Strain Name:
C57BL/6J-MtgxR8238Btlr/Mmmh
Stock Number:
067670-MU
Citation ID:
RRID:MMRRC_067670-MU
Other Names:
R8238 (G1)
Major Collection:

Strain Information

Fgr
Name: FGR proto-oncogene, Src family tyrosine kinase
Synonyms: Mhdaali18, Ali18
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14191
HGNC: HGNC:3697
Homologene: 3842
Tdh
Name: L-threonine dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 58865
Homologene: 10987
Etl4
Name: enhancer trap locus 4
Synonyms: Sickle tail, 6620402G01Rik, Skt, 9430077C05Rik, Etl-4, E330027G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Kif5b
Name: kinesin family member 5B
Synonyms: Khc, kinesin heavy chain
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16573
HGNC: HGNC:6324
Homologene: 55829
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: Camsap1l1, 1600013L13Rik, 4930541M15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67886
Homologene: 18927
Ipo5
Name: importin 5
Synonyms: IMB3, RanBP5, Kpnb3, 1110011C18Rik, importin beta 3, 5730478E03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70572
VEGA: 14
HGNC: HGNC:6402
Homologene: 1710
Xdh
Name: xanthine dehydrogenase
Synonyms: XO, Xox1, Xor, Xox-1, xanthine oxidase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Sec23b
Name: SEC23 homolog B, COPII coat complex component
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27054
Homologene: 74571
Hey2
Name: hairy/enhancer-of-split related with YRPW motif 2
Synonyms: Hrt2, bHLHb32, Herp1, Hesr2, CHF1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15214
HGNC: HGNC:4881
Homologene: 22705
Pard6a
Name: par-6 family cell polarity regulator alpha
Synonyms: TAX40, 0710008C04Rik, Tip-40, Par6c, PAR6alpha, 2610010A15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56513
Homologene: 9661
Atp5f1b
Name: ATP synthase F1 subunit beta
Synonyms: Atp5b
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11947
HGNC: HGNC:830
Homologene: 1273
Vps11
Name: VPS11, CORVET/HOPS core subunit
Synonyms: 1200011A11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71732
VEGA: 9
Homologene: 6673
Lrrtm4
Name: leucine rich repeat transmembrane neuronal 4
Synonyms: 7530419J18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243499
Homologene: 11807
Ncstn
Name: nicastrin
Synonyms: nicastrin, Nct, D1Dau13e, 9430068N19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 59287
Homologene: 41029
Nsun3
Name: NOL1/NOP2/Sun domain family member 3
Synonyms: 6720484A09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106338
Homologene: 65358
Aoc1l3
Name: amine oxidase copper containing 1-like 3
Synonyms: SVS I, Svs1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243377
HGNC: HGNC:80
Homologene: 18250
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: E330028L06Rik, DPD
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: D16Ertd642e, Wdr52, 6330444M21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212517
Homologene: 75085
Hspb7
Name: heat shock protein family, member 7 (cardiovascular)
Synonyms: cvHsp, Hsp25-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 29818
HGNC: HGNC:5249
Homologene: 8480
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 252866
Homologene: 78104
Slc7a14
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241919
Homologene: 76320
Vmn1r231
Name: vomeronasal 1 receptor 231
Synonyms: V1re7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171230
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74521
Homologene: 12571
Glipr1
Name: GLI pathogenesis related 1
Synonyms: RTVP-1, 2410114O14Rik, mRTVP-1, RTVP1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73690
Homologene: 21357
Mup6
Name: major urinary protein 6
Synonyms: Gm12544
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 620807
Homologene: 74304
Vmn2r92
Name: vomeronasal 2, receptor 92
Synonyms: EG627111
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627111
Homologene: 115024
Iqsec1
Name: IQ motif and Sec7 domain 1
Synonyms: BRAG2, cI-43, D6Ertd349e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232227
Homologene: 82429
Or13a27
Name: olfactory receptor family 13 subfamily A member 27
Synonyms: MOR253-6, GA_x6K02T2PBJ9-42496183-42495251, Olfr60, IH6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18361
Homologene: 34961
Cabp5
Name: calcium binding protein 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29865
Homologene: 8486
Slc36a3
Name: solute carrier family 36 (proton/amino acid symporter), member 3
Synonyms: tramdorin2, PAT3, TRAMD2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 215332
Homologene: 76175
Alx1
Name: ALX homeobox 1
Synonyms: Cart1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216285
HGNC: HGNC:1494
Homologene: 5075
Ak1
Name: adenylate kinase 1
Synonyms: B430205N08Rik, Ak-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11636
HGNC: HGNC:361
Homologene: 20135
Oaf
Name: out at first homolog
Synonyms: D9Ucla1, D130038B21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102644
VEGA: 9
Homologene: 14334
Or55b10
Name: olfactory receptor family 55 subfamily B member 10
Synonyms: GA_x6K02T2PBJ9-5216160-5215210, S50, Olfr545, MOR42-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258837
Homologene: 17410
Gm10799
Name: predicted gene 10799
Type: Gene
Species: Mouse
Chromosome: 2
Vmn2r36
Name: vomeronasal 2, receptor 36
Synonyms: Gm3991
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042653
Homologene: 113703
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 136,294,026 bp
  • G to T, chromosome 1 at 172,072,476 bp
  • C to T, chromosome 2 at 20,806,531 bp
  • T to A, chromosome 2 at 32,633,669 bp
  • A to G, chromosome 2 at 104,068,151 bp
  • T to C, chromosome 2 at 144,564,648 bp
  • A to T, chromosome 2 at 177,315,318 bp
  • C to A, chromosome 3 at 31,227,151 bp
  • G to A, chromosome 3 at 119,195,193 bp
  • T to A, chromosome 4 at 60,003,634 bp
  • C to T, chromosome 4 at 132,997,521 bp
  • A to G, chromosome 4 at 141,422,546 bp
  • A to G, chromosome 6 at 48,990,041 bp
  • T to A, chromosome 6 at 80,022,685 bp
  • A to T, chromosome 6 at 90,689,930 bp
  • T to G, chromosome 7 at 7,889,016 bp
  • T to A, chromosome 7 at 13,405,452 bp
  • T to C, chromosome 7 at 102,494,620 bp
  • A to C, chromosome 7 at 140,345,890 bp
  • A to G, chromosome 8 at 43,650,956 bp
  • A to G, chromosome 8 at 105,702,734 bp
  • C to T, chromosome 9 at 43,239,345 bp
  • T to C, chromosome 9 at 44,352,760 bp
  • T to A, chromosome 10 at 30,840,663 bp
  • C to T, chromosome 10 at 103,022,215 bp
  • C to T, chromosome 10 at 111,993,440 bp
  • T to A, chromosome 10 at 128,085,150 bp
  • C to T, chromosome 11 at 55,131,607 bp
  • A to C, chromosome 12 at 103,590,807 bp
  • C to T, chromosome 14 at 63,495,724 bp
  • A to T, chromosome 14 at 120,935,240 bp
  • G to A, chromosome 16 at 44,415,305 bp
  • A to G, chromosome 16 at 62,770,713 bp
  • G to T, chromosome 17 at 18,185,016 bp
  • T to C, chromosome 17 at 20,890,378 bp
  • G to T, chromosome 17 at 73,886,417 bp
  • T to A, chromosome 18 at 6,227,619 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8238 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067670-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.