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Strain Detail Sheet

Published:
Revised: 03/02/2024

Strain Name:
C57BL/6J-MtgxR8171Btlr/Mmmh
Stock Number:
067597-MU
Citation ID:
RRID:MMRRC_067597-MU
Other Names:
R8171 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Fgb
Name: fibrinogen beta chain
Synonyms: 2510049G14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110135
HGNC: HGNC:3662
Homologene: 3772

Additional Resources
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IMSR
Gene Ontology
BioGPS
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KOMP Phenotyping
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ClinGen
Atic
Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Synonyms: 2610509C24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108147
HGNC: HGNC:794
Homologene: 2983

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Gldc
Name: glycine decarboxylase
Synonyms: D19Wsu57e, D030049L12Rik, b2b2679Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Plin2
Name: perilipin 2
Synonyms: Adrp, adipophilin, ADPH, Adfp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11520
HGNC: HGNC:248
Homologene: 872

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20562
Homologene: 2302

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Rai14
Name: retinoic acid induced 14
Synonyms: 1700020L11Rik, Ankycorbin, Norpeg, 1700008J19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75646
VEGA: 15
Homologene: 9199

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 45,822,546 bp
  • T to C, chromosome 1 at 71,569,873 bp
  • T to C, chromosome 1 at 93,189,001 bp
  • T to A, chromosome 1 at 140,509,465 bp
  • A to G, chromosome 1 at 165,306,436 bp
  • T to C, chromosome 1 at 177,796,351 bp
  • C to A, chromosome 2 at 31,914,971 bp
  • C to T, chromosome 2 at 50,190,747 bp
  • G to A, chromosome 2 at 60,314,228 bp
  • A to G, chromosome 2 at 65,530,810 bp
  • A to G, chromosome 2 at 89,881,065 bp
  • A to G, chromosome 2 at 156,048,231 bp
  • T to C, chromosome 3 at 36,975,713 bp
  • T to C, chromosome 3 at 83,042,515 bp
  • A to G, chromosome 3 at 92,571,778 bp
  • A to T, chromosome 3 at 142,312,187 bp
  • A to T, chromosome 4 at 86,657,112 bp
  • A to T, chromosome 4 at 148,115,666 bp
  • T to A, chromosome 5 at 25,516,554 bp
  • T to A, chromosome 5 at 74,002,693 bp
  • T to A, chromosome 5 at 76,266,414 bp
  • A to T, chromosome 5 at 98,872,669 bp
  • A to T, chromosome 5 at 115,483,023 bp
  • A to G, chromosome 5 at 121,318,756 bp
  • A to G, chromosome 5 at 123,879,089 bp
  • A to G, chromosome 5 at 130,300,014 bp
  • G to A, chromosome 5 at 139,971,357 bp
  • A to T, chromosome 5 at 146,085,774 bp
  • C to T, chromosome 6 at 8,593,167 bp
  • T to A, chromosome 6 at 18,258,288 bp
  • G to A, chromosome 6 at 89,357,120 bp
  • T to C, chromosome 6 at 122,609,903 bp
  • A to T, chromosome 7 at 7,204,097 bp
  • A to G, chromosome 7 at 47,053,764 bp
  • A to G, chromosome 7 at 90,409,470 bp
  • C to T, chromosome 7 at 106,714,618 bp
  • T to A, chromosome 7 at 106,714,619 bp
  • A to G, chromosome 7 at 127,791,227 bp
  • A to T, chromosome 7 at 140,336,230 bp
  • G to A, chromosome 7 at 141,861,000 bp
  • T to A, chromosome 8 at 80,509,463 bp
  • T to A, chromosome 8 at 80,615,240 bp
  • T to A, chromosome 8 at 91,025,387 bp
  • A to G, chromosome 8 at 105,147,207 bp
  • A to G, chromosome 9 at 18,409,227 bp
  • A to G, chromosome 9 at 21,933,711 bp
  • T to A, chromosome 9 at 57,700,196 bp
  • A to T, chromosome 9 at 64,973,250 bp
  • C to T, chromosome 9 at 87,042,810 bp
  • T to A, chromosome 9 at 106,440,761 bp
  • A to T, chromosome 9 at 113,903,906 bp
  • C to T, chromosome 9 at 116,130,006 bp
  • A to T, chromosome 9 at 121,778,557 bp
  • A to G, chromosome 10 at 80,639,802 bp
  • T to C, chromosome 10 at 80,834,761 bp
  • C to T, chromosome 10 at 88,523,003 bp
  • T to C, chromosome 10 at 94,074,332 bp
  • T to A, chromosome 10 at 94,768,935 bp
  • C to T, chromosome 10 at 112,078,384 bp
  • T to C, chromosome 10 at 117,683,315 bp
  • T to C, chromosome 10 at 128,918,100 bp
  • A to G, chromosome 11 at 67,202,572 bp
  • G to A, chromosome 11 at 70,973,898 bp
  • A to G, chromosome 11 at 97,175,747 bp
  • T to A, chromosome 12 at 30,104,046 bp
  • C to A, chromosome 12 at 57,673,310 bp
  • A to G, chromosome 12 at 59,070,437 bp
  • A to G, chromosome 12 at 80,196,393 bp
  • T to C, chromosome 13 at 46,778,968 bp
  • T to A, chromosome 13 at 75,090,091 bp
  • T to A, chromosome 13 at 105,109,783 bp
  • T to C, chromosome 13 at 117,602,734 bp
  • A to T, chromosome 14 at 30,937,090 bp
  • G to T, chromosome 14 at 31,297,110 bp
  • G to T, chromosome 14 at 32,662,025 bp
  • A to T, chromosome 14 at 60,046,044 bp
  • G to A, chromosome 15 at 6,423,926 bp
  • G to A, chromosome 15 at 10,633,163 bp
  • G to T, chromosome 15 at 64,110,966 bp
  • C to A, chromosome 15 at 76,363,619 bp
  • A to T, chromosome 15 at 85,797,876 bp
  • A to T, chromosome 15 at 99,248,732 bp
  • G to A, chromosome 16 at 37,208,054 bp
  • G to T, chromosome 16 at 56,111,726 bp
  • G to T, chromosome 16 at 97,424,586 bp
  • T to C, chromosome 17 at 22,573,092 bp
  • T to A, chromosome 17 at 34,582,509 bp
  • A to G, chromosome 17 at 35,510,036 bp
  • A to T, chromosome 17 at 56,389,534 bp
  • T to A, chromosome 18 at 42,180,380 bp
  • T to A, chromosome 18 at 60,300,078 bp
  • A to G, chromosome 18 at 65,305,983 bp
  • G to A, chromosome 19 at 17,120,518 bp
  • A to T, chromosome 19 at 30,133,761 bp
  • C to A, chromosome 19 at 41,727,073 bp
  • A to G, chromosome 19 at 44,069,329 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8171 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
067597-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.