Strain Name:
C57BL/6J-MtgxR8158Btlr/Mmmh
Stock Number:
067584-MU
Citation ID:
RRID:MMRRC_067584-MU
Other Names:
R8158 (G1)
Major Collection:

Strain Information

Tyr
Name: tyrosinase
Synonyms: Oca1, skc35
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22173
Homologene: 30969
Scarb1
Name: scavenger receptor class B, member 1
Synonyms: Cla-1, Hdlq1, SRBI, D5Ertd460e, Chohd1, SR-BI, Cd36l1, Srb1, Chohd1, Hlb398
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Abl2
Name: ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms: Abll, Arg
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11352
HGNC: HGNC:77
Homologene: 5278
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Agrn
Name: agrin
Synonyms: Agrin, NMF380, nmf380
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Zfhx3
Name: zinc finger homeobox 3
Synonyms: A230102L03Rik, Sci, WBP9, Atbf1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Sec23ip
Name: Sec23 interacting protein
Synonyms: p125, D7Ertd373e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207352
Homologene: 38288
Sin3a
Name: transcriptional regulator, SIN3A (yeast)
Synonyms: mSin3A, Sin3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20466
Homologene: 32124
Csad
Name: cysteine sulfinic acid decarboxylase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 246277
VEGA: 15
Homologene: 41086
Qrich1
Name: glutamine-rich 1
Synonyms: b2b2404Clo, 2610028H07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69232
Homologene: 9803
Apaf1
Name: apoptotic peptidase activating factor 1
Synonyms: 6230400I06Rik, Apaf1l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11783
HGNC: HGNC:576
Homologene: 7626
Camsap1
Name: calmodulin regulated spectrin-associated protein 1
Synonyms: PRO2405, 9530003A05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227634
Homologene: 19202
Mrgpra1
Name: MAS-related GPR, member A1
Synonyms: MrgA1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233221
Homologene: 79615
Otof
Name: otoferlin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Zp3
Name: zona pellucida glycoprotein 3
Synonyms: Zp-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22788
Homologene: 5178
Il1f10
Name: interleukin 1 family, member 10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215274
Homologene: 17690
Kif7
Name: kinesin family member 7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16576
Homologene: 72555
Tcea3
Name: transcription elongation factor A (SII), 3
Synonyms: SII-K1, S-II
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21401
Homologene: 20684
Med6
Name: mediator complex subunit 6
Synonyms: 1500012F11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69792
Homologene: 3990
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: LTRPC2, Trrp7, TRPC7, 9830168K16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28240
Homologene: 20709
Nr2e1
Name: nuclear receptor subfamily 2, group E, member 1
Synonyms: Nr2e1, Mtll, tailless, Tlx
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21907
HGNC: HGNC:7973
Homologene: 37750
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: C130041O22Rik, Zfh4, Zfh-4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Itga9
Name: integrin alpha 9
Synonyms: 2610002H11Rik, D9Ertd428e, 6720458D17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104099
HGNC: HGNC:6145
Homologene: 1664
Irs1
Name: insulin receptor substrate 1
Synonyms: IRS-1, G972R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16367
HGNC: HGNC:6125
Homologene: 4049
Zfp282
Name: zinc finger protein 282
Synonyms: HUB1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101095
Homologene: 2647
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Sclt1
Name: sodium channel and clathrin linker 1
Synonyms: 4931421F20Rik, 2610207F23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67161
Homologene: 27031
Zcchc4
Name: zinc finger, CCHC domain containing 4
Synonyms: 4930449I23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78796
Homologene: 14632
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215772
Homologene: 100289
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624845
Homologene: 83483
Slc9a3
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3
Synonyms: NHE3, 9030624O13Rik, NHE-3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105243
VEGA: 13
Homologene: 55804
Slc34a2
Name: solute carrier family 34 (sodium phosphate), member 2
Synonyms: Npt2b, NaPi-2b, type IIb Na/Picotransporter, D5Ertd227e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20531
Homologene: 2297
Tektl1
Name: tektin like 1
Synonyms: Ccdc105, 4931413A09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70976
VEGA: 10
Homologene: 18299
Dnajb7
Name: DnaJ heat shock protein family (Hsp40) member B7
Synonyms: 4933424H20Rik, mDj5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 57755
Homologene: 77343
Or14a260
Name: olfactory receptor family 14 subfamily A member 260
Synonyms: Olfr307, GA_x6K02T2NHDJ-9772012-9772953, MOR219-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258610
Clnk
Name: cytokine-dependent hematopoietic cell linker
Synonyms: MIST
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27278
Homologene: 8450
Oas2
Name: 2'-5' oligoadenylate synthetase 2
Synonyms: Oasl11, 2'-5' oligoadenylate synthetase-like 11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246728
HGNC: HGNC:8087
Homologene: 49478
Cgrrf1
Name: cell growth regulator with ring finger domain 1
Synonyms: CGR19, 1810009H17Rik, 1110038G02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68755
Homologene: 4789
Amer3
Name: APC membrane recruitment 3
Synonyms: Fam123c, 9430069J07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211383
Homologene: 51888
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: brm, Snf2l2, 2610209L14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67155
Homologene: 2308
Rasip1
Name: Ras interacting protein 1
Synonyms: 2610025P08Rik, Rain
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69903
Homologene: 9847
Cbr2
Name: carbonyl reductase 2
Synonyms: MLCR, lung carbonyl reductase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12409
Homologene: 104184
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666085
Homologene: 104040
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
Rgl2
Name: ral guanine nucleotide dissociation stimulator-like 2
Synonyms: Rab2l, Rlf, KE1.5, Rgt2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19732
HGNC: HGNC:9769
Homologene: 3494
Or1e33
Name: olfactory receptor family 1 subfamily E member 33
Synonyms: Olfr393, GA_x6K02T2P1NL-4004140-4003208, MOR135-7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259010
Homologene: 79335
Or13a27
Name: olfactory receptor family 13 subfamily A member 27
Synonyms: Olfr60, IH6, MOR253-6, GA_x6K02T2PBJ9-42496183-42495251
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18361
Homologene: 34961
Spaca7b
Name: sperm acrosome associated 7B
Synonyms: GC14, 1700016D06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76413
Serpina1e
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1E
Synonyms: PI5, Spi1-5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20704
HGNC: HGNC:8941
Homologene: 20103
Tmcc1
Name: transmembrane and coiled coil domains 1
Synonyms: 3632431M01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330401
Homologene: 8995
Or8k17
Name: olfactory receptor family 8 subfamily K member 17
Synonyms: GA_x6K02T2Q125-47716657-47715716, Olfr1048, MOR187-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259016
Or8w1
Name: olfactory receptor family 8 subfamily U member 1
Synonyms: GA_x6K02T2Q125-49140947-49140021, Olfr1132, MOR177-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258833
Homologene: 121518
Dok6
Name: docking protein 6
Synonyms: Dok-6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 623279
Homologene: 45143
Lsm11
Name: U7 snRNP-specific Sm-like protein LSM11
Synonyms: 2210404M20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72290
Homologene: 32693
Krtap31-1
Name: keratin associated protein 31-1
Synonyms: 4733401H21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70831
Homologene: 134336
Mfsd4b2
Name: major facilitator superfamily domain containing 4B2
Synonyms: Mfsd4b2-ps, 2010001E11Rik, Mfsd4b2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72045
Homologene: 129931
Klhl41
Name: kelch-like 41
Synonyms: Kbtbd10, LOC228003
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228003
Homologene: 4421
H2bc14
Name: H2B clustered histone 14
Synonyms: Hist1h2bm
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319186
Homologene: 135961
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 34,587,660 bp
  • C to T, chromosome 1 at 82,289,533 bp
  • T to A, chromosome 1 at 156,642,069 bp
  • T to G, chromosome 2 at 24,291,255 bp
  • A to T, chromosome 2 at 25,944,428 bp
  • A to T, chromosome 2 at 69,671,161 bp
  • T to C, chromosome 2 at 86,236,160 bp
  • T to A, chromosome 2 at 87,634,889 bp
  • A to T, chromosome 2 at 150,409,176 bp
  • T to A, chromosome 3 at 5,398,950 bp
  • A to G, chromosome 3 at 41,671,482 bp
  • G to A, chromosome 4 at 136,273,716 bp
  • A to G, chromosome 4 at 156,173,889 bp
  • C to T, chromosome 5 at 30,380,194 bp
  • C to A, chromosome 5 at 38,794,911 bp
  • T to C, chromosome 5 at 52,815,918 bp
  • A to G, chromosome 5 at 53,060,840 bp
  • T to C, chromosome 5 at 120,749,773 bp
  • T to C, chromosome 5 at 125,303,137 bp
  • T to A, chromosome 5 at 135,985,564 bp
  • A to T, chromosome 6 at 47,890,692 bp
  • T to A, chromosome 6 at 116,043,474 bp
  • A to T, chromosome 7 at 12,615,961 bp
  • A to G, chromosome 7 at 45,632,519 bp
  • A to T, chromosome 7 at 47,335,456 bp
  • T to C, chromosome 7 at 79,704,694 bp
  • T to A, chromosome 7 at 86,335,677 bp
  • T to A, chromosome 7 at 87,472,516 bp
  • T to C, chromosome 7 at 116,342,997 bp
  • T to G, chromosome 7 at 128,767,640 bp
  • T to C, chromosome 7 at 140,345,249 bp
  • T to A, chromosome 8 at 11,665,056 bp
  • T to A, chromosome 8 at 108,948,721 bp
  • A to G, chromosome 9 at 57,113,544 bp
  • T to C, chromosome 9 at 108,110,033 bp
  • C to A, chromosome 9 at 108,556,037 bp
  • T to C, chromosome 9 at 118,877,143 bp
  • C to T, chromosome 10 at 10,378,734 bp
  • G to A, chromosome 10 at 39,922,068 bp
  • T to C, chromosome 10 at 42,582,885 bp
  • G to T, chromosome 10 at 77,947,897 bp
  • G to C, chromosome 10 at 78,748,675 bp
  • A to C, chromosome 10 at 79,377,802 bp
  • C to T, chromosome 10 at 91,059,658 bp
  • A to T, chromosome 11 at 45,933,997 bp
  • T to A, chromosome 11 at 73,847,871 bp
  • T to G, chromosome 11 at 99,908,075 bp
  • A to T, chromosome 11 at 120,730,297 bp
  • T to C, chromosome 12 at 81,573,903 bp
  • G to T, chromosome 12 at 103,951,095 bp
  • T to C, chromosome 13 at 21,722,461 bp
  • T to C, chromosome 13 at 48,817,760 bp
  • T to C, chromosome 13 at 74,155,122 bp
  • T to C, chromosome 14 at 46,853,735 bp
  • T to C, chromosome 15 at 64,783,806 bp
  • T to A, chromosome 15 at 81,407,399 bp
  • T to C, chromosome 15 at 102,177,762 bp
  • T to C, chromosome 17 at 33,936,944 bp
  • T to C, chromosome 18 at 89,473,947 bp
  • A to C, chromosome 19 at 26,682,048 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8158 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067584-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.