Strain Name:
C57BL/6J-MtgxR8109Btlr/Mmmh
Stock Number:
067538-MU
Citation ID:
RRID:MMRRC_067538-MU
Other Names:
R8109 (G1)
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: HALR, E330008K23Rik, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Met
Name: met proto-oncogene
Synonyms: HGF receptor, Par4, c-Met
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Pdzd2
Name: PDZ domain containing 2
Synonyms: LOC223364, 4930537L06Rik, Pdzk3, A930022H17Rik, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Llgl2
Name: LLGL2 scribble cell polarity complex component
Synonyms: 9130006H11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217325
HGNC: HGNC:6629
Homologene: 3323
Tdg
Name: thymine DNA glycosylase
Synonyms: E130317C12Rik, Jza1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21665
Homologene: 2415
Thrap3
Name: thyroid hormone receptor associated protein 3
Synonyms: Trap150, 9330151F09Rik, B230333E16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230753
Homologene: 31289
Zfp341
Name: zinc finger protein 341
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228807
Homologene: 13127
Clasp2
Name: CLIP associating protein 2
Synonyms: 8030404L10Rik, CLASP2gamma, CLASP2beta, CLASP2, 1500004F14Rik, CLASP2alpha
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76499
VEGA: 9
Homologene: 24944
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, PX-RICS, 3426406O18Rik, Grit, GC-GAP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330914
Homologene: 8812
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, AnkG, 2900054D09Rik, Ankyrin-3, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: 2610040L17Rik, 9330187F13Rik, D3Bwg1534e, Ten-m2, Odz2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23964
Homologene: 22672
Aars1
Name: alanyl-tRNA synthetase 1
Synonyms: Aars
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234734
HGNC: HGNC:20
Homologene: 1213
Tnc
Name: tenascin C
Synonyms: C130033P17Rik, TN, hexabrachion, Hxb, cytotactin, tenascin-C, TN-C
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Adamts12
Name: ADAM metallopeptidase with thrombospondin type 1 motif 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Adamtsl1
Name: ADAMTS-like 1
Synonyms: 5930437A14Rik, punctin-1, 6720426B09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77739
Homologene: 64642
Flrt2
Name: fibronectin leucine rich transmembrane protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399558
HGNC: HGNC:3761
Homologene: 8291
Sdf4
Name: stromal cell derived factor 4
Synonyms: Cab45
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20318
Homologene: 32121
Pard6g
Name: par-6 family cell polarity regulator gamma
Synonyms: 2410049N21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93737
VEGA: 18
Homologene: 36487
Zfp874a
Name: zinc finger protein 874a
Synonyms: Rslcan15, C330011K17Rik, Zfp874
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238692
Homologene: 135597
Tinagl1
Name: tubulointerstitial nephritis antigen-like 1
Synonyms: Arg1, androgen-regulated gene 1, Lcn7, 1110021J17Rik, AZ-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 94242
Homologene: 41472
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269959
Homologene: 18912
Zc3hav1
Name: zinc finger CCCH type, antiviral 1
Synonyms: 1200014N16Rik, 9130009D18Rik, 9830115L13Rik, ZAP, 2900058M19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78781
Homologene: 10585
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: A930038D23Rik, Ae3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20536
Homologene: 129474
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20957
Homologene: 2389
Plpp6
Name: phospholipid phosphatase 6
Synonyms: 4932443D16Rik, Ppapdc2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74411
Homologene: 45228
Rhobtb2
Name: Rho-related BTB domain containing 2
Synonyms: E130206H14Rik, Dbc2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 246710
VEGA: 14
Homologene: 22873
Flg
Name: filaggrin
Synonyms: ft, fillagrin, profilaggrin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14246
VEGA: 3
Pcnx1
Name: pecanex 1
Synonyms: Pcnx, 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Nsun4
Name: NOL1/NOP2/Sun domain family, member 4
Synonyms: 2310010O12Rik, 2810405F18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72181
Homologene: 12455
Ephb1
Name: Eph receptor B1
Synonyms: Net, Elkh, Elk, C130099E04Rik, Hek6, Cek6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270190
HGNC: HGNC:3392
Homologene: 20936
Acte1
Name: actin, epsilon 1
Synonyms: Gm498, LOC244239
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102636989
Homologene: 131918
Rsph10b
Name: radial spoke head 10 homolog B (Chlamydomonas)
Synonyms: 4930526H21Rik, Rsph10b2
Type: Gene
Species: Mouse
Chromosome: 5
Homologene: 18321
Gmcl1
Name: germ cell-less, spermatogenesis associated 1
Synonyms: 2810049L19Rik, Gcl, mglc-1, Btbd13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23885
Homologene: 8021
Bst2
Name: bone marrow stromal cell antigen 2
Synonyms: C87040, 2310015I10Rik, Bst-2, GREG
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69550
HGNC: HGNC:1119
Homologene: 138472
Dcaf7
Name: DDB1 and CUL4 associated factor 7
Synonyms: 1700012F10Rik, 2610037L01Rik, Wdr68
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71833
Homologene: 55930
Ube4a
Name: ubiquitination factor E4A
Synonyms: 4732444G18Rik, UFD2b, 9930123J21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 140630
Homologene: 3517
Gpr137b
Name: G protein-coupled receptor 137B
Synonyms: C80741, 2310041G17Rik, Tm7sf1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83924
VEGA: 13
Homologene: 2454
Or1j19
Name: olfactory receptor family 1 subfamily J member 19
Synonyms: GA_x6K02T2NLDC-33481050-33481991, MOR136-8, Olfr348
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258946
HGNC: HGNC:8209
Homologene: 105219
Mmp25
Name: matrix metallopeptidase 25
Synonyms: MT6-MMP, F730048C11Rik, Leukolysin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240047
VEGA: 17
Homologene: 23375
Pcdh1
Name: protocadherin 1
Synonyms: 2010005A06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75599
HGNC: HGNC:8655
Homologene: 12613
Smo
Name: smoothened, frizzled class receptor
Synonyms: E130215L21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319757
Homologene: 4115
Atxn7l2
Name: ataxin 7-like 2
Synonyms: 2610528J18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72522
Homologene: 17728
Vmn1r229
Name: vomeronasal 1 receptor 229
Synonyms: V1re1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171224
Homologene: 74319
Gdpgp1
Name: GDP-D-glucose phosphorylase 1
Synonyms: D330012F22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269952
Homologene: 33436
Tpm3-rs7
Name: tropomyosin 3, related sequence 7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 621054
VEGA: 14
Jph2
Name: junctophilin 2
Synonyms: JP-2, 1110002E14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59091
Homologene: 10714
Ceacam11
Name: CEA cell adhesion molecule 11
Synonyms: Ceacam11-C4, Ceacam11-C1, Ceacam11-C3, 1600015D01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66996
HGNC: HGNC:1819
Homologene: 135962
Sox18
Name: SRY (sex determining region Y)-box 18
Synonyms: Sry-related HMG-box gene 18, Ragl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20672
Homologene: 7546
Brcc3dc
Name: BRCA1/BRCA2-containing complex, subunit 3, domain containing
Synonyms: Gm5136
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 368203
VEGA: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 75,551,804 bp
  • T to A, chromosome 2 at 36,786,606 bp
  • A to T, chromosome 2 at 154,627,900 bp
  • T to C, chromosome 2 at 163,339,286 bp
  • A to G, chromosome 2 at 181,671,500 bp
  • A to T, chromosome 3 at 93,290,427 bp
  • A to T, chromosome 3 at 102,851,602 bp
  • G to A, chromosome 3 at 108,203,301 bp
  • A to G, chromosome 4 at 64,008,763 bp
  • T to C, chromosome 4 at 86,248,069 bp
  • A to T, chromosome 4 at 116,051,843 bp
  • C to A, chromosome 4 at 126,186,480 bp
  • T to A, chromosome 4 at 130,169,330 bp
  • C to T, chromosome 4 at 156,009,838 bp
  • T to C, chromosome 5 at 25,281,384 bp
  • A to C, chromosome 5 at 143,985,530 bp
  • T to C, chromosome 6 at 17,562,237 bp
  • A to G, chromosome 6 at 29,755,523 bp
  • T to C, chromosome 6 at 38,329,179 bp
  • G to T, chromosome 6 at 86,721,426 bp
  • A to G, chromosome 7 at 17,975,318 bp
  • T to C, chromosome 7 at 80,238,833 bp
  • T to A, chromosome 7 at 82,602,279 bp
  • C to T, chromosome 7 at 143,897,466 bp
  • A to T, chromosome 8 at 71,537,346 bp
  • T to C, chromosome 8 at 111,040,652 bp
  • A to G, chromosome 9 at 32,181,854 bp
  • T to C, chromosome 9 at 44,935,483 bp
  • G to A, chromosome 9 at 102,041,023 bp
  • T to A, chromosome 9 at 113,911,520 bp
  • T to C, chromosome 10 at 69,990,318 bp
  • T to A, chromosome 10 at 82,644,519 bp
  • A to G, chromosome 10 at 108,699,659 bp
  • T to C, chromosome 11 at 36,008,310 bp
  • T to C, chromosome 11 at 106,046,778 bp
  • T to C, chromosome 11 at 115,850,793 bp
  • C to T, chromosome 12 at 81,918,819 bp
  • T to C, chromosome 12 at 95,780,559 bp
  • T to C, chromosome 13 at 13,359,406 bp
  • A to C, chromosome 13 at 67,449,444 bp
  • T to A, chromosome 14 at 12,488,975 bp
  • C to A, chromosome 14 at 69,800,631 bp
  • A to G, chromosome 14 at 113,315,340 bp
  • A to C, chromosome 15 at 11,331,791 bp
  • G to A, chromosome 15 at 12,373,506 bp
  • T to C, chromosome 17 at 20,815,006 bp
  • A to G, chromosome 17 at 23,644,794 bp
  • A to G, chromosome 18 at 38,198,996 bp
  • T to C, chromosome 18 at 80,117,443 bp
  • T to A, chromosome 19 at 28,964,491 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8109 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067538-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.