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Strain Name:
C57BL/6J-MtgxR8053Btlr/Mmmh
Stock Number:
067490-MU
Citation ID:
RRID:MMRRC_067490-MU
Other Names:
R8053 (G1)
Major Collection:

Strain Information

Vangl2
Name: VANGL planar cell polarity 2
Synonyms: Lpp1, C530001F03Rik, skam17Jus, Ltap, strabismus, loop-tail, ska17, Lootl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 93840
Homologene: 62161
Map2k5
Name: mitogen-activated protein kinase kinase 5
Synonyms: MEK5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23938
VEGA: 9
HGNC: HGNC:6845
Homologene: 115933
Chrna3
Name: cholinergic receptor, nicotinic, alpha polypeptide 3
Synonyms: (a)3, alpha 3, neuronal nicotinic acetylcholine receptor, alpha 3 subunit, Acra-3, Acra3, A730007P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110834
VEGA: 9
HGNC: HGNC:1957
Homologene: 591
Sema3c
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Synonyms: Semae, 1110036B02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20348
Homologene: 36201
Eomes
Name: eomesodermin
Synonyms: Tbr2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13813
HGNC: HGNC:3372
Homologene: 3971
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Mthfd1
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
Synonyms: Mthfd, DCS, E430024A07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 108156
VEGA: 12
HGNC: HGNC:7432
Homologene: 55940
Cyrib
Name: CYFIP related Rac1 interactor B
Synonyms: 0910001A06Rik, Fam49b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223601
VEGA: 15
Homologene: 9599
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Tmem199
Name: transmembrane protein 199
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195040
Homologene: 45125
Rev1
Name: REV1, DNA directed polymerase
Synonyms: REV1, 1110027I23Rik, Rev1l
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56210
Homologene: 32309
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Exoc4
Name: exocyst complex component 4
Synonyms: Sec8, Sec8l1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20336
Homologene: 40654
Chd4
Name: chromodomain helicase DNA binding protein 4
Synonyms: D6Ertd380e, 9530019N15Rik, Mi-2beta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107932
HGNC: HGNC:1919
Homologene: 68175
Wapl
Name: WAPL cohesin release factor
Synonyms: A530089A20Rik, Wapal
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218914
Homologene: 41002
Prdm15
Name: PR domain containing 15
Synonyms: Zfp298, E130018M06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 114604
Homologene: 56941
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, SYNE-1, enaptin165, A330049M09Rik, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Melk
Name: maternal embryonic leucine zipper kinase
Synonyms: MPK38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17279
Homologene: 32111
Hrh2
Name: histamine receptor H2
Synonyms: H2r
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15466
HGNC: HGNC:5183
Homologene: 40613
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Elf2
Name: E74-like factor 2
Synonyms: NERF-2, 2610036A20Rik, A230104O07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69257
HGNC: HGNC:3317
Homologene: 5006
Hectd3
Name: HECT domain E3 ubiquitin protein ligase 3
Synonyms: 1700064K09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76608
Homologene: 18426
Slc16a6
Name: solute carrier family 16 (monocarboxylic acid transporters), member 6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104681
Homologene: 20984
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, ALS2CR17, A530083I02Rik, 2310076G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Clec4a2
Name: C-type lectin domain family 4, member a2
Synonyms: dendritic cell immunoreceptor, DCIR, Clecsf6, Dcir1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26888
Homologene: 49291
Adar
Name: adenosine deaminase, RNA-specific
Synonyms: ADAR1, mZaADAR, Adar1p150, Adar1p110
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56417
HGNC: HGNC:225
Homologene: 9281
Rexo2
Name: RNA exonuclease 2
Synonyms: 1810038D15Rik, Sfn, Smfn, Rex2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104444
VEGA: 9
Homologene: 6447
Smad6
Name: SMAD family member 6
Synonyms: Smad 6, Madh6, b2b390Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17130
HGNC: HGNC:6772
Homologene: 4079
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 5330435L01Rik, 4632412F08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Sis
Name: sucrase isomaltase
Synonyms: Si-s, sucrase-isomaltase, 2010204N08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69983
Homologene: 37424
Sugct
Name: succinyl-CoA glutarate-CoA transferase
Synonyms: 5033411D12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 192136
VEGA: 13
Homologene: 11681
Fgd5
Name: FYVE, RhoGEF and PH domain containing 5
Synonyms: ZFYVE23, C330025N11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232237
Homologene: 27798
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: LOC380730, Gm884
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Taar6
Name: trace amine-associated receptor 6
Synonyms: LOC215855
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215855
Homologene: 27874
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Gpr75
Name: G protein-coupled receptor 75
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237716
HGNC: HGNC:4526
Homologene: 4945
Or2j3
Name: olfactory receptor family 2 subfamily J member 3
Synonyms: GA_x6K02T2PSCP-2749525-2748587, MOR256-18, Olfr137
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258481
Homologene: 128084
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: EG381742, Zfp469
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231861
Homologene: 45603
Rab20
Name: RAB20, member RAS oncogene family
Synonyms: D8Ertd350e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19332
Homologene: 9856
Sh3rf2
Name: SH3 domain containing ring finger 2
Synonyms: RNF158, 9130023G24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269016
Homologene: 17618
Daglb
Name: diacylglycerol lipase, beta
Synonyms: E330036I19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231871
Homologene: 34715
Crocc
Name: ciliary rootlet coiled-coil, rootletin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230872
Homologene: 16811
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241175
Homologene: 104295
Or10ak7
Name: olfactory receptor family 10 subfamily AK member 7
Synonyms: GA_x6K02T2QD9B-18602750-18603691, MOR259-1, MOR259-13, MOR259-1, Olfr1519, Olfr1328
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258394
Homologene: 121524
Krt16
Name: keratin 16
Synonyms: K16, Krt1-16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16666
HGNC: HGNC:6423
Homologene: 21145
Fdxr
Name: ferredoxin reductase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14149
HGNC: HGNC:3642
Homologene: 3033
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241066
Homologene: 11689
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm29096, Gm6976
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Zfp874b
Name: zinc finger protein 874b
Synonyms: 9630025I21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408067
Homologene: 135597
Phc2
Name: polyhomeotic 2
Synonyms: Mph2, D4Ertd810e, Edr2, D130050K19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54383
HGNC: HGNC:3183
Homologene: 75090
Or4c123
Name: olfactory receptor family 4 subfamily C member 123
Synonyms: GA_x6K02T2Q125-50741934-50741017, MOR237-1, Olfr1230
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258785
Homologene: 81570
Ankrd55
Name: ankyrin repeat domain 55
Synonyms: C030011J08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77318
VEGA: 13
Homologene: 12674
Krtap4-22
Name: keratin associated protein 4-22
Synonyms: Gm11595
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Dtx3l
Name: deltex 3-like, E3 ubiquitin ligase
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 209200
Homologene: 51375
Desi2
Name: desumoylating isopeptidase 2
Synonyms: 5830417C01Rik, Fam152a, Pppde1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78825
Homologene: 56741
Pramel12
Name: PRAME like 12
Synonyms: 4732496O08Rik, Pramef8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242736
Homologene: 128393
Crisp4
Name: cysteine-rich secretory protein 4
Synonyms: 9230112K08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78081
HGNC: HGNC:304
Homologene: 81683
Or5g23
Name: olfactory receptor family 5 subfamily G member 23
Synonyms: GA_x6K02T2Q125-47087719-47086775, MOR175-9, Olfr1000
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257899
Cyp2ab1
Name: cytochrome P450, family 2, subfamily ab, polypeptide 1
Synonyms: EG224044
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224044
Homologene: 120487
Or1e31
Name: olfactory receptor family 1 subfamily E member 31
Synonyms: GA_x6K02T2P1NL-3951666-3950698, MOR135-24, MOR135-30_i, Olfr391-ps1, Olfr391-ps, Olfr391
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258236
Gm8267
Name: predicted gene 8267
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 666744
Homologene: 115686
Pcdhga4
Name: protocadherin gamma subfamily A, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93712
HGNC: HGNC:8702
Homologene: 81866
Vmn2r40
Name: vomeronasal 2, receptor 40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042781
Homologene: 113703
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 18,124,274 bp
  • T to C, chromosome 1 at 38,063,141 bp
  • A to T, chromosome 1 at 60,128,038 bp
  • A to G, chromosome 1 at 60,279,795 bp
  • G to A, chromosome 1 at 71,349,169 bp
  • T to A, chromosome 1 at 100,390,677 bp
  • A to G, chromosome 1 at 164,192,769 bp
  • A to G, chromosome 1 at 172,004,736 bp
  • G to A, chromosome 1 at 178,237,916 bp
  • A to T, chromosome 2 at 20,661,963 bp
  • T to A, chromosome 2 at 52,286,017 bp
  • T to C, chromosome 2 at 85,608,890 bp
  • A to T, chromosome 2 at 89,297,196 bp
  • G to A, chromosome 2 at 142,853,714 bp
  • A to T, chromosome 2 at 177,769,631 bp
  • A to G, chromosome 3 at 51,308,130 bp
  • A to T, chromosome 3 at 72,949,568 bp
  • T to C, chromosome 3 at 89,747,285 bp
  • A to G, chromosome 4 at 44,318,109 bp
  • T to C, chromosome 4 at 117,000,858 bp
  • A to G, chromosome 4 at 118,934,111 bp
  • C to T, chromosome 4 at 128,709,640 bp
  • A to G, chromosome 4 at 141,042,919 bp
  • C to A, chromosome 4 at 143,417,638 bp
  • C to T, chromosome 5 at 17,655,022 bp
  • C to G, chromosome 5 at 93,273,343 bp
  • G to T, chromosome 5 at 142,750,630 bp
  • A to G, chromosome 5 at 143,503,269 bp
  • A to G, chromosome 6 at 33,332,256 bp
  • G to A, chromosome 6 at 91,989,444 bp
  • T to C, chromosome 6 at 123,128,039 bp
  • G to T, chromosome 6 at 125,128,816 bp
  • T to C, chromosome 7 at 8,908,246 bp
  • C to A, chromosome 7 at 87,370,047 bp
  • A to T, chromosome 7 at 141,698,332 bp
  • G to T, chromosome 8 at 11,454,443 bp
  • A to G, chromosome 9 at 48,475,118 bp
  • T to A, chromosome 9 at 55,015,390 bp
  • T to A, chromosome 9 at 63,343,425 bp
  • A to G, chromosome 9 at 64,020,507 bp
  • A to G, chromosome 9 at 118,480,553 bp
  • T to A, chromosome 10 at 5,052,658 bp
  • A to G, chromosome 10 at 23,985,246 bp
  • C to A, chromosome 10 at 41,644,581 bp
  • A to T, chromosome 11 at 30,891,559 bp
  • T to C, chromosome 11 at 73,798,996 bp
  • A to G, chromosome 11 at 78,507,786 bp
  • G to A, chromosome 11 at 99,772,128 bp
  • T to C, chromosome 11 at 100,246,787 bp
  • T to A, chromosome 11 at 103,604,566 bp
  • G to A, chromosome 11 at 109,458,569 bp
  • C to T, chromosome 11 at 113,854,351 bp
  • T to A, chromosome 11 at 115,269,839 bp
  • A to G, chromosome 11 at 119,402,647 bp
  • C to T, chromosome 12 at 18,533,727 bp
  • T to A, chromosome 12 at 76,280,508 bp
  • T to A, chromosome 13 at 17,301,969 bp
  • A to G, chromosome 13 at 54,214,085 bp
  • A to T, chromosome 13 at 63,190,531 bp
  • A to T, chromosome 13 at 67,474,098 bp
  • C to T, chromosome 13 at 112,323,153 bp
  • C to T, chromosome 14 at 34,692,321 bp
  • A to T, chromosome 14 at 44,724,850 bp
  • T to C, chromosome 15 at 63,941,983 bp
  • T to C, chromosome 16 at 20,314,268 bp
  • T to C, chromosome 16 at 35,938,952 bp
  • T to A, chromosome 16 at 49,142,939 bp
  • A to G, chromosome 16 at 97,835,607 bp
  • A to G, chromosome 17 at 8,974,772 bp
  • G to A, chromosome 17 at 34,704,179 bp
  • A to T, chromosome 17 at 38,305,210 bp
  • A to G, chromosome 18 at 37,686,255 bp
  • T to A, chromosome 18 at 42,153,022 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8053 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067490-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.