Strain Name:
C57BL/6J-MtgxR8244Btlr/Mmmh
Stock Number:
067672-MU
Citation ID:
RRID:MMRRC_067672-MU
Other Names:
R8244 (G1)
Major Collection:

Strain Information

Rtn4rl1
Name: reticulon 4 receptor-like 1
Synonyms: Ngrh2, Ngrl2, Ngr3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237847
Homologene: 18611
Pxn
Name: paxillin
Synonyms: Pax
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19303
HGNC: HGNC:9718
Homologene: 37697
Efr3a
Name: EFR3 homolog A
Synonyms: A130089M23Rik, C920006C10Rik, D030063F01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76740
Homologene: 44222
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Mhdadsk9, Dsk9, Nf-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Wdr20
Name: WD repeat domain 20
Synonyms: 2310040A13Rik, Wdr20a
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69641
Homologene: 32684
Clptm1
Name: cleft lip and palate associated transmembrane protein 1
Synonyms: HS9, N14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56457
HGNC: HGNC:2087
Homologene: 37464
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Zfp516
Name: zinc finger protein 516
Synonyms: Zfp26l, C330029B10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Epha8
Name: Eph receptor A8
Synonyms: Eek, EphA8, Hek3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Cramp1
Name: cramped chromatin regulator 1
Synonyms: Cramp1l, 5830477H08Rik, Tce4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Ehmt2
Name: euchromatic histone lysine N-methyltransferase 2
Synonyms: KMT1C, Bat8, D17Ertd710e, G9a, NG36
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110147
Homologene: 48460
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: C330002D13Rik, Coh1, 1810042B05Rik, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Tmem131
Name: transmembrane protein 131
Synonyms: 2610524E03Rik, CC28, Neg, D1Bwg0491e, Rw1, YR-23
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56030
Homologene: 32428
Atf7
Name: activating transcription factor 7
Synonyms: 1110012F10Rik, 9430065F09Rik, C130020M04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223922
HGNC: HGNC:792
Homologene: 4994
Ap5z1
Name: adaptor-related protein complex 5, zeta 1 subunit
Synonyms: C330006K01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231855
Homologene: 18213
Gfpt1
Name: glutamine fructose-6-phosphate transaminase 1
Synonyms: GFAT, GFAT1, 2810423A18Rik, GFA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14583
HGNC: HGNC:4241
Homologene: 68220
Cbx3
Name: chromobox 3
Synonyms: heterochromatin protein 1 gamma, HP1g, M32
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12417
HGNC: HGNC:1553
Homologene: 40583
2310022A10Rik
Name: RIKEN cDNA 2310022A10 gene
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66367
Homologene: 35272
Zfp979
Name: zinc finger protein 979
Synonyms: Ssm1, 2610305D13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 112422
Homologene: 133076
Slc44a4
Name: solute carrier family 44, member 4
Synonyms: NG22, 2210409B01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70129
Homologene: 11359
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, CED-5, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Mapk11
Name: mitogen-activated protein kinase 11
Synonyms: Prkm11, Sapk2, p38beta, P38b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19094
VEGA: 15
HGNC: HGNC:6873
Homologene: 55684
Sall3
Name: spalt like transcription factor 3
Synonyms: Msal, Msal-1, B130022O04Rik, Spalt, Salt
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20689
VEGA: 18
Homologene: 18142
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Sim2
Name: single-minded family bHLH transcription factor 2
Synonyms: bHLHe15
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20465
VEGA: 16
Homologene: 3716
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Zscan20
Name: zinc finger and SCAN domains 20
Synonyms: Zfp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269585
Homologene: 51463
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319695
Homologene: 85163
Ahnak
Name: AHNAK nucleoprotein
Synonyms: 2310047C17Rik, 1110004P15Rik, DY6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Tom1l1
Name: target of myb1-like 1 (chicken)
Synonyms: Srcasm, 2310045L10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71943
Homologene: 38055
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, E030037J05Rik, 1110018I21Rik, Tns, E030018G17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21961
Homologene: 11219
Lrrc9
Name: leucine rich repeat containing 9
Synonyms: 4921529O18Rik, 4930432K16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 78257
Homologene: 12692
Dgkq
Name: diacylglycerol kinase, theta
Synonyms: Dgk theta, 110kDa, Dagk4, DAGK7, Dgkd
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 110524
HGNC: HGNC:2856
Homologene: 20352
Pramel27
Name: PRAME like 27
Synonyms: Gm13103
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194225
Homologene: 129883
Apc2
Name: APC regulator of WNT signaling pathway 2
Synonyms: APCL
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23805
Homologene: 4299
Sox1
Name: SRY (sex determining region Y)-box 1
Synonyms: Sox-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20664
Homologene: 133765
Igsf23
Name: immunoglobulin superfamily, member 23
Synonyms: 2210010C17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70080
Homologene: 52756
Sh2b2
Name: SH2B adaptor protein 2
Synonyms: Aps
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23921
Homologene: 10309
Lztfl1
Name: leucine zipper transcription factor-like 1
Synonyms: 6130400H19Rik, 5530402H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93730
HGNC: HGNC:6741
Homologene: 41368
Arid3c
Name: AT-rich interaction domain 3C
Synonyms: OTTMUSG00000006683
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 550619
Homologene: 72499
Ptx4
Name: pentraxin 4
Synonyms: 1110018H23Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68509
VEGA: 17
Homologene: 19179
Pdcd4
Name: programmed cell death 4
Synonyms: MA-3, D19Ucla1, TIS
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18569
VEGA: 19
HGNC: HGNC:8763
Homologene: 7879
Alg5
Name: ALG5 dolichyl-phosphate beta-glucosyltransferase
Synonyms: 1500026A19Rik, 2600005J22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66248
Homologene: 7060
Gm21680
Name: predicted gene, 21680
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100862368
Homologene: 69402
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,808,893 bp
  • A to G, chromosome 1 at 72,651,024 bp
  • G to T, chromosome 1 at 73,937,251 bp
  • T to C, chromosome 2 at 41,506,782 bp
  • T to A, chromosome 2 at 76,828,707 bp
  • A to G, chromosome 3 at 54,738,800 bp
  • T to G, chromosome 4 at 41,729,997 bp
  • T to C, chromosome 4 at 128,585,966 bp
  • G to T, chromosome 4 at 136,938,586 bp
  • T to C, chromosome 4 at 143,853,284 bp
  • A to T, chromosome 4 at 147,613,476 bp
  • T to C, chromosome 5 at 25,968,985 bp
  • A to G, chromosome 5 at 108,648,712 bp
  • C to T, chromosome 5 at 115,552,243 bp
  • G to T, chromosome 5 at 136,227,437 bp
  • A to T, chromosome 5 at 142,473,980 bp
  • T to A, chromosome 6 at 40,750,586 bp
  • C to T, chromosome 6 at 51,475,370 bp
  • T to A, chromosome 6 at 87,063,631 bp
  • A to T, chromosome 7 at 19,638,991 bp
  • A to T, chromosome 7 at 19,941,873 bp
  • T to C, chromosome 7 at 27,571,579 bp
  • A to G, chromosome 7 at 130,728,676 bp
  • GGGCGGCGGCGGCGGCGG to GGGCGGCGGCGGCGG, chromosome 8 at 12,396,468 bp
  • T to A, chromosome 9 at 123,712,449 bp
  • A to T, chromosome 10 at 80,315,332 bp
  • A to T, chromosome 11 at 34,695,453 bp
  • T to C, chromosome 11 at 75,265,450 bp
  • T to C, chromosome 11 at 79,440,924 bp
  • T to C, chromosome 11 at 90,657,821 bp
  • A to T, chromosome 12 at 8,010,548 bp
  • A to G, chromosome 12 at 72,499,610 bp
  • G to A, chromosome 12 at 110,793,642 bp
  • A to T, chromosome 14 at 47,674,823 bp
  • G to T, chromosome 15 at 35,917,203 bp
  • G to A, chromosome 15 at 65,815,368 bp
  • G to T, chromosome 15 at 89,145,804 bp
  • A to G, chromosome 15 at 102,528,866 bp
  • T to A, chromosome 16 at 94,109,363 bp
  • T to A, chromosome 17 at 24,971,410 bp
  • A to G, chromosome 17 at 25,122,865 bp
  • A to G, chromosome 17 at 34,905,262 bp
  • T to C, chromosome 17 at 34,921,572 bp
  • G to A, chromosome 18 at 80,973,754 bp
  • G to T, chromosome 18 at 82,956,333 bp
  • C to T, chromosome 19 at 9,015,673 bp
  • A to G, chromosome 19 at 53,907,534 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8244 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067672-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.