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Strain Name:
C57BL/6J-MtgxR8084Btlr/Mmmh
Stock Number:
067517-MU
Citation ID:
RRID:MMRRC_067517-MU
Other Names:
R8084 (G1)
Major Collection:

Strain Information

Ddx23
Name: DEAD box helicase 23
Synonyms: 4921506D17Rik, 3110082M05Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74351
Homologene: 3542
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Arip4, G630026H09Rik, Srisnf2l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81000
Homologene: 56698
Osbpl1a
Name: oxysterol binding protein-like 1A
Synonyms: LOC328902, G430090F17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 64291
Homologene: 84746
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Ash2l
Name: ASH2 like histone lysine methyltransferase complex subunit
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23808
HGNC: HGNC:744
Homologene: 3436
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Scrib
Name: scribbled planar cell polarity
Synonyms: Scrb1, Crc
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 65,071,822 bp
  • A to G, chromosome 1 at 74,364,356 bp
  • C to T, chromosome 1 at 74,747,207 bp
  • A to G, chromosome 1 at 75,555,945 bp
  • G to A, chromosome 1 at 78,692,127 bp
  • T to A, chromosome 2 at 18,109,826 bp
  • T to A, chromosome 2 at 24,685,796 bp
  • T to A, chromosome 2 at 25,433,967 bp
  • T to C, chromosome 2 at 37,537,305 bp
  • T to G, chromosome 2 at 59,962,236 bp
  • C to A, chromosome 2 at 69,509,369 bp
  • T to A, chromosome 2 at 150,642,781 bp
  • T to C, chromosome 3 at 90,136,058 bp
  • C to T, chromosome 4 at 46,736,349 bp
  • A to T, chromosome 4 at 48,431,066 bp
  • A to G, chromosome 4 at 134,128,079 bp
  • G to A, chromosome 4 at 135,934,803 bp
  • A to C, chromosome 5 at 27,631,399 bp
  • C to T, chromosome 5 at 103,612,461 bp
  • T to C, chromosome 5 at 149,588,133 bp
  • G to A, chromosome 6 at 3,687,615 bp
  • C to T, chromosome 6 at 25,771,536 bp
  • A to C, chromosome 6 at 43,305,167 bp
  • C to A, chromosome 6 at 119,300,352 bp
  • A to G, chromosome 6 at 127,639,172 bp
  • C to T, chromosome 6 at 132,571,859 bp
  • T to C, chromosome 6 at 135,733,488 bp
  • G to T, chromosome 7 at 19,181,224 bp
  • G to T, chromosome 7 at 25,225,312 bp
  • A to G, chromosome 7 at 28,750,285 bp
  • A to G, chromosome 7 at 51,579,539 bp
  • A to T, chromosome 7 at 68,237,771 bp
  • T to C, chromosome 8 at 13,303,873 bp
  • A to G, chromosome 8 at 25,831,294 bp
  • T to C, chromosome 8 at 86,861,008 bp
  • G to T, chromosome 8 at 94,087,428 bp
  • T to A, chromosome 9 at 40,211,242 bp
  • T to A, chromosome 9 at 66,475,935 bp
  • G to A, chromosome 9 at 106,713,502 bp
  • G to A, chromosome 9 at 113,847,755 bp
  • T to C, chromosome 10 at 42,930,606 bp
  • T to C, chromosome 10 at 107,608,433 bp
  • G to A, chromosome 10 at 128,041,531 bp
  • G to A, chromosome 10 at 128,199,256 bp
  • A to T, chromosome 10 at 129,526,940 bp
  • A to T, chromosome 11 at 55,004,008 bp
  • G to T, chromosome 11 at 86,535,436 bp
  • G to A, chromosome 11 at 113,827,089 bp
  • A to T, chromosome 11 at 116,535,078 bp
  • T to G, chromosome 12 at 32,195,688 bp
  • A to T, chromosome 12 at 78,820,851 bp
  • A to G, chromosome 12 at 100,384,173 bp
  • T to C, chromosome 12 at 102,562,069 bp
  • T to C, chromosome 13 at 13,185,954 bp
  • A to G, chromosome 14 at 7,907,243 bp
  • A to T, chromosome 14 at 30,899,443 bp
  • C to T, chromosome 14 at 47,407,841 bp
  • T to A, chromosome 14 at 55,576,449 bp
  • T to C, chromosome 14 at 121,983,305 bp
  • C to A, chromosome 15 at 25,969,799 bp
  • A to T, chromosome 15 at 28,387,953 bp
  • G to A, chromosome 15 at 76,066,091 bp
  • C to T, chromosome 15 at 78,672,460 bp
  • A to G, chromosome 15 at 98,658,264 bp
  • A to T, chromosome 15 at 98,842,064 bp
  • A to T, chromosome 15 at 99,167,080 bp
  • T to C, chromosome 16 at 87,354,340 bp
  • T to G, chromosome 17 at 23,953,270 bp
  • T to A, chromosome 17 at 34,157,353 bp
  • A to T, chromosome 18 at 12,905,042 bp
  • A to C, chromosome 18 at 37,506,173 bp
  • A to T, chromosome 18 at 77,340,149 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8084 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067517-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.