76,791,095 bp
  • G to A, chromosome 2 at 153,783,804 bp
  • T to C, chromosome 3 at 37,091,971 bp
  • T to C, chromosome 3 at 103,803,386 bp
  • C to T, chromosome 4 at 43,665,514 bp
  • C to T, chromosome 4 at 46,736,349 bp
  • A to T, chromosome 4 at 149,125,305 bp
  • T to C, chromosome 5 at 31,169,873 bp
  • C to T, chromosome 5 at 38,299,851 bp
  • T to A, chromosome 5 at 72,604,660 bp
  • G to C, chromosome 5 at 124,082,027 bp
  • T to A, chromosome 5 at 138,455,188 bp
  • T to C, chromosome 6 at 18,054,641 bp
  • T to C, chromosome 6 at 22,308,460 bp
  • T to C, chromosome 6 at 38,818,468 bp
  • T to C, chromosome 6 at 54,615,245 bp
  • G to T, chromosome 6 at 69,016,637 bp
  • C to T, chromosome 6 at 96,863,886 bp
  • C to G, chromosome 6 at 113,315,041 bp
  • T to A, chromosome 7 at 103,777,400 bp
  • T to A, chromosome 7 at 104,704,428 bp
  • T to C, chromosome 7 at 127,541,758 bp
  • A to G, chromosome 7 at 128,085,646 bp
  • A to G, chromosome 8 at 94,306,302 bp
  • A to C, chromosome 8 at 94,853,157 bp
  • T to A, chromosome 9 at 14,593,361 bp
  • A to T, chromosome 10 at 43,021,167 bp
  • A to T, chromosome 10 at 79,668,235 bp
  • T to A, chromosome 11 at 32,207,569 bp
  • T to C, chromosome 11 at 49,261,943 bp
  • T to G, chromosome 11 at 51,048,140 bp
  • T to C, chromosome 11 at 68,790,244 bp
  • C to T, chromosome 11 at 97,531,916 bp
  • T to C, chromosome 12 at 111,832,342 bp
  • T to A, chromosome 13 at 32,843,050 bp
  • T to A, chromosome 13 at 50,702,864 bp
  • T to C, chromosome 13 at 51,847,767 bp
  • T to A, chromosome 13 at 73,648,955 bp
  • T to A, chromosome 14 at 20,708,004 bp
  • C to A, chromosome 14 at 21,985,006 bp
  • G to A, chromosome 15 at 76,064,582 bp
  • T to C, chromosome 16 at 44,432,138 bp
  • C to A, chromosome 17 at 27,767,943 bp
  • C to A, chromosome 17 at 34,578,090 bp
  • C to T, chromosome 17 at 37,701,435 bp
  • T to C, chromosome 17 at 78,934,599 bp
  • A to G, chromosome 18 at 37,742,671 bp
  • A to G, chromosome 18 at 46,958,919 bp
  • A to G, chromosome 19 at 45,007,838 bp
  • G to A, chromosome 19 at 47,859,460 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7994 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046035-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.