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Strain Name:
C57BL/6J-MtgxR8137Btlr/Mmmh
Stock Number:
067565-MU
Citation ID:
RRID:MMRRC_067565-MU
Other Names:
R8137 (G1)
Major Collection:

Strain Information

Klf2
Name: Kruppel-like transcription factor 2 (lung)
Synonyms: Lklf
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16598
HGNC: HGNC:6347
Homologene: 133978
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 1810033J14Rik, D230038D11Rik, 9530077A04Rik, Mll5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Wdr59
Name: WD repeat domain 59
Synonyms: 5430401O09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319481
Homologene: 38685
Srebf2
Name: sterol regulatory element binding factor 2
Synonyms: SREBP-2, nuc, SREBP2, SREBP2gc, bHLHd2, lop13
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20788
VEGA: 15
Homologene: 20966
Cnot4
Name: CCR4-NOT transcription complex, subunit 4
Synonyms: Not4h, Not4, Not4hp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 53621
HGNC: HGNC:7880
Homologene: 40870
Gspt1
Name: G1 to S phase transition 1
Synonyms: Gst-1, Gst-1, G1st
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14852
HGNC: HGNC:4621
Homologene: 68226
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 33,782,075 bp
  • A to G, chromosome 1 at 46,233,753 bp
  • G to A, chromosome 1 at 60,147,965 bp
  • C to T, chromosome 1 at 96,821,245 bp
  • A to G, chromosome 1 at 154,205,364 bp
  • C to T, chromosome 1 at 156,063,668 bp
  • A to G, chromosome 1 at 173,761,622 bp
  • T to C, chromosome 2 at 76,211,039 bp
  • T to A, chromosome 2 at 76,969,929 bp
  • T to C, chromosome 2 at 88,896,669 bp
  • A to T, chromosome 2 at 119,175,356 bp
  • C to T, chromosome 2 at 121,366,738 bp
  • T to C, chromosome 2 at 148,043,848 bp
  • A to T, chromosome 3 at 18,097,601 bp
  • C to T, chromosome 3 at 65,957,870 bp
  • T to C, chromosome 3 at 72,889,045 bp
  • T to C, chromosome 4 at 133,588,562 bp
  • A to G, chromosome 4 at 143,699,265 bp
  • A to G, chromosome 5 at 23,501,954 bp
  • T to A, chromosome 5 at 30,934,405 bp
  • T to C, chromosome 5 at 120,777,500 bp
  • C to T, chromosome 5 at 125,037,893 bp
  • G to A, chromosome 6 at 35,046,287 bp
  • A to T, chromosome 6 at 92,190,022 bp
  • A to C, chromosome 7 at 28,105,071 bp
  • T to G, chromosome 7 at 126,778,097 bp
  • T to C, chromosome 8 at 72,320,244 bp
  • T to A, chromosome 8 at 84,041,091 bp
  • T to C, chromosome 8 at 111,485,379 bp
  • T to C, chromosome 9 at 18,645,676 bp
  • A to G, chromosome 9 at 72,944,858 bp
  • A to G, chromosome 10 at 52,125,837 bp
  • T to C, chromosome 10 at 53,622,980 bp
  • T to C, chromosome 10 at 81,273,691 bp
  • T to C, chromosome 10 at 93,939,292 bp
  • C to T, chromosome 10 at 118,859,884 bp
  • A to G, chromosome 10 at 127,193,172 bp
  • T to C, chromosome 11 at 5,959,368 bp
  • T to G, chromosome 11 at 89,453,177 bp
  • T to A, chromosome 11 at 101,763,982 bp
  • T to A, chromosome 12 at 116,059,648 bp
  • T to C, chromosome 13 at 67,592,742 bp
  • T to A, chromosome 13 at 96,088,663 bp
  • C to T, chromosome 15 at 82,178,765 bp
  • T to C, chromosome 15 at 90,968,442 bp
  • A to G, chromosome 16 at 11,240,668 bp
  • A to G, chromosome 16 at 19,515,096 bp
  • A to G, chromosome 17 at 8,974,815 bp
  • A to G, chromosome 17 at 20,113,793 bp
  • T to C, chromosome 17 at 20,234,704 bp
  • A to T, chromosome 18 at 10,474,357 bp
  • A to G, chromosome 18 at 56,594,581 bp
  • A to T, chromosome 18 at 71,378,712 bp
  • A to T, chromosome 19 at 4,737,403 bp
  • A to T, chromosome 19 at 40,605,341 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8137 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067565-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.