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Strain Name:
C57BL/6J-MtgxR8184Btlr/Mmmh
Stock Number:
067607-MU
Citation ID:
RRID:MMRRC_067607-MU
Other Names:
R8184 (G1)
Major Collection:

Strain Information

Slc1a2
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2
Synonyms: GLT1, MGLT1, Eaat2, 1700091C19Rik, GLT-1, 2900019G14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20511
Homologene: 3075
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Sirt2
Name: sirtuin 2
Synonyms: SIR2L2, 5730427M03Rik, Sir2l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64383
Homologene: 40823
Dock6
Name: dedicator of cytokinesis 6
Synonyms: 2410095B20Rik, 4931431C02Rik, C330023D02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Kazn
Name: kazrin, periplakin interacting protein
Synonyms: 2310007B04Rik, 9030409G11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71529
Homologene: 16235
Ints8
Name: integrator complex subunit 8
Synonyms: D130008D20Rik, 2810013E07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72656
Homologene: 9888
Pspc1
Name: paraspeckle protein 1
Synonyms: 5730470C09Rik, PSP1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66645
Homologene: 10108
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, D430004I05Rik, A130082H20Rik, TIF1alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21848
Homologene: 20830
Pdcd11
Name: programmed cell death 11
Synonyms: ALG-4, 1110021I22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Snw1
Name: SNW domain containing 1
Synonyms: SKIP, NCoA-62, SNW1, 2310008B08Rik, Skiip
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66354
VEGA: 12
Homologene: 56557
Rtca
Name: RNA 3'-terminal phosphate cyclase
Synonyms: 2310009A18Rik, Rtcd1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66368
Homologene: 2766
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Casr
Name: calcium-sensing receptor
Synonyms: CaR, Gprc2a, cation sensing receptor
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12374
HGNC: HGNC:1514
Homologene: 332
Brf2
Name: BRF2, RNA polymerase III transcription initiation factor 50kDa subunit
Synonyms: 2700059M06Rik, BRFU, TFIIIB50, 5730512K07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66653
Homologene: 10127
Gbx2
Name: gastrulation brain homeobox 2
Synonyms: MMoxA, Gbx-2, Stra7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14472
HGNC: HGNC:4186
Homologene: 1138
Copg1
Name: coatomer protein complex, subunit gamma 1
Synonyms: D6Ertd71e, D6Wsu16e, Copg
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54161
HGNC: HGNC:2236
Homologene: 56745
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: D330050P16Rik, 2010013B10Rik, A230048G03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Clec10a
Name: C-type lectin domain family 10, member A
Synonyms: CD301a, Mgl1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17312
Homologene: 7836
Baiap3
Name: BAI1-associated protein 3
Synonyms: LOC381076
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 545192
HGNC: HGNC:948
Homologene: 20844
Gnai1
Name: G protein subunit alpha i1
Synonyms: Gialpha1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14677
HGNC: HGNC:4384
Homologene: 74417
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Nlgn1
Name: neuroligin 1
Synonyms: 6330415N05Rik, NL1, Nlg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192167
Homologene: 56690
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: B930001P07Rik, 6330504P12Rik, MLSN2, melastatin 2, LTRPC3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Dock10
Name: dedicator of cytokinesis 10
Synonyms: Jr5, Jr4, 9330153B10Rik, ZIZ3, A630054M16Rik, Zizimin3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210293
Homologene: 45952
Slco3a1
Name: solute carrier organic anion transporter family, member 3a1
Synonyms: MJAM, OATP-D, 5830414C08Rik, Anr1, Slc21a11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108116
Homologene: 40862
Gne
Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Synonyms: 2310066H07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50798
Homologene: 3996
Hecw2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: D030049F17Rik, Nedl2, A730039N16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329152
Homologene: 66192
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Hpx
Name: hemopexin
Synonyms: hx, Hpxn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15458
HGNC: HGNC:5171
Homologene: 511
Ccdc83
Name: coiled-coil domain containing 83
Synonyms: 4930549K11Rik, 4930554C01Rik, 4932423M01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75338
Homologene: 32709
Fbxo43
Name: F-box protein 43
Synonyms: 4930533G20Rik, XErp1 homolog, endogenous meiotic inhibitor 2, Emi2, early mitotic inhibitor 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78803
VEGA: 15
Homologene: 66393
Tmem63c
Name: transmembrane protein 63c
Synonyms: 9330187M14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217733
Homologene: 33129
Lrrc8e
Name: leucine rich repeat containing 8 family, member E
Synonyms: C87354, 1810049O03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72267
Homologene: 11817
Pla2g6
Name: phospholipase A2, group VI
Synonyms: iPLA2, iPLA2beta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 53357
HGNC: HGNC:9039
Homologene: 2635
Zfp503
Name: zinc finger protein 503
Synonyms: B830002A16Rik, Nolz-1, Nolz1, ZNF503, Zpo2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218820
Homologene: 41888
Accsl
Name: 1-aminocyclopropane-1-carboxylate synthase (inactive)-like
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381411
Homologene: 86007
Muc21
Name: mucin 21
Synonyms: epiglycanin, Gm9573
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 672682
Hectd2
Name: HECT domain E3 ubiquitin protein ligase 2
Synonyms: A630025O09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226098
Homologene: 6280
Dus4l
Name: dihydrouridine synthase 4 like
Synonyms: 2700089B10Rik, 2310069P03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71916
VEGA: 12
Homologene: 6535
Zfp764l1
Name: zinc finger protein 764 like 1
Synonyms: E430018J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101604
Homologene: 138471
Polm
Name: polymerase (DNA directed), mu
Synonyms: Tdt-N, B230309I03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54125
HGNC: HGNC:9185
Homologene: 41170
Mrps11
Name: mitochondrial ribosomal protein S11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67994
Homologene: 32554
Vmn2r44
Name: vomeronasal 2, receptor 44
Synonyms: EG434113
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434113
Homologene: 113703
Neurl3
Name: neuralized E3 ubiquitin protein ligase 3
Synonyms: 2010300P06Rik, Lincr
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214854
Homologene: 35002
Smpd5
Name: sphingomyelin phosphodiesterase 5
Synonyms: Gm10345
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 100503915
Homologene: 132205
Pbp2
Name: phosphatidylethanolamine binding protein 2
Synonyms: Pebp-2, 1700023A18Rik, Pebp2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76400
HGNC: HGNC:8630
Homologene: 135930
Amica1
Name:
Type: Gene
Species: Mouse
Chromosome: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,269,581 bp
  • T to G, chromosome 1 at 53,627,035 bp
  • A to G, chromosome 1 at 54,040,387 bp
  • G to A, chromosome 1 at 80,552,752 bp
  • A to T, chromosome 1 at 89,928,828 bp
  • T to C, chromosome 2 at 76,779,299 bp
  • T to C, chromosome 2 at 93,855,741 bp
  • T to A, chromosome 2 at 102,737,852 bp
  • T to C, chromosome 3 at 25,436,199 bp
  • C to A, chromosome 3 at 116,507,824 bp
  • A to T, chromosome 4 at 11,204,534 bp
  • T to C, chromosome 4 at 44,084,061 bp
  • A to G, chromosome 4 at 142,118,130 bp
  • A to G, chromosome 5 at 18,291,506 bp
  • T to C, chromosome 6 at 37,871,307 bp
  • T to C, chromosome 6 at 87,890,014 bp
  • T to C, chromosome 6 at 135,310,262 bp
  • A to T, chromosome 7 at 8,368,228 bp
  • G to A, chromosome 7 at 28,787,766 bp
  • A to G, chromosome 7 at 74,359,829 bp
  • T to C, chromosome 7 at 78,783,377 bp
  • A to T, chromosome 7 at 85,952,246 bp
  • G to T, chromosome 7 at 90,224,078 bp
  • A to T, chromosome 7 at 105,592,145 bp
  • C to T, chromosome 7 at 127,393,324 bp
  • T to G, chromosome 8 at 4,235,140 bp
  • T to C, chromosome 8 at 27,123,985 bp
  • A to T, chromosome 9 at 21,830,300 bp
  • T to A, chromosome 9 at 45,088,812 bp
  • T to A, chromosome 11 at 5,831,707 bp
  • A to T, chromosome 11 at 70,169,816 bp
  • A to G, chromosome 12 at 31,640,818 bp
  • A to T, chromosome 12 at 87,061,554 bp
  • T to C, chromosome 12 at 87,453,903 bp
  • T to C, chromosome 14 at 21,985,951 bp
  • T to C, chromosome 14 at 56,764,243 bp
  • C to T, chromosome 15 at 36,162,339 bp
  • A to G, chromosome 15 at 76,295,726 bp
  • A to G, chromosome 15 at 79,287,122 bp
  • T to C, chromosome 15 at 101,929,752 bp
  • T to A, chromosome 16 at 36,509,746 bp
  • G to T, chromosome 16 at 93,776,993 bp
  • A to G, chromosome 17 at 25,248,525 bp
  • A to G, chromosome 17 at 35,622,830 bp
  • A to T, chromosome 17 at 78,814,233 bp
  • T to C, chromosome 19 at 22,918,696 bp
  • T to A, chromosome 19 at 36,604,354 bp
  • T to A, chromosome 19 at 47,113,352 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8184 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067607-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.