Strain Name:
C57BL/6J-MtgxR8248Btlr/Mmmh
Stock Number:
067675-MU
Citation ID:
RRID:MMRRC_067675-MU
Other Names:
R8248 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Itch
Name: itchy, E3 ubiquitin protein ligase
Synonyms: 6720481N21Rik, C230047C07Rik, 8030492O04Rik, AIP4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16396
Homologene: 88442
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: 6330503C17Rik, Zfp262
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67785
Homologene: 35470
Evi5
Name: ecotropic viral integration site 5
Synonyms: NB4S
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14020
HGNC: HGNC:3501
Homologene: 121902
Dcp1a
Name: decapping mRNA 1A
Synonyms: 1110066A22Rik, SMIF, 4930568L04Rik, D14Ertd817e, Mitc1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75901
VEGA: 14
Homologene: 10178
Sh3gl1
Name: SH3-domain GRB2-like 1
Synonyms: SH3P8, EEN, endophilin II, Sh3d2b, endophilin A2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20405
VEGA: 17
Homologene: 55709
Syn3
Name: synapsin III
Synonyms: Synapsin IIIa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27204
Homologene: 68320
Bloc1s6
Name: biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
Synonyms: BLOC-1 subunit, BLOC-1, Pldn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18457
HGNC: HGNC:8549
Homologene: 40841
Ahi1
Name: Abelson helper integration site 1
Synonyms: Ahi-1, 1700015F03Rik, D10Bwg0629e, Jouberin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Mfap1a
Name: microfibrillar-associated protein 1A
Synonyms: 4432409M24Rik, Mfap1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67532
HGNC: HGNC:7032
Homologene: 4332
Pfas
Name: phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
Synonyms: 4432409B16Rik, Sofa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237823
HGNC: HGNC:8863
Homologene: 5970
Gpr165
Name: G protein-coupled receptor 165
Synonyms: 6530406P05Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 76206
Homologene: 85287
Adam32
Name: a disintegrin and metallopeptidase domain 32
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 353188
Homologene: 17021
Itsn2
Name: intersectin 2
Synonyms: Sh3p18, Ese2, Eh domain, SH3 domain regulator of endocytosis 2, Sh3d1B
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Pmm1
Name: phosphomannomutase 1
Synonyms: Secp53 (yeast) homolog
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29858
HGNC: HGNC:9114
Homologene: 90898
Snx11
Name: sorting nexin 11
Synonyms: 4933439F10Rik, A930041K09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74479
Homologene: 12568
Dnajb2
Name: DnaJ heat shock protein family (Hsp40) member B2
Synonyms: mDj8, 2700059H22Rik, Dnajb10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56812
HGNC: HGNC:5228
Homologene: 4902
Lrrc8c
Name: leucine rich repeat containing 8 family, member C
Synonyms: E430036I04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100604
Homologene: 12997
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Pram1
Name: PML-RAR alpha-regulated adaptor molecule 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 378460
Homologene: 12963
Tnr
Name: tenascin R
Synonyms: janusin, restrictin, TN-R, J1-tenascin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21960
Homologene: 124416
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
Synonyms: Arhgap14, D130026O08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259302
Homologene: 56686
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Il1a
Name: interleukin 1 alpha
Synonyms: Il-1a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16175
HGNC: HGNC:5991
Homologene: 480
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78309
Homologene: 56696
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Golga7b
Name: golgin A7B
Synonyms: 4933417O08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71146
Homologene: 28514
Gm7298
Name: predicted gene 7298
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 640530
HGNC: HGNC:9750
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: MSF, DOL54, lubricin, SZP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: 4930572H05Rik, Arhgap13
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117600
Homologene: 56898
Kdm1b
Name: lysine (K)-specific demethylase 1B
Synonyms: 4632428N09Rik, Aof1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218214
Homologene: 14695
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Dpy19l1
Name: dpy-19 like C-mannosyltransferase 1
Synonyms: 1100001I19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244745
Homologene: 14762
Slc22a30
Name: solute carrier family 22, member 30
Synonyms: C730048C13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319800
Homologene: 77136
Prpf40b
Name: pre-mRNA processing factor 40B
Synonyms: 2610317D23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54614
Homologene: 81828
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: FetA, 4930417M19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320571
Homologene: 99882
H2-Q2
Name: histocompatibility 2, Q region locus 2
Synonyms: H-2Q2, Gm11132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15013
Homologene: 128352
Lats1
Name: large tumor suppressor
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16798
VEGA: 10
HGNC: HGNC:6514
Homologene: 55843
Agbl2
Name: ATP/GTP binding protein-like 2
Synonyms: A430081C19Rik, Ccp2, Ccp2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271813
Homologene: 11715
Stac
Name: src homology three (SH3) and cysteine rich domain
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20840
Homologene: 2371
Krtap12-21
Name: keratin associated protein 12-21
Synonyms: Gm10142
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100502921
VEGA: 10
Homologene: 135713
Rgs6
Name: regulator of G-protein signaling 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 50779
Homologene: 68385
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG668547, Vmn2r119, EG383258
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 383258
Homologene: 129687
Elmo1
Name: engulfment and cell motility 1
Synonyms: CED-12, C230095H21Rik, 6330578D22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 140580
Homologene: 56685
Galnt7
Name: polypeptide N-acetylgalactosaminyltransferase 7
Synonyms: ppGaNTase-T7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108150
HGNC: HGNC:4129
Homologene: 9685
Nudt7
Name: nudix hydrolase 7
Synonyms: 1300007B24Rik, 2210404C19Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67528
HGNC: HGNC:8054
Homologene: 41564
Rftn1
Name: raftlin lipid raft linker 1
Synonyms: 2310015N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76438
Homologene: 18745
Qars1
Name: glutaminyl-tRNA synthetase 1
Synonyms: 1110018N24Rik, 1200016L19Rik, Qars
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 97541
HGNC: HGNC:9751
Homologene: 133975
Rps6kb2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: S6K2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58988
Homologene: 68374
A930003A15Rik
Name: RIKEN cDNA A930003A15 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68162
VEGA: 16
Rom1
Name: rod outer segment membrane protein 1
Synonyms: Rom-1, Tspan23, M101156, Rgsc1156
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19881
VEGA: 19
Homologene: 276
Clk2
Name: CDC-like kinase 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12748
HGNC: HGNC:2069
Homologene: 33303
Fam76b
Name: family with sequence similarity 76, member B
Synonyms: 2810485I05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72826
Homologene: 25107
Gpr25
Name: G protein-coupled receptor 25
Synonyms: LOC383563
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383563
HGNC: HGNC:4480
Homologene: 3872
Myl10
Name: myosin, light chain 10, regulatory
Synonyms: PLRLC-C, PLRLC-B, PLRLC-A, PLRLC, 1700027I08Rik, Mylc2pl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59310
Homologene: 69341
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 75,243,582 bp
  • C to A, chromosome 1 at 136,260,677 bp
  • T to C, chromosome 1 at 150,455,126 bp
  • T to C, chromosome 1 at 159,892,093 bp
  • G to A, chromosome 2 at 90,797,564 bp
  • G to T, chromosome 2 at 121,506,495 bp
  • A to T, chromosome 2 at 122,742,645 bp
  • T to C, chromosome 2 at 129,302,961 bp
  • T to C, chromosome 2 at 155,206,383 bp
  • G to A, chromosome 3 at 89,173,504 bp
  • T to A, chromosome 3 at 126,937,785 bp
  • T to A, chromosome 4 at 43,366,072 bp
  • C to A, chromosome 4 at 126,905,369 bp
  • A to T, chromosome 5 at 105,607,867 bp
  • A to G, chromosome 5 at 107,818,887 bp
  • G to C, chromosome 5 at 136,697,971 bp
  • T to C, chromosome 6 at 112,723,143 bp
  • A to C, chromosome 6 at 121,787,443 bp
  • A to T, chromosome 7 at 29,069,121 bp
  • G to T, chromosome 7 at 104,769,794 bp
  • A to G, chromosome 8 at 24,901,470 bp
  • T to A, chromosome 8 at 57,538,188 bp
  • A to G, chromosome 8 at 114,151,997 bp
  • T to C, chromosome 9 at 13,831,102 bp
  • T to C, chromosome 9 at 24,502,895 bp
  • G to A, chromosome 9 at 108,509,452 bp
  • T to A, chromosome 9 at 111,593,745 bp
  • T to A, chromosome 10 at 7,705,903 bp
  • T to A, chromosome 10 at 20,972,092 bp
  • T to C, chromosome 10 at 39,061,379 bp
  • T to A, chromosome 10 at 77,716,116 bp
  • T to A, chromosome 10 at 86,135,021 bp
  • A to G, chromosome 10 at 121,804,817 bp
  • T to C, chromosome 11 at 69,000,263 bp
  • A to G, chromosome 11 at 96,769,933 bp
  • T to C, chromosome 12 at 4,662,052 bp
  • A to G, chromosome 12 at 83,137,704 bp
  • T to C, chromosome 13 at 20,600,201 bp
  • T to A, chromosome 13 at 47,071,878 bp
  • T to C, chromosome 13 at 102,738,721 bp
  • C to T, chromosome 14 at 30,479,598 bp
  • A to G, chromosome 14 at 30,522,926 bp
  • C to T, chromosome 15 at 4,931,104 bp
  • T to G, chromosome 15 at 44,543,546 bp
  • A to C, chromosome 15 at 81,960,731 bp
  • A to G, chromosome 15 at 99,316,285 bp
  • T to C, chromosome 16 at 19,883,806 bp
  • T to C, chromosome 17 at 33,641,164 bp
  • A to G, chromosome 17 at 35,344,865 bp
  • A to C, chromosome 17 at 46,530,014 bp
  • G to T, chromosome 17 at 50,047,380 bp
  • T to C, chromosome 17 at 55,610,936 bp
  • A to G, chromosome 17 at 56,019,038 bp
  • T to A, chromosome 19 at 4,156,988 bp
  • A to T, chromosome 19 at 8,370,199 bp
  • T to A, chromosome 19 at 8,928,681 bp
  • T to A, chromosome 19 at 9,001,946 bp
  • A to T, chromosome 19 at 42,266,871 bp
  • C to A, chromosome X at 96,714,017 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8248 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067675-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.