Strain Name:
C57BL/6J-MtgxR8223Btlr/Mmmh
Stock Number:
067641-MU
Citation ID:
RRID:MMRRC_067641-MU
Other Names:
R8223 (G1)
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: Mll3, HALR, E330008K23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Adgre1
Name: adhesion G protein-coupled receptor E1
Synonyms: DD7A5-7, EGF-TM7, Ly71, TM7LN3, F4/80, Emr1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13733
VEGA: 17
HGNC: HGNC:3336
Homologene: 1493
Efemp1
Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216616
HGNC: HGNC:3218
Homologene: 3028
Morf4l1
Name: mortality factor 4 like 1
Synonyms: TEG-189, Tex189, MORFRG15, MRG15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21761
Homologene: 86043
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: 4930502N04Rik, A630020C16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74996
Homologene: 9929
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: Dopey1, D9Ertd809e, B130005I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Ints9
Name: integrator complex subunit 9
Synonyms: D14Ertd231e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 210925
VEGA: 14
Homologene: 10096
Rpap3
Name: RNA polymerase II associated protein 3
Synonyms: D15Ertd682e, 2310042P20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71919
VEGA: 15
Homologene: 11613
Dars1
Name: aspartyl-tRNA synthetase 1
Synonyms: Dars, 5730439G15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226414
HGNC: HGNC:2678
Homologene: 1032
Tox
Name: thymocyte selection-associated high mobility group box
Synonyms: 1700007F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 252838
Homologene: 8822
Ldlr
Name: low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16835
VEGA: 9
HGNC: HGNC:6547
Homologene: 55469
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Ganab
Name: alpha glucosidase 2 alpha neutral subunit
Synonyms: GluII, G2an
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14376
VEGA: 19
HGNC: HGNC:4138
Homologene: 5426
Cacfd1
Name: calcium channel flower domain containing 1
Synonyms: 5930434B04Rik, mFwe
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381356
HGNC: HGNC:1365
Homologene: 41182
Map2
Name: microtubule-associated protein 2
Synonyms: Mtap2, G1-397-34, repro4, MAP-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Ola1
Name: Obg-like ATPase 1
Synonyms: Gtpbp9, 2810409H07Rik, 2810405J23Rik, 2510025G09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67059
Homologene: 5361
Usp6nl
Name: USP6 N-terminal like
Synonyms: TRE2NL
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98910
Homologene: 6879
Slc15a4
Name: solute carrier family 15, member 4
Synonyms: PTR4, C130069N12Rik, PHT1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100561
Homologene: 26432
Tmeff2
Name: transmembrane protein with EGF-like and two follistatin-like domains 2
Synonyms: 4832418D20Rik, 7630402F16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56363
Homologene: 9417
Zfpm2
Name: zinc finger protein, multitype 2
Synonyms: FOG2, FOG-2, B330005D23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22762
VEGA: 15
Homologene: 8008
Tub
Name: TUB bipartite transcription factor
Synonyms: tub, rd5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22141
Homologene: 31147
Trim9
Name: tripartite motif-containing 9
Synonyms: C030048G07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 94090
VEGA: 12
Homologene: 9045
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
Dchs1
Name: dachsous cadherin related 1
Synonyms: 3110041P15Rik, C130033F22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Eml1
Name: echinoderm microtubule associated protein like 1
Synonyms: ELP79, heco, 1110008N23Rik, A930030P13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68519
HGNC: HGNC:3330
Homologene: 20931
Kdm7a
Name: lysine (K)-specific demethylase 7A
Synonyms: A630082K20Rik, ENSMUSG00000073143, Jhdm1d, Kdm7a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 338523
Homologene: 25281
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, C030048J01Rik, LOC235639, Lba1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Taar2
Name: trace amine-associated receptor 2
Synonyms: Gpr58
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209512
HGNC: HGNC:4514
Homologene: 110760
Chadl
Name: chondroadherin-like
Synonyms: D930017K21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 214685
Homologene: 130044
Crxos
Name: cone-rod homeobox, opposite strand
Synonyms: Egam1, Crxos1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546024
Homologene: 136482
Vmn2r5
Name: vomeronasal 2, receptor 5
Synonyms: EG667060
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667060
Capn2
Name: calpain 2
Synonyms: Capa2, m-calpain, Capa-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12334
HGNC: HGNC:1479
Homologene: 1326
Klhl10
Name: kelch-like 10
Synonyms: 4921517C11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66720
Homologene: 12018
Vmn1r45
Name: vomeronasal 1 receptor 45
Synonyms: V1ra2, V1r2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22297
Homologene: 130651
Serpinb11
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
Synonyms: 2310046M08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66957
Homologene: 41653
Cyp4f39
Name: cytochrome P450, family 4, subfamily f, polypeptide 39
Synonyms: 4732474A20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320997
VEGA: 17
Homologene: 69814
Vmn1r217
Name: vomeronasal 1 receptor 217
Synonyms: V1rh14
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171273
Homologene: 110880
Plagl2
Name: pleiomorphic adenoma gene-like 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54711
HGNC: HGNC:9047
Homologene: 1994
Hdgfl1
Name: HDGF like 1
Synonyms: Hdgfrp1, HRP-1, Pwwp1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15192
Homologene: 56406
Or9i2
Name: olfactory receptor family 9 subfamily I member 2
Synonyms: GA_x6K02T2RE5P-4171358-4170411, Olfr1501, MOR212-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258626
Homologene: 64899
Ube4a
Name: ubiquitination factor E4A
Synonyms: UFD2b, 9930123J21Rik, 4732444G18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 140630
Homologene: 3517
Pdlim3
Name: PDZ and LIM domain 3
Synonyms: ALP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 53318
Homologene: 75063
Laptm5
Name: lysosomal-associated protein transmembrane 5
Synonyms: E3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16792
Homologene: 4922
Arhgap31
Name: Rho GTPase activating protein 31
Synonyms: CdGAP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12549
Homologene: 10644
Lrrc38
Name: leucine rich repeat containing 38
Synonyms: A230053A07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242735
Homologene: 77949
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Sry
Name: sex determining region of Chr Y
Synonyms: Tdf, Tdy
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 21674
Lrrc14
Name: leucine rich repeat containing 14
Synonyms: E130306I01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223664
Homologene: 40970
Or7e166
Name: olfactory receptor family 7 subfamily E member 166
Synonyms: Olfr857, MOR146-8P, GA_x6K02T2PVTD-13452606-13453535
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257963
Homologene: 134093
Or1j19
Name: olfactory receptor family 1 subfamily J member 19
Synonyms: MOR136-8, Olfr348, GA_x6K02T2NLDC-33481050-33481991
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258946
HGNC: HGNC:8209
Homologene: 105219
Nab2
Name: Ngfi-A binding protein 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17937
HGNC: HGNC:7627
Homologene: 4353
Gusb
Name: glucuronidase, beta
Synonyms: g, Gus-u, Gur, Gut, Gus-t, Gus, asd, Gus-s, Gus-r, adipose storage deficiency
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 110006
HGNC: HGNC:4696
Homologene: 37271
Hcn1
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1
Synonyms: hyperpolarization-activated, cyclic nucleotide-gated K+ 1, HAC2, C630013B14Rik, Bcng1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15165
HGNC: HGNC:4845
Homologene: 32093
Fdx1
Name: ferredoxin 1
Synonyms: ADRENODOXIN
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14148
VEGA: 9
HGNC: HGNC:3638
Homologene: 31216
Xkr8
Name: X-linked Kx blood group related 8
Synonyms: LOC381560, 4931440N07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381560
Homologene: 23068
Apold1
Name: apolipoprotein L domain containing 1
Synonyms: LOC381823
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381823
Homologene: 12781
Or1o2
Name: olfactory receptor family 1 subfamily O member 2
Synonyms: Olfr97, MOR156-2, GA_x6K02T2PSCP-1672287-1671355
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258505
Homologene: 133051
Thnsl1
Name: threonine synthase-like 1 (bacterial)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208967
Homologene: 32609
Rad18
Name: RAD18 E3 ubiquitin protein ligase
Synonyms: 2810024C04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58186
Homologene: 48572
Mfsd4b5
Name: major facilitator superfamily domain containing 4B5
Synonyms: BC021785
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215928
Homologene: 129849
Cyp4f14
Name: cytochrome P450, family 4, subfamily f, polypeptide 14
Synonyms: 1300014O15Rik, leukotriene B4 omega hydroxylase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64385
VEGA: 17
Homologene: 81872
Slc25a4
Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
Synonyms: Ant1, adenine nucleotide translocase-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11739
Homologene: 36058
Lysmd3
Name: LysM, putative peptidoglycan-binding, domain containing 3
Synonyms: 1110030H10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 80289
VEGA: 13
Homologene: 12722
Smok3c
Name: sperm motility kinase 3C
Synonyms: EG622486
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622486
Homologene: 128738
Hes3
Name: hes family bHLH transcription factor 3
Synonyms: bHLHb43
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15207
Homologene: 7358
Igkv2-112
Name: immunoglobulin kappa variable 2-112
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381776
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 51,133,120 bp
  • T to C, chromosome 1 at 66,425,490 bp
  • T to C, chromosome 1 at 107,377,532 bp
  • T to C, chromosome 1 at 128,372,224 bp
  • A to G, chromosome 1 at 182,482,534 bp
  • T to A, chromosome 2 at 6,430,516 bp
  • T to A, chromosome 2 at 21,212,113 bp
  • T to C, chromosome 2 at 27,018,384 bp
  • T to A, chromosome 2 at 36,787,397 bp
  • A to G, chromosome 2 at 73,099,350 bp
  • G to T, chromosome 2 at 153,231,541 bp
  • T to C, chromosome 3 at 59,086,363 bp
  • A to T, chromosome 3 at 64,491,305 bp
  • A to G, chromosome 4 at 6,842,408 bp
  • T to C, chromosome 4 at 130,926,200 bp
  • G to A, chromosome 4 at 132,730,935 bp
  • G to A, chromosome 4 at 143,350,733 bp
  • T to G, chromosome 4 at 143,571,960 bp
  • T to A, chromosome 4 at 152,287,115 bp
  • A to T, chromosome 5 at 25,324,218 bp
  • A to G, chromosome 5 at 127,609,016 bp
  • A to G, chromosome 5 at 129,990,112 bp
  • T to C, chromosome 5 at 138,065,393 bp
  • A to T, chromosome 6 at 39,149,301 bp
  • T to C, chromosome 6 at 68,220,595 bp
  • T to A, chromosome 6 at 85,643,240 bp
  • T to A, chromosome 6 at 89,933,092 bp
  • T to A, chromosome 6 at 112,688,021 bp
  • T to A, chromosome 6 at 134,984,185 bp
  • T to C, chromosome 7 at 15,897,469 bp
  • G to T, chromosome 7 at 105,762,617 bp
  • T to A, chromosome 7 at 109,029,326 bp
  • A to G, chromosome 7 at 112,104,376 bp
  • A to T, chromosome 8 at 45,900,525 bp
  • A to G, chromosome 8 at 46,210,859 bp
  • T to C, chromosome 9 at 19,713,409 bp
  • A to G, chromosome 9 at 21,747,250 bp
  • A to G, chromosome 9 at 44,960,035 bp
  • A to T, chromosome 9 at 51,948,621 bp
  • T to A, chromosome 9 at 86,518,292 bp
  • G to A, chromosome 9 at 90,097,422 bp
  • T to A, chromosome 9 at 111,365,889 bp
  • T to A, chromosome 10 at 23,941,350 bp
  • A to G, chromosome 10 at 39,970,250 bp
  • C to T, chromosome 10 at 107,699,638 bp
  • C to A, chromosome 10 at 127,662,776 bp
  • T to C, chromosome 11 at 28,854,528 bp
  • G to T, chromosome 11 at 60,702,822 bp
  • T to A, chromosome 11 at 83,121,419 bp
  • C to T, chromosome 11 at 100,447,401 bp
  • C to T, chromosome 12 at 70,251,015 bp
  • T to G, chromosome 12 at 108,536,310 bp
  • T to C, chromosome 13 at 23,114,199 bp
  • A to G, chromosome 13 at 26,770,064 bp
  • T to A, chromosome 13 at 81,669,267 bp
  • A to T, chromosome 13 at 117,873,870 bp
  • C to T, chromosome 14 at 65,020,360 bp
  • T to C, chromosome 15 at 40,752,959 bp
  • T to C, chromosome 15 at 76,714,556 bp
  • T to C, chromosome 15 at 81,695,134 bp
  • T to A, chromosome 15 at 97,691,304 bp
  • G to A, chromosome 16 at 38,603,722 bp
  • T to C, chromosome 17 at 32,470,865 bp
  • A to C, chromosome 17 at 32,911,653 bp
  • T to C, chromosome 17 at 37,231,836 bp
  • T to A, chromosome 17 at 57,361,692 bp
  • A to T, chromosome 19 at 8,910,828 bp
  • G to T, chromosome 19 at 13,838,861 bp
  • T to A, chromosome Y at 2,663,204 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8223 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067641-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.