Strain Name:
C57BL/6J-MtgxR8051Btlr/Mmmh
Stock Number:
067488-MU
Citation ID:
RRID:MMRRC_067488-MU
Other Names:
R8051 (G1)
Major Collection:

Strain Information

Tyrp1
Name: tyrosinase-related protein 1
Synonyms: Tyrp, TRP-1, Oca3, isa, TRP1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22178
Homologene: 464
Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: A930033B01Rik, PSGAP-m, PSGAP-s
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78514
Homologene: 12695
Lamb3
Name: laminin, beta 3
Synonyms: nicein, 125kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16780
HGNC: HGNC:6490
Homologene: 191
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: my, b2b1562Clo, 6030440P17Rik, ne, 8430406N05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Spns1
Name: SPNS lysolipid transporter 1, lysophospholipid
Synonyms: 2210013K02Rik, spinster homolog
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73658
Homologene: 41530
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alphaII-spectrin, 2610027H02Rik, Spna-2, alpha-fodrin, Spna2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20740
Homologene: 2353
Tmem121
Name: transmembrane protein 121
Synonyms: 2410008J05Rik, Hole
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69195
Homologene: 11900
Adgrl3
Name: adhesion G protein-coupled receptor L3
Synonyms: 5430402I23Rik, LEC3, Lphn3, D130075K09Rik, lectomedin 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319387
Homologene: 22878
Dlg4
Name: discs large MAGUK scaffold protein 4
Synonyms: SAP90, SAP90A, PSD-95, Dlgh4, PSD95
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13385
HGNC: HGNC:2903
Homologene: 1047
Fnbp4
Name: formin binding protein 4
Synonyms: FBP30
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 55935
Homologene: 9087
Klc1
Name: kinesin light chain 1
Synonyms: Kns2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16593
HGNC: HGNC:6387
Homologene: 4056
Rbm33
Name: RNA binding motif protein 33
Synonyms: 3200001K10Rik, 6430512A10Rik, Prr8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381626
Homologene: 137386
Efemp2
Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 2
Synonyms: Fbln4, 0610011K11Rik, fibulin-4, MBP1, fibulin 4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58859
HGNC: HGNC:3219
Homologene: 32339
Il17re
Name: interleukin 17 receptor E
Synonyms: Il25r
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 57890
Homologene: 17109
Zfp57
Name: zinc finger protein 57
Synonyms: G19
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22715
Homologene: 7603
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: 9930021N24Rik, MOZ, Myst3, Zfp220
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244349
Homologene: 4924
Flt3
Name: FMS-like tyrosine kinase 3
Synonyms: wmfl, Flk-2, CD135, Flk2, Flt-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14255
HGNC: HGNC:3765
Homologene: 3040
Irf4
Name: interferon regulatory factor 4
Synonyms: Spip, IRF-4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16364
HGNC: HGNC:6119
Homologene: 1842
Lmo2
Name: LIM domain only 2
Synonyms: Rhom-2, Rbtn-2, Rbtn2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16909
HGNC: HGNC:6642
Homologene: 4072
Rap1gap2
Name: RAP1 GTPase activating protein 2
Synonyms: Garnl4, LOC380710
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380711
Homologene: 56695
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Bltp2
Name: bridge-like lipid transfer protein family member 2
Synonyms: 2610507B11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72503
Homologene: 34730
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: vascular endothelial growth factor receptor-1, Flt-1, VEGFR1, VEGFR-1, sFlt1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Or12d17
Name: olfactory receptor family 12 subfamily D member 17
Synonyms: MOR250-1, Olfr109, GA_x6K02T2PSCP-1914078-1915022
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258832
Homologene: 12811
Slc20a1
Name: solute carrier family 20, member 1
Synonyms: Glvr1, PiT-1, Glvr-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20515
Homologene: 38049
Or11g26
Name: olfactory receptor family 11 subfamily G member 26
Synonyms: MOR106-6, GA_x6K02T2PMLR-6224293-6225228, Olfr742
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258422
Homologene: 74163
Chtf18
Name: CTF18, chromosome transmission fidelity factor 18
Synonyms: 6030457M03Rik, CTF18
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214901
Homologene: 32532
Zkscan4
Name: zinc finger with KRAB and SCAN domains 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544922
Homologene: 128718
Ano9
Name: anoctamin 9
Synonyms: 5430425C04Rik, Tp53i5, Trp53i5, Tmem16j
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71345
Homologene: 67083
Krt26
Name: keratin 26
Synonyms: 4732407F15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320864
Homologene: 37118
Il27ra
Name: interleukin 27 receptor, alpha
Synonyms: Tccr, WSX-1, IL-27R
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50931
Homologene: 3562
Dsc3
Name: desmocollin 3
Synonyms: 5430426I24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13507
VEGA: 18
HGNC: HGNC:3037
Homologene: 1462
Gabbr2
Name: gamma-aminobutyric acid type B receptor subunit 2
Synonyms: Gababr2, GB2, LOC242425, Gpr51
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Acan
Name: aggrecan
Synonyms: Cspg1, Agc1, b2b183Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11595
HGNC: HGNC:319
Homologene: 137204
Spata18
Name: spermatogenesis associated 18
Synonyms: 1700067I02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73472
Homologene: 17057
Selplg
Name: selectin, platelet (p-selectin) ligand
Synonyms: Psgl1, CD162, Psgl-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20345
Homologene: 2261
Zfy2
Name: zinc finger protein 2, Y-linked
Synonyms: Zfy-2
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 22768
Homologene: 56456
Btnl2
Name: butyrophilin-like 2
Synonyms: NG9, butyrophylin-like MHC class II associated, BTL-II, BTLN2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 547431
HGNC: HGNC:1142
Homologene: 10482
Try4
Name: trypsin 4
Synonyms: 0910001B19Rik, Td
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22074
Homologene: 106639
Klhl22
Name: kelch-like 22
Synonyms: Kelchl, 2610318I18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224023
Homologene: 23784
Tacstd2
Name: tumor-associated calcium signal transducer 2
Synonyms: EGP-1, Ly97, TROP2, GA733-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56753
Homologene: 1763
Plppr3
Name: phospholipid phosphatase related 3
Synonyms: BC005764, Lppr3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216152
Homologene: 11769
C4bp
Name: complement component 4 binding protein
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12269
HGNC: HGNC:1325
Cavin2
Name: caveolae associated 2
Synonyms: cavin 2, Sdpr
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20324
Homologene: 3422
Crisp3
Name: cysteine-rich secretory protein 3
Synonyms: SGP28, CRISP-3, Aeg2, CRS3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11572
Homologene: 135665
Ninj1
Name: ninjurin 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18081
HGNC: HGNC:7824
Homologene: 88815
Rab2b
Name: RAB2B, member RAS oncogene family
Synonyms: 1500012D09Rik, D530043M21Rik, 4930528G15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76338
Homologene: 23789
Gm36864
Name: predicted gene, 36864
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102640913
Homologene: 141046
Rhox9
Name: reproductive homeobox 9
Synonyms: Gpbox, 1600026O01Rik, Psx2
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 104384
Homologene: 137216
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 51,301,124 bp
  • A to T, chromosome 1 at 130,655,968 bp
  • T to C, chromosome 1 at 193,330,067 bp
  • C to T, chromosome 2 at 30,030,159 bp
  • T to C, chromosome 2 at 90,777,739 bp
  • T to A, chromosome 2 at 103,970,700 bp
  • C to T, chromosome 2 at 125,306,463 bp
  • T to C, chromosome 2 at 129,208,200 bp
  • T to C, chromosome 3 at 53,535,355 bp
  • C to T, chromosome 4 at 46,736,349 bp
  • C to A, chromosome 4 at 80,837,660 bp
  • A to G, chromosome 5 at 28,352,625 bp
  • A to T, chromosome 5 at 73,669,720 bp
  • A to G, chromosome 5 at 81,465,266 bp
  • G to A, chromosome 5 at 113,819,441 bp
  • T to G, chromosome 5 at 147,358,955 bp
  • T to C, chromosome 5 at 147,582,691 bp
  • A to G, chromosome 6 at 41,305,062 bp
  • T to C, chromosome 6 at 67,535,399 bp
  • G to T, chromosome 6 at 113,459,367 bp
  • A to T, chromosome 7 at 44,242,552 bp
  • T to A, chromosome 7 at 79,100,779 bp
  • T to C, chromosome 7 at 126,372,536 bp
  • T to A, chromosome 7 at 141,104,532 bp
  • T to C, chromosome 8 at 22,910,249 bp
  • A to G, chromosome 8 at 77,517,680 bp
  • A to G, chromosome 8 at 84,033,949 bp
  • T to A, chromosome 10 at 79,867,004 bp
  • C to A, chromosome 11 at 70,031,642 bp
  • G to T, chromosome 11 at 74,395,825 bp
  • G to A, chromosome 11 at 78,273,412 bp
  • A to T, chromosome 11 at 99,337,846 bp
  • T to G, chromosome 11 at 103,503,126 bp
  • T to A, chromosome 12 at 111,781,950 bp
  • C to T, chromosome 12 at 113,188,867 bp
  • G to A, chromosome 13 at 21,484,653 bp
  • A to G, chromosome 13 at 30,761,473 bp
  • T to A, chromosome 13 at 49,193,812 bp
  • C to A, chromosome 14 at 50,515,643 bp
  • T to C, chromosome 14 at 52,268,696 bp
  • A to T, chromosome 16 at 17,792,579 bp
  • C to A, chromosome 17 at 25,723,479 bp
  • T to A, chromosome 17 at 34,363,499 bp
  • T to A, chromosome 17 at 37,009,893 bp
  • G to A, chromosome 17 at 37,466,322 bp
  • A to T, chromosome 17 at 40,232,560 bp
  • A to T, chromosome 18 at 19,981,213 bp
  • T to A, chromosome 19 at 5,476,067 bp
  • C to T, chromosome X at 37,901,376 bp
  • A to T, chromosome Y at 2,117,380 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8051 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067488-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.