Strain Name:
C57BL/6J-MtgxR8245Btlr/Mmmh
Stock Number:
067673-MU
Citation ID:
RRID:MMRRC_067673-MU
Other Names:
R8245 (G1)
Major Collection:

Strain Information

Hps5
Name: HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
Synonyms: ru-2, ruby eye 2, ru2, Hermansky-Pudlak syndrome 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246694
Homologene: 35333
Ippk
Name: inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Synonyms: 1810043M15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75678
VEGA: 13
Homologene: 41495
Lhx9
Name: LIM homeobox protein 9
Synonyms: LH2B, Lhx9 alpha, 3110009O07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16876
Homologene: 7816
Stam2
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: Hbp, 1200004O12Rik, 5730456G07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56324
Homologene: 68490
Gfpt2
Name: glutamine fructose-6-phosphate transaminase 2
Synonyms: GFAT2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14584
HGNC: HGNC:4242
Homologene: 68439
Cnot2
Name: CCR4-NOT transcription complex, subunit 2
Synonyms: 2600016M12Rik, 2810470K03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72068
HGNC: HGNC:7878
Homologene: 40953
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Rexo4
Name: REX4, 3'-5' exonuclease
Synonyms: XPMC2H, Rex4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227656
Homologene: 133948
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Sipa1l3
Name: signal-induced proliferation-associated 1 like 3
Synonyms: 2610511M17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74206
Homologene: 77938
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228850
Homologene: 10666
Tpp2
Name: tripeptidyl peptidase II
Synonyms: TppII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22019
Homologene: 2471
Zfp516
Name: zinc finger protein 516
Synonyms: C330029B10Rik, Zfp26l
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Stat1
Name: signal transducer and activator of transcription 1
Synonyms: 2010005J02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20846
Homologene: 21428
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Stag1
Name: STAG1 cohesin complex component
Synonyms: SA-1, Scc3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20842
Homologene: 21191
Ints12
Name: integrator complex subunit 12
Synonyms: A230056J18Rik, 4930529N21Rik, 2810027J24Rik, 1110020M19Rik, Phf22
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71793
Homologene: 32474
Tonsl
Name: tonsoku-like, DNA repair protein
Synonyms: 2810439M11Rik, Nfkbil2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72749
HGNC: HGNC:7801
Homologene: 22754
Cep128
Name: centrosomal protein 128
Synonyms: 5430424K18Rik, 4930534B04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75216
Homologene: 35315
Trh
Name: thyrotropin releasing hormone
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22044
Homologene: 5163
Dapk1
Name: death associated protein kinase 1
Synonyms: 2310039H24Rik, D13Ucla1, 2810425C21Rik, DAP-Kinase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Atf7ip2
Name: activating transcription factor 7 interacting protein 2
Synonyms: 4930558K11Rik, PSM2, Get-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75329
Homologene: 23509
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: A930007H10Rik, C820010P03Rik, 0910001L17Rik, Ugcgl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320011
Homologene: 10586
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: Cngb1, Cngb1b, BC016201
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Adamts13
Name: ADAM metallopeptidase with thrombospondin type 1 motif 13
Synonyms: LOC279028, vWF-CP mRNA for von Willebrand factor-cleaving
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 279028
HGNC: HGNC:1366
Homologene: 16372
Cdipt
Name: CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Synonyms: 9530042F15Rik, D7Bwg0575e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52858
HGNC: HGNC:1769
Homologene: 7159
Sall3
Name: spalt like transcription factor 3
Synonyms: Msal, Msal-1, Spalt, Salt, B130022O04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20689
VEGA: 18
Homologene: 18142
Myo6
Name: myosin VI
Synonyms: Tlc, Myo6rsv, rsv
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17920
HGNC: HGNC:7605
Homologene: 56417
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Col27a1
Name: collagen, type XXVII, alpha 1
Synonyms: 5730512J02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 373864
Homologene: 69400
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
H2-M10.6
Name: histocompatibility 2, M region locus 10.6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 399549
Homologene: 117973
Vmn1r179
Name: vomeronasal 1 receptor 179
Synonyms: V1rd17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404286
Homologene: 134022
Fer1l4
Name: fer-1 like family member 4
Synonyms: 9130402C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74562
Homologene: 19075
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Fsip1
Name: fibrous sheath-interacting protein 1
Synonyms: 4933432K11Rik, 1700012M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71313
Homologene: 12390
Nrp1
Name: neuropilin 1
Synonyms: Neuropilin-1, NP-1, NPN-1, Npn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Abcc9
Name: ATP-binding cassette, sub-family C member 9
Synonyms: SUR2B, SUR2A, Sur2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Bpifb9a
Name: BPI fold containing family B, member 9A
Synonyms: vomeromodulin, 4833413D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71425
Homologene: 128535
Txlnb
Name: taxilin beta
Synonyms: Mdp77, 2310001N14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 378431
Homologene: 44534
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Postn
Name: periostin, osteoblast specific factor
Synonyms: OSF-2, Periostin, Osf2, peri, A630052E07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 50706
Homologene: 4730
Ildr1
Name: immunoglobulin-like domain containing receptor 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106347
Homologene: 15892
Dhrs2
Name: dehydrogenase/reductase member 2
Synonyms: SDR family, 5430405K24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71412
Homologene: 69438
Oxa1l
Name: oxidase assembly 1-like
Synonyms: 1810020M02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69089
HGNC: HGNC:8526
Homologene: 31281
Ercc4
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4
Synonyms: Xpf
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50505
HGNC: HGNC:3436
Homologene: 3836
Or2ag16
Name: olfactory receptor family 2 subfamily AG member 16
Synonyms: GA_x6K02T2PBJ9-9130754-9129519, MOR283-3, Olfr698
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258595
Homologene: 133598
Or7g18
Name: olfactory receptor family 7 subfamily G member 18
Synonyms: GA_x6K02T2PVTD-12618399-12619337, MOR152-1, Olfr830
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258559
HGNC: HGNC:8466
Homologene: 79360
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: A930009L15Rik, 4930544G21Rik, SKIP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77629
Homologene: 18172
Vmn2r8
Name: vomeronasal 2, receptor 8
Synonyms: EG627479
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627479
Homologene: 129606
Fhod3
Name: formin homology 2 domain containing 3
Synonyms: A930009H06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225288
VEGA: 18
Homologene: 45323
Or9g4b
Name: olfactory receptor family 9 subfamily G member 4B
Synonyms: GA_x6K02T2Q125-47264151-47265089, MOR213-3, Olfr1015
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258564
Homologene: 115499
Bmp8b
Name: bone morphogenetic protein 8b
Synonyms: Op3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12164
HGNC: HGNC:1075
Homologene: 130625
Poglut2
Name: protein O-glucosyltransferase 2
Synonyms: EP58, 1810049A15Rik, 5730416C13Rik, Kdel1, Kdelc1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72050
Homologene: 11367
Nudt7
Name: nudix hydrolase 7
Synonyms: 1300007B24Rik, 2210404C19Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67528
HGNC: HGNC:8054
Homologene: 41564
Adam4
Name: a disintegrin and metallopeptidase domain 4
Synonyms: tMDCV
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11498
Homologene: 86950
Tmem225
Name: transmembrane protein 225
Synonyms: 1700030E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75667
VEGA: 9
Homologene: 52854
Or4d2b
Name: olfactory receptor family 4 subfamily D member 2B
Synonyms: GA_x6K02T2PAEV-9536824-9535889, MOR240-3, Olfr462
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258406
HGNC: HGNC:8294
Homologene: 64870
Rabep2
Name: rabaptin, RAB GTPase binding effector protein 2
Synonyms: 2610011A08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70314
Homologene: 23489
Ciao1
Name: cytosolic iron-sulfur protein assembly 1
Synonyms: Wdr39
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26371
Homologene: 55850
Ndufaf4
Name: NADH:ubiquinone oxidoreductase complex assembly factor 4
Synonyms: 3000003G13Rik, 1110007M04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68493
Homologene: 40928
Hand2
Name: heart and neural crest derivatives expressed 2
Synonyms: dHAND, Thing2, Hed, Ehand2, bHLHa26
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15111
HGNC: HGNC:4808
Homologene: 32092
Gm9637
Name: predicted gene 9637
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102635833
VEGA: 14
Gm44444
Name: predicted gene, 44444
Type: Gene
Species: Mouse
Chromosome: 10
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,165,564 bp
  • G to A, chromosome 1 at 43,983,552 bp
  • A to T, chromosome 1 at 44,117,066 bp
  • G to A, chromosome 1 at 52,155,019 bp
  • A to G, chromosome 1 at 83,278,771 bp
  • G to T, chromosome 1 at 138,838,441 bp
  • A to G, chromosome 2 at 26,960,338 bp
  • A to C, chromosome 2 at 26,990,556 bp
  • G to T, chromosome 2 at 52,714,919 bp
  • G to T, chromosome 2 at 82,981,002 bp
  • A to G, chromosome 2 at 85,785,775 bp
  • T to A, chromosome 2 at 118,244,878 bp
  • A to G, chromosome 2 at 127,246,484 bp
  • G to A, chromosome 2 at 154,262,726 bp
  • A to G, chromosome 2 at 156,045,014 bp
  • G to A, chromosome 2 at 158,443,336 bp
  • A to T, chromosome 2 at 181,238,102 bp
  • A to T, chromosome 3 at 54,376,047 bp
  • A to G, chromosome 3 at 133,108,872 bp
  • A to G, chromosome 4 at 24,898,648 bp
  • T to G, chromosome 4 at 63,225,803 bp
  • T to C, chromosome 4 at 123,114,739 bp
  • T to C, chromosome 5 at 108,798,070 bp
  • T to A, chromosome 6 at 12,379,593 bp
  • C to T, chromosome 6 at 92,243,069 bp
  • T to A, chromosome 6 at 142,594,144 bp
  • T to A, chromosome 6 at 146,373,106 bp
  • T to A, chromosome 7 at 23,928,971 bp
  • A to G, chromosome 7 at 29,400,364 bp
  • G to A, chromosome 7 at 46,769,061 bp
  • GGCGGCGGC to GGCGGCGGCTGCGGCGGC, chromosome 7 at 97,579,915 bp
  • T to C, chromosome 7 at 106,753,167 bp
  • A to G, chromosome 7 at 126,440,408 bp
  • G to T, chromosome 7 at 126,979,560 bp
  • A to G, chromosome 7 at 130,729,573 bp
  • A to G, chromosome 8 at 57,321,959 bp
  • A to G, chromosome 8 at 95,297,780 bp
  • A to T, chromosome 8 at 114,136,340 bp
  • T to A, chromosome 8 at 128,487,953 bp
  • T to C, chromosome 9 at 18,875,830 bp
  • G to T, chromosome 9 at 40,150,659 bp
  • C to T, chromosome 9 at 80,254,947 bp
  • C to A, chromosome 9 at 100,929,893 bp
  • A to G, chromosome 10 at 17,841,457 bp
  • T to A, chromosome 10 at 116,510,389 bp
  • T to C, chromosome 10 at 129,410,106 bp
  • A to G, chromosome 11 at 49,823,958 bp
  • T to A, chromosome 11 at 59,022,240 bp
  • C to T, chromosome 11 at 69,739,953 bp
  • G to A, chromosome 11 at 87,889,617 bp
  • A to T, chromosome 12 at 81,419,883 bp
  • T to C, chromosome 12 at 90,999,645 bp
  • C to T, chromosome 13 at 49,446,342 bp
  • T to A, chromosome 13 at 60,730,896 bp
  • A to T, chromosome 14 at 19,402,598 bp
  • T to C, chromosome 14 at 54,367,817 bp
  • T to A, chromosome 14 at 55,241,180 bp
  • A to T, chromosome 15 at 76,636,822 bp
  • A to G, chromosome 16 at 10,201,398 bp
  • G to C, chromosome 16 at 13,130,137 bp
  • A to G, chromosome 16 at 36,709,521 bp
  • T to C, chromosome 17 at 36,813,263 bp
  • T to A, chromosome 18 at 25,113,616 bp
  • G to A, chromosome 18 at 80,973,754 bp
  • G to T, chromosome 18 at 82,956,333 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8245 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067673-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.