Strain Name:
C57BL/6J-MtgxR8231Btlr/Mmmh
Stock Number:
067663-MU
Citation ID:
RRID:MMRRC_067663-MU
Other Names:
R8231 (G1)
Major Collection:

Strain Information

Thbs4
Name: thrombospondin 4
Synonyms: TSP-4, TSP4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21828
Homologene: 20691
Dbh
Name: dopamine beta hydroxylase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13166
HGNC: HGNC:2689
Homologene: 615
Ptpra
Name: protein tyrosine phosphatase receptor type A
Synonyms: PTPalpha, Ptpa, RPTPalpha, RPTRalpha, PTP[a]
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19262
HGNC: HGNC:9664
Homologene: 20621
Dnajc2
Name: DnaJ heat shock protein family (Hsp40) member C2
Synonyms: Mida1, Zrf2, Zrf1, MIDA1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22791
Homologene: 31656
Pibf1
Name: progesterone immunomodulatory binding factor 1
Synonyms: 1700017E21Rik, 4933439E17Rik, 4933438D16Rik, D14Ertd581e, 4930513H15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52023
VEGA: 14
Homologene: 4628
Ttc27
Name: tetratricopeptide repeat domain 27
Synonyms: 2610511O17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74196
VEGA: 17
Homologene: 41191
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208628
Homologene: 32227
Golga5
Name: golgin A5
Synonyms: Ret-II
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27277
VEGA: 12
HGNC: HGNC:4428
Homologene: 38009
Gpatch2l
Name: G patch domain containing 2 like
Synonyms: 1700020O03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70373
VEGA: 12
Homologene: 9942
Dock4
Name: dedicator of cytokinesis 4
Synonyms: EST N28122, 6330411N01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Tbc1d15
Name: TBC1 domain family, member 15
Synonyms: Ly6dl, 4432405K22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66687
VEGA: 10
Homologene: 11249
Abcg8
Name: ATP binding cassette subfamily G member 8
Synonyms: Sterolin-2, 1300003C16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67470
Homologene: 23361
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Acsf2
Name: acyl-CoA synthetase family member 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 264895
Homologene: 23519
Ints7
Name: integrator complex subunit 7
Synonyms: 5930412E23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77065
Homologene: 9136
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Fam38a, Piezo1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234839
Homologene: 124356
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Nyap2
Name: neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
Synonyms: Jr6, 9430031J16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241134
Homologene: 18239
Cul9
Name: cullin 9
Synonyms: Parc, 1810035I07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78309
Homologene: 56696
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: 2410089E03Rik, Jbts17, b2b012Clo, Hug
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Tdrd6
Name: tudor domain containing 6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210510
Homologene: 19364
Adamts16
Name: ADAM metallopeptidase with thrombospondin type 1 motif 16
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271127
Homologene: 15146
Duox2
Name: dual oxidase 2
Synonyms: A430065P05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214593
Homologene: 9689
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 252866
Homologene: 78104
Atp6v0d2
Name: ATPase, H+ transporting, lysosomal V0 subunit D2
Synonyms: 1620401A02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242341
Homologene: 72090
Pnma8b
Name: PNMA family member 8B
Synonyms: Pnmal2, EG434128
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434128
Homologene: 35491
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Stat6
Name: signal transducer and activator of transcription 6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20852
Homologene: 2373
Kyat1
Name: kynurenine aminotransferase 1
Synonyms: cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase), Ccbl1, 2010009K05Rik, Kat1, KATI
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70266
HGNC: HGNC:1564
Homologene: 37872
Sox5
Name: SRY (sex determining region Y)-box 5
Synonyms: A730017D01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20678
Homologene: 21378
Cyp2a4
Name: cytochrome P450, family 2, subfamily a, polypeptide 4
Synonyms: testosterone 15alpha-hydroxylase, D7Ucla4, Cyp15a1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13086
Homologene: 85917
Snx22
Name: sorting nexin 22
Synonyms: LOC382083
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382083
VEGA: 9
Homologene: 11723
Ccdc121
Name: coiled-coil domain containing 121
Synonyms: 4930548H24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67656
Zfp131
Name: zinc finger protein 131
Synonyms: Znf131, 2610109I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72465
VEGA: 13
Homologene: 12464
Btg4
Name: BTG anti-proliferation factor 4
Synonyms: PC3B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56057
VEGA: 9
Homologene: 9734
Rce1
Name: Ras converting CAAX endopeptidase 1
Synonyms: D19Ertd98e, D19Ertd283e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19671
VEGA: 19
Homologene: 3769
Dennd11
Name: DENN domain containing 11
Synonyms: E330009J07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243780
Homologene: 82355
Tmem255b
Name: transmembrane protein 255B
Synonyms: Fam70b, LOC272465
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 272465
Homologene: 18804
Rmdn1
Name: regulator of microtubule dynamics 1
Synonyms: 5730501K14Rik, Fam82b, 5033415E11Rik, 2410005O16Rik, 6430576D04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66302
Homologene: 41093
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 81,192,131 bp
  • T to A, chromosome 1 at 191,596,353 bp
  • C to T, chromosome 2 at 27,170,543 bp
  • T to C, chromosome 2 at 30,191,966 bp
  • C to A, chromosome 2 at 52,235,479 bp
  • A to T, chromosome 2 at 122,289,563 bp
  • A to G, chromosome 2 at 130,537,603 bp
  • T to C, chromosome 4 at 19,586,853 bp
  • A to G, chromosome 4 at 19,881,451 bp
  • C to G, chromosome 4 at 154,252,518 bp
  • T to C, chromosome 5 at 21,761,691 bp
  • T to A, chromosome 5 at 31,486,207 bp
  • A to G, chromosome 5 at 123,782,896 bp
  • A to T, chromosome 6 at 40,418,612 bp
  • G to T, chromosome 6 at 144,028,288 bp
  • T to C, chromosome 7 at 16,946,590 bp
  • G to A, chromosome 7 at 26,312,937 bp
  • A to G, chromosome 8 at 13,454,225 bp
  • A to T, chromosome 8 at 16,697,923 bp
  • A to T, chromosome 8 at 43,651,622 bp
  • A to G, chromosome 8 at 122,506,097 bp
  • A to G, chromosome 9 at 51,116,568 bp
  • A to T, chromosome 9 at 66,068,198 bp
  • T to C, chromosome 10 at 115,229,140 bp
  • A to G, chromosome 10 at 127,646,973 bp
  • C to G, chromosome 11 at 94,561,362 bp
  • T to A, chromosome 12 at 40,702,951 bp
  • A to G, chromosome 12 at 85,260,798 bp
  • T to C, chromosome 12 at 86,244,189 bp
  • T to C, chromosome 12 at 102,472,299 bp
  • A to G, chromosome 13 at 70,777,480 bp
  • A to T, chromosome 13 at 92,774,844 bp
  • A to G, chromosome 13 at 119,775,812 bp
  • T to G, chromosome 14 at 99,186,561 bp
  • T to C, chromosome 15 at 8,219,027 bp
  • T to C, chromosome 17 at 43,622,135 bp
  • T to C, chromosome 17 at 46,520,501 bp
  • C to A, chromosome 17 at 74,717,964 bp
  • C to T, chromosome 17 at 84,692,785 bp
  • A to T, chromosome 19 at 4,625,050 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8231 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067663-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.