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Strain Name:
C57BL/6J-MtgxR8022Btlr/Mmmh
Stock Number:
067461-MU
Citation ID:
RRID:MMRRC_067461-MU
Other Names:
R8022 (G1)
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Thbs4
Name: thrombospondin 4
Synonyms: TSP-4, TSP4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21828
Homologene: 20691
Slc12a8
Name: solute carrier family 12 (potassium/chloride transporters), member 8
Synonyms: E330020C02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 171286
Homologene: 11628
Magi1
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms: WWP3, Gukmi1, AIP3, BAP1, Baiap1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14924
HGNC: HGNC:946
Homologene: 31257
Slc25a12
Name: solute carrier family 25 (mitochondrial carrier, Aralar), member 12
Synonyms: B230107K20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78830
Homologene: 48235
Cyp39a1
Name: cytochrome P450, family 39, subfamily a, polypeptide 1
Synonyms: oxysterol 7-alpha-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56050
VEGA: 17
Homologene: 9580
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 60,260,272 bp
  • T to C, chromosome 1 at 87,153,330 bp
  • T to A, chromosome 1 at 110,061,108 bp
  • G to A, chromosome 2 at 4,752,779 bp
  • A to T, chromosome 2 at 71,275,189 bp
  • T to C, chromosome 2 at 127,577,924 bp
  • C to A, chromosome 2 at 143,956,792 bp
  • A to T, chromosome 2 at 145,918,566 bp
  • A to T, chromosome 2 at 173,118,766 bp
  • A to G, chromosome 2 at 178,355,062 bp
  • A to T, chromosome 3 at 88,326,520 bp
  • T to G, chromosome 3 at 89,609,703 bp
  • A to T, chromosome 3 at 95,338,599 bp
  • T to A, chromosome 3 at 95,347,085 bp
  • A to G, chromosome 3 at 105,458,873 bp
  • A to T, chromosome 3 at 144,805,766 bp
  • T to A, chromosome 4 at 8,751,605 bp
  • T to C, chromosome 4 at 45,062,062 bp
  • T to A, chromosome 4 at 48,051,510 bp
  • G to T, chromosome 4 at 63,144,197 bp
  • A to G, chromosome 4 at 101,782,557 bp
  • G to A, chromosome 4 at 108,012,276 bp
  • C to T, chromosome 4 at 108,189,568 bp
  • T to A, chromosome 4 at 125,065,530 bp
  • T to C, chromosome 4 at 132,732,338 bp
  • C to T, chromosome 4 at 150,638,309 bp
  • C to T, chromosome 5 at 25,281,680 bp
  • G to T, chromosome 5 at 31,068,806 bp
  • T to A, chromosome 5 at 33,409,504 bp
  • A to G, chromosome 5 at 45,681,794 bp
  • A to T, chromosome 5 at 114,223,854 bp
  • A to T, chromosome 5 at 115,127,043 bp
  • A to G, chromosome 5 at 120,756,966 bp
  • T to C, chromosome 5 at 142,470,149 bp
  • A to T, chromosome 5 at 143,967,232 bp
  • T to A, chromosome 5 at 145,977,668 bp
  • C to T, chromosome 6 at 91,519,561 bp
  • T to C, chromosome 6 at 93,697,365 bp
  • T to C, chromosome 6 at 97,248,299 bp
  • T to A, chromosome 7 at 24,714,174 bp
  • T to A, chromosome 7 at 39,409,376 bp
  • T to A, chromosome 7 at 99,473,239 bp
  • A to T, chromosome 7 at 112,303,767 bp
  • G to A, chromosome 7 at 126,169,254 bp
  • T to G, chromosome 8 at 70,312,803 bp
  • G to A, chromosome 8 at 85,095,613 bp
  • A to G, chromosome 8 at 93,069,315 bp
  • C to A, chromosome 8 at 109,832,735 bp
  • T to C, chromosome 8 at 122,887,593 bp
  • G to T, chromosome 9 at 49,564,892 bp
  • A to G, chromosome 9 at 56,925,340 bp
  • A to T, chromosome 9 at 62,060,591 bp
  • A to C, chromosome 9 at 107,543,061 bp
  • A to G, chromosome 9 at 108,114,404 bp
  • A to G, chromosome 9 at 108,378,471 bp
  • T to C, chromosome 10 at 45,700,970 bp
  • A to C, chromosome 10 at 58,485,861 bp
  • T to C, chromosome 10 at 81,031,277 bp
  • G to A, chromosome 10 at 85,146,402 bp
  • A to T, chromosome 10 at 94,044,344 bp
  • A to T, chromosome 10 at 129,776,785 bp
  • C to A, chromosome 11 at 9,023,376 bp
  • A to C, chromosome 11 at 73,322,206 bp
  • A to G, chromosome 11 at 74,084,068 bp
  • G to A, chromosome 11 at 96,772,854 bp
  • A to G, chromosome 11 at 100,624,287 bp
  • C to A, chromosome 12 at 81,377,720 bp
  • A to T, chromosome 12 at 110,855,098 bp
  • A to T, chromosome 13 at 75,099,293 bp
  • T to G, chromosome 13 at 92,752,447 bp
  • A to G, chromosome 14 at 31,265,014 bp
  • C to T, chromosome 14 at 52,778,827 bp
  • T to A, chromosome 14 at 56,157,446 bp
  • A to G, chromosome 15 at 25,843,479 bp
  • C to G, chromosome 15 at 27,749,866 bp
  • C to T, chromosome 15 at 82,178,765 bp
  • G to A, chromosome 15 at 82,616,114 bp
  • C to A, chromosome 16 at 21,777,820 bp
  • A to G, chromosome 16 at 33,625,086 bp
  • A to G, chromosome 16 at 56,006,020 bp
  • T to A, chromosome 17 at 12,718,795 bp
  • T to C, chromosome 17 at 43,746,577 bp
  • T to G, chromosome 17 at 47,466,236 bp
  • A to G, chromosome 17 at 47,728,776 bp
  • T to A, chromosome 17 at 78,315,555 bp
  • T to C, chromosome 17 at 87,646,308 bp
  • A to G, chromosome 18 at 16,590,301 bp
  • C to T, chromosome 18 at 43,315,101 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8022 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067461-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.