Strain Name:
C57BL/6J-MtgxR7999Btlr/Mmmh
Stock Number:
046039-MU
Citation ID:
RRID:MMRRC_046039-MU
Other Names:
R7999 (G1)
Major Collection:

Strain Information

Sall4
Name: spalt like transcription factor 4
Synonyms: Tex20, C330011P20Rik, 5730441M18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99377
Homologene: 10716
Fiz1
Name: Flt3 interacting zinc finger protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23877
Homologene: 22663
Utp20
Name: UTP20 small subunit processome component
Synonyms: 3830408P06Rik, DRIM, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: Bat2l, 5830434P21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227723
Homologene: 106649
Dnajc24
Name: DnaJ heat shock protein family (Hsp40) member C24
Synonyms: MmDjC7, Zcsl3, 1700030A21Rik, Dph4, 2610027M02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99349
Homologene: 41704
B3galnt1
Name: UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1
Synonyms: Globoside blood group, Mbrn 1, B3galt3, Brainiac 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26879
HGNC: HGNC:918
Homologene: 32457
Triobp
Name: TRIO and F-actin binding protein
Synonyms: EST478828, Mus EST 478828, Tara
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110253
Homologene: 5104
Tdg
Name: thymine DNA glycosylase
Synonyms: Jza1, E130317C12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21665
Homologene: 2415
Skil
Name: SKI-like
Synonyms: sno-dE3, 9130011J04Rik, SnoN2, Skir, SnoN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20482
Homologene: 3948
Aspscr1
Name: ASPSCR1 tether for SLC2A4, UBX domain containing
Synonyms: TUG, 1190006K01Rik, RCC17, ASPL, ASPC, ASPCR1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68938
Homologene: 41550
Kat7
Name: K(lysine) acetyltransferase 7
Synonyms: Hboa, Hbo1, Myst2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217127
Homologene: 5134
Cog3
Name: component of oligomeric golgi complex 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338337
VEGA: 14
Homologene: 5854
Gtpbp4
Name: GTP binding protein 4
Synonyms: 2610028C09Rik, Crfg, Nog1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69237
VEGA: 13
Homologene: 7100
Zbtb17
Name: zinc finger and BTB domain containing 17
Synonyms: Miz1, mZ13, Zfp100
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22642
Homologene: 2575
Hnf1a
Name: HNF1 homeobox A
Synonyms: hepatocyte nuclear factor 1, Hnf1alpha, Tcf1, HNF1, HNF1[a], HNF1-alpha, Hnf-1, LFB1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21405
Homologene: 459
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TAF3B1, Tfnr, TFC5, TFIIIB90, TFIIIB150, B130055N23Rik, G630013P12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544971
Homologene: 34582
Lonp2
Name: lon peptidase 2, peroxisomal
Synonyms: 1300002A08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66887
Homologene: 12050
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Ahi1
Name: Abelson helper integration site 1
Synonyms: 1700015F03Rik, Ahi-1, Jouberin, D10Bwg0629e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Trak1
Name: trafficking protein, kinesin binding 1
Synonyms: hyrt, 2310001H13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67095
Homologene: 25103
Sp2
Name: Sp2 transcription factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78912
Homologene: 2340
Rasa3
Name: RAS p21 protein activator 3
Synonyms: R-Ras gap, scat, GAPIII activator 3, GAPIII, Ras GTPase-activating protein III, hlb381
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19414
Homologene: 7217
Rpf2
Name: ribosome production factor 2 homolog
Synonyms: Bxdc1, 2810470K21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67239
Homologene: 6404
Zfp975
Name: zinc finger protein 975
Synonyms: Gm5595
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434179
Homologene: 134004
Enam
Name: enamelin
Synonyms: abte
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13801
HGNC: HGNC:3344
Homologene: 9698
Samd4
Name: sterile alpha motif domain containing 4
Synonyms: Smaug, 1700111L17Rik, 1700024G08Rik, sunk, 4933436G17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74480
Homologene: 19167
Capn11
Name: calpain 11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268958
HGNC: HGNC:1478
Homologene: 21392
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Mmrn2
Name: multimerin 2
Synonyms: Emilin3, EndoGlyx-1, ENDOGLYX1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105450
VEGA: 14
Homologene: 11697
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: Sn, CD169, Siglec-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20612
Homologene: 124458
Zfp605
Name: zinc finger protein 605
Synonyms: A830023I12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 675812
Homologene: 52335
Ints11
Name: integrator complex subunit 11
Synonyms: Cpsf3l, 2410006F12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71957
Homologene: 9894
Nlrp9c
Name: NLR family, pyrin domain containing 9C
Synonyms: Nalp-zeta, Nalp9c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330490
Homologene: 116072
Ces1f
Name: carboxylesterase 1F
Synonyms: TGH-2, CesML1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234564
HGNC: HGNC:1863
Homologene: 134311
Dnaaf9
Name: dynein axonemal assembly factor 9
Synonyms: 4930402H24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228602
Homologene: 12623
Prpsap1
Name: phosphoribosyl pyrophosphate synthetase-associated protein 1
Synonyms: PAP39, 5730409F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67763
HGNC: HGNC:9466
Homologene: 55687
Jakmip2
Name: janus kinase and microtubule interacting protein 2
Synonyms: 6430702L21Rik, D930046L20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76217
VEGA: 18
Homologene: 8866
Duox2
Name: dual oxidase 2
Synonyms: A430065P05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214593
Homologene: 9689
Tdrd7
Name: tudor domain containing 7
Synonyms: 5730495N10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100121
Homologene: 8618
Mre11a
Name: MRE11A homolog A, double strand break repair nuclease
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17535
HGNC: HGNC:7230
Homologene: 4083
Syna
Name: syncytin a
Synonyms: Gm52, syncytin-A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 214292
Homologene: 86751
Snip1
Name: Smad nuclear interacting protein 1
Synonyms: 2410133M08Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76793
Homologene: 110886
Ephx4
Name: epoxide hydrolase 4
Synonyms: LOC384214, Abhd7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384214
Homologene: 62402
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: Wbp7, 2610014H22Rik, Mll2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75410
Homologene: 22838
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cav2.2, Cchn1a, alpha(1B)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Vmn2r59
Name: vomeronasal 2, receptor 59
Synonyms: EG628444
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628444
Homologene: 129683
Shoc1
Name: shortage in chiasmata 1
Synonyms: Mzip2, LOC242489, AI481877, Gm426
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100155
Homologene: 79783
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Armc2
Name: armadillo repeat containing 2
Synonyms: 2610018I05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213402
Homologene: 41848
Uts2r
Name: urotensin 2 receptor
Synonyms: urotensin II receptor, Gpr14, UTR2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217369
HGNC: HGNC:4468
Homologene: 10345
Gmcl1
Name: germ cell-less, spermatogenesis associated 1
Synonyms: 2810049L19Rik, mglc-1, Btbd13, Gcl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23885
Homologene: 8021
Ren1
Name: renin 1 structural
Synonyms: Ren1c, Ren, Ren-1, Ren1d, Rn-1, Rnr, Ren-A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19701
HGNC: HGNC:9958
Homologene: 20151
Gpr137b
Name: G protein-coupled receptor 137B
Synonyms: Tm7sf1, C80741, 2310041G17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83924
VEGA: 13
Homologene: 2454
Ints5
Name: integrator complex subunit 5
Synonyms: 1110055N21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109077
Homologene: 35303
Rbm24
Name: RNA binding motif protein 24
Synonyms: 6330546B05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 666794
VEGA: 13
Homologene: 23015
Zfp764l1
Name: zinc finger protein 764 like 1
Synonyms: E430018J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101604
Homologene: 138471
Lrfn3
Name: leucine rich repeat and fibronectin type III domain containing 3
Synonyms: A530045B06Rik, SALM4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233067
Homologene: 11558
Gsdmd
Name: gasdermin D
Synonyms: DF5L, 1810036L03Rik, Dfna5l, Gsdmdc1, M2-4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69146
VEGA: 15
Homologene: 12299
Bak1
Name: BCL2-antagonist/killer 1
Synonyms: Bak, N-Bak
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12018
HGNC: HGNC:949
Homologene: 917
Prl3d2
Name: prolactin family 3, subfamily d, member 1
Synonyms: PL-Ib, Plib
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 215028
Homologene: 137215
Nr2e3
Name: nuclear receptor subfamily 2, group E, member 3
Synonyms: photoreceptor-specific nuclear receptor, Pnr, RNR
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23958
HGNC: HGNC:7974
Homologene: 84397
Mup9
Name: major urinary protein 9
Synonyms: Gm14076
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100038948
Homologene: 74304
Or4a79
Name: olfactory receptor family 4 subfamily A member 79
Synonyms: MOR231-22_p, Olfr1252, GA_x6K02T2Q125-51162884-51161940
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404331
Homologene: 128094
Defa29
Name: defensin, alpha, 29
Synonyms: 2010300L12Rik, CRS1C-2, Defcr-rs1, 2010319H24Rik, Defa-rs1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13218
Homologene: 85974
Ggnbp1
Name: gametogenetin binding protein 1
Synonyms: 0610031G08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70772
Homologene: 79568
Zfp551
Name: zinc finger protein 551
Synonyms: 9630004E07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 619331
Homologene: 64631
Eppk1
Name: epiplakin 1
Synonyms: EPIPL1, EPPK
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223650
VEGA: 15
Homologene: 20006
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 133,354,866 bp
  • A to T, chromosome 2 at 24,650,626 bp
  • C to T, chromosome 2 at 32,194,414 bp
  • A to G, chromosome 2 at 89,722,000 bp
  • T to A, chromosome 2 at 105,981,020 bp
  • C to T, chromosome 2 at 122,283,467 bp
  • C to A, chromosome 2 at 130,737,452 bp
  • T to C, chromosome 2 at 131,071,163 bp
  • C to T, chromosome 2 at 168,752,641 bp
  • A to G, chromosome 3 at 31,097,602 bp
  • A to G, chromosome 3 at 69,575,215 bp
  • G to A, chromosome 4 at 46,010,902 bp
  • G to C, chromosome 4 at 59,094,162 bp
  • A to G, chromosome 4 at 60,418,203 bp
  • T to C, chromosome 4 at 125,071,381 bp
  • G to A, chromosome 4 at 141,461,823 bp
  • A to G, chromosome 4 at 155,886,956 bp
  • A to T, chromosome 5 at 88,503,702 bp
  • A to T, chromosome 5 at 107,419,833 bp
  • T to A, chromosome 5 at 110,128,434 bp
  • A to T, chromosome 5 at 114,960,174 bp
  • A to G, chromosome 5 at 124,725,258 bp
  • T to C, chromosome 5 at 134,559,192 bp
  • G to T, chromosome 6 at 86,721,426 bp
  • T to C, chromosome 6 at 121,880,896 bp
  • A to T, chromosome 7 at 5,008,998 bp
  • A to T, chromosome 7 at 12,417,211 bp
  • A to G, chromosome 7 at 26,385,489 bp
  • A to G, chromosome 7 at 30,360,024 bp
  • A to G, chromosome 7 at 30,576,774 bp
  • A to G, chromosome 7 at 42,046,832 bp
  • A to T, chromosome 7 at 42,662,932 bp
  • G to A, chromosome 7 at 100,459,889 bp
  • T to A, chromosome 7 at 127,392,428 bp
  • A to G, chromosome 8 at 13,631,805 bp
  • A to T, chromosome 8 at 21,326,843 bp
  • A to G, chromosome 8 at 86,634,909 bp
  • A to T, chromosome 8 at 93,262,995 bp
  • A to T, chromosome 9 at 14,799,669 bp
  • A to G, chromosome 9 at 59,948,999 bp
  • G to A, chromosome 9 at 121,460,425 bp
  • A to G, chromosome 10 at 20,965,681 bp
  • C to T, chromosome 10 at 40,223,884 bp
  • C to T, chromosome 10 at 42,011,958 bp
  • A to G, chromosome 10 at 82,641,382 bp
  • A to T, chromosome 10 at 88,770,388 bp
  • A to G, chromosome 11 at 95,284,109 bp
  • A to T, chromosome 11 at 96,961,837 bp
  • A to T, chromosome 11 at 116,490,216 bp
  • T to C, chromosome 11 at 120,678,522 bp
  • G to A, chromosome 11 at 121,160,669 bp
  • T to C, chromosome 13 at 8,987,286 bp
  • T to C, chromosome 13 at 13,359,406 bp
  • A to G, chromosome 13 at 27,123,966 bp
  • A to T, chromosome 13 at 46,419,031 bp
  • A to G, chromosome 13 at 100,058,896 bp
  • G to A, chromosome 14 at 34,397,922 bp
  • G to T, chromosome 14 at 47,064,247 bp
  • G to T, chromosome 14 at 75,747,093 bp
  • T to A, chromosome 15 at 75,863,446 bp
  • T to C, chromosome 15 at 76,109,004 bp
  • T to C, chromosome 15 at 76,109,135 bp
  • T to C, chromosome 15 at 78,959,944 bp
  • A to G, chromosome 17 at 27,021,306 bp
  • C to T, chromosome 17 at 27,029,645 bp
  • T to C, chromosome 17 at 45,639,206 bp
  • G to A, chromosome 18 at 43,563,333 bp
  • T to C, chromosome 19 at 8,897,043 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7999 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046039-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.