Strain Name:
C57BL/6J-MtgxR8040Btlr/Mmmh
Stock Number:
067477-MU
Citation ID:
RRID:MMRRC_067477-MU
Other Names:
R8040 (G1)
Major Collection:

Strain Information

Adcy10
Name: adenylate cyclase 10
Synonyms: soluble adenylyl cyclase, 4930431D04Rik, sAC, Sacy
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271639
Homologene: 10188
Cxcr4
Name: C-X-C motif chemokine receptor 4
Synonyms: PB-CKR, Cmkar4, b2b220Clo, CD184, Sdf1r, fusin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12767
HGNC: HGNC:2561
Homologene: 20739
Cltc
Name: clathrin heavy chain
Synonyms: CHC
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Dock9
Name: dedicator of cytokinesis 9
Synonyms: Zizimin1, D14Wsu89e, B230309H04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Pml
Name: promyelocytic leukemia
Synonyms: Trim19, 1200009E24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18854
HGNC: HGNC:9113
Homologene: 13245
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: 1600013L13Rik, 4930541M15Rik, Camsap1l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67886
Homologene: 18927
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: Ugcgl1, A930007H10Rik, C820010P03Rik, 0910001L17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320011
Homologene: 10586
Nceh1
Name: neutral cholesterol ester hydrolase 1
Synonyms: CPO-BP, mKIAA1363, B230106I24Rik, Aadacl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320024
Homologene: 23251
Tent4a
Name: terminal nucleotidyltransferase 4A
Synonyms: Pols, TRF4-1, TRF4, Papd7, LAK-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210106
Homologene: 5089
Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
Synonyms: D130026O08Rik, Arhgap14
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259302
Homologene: 56686
Plb1
Name: phospholipase B1
Synonyms: 4930433E17Rik, 4632413E21Rik, 4930539A06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665270
Homologene: 82108
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Pfdn6
Name: prefoldin subunit 6
Synonyms: H-2Ke2, Ke-2, H2-Ke2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14976
HGNC: HGNC:4926
Homologene: 40720
Sclt1
Name: sodium channel and clathrin linker 1
Synonyms: 4931421F20Rik, 2610207F23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67161
Homologene: 27031
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Golgb1
Name: golgin B1
Synonyms: 6330407A06Rik, Gm6840, C130074L01Rik, F730017E11Rik, Giantin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Cyp4a12a
Name: cytochrome P450, family 4, subfamily a, polypeptide 12a
Synonyms: Cyp4a12
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277753
Homologene: 134044
Parp2
Name: poly (ADP-ribose) polymerase family, member 2
Synonyms: Adprt2, Aspartl2, Adprtl2, C78626, PARP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11546
VEGA: 14
HGNC: HGNC:272
Homologene: 4004
Hcls1
Name: hematopoietic cell specific Lyn substrate 1
Synonyms: HS1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15163
HGNC: HGNC:4844
Homologene: 38034
Serpina3b
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3B
Synonyms: A030003A19Rik, 6A1, alpha-1 antiproteinase, antitrypsin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 271047
HGNC: HGNC:16
Homologene: 120222
Kcnk4
Name: potassium channel, subfamily K, member 4
Synonyms: TRAAKt
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16528
VEGA: 19
HGNC: HGNC:6279
Homologene: 7391
Vmn1r87
Name: vomeronasal 1 receptor 87
Synonyms: V1rk1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171261
Homologene: 134023
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: A230044C21Rik, Caps2, cpd2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240776
Homologene: 16121
Ano8
Name: anoctamin 8
Synonyms: Tmem16h
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382014
Homologene: 124473
Or6n1
Name: olfactory receptor family 6 subfamily N member 1
Synonyms: Olfr429, GA_x6K02T2P20D-21090094-21089156, MOR105-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258717
Homologene: 17366
Vmn2r107
Name: vomeronasal 2, receptor 107
Synonyms: V2r6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22312
Homologene: 129750
Adam21
Name: a disintegrin and metallopeptidase domain 21
Synonyms: ADAM31
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56622
HGNC: HGNC:200
Homologene: 68365
Mdp1
Name: magnesium-dependent phosphatase 1
Synonyms: 1810034K20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67881
VEGA: 14
Homologene: 5846
Or6x1
Name: olfactory receptor family 6 subfamily X member 1
Synonyms: Olfr986, GA_x6K02T2PVTD-33886895-33887833, MOR104-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258608
VEGA: 9
Homologene: 105185
Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Synonyms: MDR3, Pgp, P-glycoprotein, Pgy-3, Evi32, mdr-3, Mdr1a, multiple drug resistant 1a, Pgy3, P-gp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Or8d1
Name: olfactory receptor family 8 subfamily D member 1
Synonyms: GA_x6K02T2PVTD-32550930-32551856, Olfr26, MOR171-9, MTPCR09
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18324
VEGA: 9
HGNC: HGNC:8481
Homologene: 79676
Il1r1
Name: interleukin 1 receptor, type I
Synonyms: Il1r-1, IL-1 receptor alpha chain, IL-1R1, CD121a, IL-iR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16177
HGNC: HGNC:5993
Homologene: 677
Kcna1
Name: potassium voltage-gated channel, shaker-related subfamily, member 1
Synonyms: mceph, Mk-1, MBK1, Kv1.1, Shak, mouse brain potassium channel protein-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16485
HGNC: HGNC:6218
Homologene: 183
Sowahb
Name: sosondowah ankyrin repeat domain family member B
Synonyms: 5730467H21Rik, Ankrd56
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78088
Homologene: 18429
Plat
Name: plasminogen activator, tissue
Synonyms: t-PA, tPA, D8Ertd2e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18791
HGNC: HGNC:9051
Homologene: 717
Prodh2
Name: proline dehydrogenase (oxidase) 2
Synonyms: 2510038B11Rik, POX1, 2510028N04Rik, MmPOX1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56189
Homologene: 36381
Dnal4
Name: dynein, axonemal, light chain 4
Synonyms: Dnalc4, D15Ertd424e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54152
HGNC: HGNC:2955
Homologene: 38094
Allc
Name: allantoicase
Synonyms: 1700012B22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 94041
Homologene: 6202
Cwc25
Name: CWC25 spliceosome-associated protein
Synonyms: 1300013D05Rik, Ccdc49, R75228
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67480
Homologene: 135922
Or5d20-ps1
Name: olfactory receptor family 5 subfamily D member 20, pseudogene 1
Synonyms: Olfr1165-ps, GA_x6K02T2Q125-49593880-49592930, MOR174-7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258642
Cfap91
Name: cilia and flagella associated protein 91
Synonyms: Spata26, 4932425I24Rik, Maats1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320214
Homologene: 33470
Ccl19
Name: C-C motif chemokine ligand 19
Synonyms: exodus-3, Gm2023, CKb11, Scya19
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 24047
Homologene: 4569
Zscan4-ps3
Name: zinc finger and SCAN domain containing 4, pseudogene 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043042
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,211,473 bp
  • A to T, chromosome 1 at 40,313,349 bp
  • A to G, chromosome 1 at 128,589,798 bp
  • T to C, chromosome 1 at 136,281,247 bp
  • G to A, chromosome 1 at 140,450,217 bp
  • A to G, chromosome 1 at 165,552,024 bp
  • T to C, chromosome 1 at 174,089,157 bp
  • T to A, chromosome 2 at 88,101,359 bp
  • A to G, chromosome 3 at 27,241,225 bp
  • T to C, chromosome 3 at 38,981,666 bp
  • C to T, chromosome 3 at 41,657,376 bp
  • T to C, chromosome 4 at 42,756,297 bp
  • A to G, chromosome 4 at 115,326,215 bp
  • A to T, chromosome 5 at 8,715,035 bp
  • T to A, chromosome 5 at 32,273,069 bp
  • A to G, chromosome 5 at 93,043,433 bp
  • C to A, chromosome 6 at 23,412,943 bp
  • C to T, chromosome 6 at 112,739,364 bp
  • C to T, chromosome 6 at 126,642,740 bp
  • T to A, chromosome 7 at 11,612,673 bp
  • T to A, chromosome 7 at 13,132,159 bp
  • A to G, chromosome 7 at 30,506,411 bp
  • G to T, chromosome 8 at 22,772,232 bp
  • T to C, chromosome 8 at 71,482,168 bp
  • T to A, chromosome 9 at 38,855,164 bp
  • A to G, chromosome 9 at 40,187,421 bp
  • C to A, chromosome 9 at 58,234,685 bp
  • A to G, chromosome 11 at 86,725,205 bp
  • A to G, chromosome 11 at 97,750,870 bp
  • T to C, chromosome 11 at 116,222,932 bp
  • T to A, chromosome 12 at 11,458,791 bp
  • A to T, chromosome 12 at 28,555,352 bp
  • T to C, chromosome 12 at 81,560,437 bp
  • A to G, chromosome 12 at 104,131,076 bp
  • A to G, chromosome 12 at 114,538,770 bp
  • A to G, chromosome 13 at 69,500,481 bp
  • T to A, chromosome 14 at 50,810,173 bp
  • T to A, chromosome 14 at 55,660,066 bp
  • G to A, chromosome 14 at 55,871,525 bp
  • C to A, chromosome 14 at 121,651,794 bp
  • T to C, chromosome 15 at 79,761,968 bp
  • A to G, chromosome 16 at 36,913,479 bp
  • A to G, chromosome 16 at 36,951,149 bp
  • A to G, chromosome 16 at 38,320,371 bp
  • G to A, chromosome 17 at 20,375,546 bp
  • T to C, chromosome 17 at 33,939,977 bp
  • T to C, chromosome 17 at 34,716,558 bp
  • A to G, chromosome 19 at 6,927,627 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8040 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067477-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.