Strain Name:
C57BL/6J-MtgxR8001Btlr/Mmmh
Stock Number:
046041-MU
Citation ID:
RRID:MMRRC_046041-MU
Other Names:
R8001 (G1)
Major Collection:

Strain Information

Tyrp1
Name: tyrosinase-related protein 1
Synonyms: TRP1, TRP-1, Oca3, isa, Tyrp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22178
Homologene: 464
Slc17a7
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
Synonyms: Vglut1, 2900052E22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72961
Homologene: 113454
Lig3
Name: ligase III, DNA, ATP-dependent
Synonyms: D11Wsu78e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16882
HGNC: HGNC:6600
Homologene: 32109
Zc3h7b
Name: zinc finger CCCH type containing 7B
Synonyms: Scrg3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20286
VEGA: 15
Homologene: 9735
Hnrnpll
Name: heterogeneous nuclear ribonucleoprotein L-like
Synonyms: 2510028H02Rik, 2810036L13Rik, Hnrpll
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72692
Homologene: 26701
Cse1l
Name: chromosome segregation 1 like
Synonyms: Capts, Cas, 2610100P18Rik, Xpo2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110750
HGNC: HGNC:2431
Homologene: 1006
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Zfp619
Name: zinc finger protein 619
Synonyms: 3000002G13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70227
Homologene: 133818
Alkbh4
Name: alkB homolog 4, lysine demethylase
Synonyms: Abj4, 2010004B12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72041
Homologene: 9747
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Smad4
Name: SMAD family member 4
Synonyms: Dpc4, DPC4, Madh4, D18Wsu70e, Smad 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17128
HGNC: HGNC:6770
Homologene: 31310
Trim33
Name: tripartite motif-containing 33
Synonyms: ectodermin, Tif1g, Ecto, 8030451N04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94093
Homologene: 9296
Acr
Name: acrosin prepropeptide
Synonyms: preproacrosin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11434
VEGA: 15
HGNC: HGNC:126
Homologene: 855
Itpkb
Name: inositol 1,4,5-trisphosphate 3-kinase B
Synonyms: E130307H12Rik, 1110033J02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320404
HGNC: HGNC:6179
Homologene: 1672
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Stk32a
Name: serine/threonine kinase 32A
Synonyms: YANK1, A930015B13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269019
VEGA: 18
Homologene: 65357
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Mab21l4
Name: mab-21-like 4
Synonyms: 2310007B03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71874
Homologene: 11761
Ogfod2
Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 2
Synonyms: 5730405M13Rik, 1300006G11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66627
Homologene: 32588
Pabpc6
Name: poly(A) binding protein, cytoplasmic 6
Synonyms: 4932702K14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67543
VEGA: 17
Homologene: 129776
Or5ac19
Name: olfactory receptor family 5 subfamily AC member 19
Synonyms: GA_x54KRFPKG5P-55483936-55483010, MOR182-2, Olfr201
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258996
Homologene: 37011
Stox2
Name: storkhead box 2
Synonyms: 4933409N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71069
Homologene: 18414
Nrxn1
Name: neurexin I
Synonyms: alpha-latrotoxin receptor (calcium-dependent), 1700062G21Rik, neurexin I alpha, 9330127H16Rik, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I alpha, neurexin I beta, A230068P09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Snap47
Name: synaptosomal-associated protein, 47
Synonyms: 1110031B06Rik, SNAP-47
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67826
Homologene: 14206
Or5b118
Name: olfactory receptor family 5 subfamily B member 118
Synonyms: MOR202-42, GA_x6K02T2RE5P-3803583-3804527, MOR202-26P, Olfr1474
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258123
Homologene: 79417
Or9k7
Name: olfactory receptor family 9 subfamily K member 7
Synonyms: Olfr827, GA_x6K02T2PULF-11878777-11877809, MOR210-5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258297
Homologene: 27117
Vmn1r25
Name: vomeronasal 1 receptor 25
Synonyms: V1rc8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113865
Homologene: 137652
Vmn2r117
Name: vomeronasal 2, receptor 117
Synonyms: EG619788, V2Rp6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 619788
Homologene: 86604
Stc1
Name: stanniocalcin 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20855
VEGA: 14
Homologene: 2374
Or51h1
Name: olfactory receptor family 51 subfamily H member 1
Synonyms: MOR10-1, Olfr555, GA_x6K02T2PBJ9-5375442-5376389
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259107
Homologene: 51817
Elmo1
Name: engulfment and cell motility 1
Synonyms: C230095H21Rik, 6330578D22Rik, CED-12
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 140580
Homologene: 56685
Psg22
Name: pregnancy-specific beta-1-glycoprotein 22
Synonyms: cea9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243862
HGNC: HGNC:1816
Homologene: 110989
Wnt8a
Name: wingless-type MMTV integration site family, member 8A
Synonyms: Stra11
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20890
VEGA: 18
Homologene: 7553
Ctrc
Name: chymotrypsin C
Synonyms: caldecrin, 1810044E12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76701
HGNC: HGNC:2523
Homologene: 21422
Erich3
Name: glutamate rich 3
Synonyms: 5031409G23Rik, 4922501L14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 209601
Homologene: 27877
Trav16d-dv11
Name: T cell receptor alpha variable 16D-DV11
Synonyms: ENSMUSG00000072535
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 547329
Snx21
Name: sorting nexin family member 21
Synonyms: 5730407K14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 101113
Homologene: 43132
Pcdhgb2
Name: protocadherin gamma subfamily B, 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93700
HGNC: HGNC:8709
Homologene: 49571
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 93,154,599 bp
  • A to T, chromosome 1 at 150,664,878 bp
  • T to C, chromosome 1 at 180,332,494 bp
  • T to C, chromosome 1 at 188,911,064 bp
  • T to C, chromosome 2 at 164,786,737 bp
  • T to A, chromosome 2 at 166,939,913 bp
  • T to C, chromosome 3 at 103,311,515 bp
  • T to C, chromosome 3 at 154,713,916 bp
  • T to C, chromosome 4 at 80,840,670 bp
  • A to T, chromosome 4 at 141,840,360 bp
  • A to T, chromosome 5 at 110,312,734 bp
  • T to G, chromosome 5 at 124,114,883 bp
  • A to G, chromosome 5 at 136,140,269 bp
  • T to A, chromosome 6 at 57,979,080 bp
  • A to T, chromosome 7 at 18,719,746 bp
  • A to G, chromosome 7 at 39,535,221 bp
  • A to T, chromosome 7 at 45,168,788 bp
  • A to T, chromosome 7 at 102,659,034 bp
  • G to A, chromosome 8 at 47,186,477 bp
  • A to G, chromosome 10 at 130,210,860 bp
  • T to A, chromosome 11 at 59,438,354 bp
  • T to A, chromosome 11 at 82,792,076 bp
  • C to A, chromosome 11 at 107,047,340 bp
  • A to G, chromosome 13 at 20,286,732 bp
  • C to T, chromosome 14 at 32,973,535 bp
  • A to G, chromosome 14 at 53,047,287 bp
  • T to A, chromosome 14 at 69,038,395 bp
  • C to A, chromosome 15 at 81,779,260 bp
  • A to G, chromosome 15 at 89,573,962 bp
  • T to C, chromosome 16 at 59,269,109 bp
  • C to A, chromosome 17 at 9,669,373 bp
  • T to A, chromosome 17 at 23,479,407 bp
  • G to A, chromosome 17 at 80,038,723 bp
  • C to T, chromosome 17 at 91,088,536 bp
  • A to T, chromosome 18 at 34,545,516 bp
  • A to T, chromosome 18 at 37,690,634 bp
  • A to T, chromosome 18 at 43,315,144 bp
  • A to G, chromosome 18 at 73,641,810 bp
  • A to G, chromosome 19 at 13,471,422 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8001 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046041-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.