Strain Name:
C57BL/6J-MtgxR8002Btlr/Mmmh
Stock Number:
046042-MU
Citation ID:
RRID:MMRRC_046042-MU
Other Names:
R8002 (G1)
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: neuroaxonal dystrophy, ROSA62, SpbIV, nmf261, 1700022P15Rik, Spnb4, dyn, 5830426A08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: aldosterone synthase, Cyp11b-2, Cyp11b, steroid-11-beta-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13072
Homologene: 128035
Cpne3
Name: copine III
Synonyms: PRO1071, CPN3, 5730450C07Rik, 5430428M23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70568
HGNC: HGNC:2316
Homologene: 20839
Atf6
Name: activating transcription factor 6
Synonyms: ESTM49, 9130025P16Rik, Atf6alpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226641
HGNC: HGNC:791
Homologene: 32015
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: Listerin, Rnf160, Zfp294, 4930528H02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Srebf2
Name: sterol regulatory element binding factor 2
Synonyms: SREBP2gc, lop13, SREBP2, SREBP-2, nuc, bHLHd2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20788
VEGA: 15
Homologene: 20966
Crot
Name: carnitine O-octanoyltransferase
Synonyms: 1200003H03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74114
HGNC: HGNC:2366
Homologene: 10899
Tomm70a
Name: translocase of outer mitochondrial membrane 70A
Synonyms: 2610044B22Rik, Tom70, D16Ium22, Tomm70a, D16Wsu109e, D16Ium22e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 28185
VEGA: 16
Homologene: 40112
Wdr62
Name: WD repeat domain 62
Synonyms: 2310038K02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233064
Homologene: 15927
Otof
Name: otoferlin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Arhgef2
Name: Rho/Rac guanine nucleotide exchange factor 2
Synonyms: Lfc, GEF-H1, LFP40, GEFH1, P40, Lbcl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16800
HGNC: HGNC:682
Homologene: 3468
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71389
Homologene: 32772
Brd8
Name: bromodomain containing 8
Synonyms: p120, SMAP, 2610007E11Rik, 4432404P07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 78656
Homologene: 41790
Nadk
Name: NAD kinase
Synonyms: 4432404C02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 192185
Homologene: 49724
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, B230373P09Rik, E030034C22Rik, G1-415-19, Dnahc1, ferf1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Jtb
Name: jumping translocation breakpoint
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23922
HGNC: HGNC:6201
Homologene: 4870
Adgrf4
Name: adhesion G protein-coupled receptor F4
Synonyms: 4632435A09Rik, Gpr115
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78249
Homologene: 51953
Marco
Name: macrophage receptor with collagenous structure
Synonyms: Scara2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17167
HGNC: HGNC:6895
Homologene: 4928
Casp1
Name: caspase 1
Synonyms: ICE, Caspase-1, interleukin 1 beta-converting enzyme, Il1bc
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12362
VEGA: 9
HGNC: HGNC:1499
Homologene: 133272
Zfp418
Name: zinc finger protein 418
Synonyms: A230102I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232854
Homologene: 119890
Alx3
Name: aristaless-like homeobox 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11694
HGNC: HGNC:449
Homologene: 4737
Atp1a3
Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide
Synonyms: Atpa-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232975
HGNC: HGNC:801
Homologene: 113729
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627636
Homologene: 115024
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: mfmi1, flamingo, EGFL2, Adgrc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Tdrd6
Name: tudor domain containing 6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210510
Homologene: 19364
Xpc
Name: xeroderma pigmentosum, complementation group C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22591
Homologene: 3401
Tigd2
Name: tigger transposable element derived 2
Synonyms: 3632410O17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68140
Homologene: 129603
Ccdc150
Name: coiled-coil domain containing 150
Synonyms: 4930511H11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78016
Homologene: 15814
Pla2g10
Name: phospholipase A2, group X
Synonyms: mGXsPLA2, PLA2GX, GX sPLA2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26565
HGNC: HGNC:9029
Homologene: 2636
Map3k13
Name: mitogen-activated protein kinase kinase kinase 13
Synonyms: C130026N12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71751
VEGA: 16
HGNC: HGNC:6852
Homologene: 37958
Ccdc81
Name: coiled-coil domain containing 81
Synonyms: 4921513D09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70884
Homologene: 128447
Rfx4
Name: regulatory factor X, 4 (influences HLA class II expression)
Synonyms: 4933412G19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71137
HGNC: HGNC:9985
Homologene: 31119
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432486
Homologene: 32576
Lpcat4
Name: lysophosphatidylcholine acyltransferase 4
Synonyms: Agpat7, Aytl3, LPEAT2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99010
Homologene: 27544
Slc26a4
Name: solute carrier family 26, member 4
Synonyms: pendrin, Pds
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23985
VEGA: 12
HGNC: HGNC:8818
Homologene: 20132
Or11h7
Name: olfactory receptor family 11 subfamily H member 7
Synonyms: Olfr746, GA_x6K02T2PMLR-6372116-6373060, MOR106-12
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258295
Homologene: 134081
Gabrg3
Name: gamma-aminobutyric acid type A receptor, subunit gamma 3
Synonyms: Gabrg-3, B230362M20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14407
HGNC: HGNC:4088
Homologene: 22444
Stard6
Name: StAR related lipid transfer domain containing 6
Synonyms: 4833424I06Rik, 1700011K09Rik, 4933429L05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 170461
Homologene: 12578
Acsm2
Name: acyl-CoA synthetase medium-chain family member 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233799
Homologene: 70404
Dqx1
Name: DEAQ RNA-dependent ATPase
Synonyms: 2310066E11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93838
Homologene: 14143
Vmn2r76
Name: vomeronasal 2, receptor 76
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 675969
Homologene: 104330
Klk1b27
Name: kallikrein 1-related peptidase b27
Synonyms: Klk21l, Klk27, mGK-27
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16619
Homologene: 68141
Septin1
Name: septin 1
Synonyms: PNUTL3, Diff6, Sept1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54204
HGNC: HGNC:2879
Homologene: 23009
Pigw
Name: phosphatidylinositol glycan anchor biosynthesis, class W
Synonyms: Gwt1, 2610044A17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70325
Homologene: 6243
Slc1a7
Name: solute carrier family 1 (glutamate transporter), member 7
Synonyms: A930031E15Rik, EAAT5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242607
Homologene: 21327
Hdac1-ps
Name: histone deacetylase 1, pseudogene
Synonyms: Gm10093, EG15181
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15181
VEGA: 17
Vmn1r21
Name: vomeronasal 1 receptor 21
Synonyms: V1rc28
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171201
Homologene: 74363
Gm13199
Name: predicted gene 13199
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 791411
Tas2r114
Name: taste receptor, type 2, member 114
Synonyms: Tas2r14, T2R14, mGR14, mt2r46
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387346
Homologene: 128355
Tspo
Name: translocator protein
Synonyms: PBR, Bzrp, Tspo1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12257
HGNC: HGNC:1158
Homologene: 574
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 54,272,497 bp
  • T to G, chromosome 1 at 120,494,780 bp
  • A to G, chromosome 1 at 170,819,254 bp
  • A to G, chromosome 2 at 5,862,647 bp
  • G to A, chromosome 2 at 112,244,354 bp
  • T to C, chromosome 2 at 160,990,321 bp
  • A to T, chromosome 3 at 88,646,810 bp
  • T to C, chromosome 3 at 90,233,944 bp
  • T to A, chromosome 3 at 107,600,739 bp
  • G to T, chromosome 3 at 108,403,969 bp
  • A to T, chromosome 4 at 19,528,232 bp
  • G to A, chromosome 4 at 108,012,276 bp
  • G to T, chromosome 4 at 155,577,198 bp
  • A to C, chromosome 5 at 8,993,599 bp
  • G to A, chromosome 5 at 30,380,610 bp
  • T to A, chromosome 6 at 57,844,214 bp
  • T to G, chromosome 6 at 59,210,509 bp
  • G to A, chromosome 6 at 83,058,577 bp
  • T to A, chromosome 6 at 91,492,305 bp
  • T to C, chromosome 6 at 131,689,139 bp
  • A to G, chromosome 7 at 7,181,874 bp
  • C to A, chromosome 7 at 25,000,671 bp
  • C to A, chromosome 7 at 27,417,992 bp
  • T to C, chromosome 7 at 30,252,360 bp
  • T to A, chromosome 7 at 44,056,021 bp
  • T to C, chromosome 7 at 56,734,968 bp
  • T to C, chromosome 7 at 86,230,063 bp
  • T to C, chromosome 7 at 89,876,135 bp
  • C to T, chromosome 7 at 119,573,257 bp
  • T to C, chromosome 7 at 127,215,902 bp
  • C to A, chromosome 9 at 5,303,164 bp
  • A to C, chromosome 10 at 84,840,857 bp
  • A to T, chromosome 10 at 88,440,268 bp
  • A to T, chromosome 11 at 84,878,423 bp
  • T to C, chromosome 12 at 31,547,970 bp
  • A to T, chromosome 14 at 31,298,722 bp
  • A to T, chromosome 14 at 50,653,857 bp
  • T to C, chromosome 15 at 74,856,032 bp
  • C to T, chromosome 15 at 82,178,765 bp
  • T to C, chromosome 15 at 83,571,439 bp
  • A to T, chromosome 16 at 13,725,048 bp
  • A to G, chromosome 16 at 21,905,128 bp
  • A to G, chromosome 16 at 57,136,734 bp
  • A to C, chromosome 16 at 87,415,947 bp
  • T to A, chromosome 17 at 19,799,249 bp
  • T to C, chromosome 17 at 42,667,792 bp
  • C to A, chromosome 17 at 43,629,819 bp
  • T to C, chromosome 17 at 78,492,287 bp
  • T to C, chromosome 18 at 34,608,556 bp
  • T to A, chromosome 18 at 70,500,526 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8002 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046042-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.