Strain Name:
C57BL/6J-MtgxR8100Btlr/Mmmh
Stock Number:
067532-MU
Citation ID:
RRID:MMRRC_067532-MU
Other Names:
R8100 (G1)
Major Collection:

Strain Information

Sf1
Name: splicing factor 1
Synonyms: Zfp162, MZFM, CW17R, WBP4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22668
Homologene: 134065
Chrna6
Name: cholinergic receptor, nicotinic, alpha polypeptide 6
Synonyms: alpha6 nAChR, Acra6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11440
Homologene: 20888
Otx1
Name: orthodenticle homeobox 1
Synonyms: jv, A730044F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Top1
Name: topoisomerase (DNA) I
Synonyms: D130064I21Rik, Top-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21969
Homologene: 2467
Cdk7
Name: cyclin dependent kinase 7
Synonyms: CRK4 PK (CDC2-related-kinase-4 protein kinase), Cdkn7, Crk4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12572
VEGA: 13
HGNC: HGNC:1778
Homologene: 1363
Zbtb32
Name: zinc finger and BTB domain containing 32
Synonyms: 4930524C15Rik, PLZP, Rog, Tzfp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 58206
Homologene: 8661
Cdk13
Name: cyclin dependent kinase 13
Synonyms: Cdc2l5, 2310015O17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69562
VEGA: 13
HGNC: HGNC:1733
Homologene: 135707
Usp30
Name: ubiquitin specific peptidase 30
Synonyms: D5Ertd483e, 6330590F17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100756
Homologene: 32789
Ptpn21
Name: protein tyrosine phosphatase, non-receptor type 21
Synonyms: PTPD1, PTPRL10
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 24000
VEGA: 12
HGNC: HGNC:9651
Homologene: 5110
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Ndc1
Name: NDC1 transmembrane nucleoporin
Synonyms: Tmem48, 2810475A17Rik, sks
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72787
Homologene: 41224
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
Kctd17
Name: potassium channel tetramerisation domain containing 17
Synonyms: 2900008M13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72844
Homologene: 23468
Tgif1
Name: TGFB-induced factor homeobox 1
Synonyms: Tgif
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21815
Homologene: 7574
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Ckmt1
Name: creatine kinase, mitochondrial 1, ubiquitous
Synonyms: UbCKmit, Mt-CK, mi-CK
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12716
Homologene: 69058
Zfp592
Name: zinc finger protein 592
Synonyms: A730014M16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233410
Homologene: 8759
Lmo7
Name: LIM domain only 7
Synonyms: LOC380928, FBXO20
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Lzts1
Name: leucine zipper, putative tumor suppressor 1
Synonyms: F37, FEZ1, PSD-Zip70
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211134
Homologene: 10873
Fbln1
Name: fibulin 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14114
HGNC: HGNC:3600
Homologene: 21295
Osbpl10
Name: oxysterol binding protein-like 10
Synonyms: 4933433D06Rik, C820004B04Rik, OPR-10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74486
Homologene: 69240
Ell3
Name: elongation factor RNA polymerase II-like 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269344
Homologene: 11859
Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Synonyms: cyclooxygenase-2, PGHS-2, prostaglandin G/H synthase, cyclooxygenase 2, Cox-2, PHS-2, COX2, Pghs2, Tis10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19225
HGNC: HGNC:9605
Homologene: 31000
Myo15a
Name: myosin XVA
Synonyms: Myo15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1203Clo, Dnahc11, avc4, b2b1289Clo, b2b1279Clo, lrd, b2b598Clo, b2b1727Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241589
Homologene: 115928
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: C030048J01Rik, LOC235639, A230061D21Rik, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Mocs3
Name: molybdenum cofactor synthesis 3
Synonyms: Uba4, 1700020H17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69372
Homologene: 6108
Skint2
Name: selection and upkeep of intraepithelial T cells 2
Synonyms: B7S3, OTTMUSG00000008540
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329919
Homologene: 136741
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Tmem30a
Name: transmembrane protein 30A
Synonyms: D9Wsu20e, 2010200I23Rik, Cdc50a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69981
Homologene: 110703
Tmem184c
Name: transmembrane protein 184C
Synonyms: 8430433H16Rik, Tmem34
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234463
Homologene: 32403
Trim7
Name: tripartite motif-containing 7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94089
Homologene: 14113
Zfp108
Name: zinc finger protein 108
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54678
Homologene: 117959
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Rbm20
Name: RNA binding motif protein 20
Synonyms: 2010003H22Rik, 1110018J23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73713
Homologene: 28386
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68655
Triml1
Name: tripartite motif family-like 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244448
Homologene: 18619
Sel1l2
Name: sel-1 suppressor of lin-12-like 2 (C. elegans)
Synonyms: LOC228684
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228684
Homologene: 16802
Pogk
Name: pogo transposable element with KRAB domain
Synonyms: BASS2, 9130401E23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71592
Homologene: 32346
Nfam1
Name: Nfat activating molecule with ITAM motif 1
Synonyms: Nfam1, 4921501M20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74039
Homologene: 12528
Zfp764l1
Name: zinc finger protein 764 like 1
Synonyms: E430018J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101604
Homologene: 138471
Ifi213
Name: interferon activated gene 213
Synonyms: Pyr-A, Pydc4, E030037K03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 623121
HGNC: HGNC:5395
Homologene: 115929
Sra1
Name: steroid receptor RNA activator 1
Synonyms: Srap
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 24068
Homologene: 11906
Or4a47
Name: olfactory receptor family 4 subfamily A member 47
Synonyms: MOR231-1, Olfr1256, GA_x6K02T2Q125-51276848-51275928
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258985
Homologene: 128157
Art1
Name: ADP-ribosyltransferase 1
Synonyms: Yac-1, ADPRT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11870
HGNC: HGNC:723
Homologene: 128621
Rwdd2b
Name: RWD domain containing 2B
Synonyms: ORF5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 53858
HGNC: HGNC:1302
Homologene: 9654
Grin2d
Name: glutamate receptor, ionotropic, NMDA2D (epsilon 4)
Synonyms: NMDAR2D, GluRepsilon4, GluN2D, NR2D
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14814
HGNC: HGNC:4588
Homologene: 648
Vmn1r175
Name: vomeronasal 1 receptor 175
Synonyms: Gm6299
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 622222
Homologene: 128341
Semg1
Name: semenogelin 1
Synonyms: SVS II, semenoclotin, Svs2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53878
Homologene: 49325
Gpr15
Name: G protein-coupled receptor 15
Synonyms: 4933439K08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71223
VEGA: 16
HGNC: HGNC:4469
Homologene: 3869
Defa29
Name: defensin, alpha, 29
Synonyms: CRS1C-2, Defcr-rs1, 2010300L12Rik, 2010319H24Rik, Defa-rs1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13218
Homologene: 85974
Ciart
Name: circadian associated repressor of transcription
Synonyms: Gm129, LOC229599
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229599
Homologene: 79670
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 150,102,721 bp
  • T to C, chromosome 1 at 155,953,402 bp
  • A to T, chromosome 1 at 166,401,942 bp
  • A to C, chromosome 1 at 173,595,182 bp
  • G to A, chromosome 2 at 89,835,685 bp
  • C to T, chromosome 2 at 104,256,942 bp
  • T to A, chromosome 2 at 121,360,777 bp
  • TCTCCTC to TCTC, chromosome 2 at 121,439,456 bp
  • C to G, chromosome 2 at 140,275,409 bp
  • T to A, chromosome 2 at 160,698,235 bp
  • A to G, chromosome 2 at 164,237,792 bp
  • A to G, chromosome 2 at 168,231,337 bp
  • G to A, chromosome 3 at 95,881,344 bp
  • A to G, chromosome 4 at 107,383,605 bp
  • A to C, chromosome 4 at 112,626,000 bp
  • T to G, chromosome 5 at 114,111,184 bp
  • A to T, chromosome 6 at 23,838,809 bp
  • C to T, chromosome 6 at 82,730,878 bp
  • G to A, chromosome 7 at 23,808,587 bp
  • T to A, chromosome 7 at 24,261,177 bp
  • CTTG to CTTGTTG, chromosome 7 at 30,591,521 bp
  • T to C, chromosome 7 at 45,833,747 bp
  • T to G, chromosome 7 at 81,024,192 bp
  • T to C, chromosome 7 at 102,107,198 bp
  • C to T, chromosome 7 at 127,393,324 bp
  • A to T, chromosome 8 at 21,326,974 bp
  • C to T, chromosome 8 at 27,413,816 bp
  • T to A, chromosome 8 at 43,138,680 bp
  • A to G, chromosome 8 at 69,140,745 bp
  • A to G, chromosome 8 at 77,604,782 bp
  • T to C, chromosome 9 at 79,774,150 bp
  • C to T, chromosome 9 at 105,878,640 bp
  • A to G, chromosome 9 at 111,392,793 bp
  • G to A, chromosome 9 at 115,167,254 bp
  • C to A, chromosome 10 at 27,041,117 bp
  • T to C, chromosome 10 at 58,490,648 bp
  • C to A, chromosome 11 at 21,999,392 bp
  • A to C, chromosome 11 at 48,849,519 bp
  • G to A, chromosome 11 at 60,517,190 bp
  • T to A, chromosome 12 at 98,682,622 bp
  • A to G, chromosome 12 at 117,966,633 bp
  • C to T, chromosome 13 at 17,803,516 bp
  • T to C, chromosome 13 at 100,706,417 bp
  • G to A, chromosome 14 at 55,772,265 bp
  • A to T, chromosome 14 at 101,900,463 bp
  • CAGCTGGAGGAGC to CAGC, chromosome 15 at 78,436,913 bp
  • T to C, chromosome 15 at 83,016,529 bp
  • T to A, chromosome 15 at 85,285,156 bp
  • T to A, chromosome 16 at 58,717,713 bp
  • A to G, chromosome 16 at 87,436,621 bp
  • A to G, chromosome 17 at 7,771,853 bp
  • C to A, chromosome 17 at 70,846,549 bp
  • A to G, chromosome 18 at 20,528,971 bp
  • C to T, chromosome 18 at 36,676,895 bp
  • T to A, chromosome 18 at 77,404,816 bp
  • A to G, chromosome 19 at 6,372,338 bp
  • T to G, chromosome 19 at 53,851,313 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8100 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067532-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.