Strain Name:
C57BL/6J-MtgxR8215Btlr/Mmmh
Stock Number:
067657-MU
Citation ID:
RRID:MMRRC_067657-MU
Other Names:
R8215 (G1)
Major Collection:

Strain Information

Ptf1a
Name: pancreas specific transcription factor, 1a
Synonyms: PTF1-p48, bHLHa29
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19213
Homologene: 10304
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: C130076O07Rik, C030017F07Rik, Bravo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Ese1, Eh domain, SH3 domain regulator of endocytosis 1, EHSH1, Intersectin-L, Sh3p17
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Nisch
Name: nischarin
Synonyms: 1200007D05Rik, 3202002H23Rik, edsn
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 64652
Homologene: 136161
Foxj3
Name: forkhead box J3
Synonyms: C330039G02Rik, Fhd6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230700
Homologene: 35243
Zfhx3
Name: zinc finger homeobox 3
Synonyms: A230102L03Rik, Atbf1, Sci, WBP9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Rere
Name: arginine glutamic acid dipeptide (RE) repeats
Synonyms: eyes3, 1110033A15Rik, atrophin-2, eyem03Jus, Atr2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68703
HGNC: HGNC:9965
Homologene: 8101
Csnk1g3
Name: casein kinase 1, gamma 3
Synonyms: 3300002K07Rik, C330049O21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70425
VEGA: 18
HGNC: HGNC:2456
Homologene: 121650
Mcm2
Name: minichromosome maintenance complex component 2
Synonyms: BM28, Mcmd2, CDCL1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17216
HGNC: HGNC:6944
Homologene: 3325
Trak1
Name: trafficking protein, kinesin binding 1
Synonyms: 2310001H13Rik, hyrt
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67095
Homologene: 25103
Tfrc
Name: transferrin receptor
Synonyms: p90, TfR1, 2610028K12Rik, Mtvr1, Trfr, CD71, E430033M20Rik, Mtvr-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22042
Homologene: 2429
Hjurp
Name: Holliday junction recognition protein
Synonyms: 6430706D22Rik, A730008H23Rik, C330011F01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381280
Homologene: 10184
Plekhg1
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 1
Synonyms: D10Ertd733e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213783
Homologene: 18897
Adamtsl1
Name: ADAMTS-like 1
Synonyms: 6720426B09Rik, 5930437A14Rik, punctin-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77739
Homologene: 64642
Krr1
Name: KRR1, small subunit (SSU) processome component, homolog (yeast)
Synonyms: 2610511F02Rik, D10Ertd773e, Hrb2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52705
HGNC: HGNC:5176
Homologene: 5114
F11r
Name: F11 receptor
Synonyms: Jcam1, BV11 antigen, ESTM33, JAM-A, Ly106, JAM-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16456
Homologene: 14255
Shq1
Name: SHQ1 homolog (S. cerevisiae)
Synonyms: 2810403P18Rik, Grim-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72171
Homologene: 31683
Clic5
Name: chloride intracellular channel 5
Synonyms: nmf318, 5730531E12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224796
VEGA: 17
Homologene: 987
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: 2900022L05Rik, Dnhd3, Dnahc2, D330014H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Chsy3
Name: chondroitin sulfate synthase 3
Synonyms: 4833446K15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 78923
VEGA: 18
Homologene: 28624
Tnr
Name: tenascin R
Synonyms: janusin, J1-tenascin, TN-R, restrictin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21960
Homologene: 124416
Or51k1
Name: olfactory receptor family 51 subfamily K member 1
Synonyms: Olfr639, GA_x6K02T2PBJ9-6747143-6746193, MOR12-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259088
Homologene: 17497
Cdh8
Name: cadherin 8
Synonyms: cad8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12564
HGNC: HGNC:1767
Homologene: 55604
Trpv2
Name: transient receptor potential cation channel, subfamily V, member 2
Synonyms: OTRPC2, Vrl1, VRL-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22368
Homologene: 7993
Gcnt3
Name: glucosaminyl (N-acetyl) transferase 3, mucin type
Synonyms: 2010013H22Rik, 2210401J11Rik, 2210021I22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72077
VEGA: 9
HGNC: HGNC:4205
Homologene: 20993
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 1110061O17Rik, 9430004C13Rik, 9630046L06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: mXin beta, myomaxin, 2310003D02Rik, Cmya3, 2310008C07Rik, A530024P18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
D930020B18Rik
Name: RIKEN cDNA D930020B18 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216393
Homologene: 87610
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: oxygen-regulated protein 1, Rp1h, Orp1, mG145, Dcdc3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
Myh3
Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic
Synonyms: Myhse, MyHC-emb, Myhs-e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17883
HGNC: HGNC:7573
Homologene: 20553
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328573
VEGA: 15
Homologene: 130065
Btn2a2
Name: butyrophilin, subfamily 2, member A2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238555
Homologene: 56012
Serpinh1
Name: serine (or cysteine) peptidase inhibitor, clade H, member 1
Synonyms: Cbp2, Cbp1, Hsp47, Serpinh2, J6, gp46, colligin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12406
HGNC: HGNC:1546
Homologene: 20331
Or5p51
Name: olfactory receptor family 5 subfamily P member 51
Synonyms: MOR204-22, Olfr470, GA_x6K02T2PBJ9-10175273-10174329
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258417
Corin
Name: corin, serine peptidase
Synonyms: Lrp4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53419
Homologene: 4804
Zbtb4
Name: zinc finger and BTB domain containing 4
Synonyms: 2310026P19Rik, 9230111I22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75580
Homologene: 10846
Mroh5
Name: maestro heat-like repeat family member 5
Synonyms: LOC268816, Gm628
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268816
Abca14
Name: ATP-binding cassette, sub-family A member 14
Synonyms: 4930539G24Rik, 1700110B15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67928
Homologene: 86128
Hoxa2
Name: homeobox A2
Synonyms: Hox-1.11
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15399
HGNC: HGNC:5103
Homologene: 4901
Kcnb1
Name: potassium voltage gated channel, Shab-related subfamily, member 1
Synonyms: Kv2.1, Shab, Kcr1-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16500
HGNC: HGNC:6231
Homologene: 37988
Or7g32
Name: olfactory receptor family 7 subfamily G member 32
Synonyms: GA_x6K02T2PVTD-13234278-13235216, Olfr851, MOR155-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258907
HGNC: HGNC:8466
Homologene: 74178
Zbtb47
Name: zinc finger and BTB domain containing 47
Synonyms: Zfp651, 4732420M22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270210
VEGA: 9
Homologene: 136302
Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Synonyms: UgtBr1, UGT1A01, Udpgt-1a, Gnt1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 394436
Homologene: 128034
Ccdc33
Name: coiled-coil domain containing 33
Synonyms: 4930535E21Rik, LOC382077
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382077
Homologene: 19641
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Schnurri-3, E030045D18Rik, 2900056N03Rik, Shn3, Krc
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16656
Homologene: 7803
Vmn2r24
Name: vomeronasal 2, receptor 24
Synonyms: EG243628
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243628
Homologene: 135915
Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Synonyms: cyclooxygenase 1, Cox-3, Pghs1, Cox-1, COX1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19224
HGNC: HGNC:9604
Homologene: 743
Or8k17
Name: olfactory receptor family 8 subfamily K member 17
Synonyms: MOR187-2, Olfr1048, GA_x6K02T2Q125-47716657-47715716
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259016
Klhl17
Name: kelch-like 17
Synonyms: actinfilin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231003
VEGA: 4
Homologene: 27075
Irx5
Name: Iroquois homeobox 5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54352
Homologene: 38105
Cd55b
Name: CD55 molecule, decay accelerating factor for complement B
Synonyms: Daf-TM, TM-DAF, complement-transmembrane, Daf2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13137
HGNC: HGNC:2665
Homologene: 479
Nedd9
Name: neural precursor cell expressed, developmentally down-regulated gene 9
Synonyms: CasL, Cas-L, HEF1, E230025G09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18003
VEGA: 13
HGNC: HGNC:7733
Homologene: 4669
Samd14
Name: sterile alpha motif domain containing 14
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217125
Homologene: 17130
Gm10837
Name: predicted gene 10837
Type: Gene
Species: Mouse
Chromosome: 14
Gm38394
Name: predicted gene, 38394
Type: Gene
Species: Mouse
Chromosome: 1
Ccdc108
Name:
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 4,245,095 bp
  • A to G, chromosome 1 at 74,910,743 bp
  • CAGAGAGAGAGAGA to CAGAGAGAGAGA, chromosome 1 at 88,211,984 bp
  • GT to GTT, chromosome 1 at 88,266,524 bp
  • CTTTT to CTTTTT, chromosome 1 at 130,419,600 bp
  • G to T, chromosome 1 at 133,658,792 bp
  • A to C, chromosome 1 at 159,888,290 bp
  • GGTGTG to GGTGTGTG, chromosome 1 at 171,463,088 bp
  • A to G, chromosome 2 at 19,445,949 bp
  • G to T, chromosome 2 at 36,251,167 bp
  • T to A, chromosome 2 at 67,516,509 bp
  • C to T, chromosome 2 at 86,236,518 bp
  • T to C, chromosome 2 at 167,104,441 bp
  • T to C, chromosome 3 at 116,788,644 bp
  • A to T, chromosome 3 at 158,209,750 bp
  • T to G, chromosome 4 at 86,343,145 bp
  • T to G, chromosome 4 at 119,621,611 bp
  • T to C, chromosome 4 at 120,122,901 bp
  • T to A, chromosome 4 at 150,616,967 bp
  • A to G, chromosome 4 at 156,230,053 bp
  • T to C, chromosome 5 at 72,305,018 bp
  • A to T, chromosome 6 at 22,132,278 bp
  • A to G, chromosome 6 at 52,163,061 bp
  • T to C, chromosome 6 at 88,897,311 bp
  • A to T, chromosome 6 at 100,671,060 bp
  • A to G, chromosome 6 at 123,779,118 bp
  • A to G, chromosome 7 at 99,346,338 bp
  • T to C, chromosome 7 at 104,012,123 bp
  • T to G, chromosome 7 at 107,844,917 bp
  • A to C, chromosome 7 at 120,294,202 bp
  • T to A, chromosome 8 at 43,626,501 bp
  • A to T, chromosome 8 at 92,359,613 bp
  • A to G, chromosome 8 at 99,030,866 bp
  • A to G, chromosome 8 at 108,950,717 bp
  • T to C, chromosome 9 at 19,497,500 bp
  • A to T, chromosome 9 at 58,032,712 bp
  • T to C, chromosome 9 at 70,034,173 bp
  • C to A, chromosome 9 at 121,469,030 bp
  • T to C, chromosome 9 at 121,767,278 bp
  • C to T, chromosome 10 at 3,957,521 bp
  • C to T, chromosome 10 at 111,979,929 bp
  • T to A, chromosome 10 at 121,667,524 bp
  • A to C, chromosome 11 at 62,590,931 bp
  • A to G, chromosome 11 at 67,101,179 bp
  • A to G, chromosome 11 at 69,435,367 bp
  • A to C, chromosome 11 at 69,778,772 bp
  • A to T, chromosome 11 at 95,014,387 bp
  • T to C, chromosome 12 at 44,564,113 bp
  • A to C, chromosome 13 at 23,481,870 bp
  • T to C, chromosome 13 at 41,338,843 bp
  • A to G, chromosome 14 at 31,186,701 bp
  • A to G, chromosome 14 at 122,490,781 bp
  • C to A, chromosome 15 at 73,819,290 bp
  • G to T, chromosome 15 at 82,065,100 bp
  • T to C, chromosome 16 at 32,625,030 bp
  • T to C, chromosome 16 at 91,812,108 bp
  • T to A, chromosome 17 at 44,275,341 bp
  • C to T, chromosome 18 at 53,948,079 bp
  • C to T, chromosome 18 at 59,175,869 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8215 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067657-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.