Strain Name:
C57BL/6J-MtgxR8251Btlr/Mmmh
Stock Number:
067677-MU
Citation ID:
RRID:MMRRC_067677-MU
Other Names:
R8251 (G1)
Major Collection:

Strain Information

St3gal5
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Synonyms: ST3Gal V, mST3Gal V, GM3-specific sialytransferase, GM3 synthase, [a]2, 3S-T, Siat9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20454
Homologene: 2893
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Gnaq
Name: guanine nucleotide binding protein, alpha q polypeptide
Synonyms: G alpha q, Gq, Galphaq, 6230401I02Rik, 1110005L02Rik, Dsk10, Dsk1, GqI
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14682
HGNC: HGNC:4390
Homologene: 1566
Kansl1
Name: KAT8 regulatory NSL complex subunit 1
Synonyms: 1700081L11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76719
Homologene: 9140
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: 5530401C11Rik, ARHGAP10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71435
Homologene: 10822
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: ANCO-2, GAC-1, 2900001A12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106585
Homologene: 9059
Taf3
Name: TATA-box binding protein associated factor 3
Synonyms: mTAFII140, 4933439M23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209361
Homologene: 35415
Snupn
Name: snurportin 1
Synonyms: 0610031A09Rik, Rnut1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66069
Homologene: 4166
Slu7
Name: SLU7 splicing factor homolog (S. cerevisiae)
Synonyms: D3Bwg0878e, D11Ertd730e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193116
Homologene: 4690
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: RPA2, RPA116, 128kDa, D630020H17Rik, Rpo1-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20017
Homologene: 7133
Dsg4
Name: desmoglein 4
Synonyms: lah, CDHF13
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16769
Homologene: 65341
Kcnj9
Name: potassium inwardly-rectifying channel, subfamily J, member 9
Synonyms: Kir3.3, Girk3, 1700085N21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16524
HGNC: HGNC:6270
Homologene: 37989
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 386750
Homologene: 8955
Cenpe
Name: centromere protein E
Synonyms: N-7 kinesin, CENP-E, 312kDa, Kif10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: polycystin-2, C030034P18Rik, TRPP2, PC2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Srpk2
Name: serine/arginine-rich protein specific kinase 2
Synonyms: mSRPK2, WBP6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20817
Homologene: 101663
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Swiss-cheese, MSws, Nte
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50767
Homologene: 21333
Ints7
Name: integrator complex subunit 7
Synonyms: 5930412E23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77065
Homologene: 9136
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, A230079K17Rik, Gm980, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Wdr17
Name: WD repeat domain 17
Synonyms: 3010002I12Rik, B230207L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244484
Homologene: 12460
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, fmd, mdg, sj, muscle dysgenesis, Cav1.1, DHPR alpha1s
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Lrguk
Name: leucine-rich repeats and guanylate kinase domain containing
Synonyms: 4921528H16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74354
Homologene: 34923
Vmn2r70
Name: vomeronasal 2, receptor 70
Synonyms: EG620835
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 670940
Homologene: 115466
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: PG10.2, IPM200, Spacrcan
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224224
Homologene: 9439
Fshr
Name: follicle stimulating hormone receptor
Synonyms: follicle-stimulating hormone receptor, Follitropin receptor, FSH-R
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14309
VEGA: 17
HGNC: HGNC:3969
Homologene: 117
Corin
Name: corin, serine peptidase
Synonyms: Lrp4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53419
Homologene: 4804
Or1j15
Name: olfactory receptor family 1 subfamily J member 15
Synonyms: GA_x6K02T2NLDC-33262744-33263673, MOR136-12, Olfr344
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258621
Acad11
Name: acyl-Coenzyme A dehydrogenase family, member 11
Synonyms: 5730439E10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102632
Homologene: 49896
Adamtsl4
Name: ADAMTS-like 4
Synonyms: Tsrc1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229595
Homologene: 23141
Mroh5
Name: maestro heat-like repeat family member 5
Synonyms: LOC268816, Gm628
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268816
Cep85l
Name: centrosomal protein 85-like
Synonyms: Gm9766
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100038725
VEGA: 10
Homologene: 52598
Krt16
Name: keratin 16
Synonyms: K16, Krt1-16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16666
HGNC: HGNC:6423
Homologene: 21145
Vps36
Name: vacuolar protein sorting 36
Synonyms: 2810408E15Rik, 1700010A24Rik, Eap45, 2210415M20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70160
Homologene: 9374
Ear2
Name: eosinophil-associated, ribonuclease A family, member 2
Synonyms: eosinophil-derived neurotoxin, liver, Rnase2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13587
Homologene: 40596
Or5p50
Name: olfactory receptor family 5 subfamily P member 50
Synonyms: GA_x6K02T2PBJ9-10152980-10152036, MOR204-21, Olfr469
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258418
Homologene: 44979
Nt5dc3
Name: 5'-nucleotidase domain containing 3
Synonyms: Gnn, C630002B14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103466
VEGA: 10
Homologene: 9571
Ifit1bl1
Name: interferon induced protein with tetratricpeptide repeats 1B like 1
Synonyms: Gm14446
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667373
Homologene: 78213
Gata6
Name: GATA binding protein 6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14465
VEGA: 18
HGNC: HGNC:4174
Homologene: 68449
Trbv21
Name: T cell receptor beta, variable 21
Synonyms: Gm16778, Tcrb-V19
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124686
Nabp1
Name: nucleic acid binding protein 1
Synonyms: 4930434H03Rik, 4930442A21Rik, 4930488J04Rik, 4933440J18Rik, Nbp1, 5830411E10Rik, Obfc2a, Ssb2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109019
Homologene: 57094
Or4a81
Name: olfactory receptor family 4 subfamily A member 81
Synonyms: GA_x6K02T2Q125-51230155-51229211, MOR231-13, Olfr1254
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258468
Homologene: 103784
Tmem126a
Name: transmembrane protein 126A
Synonyms: 1810020E01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66271
Homologene: 11939
Rbpjl
Name: recombination signal binding protein for immunoglobulin kappa J region-like
Synonyms: RBP-J kappa-like, RBP-L, Rbpsuhl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19668
Homologene: 7512
Runx1t1
Name: RUNX1 translocation partner 1
Synonyms: ETO, MTG8, Cbfa2t1h
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12395
HGNC: HGNC:1535
Homologene: 3801
Ctsr
Name: cathepsin R
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56835
VEGA: 13
Homologene: 75127
Zfp397
Name: zinc finger protein 397
Synonyms: 2810411K16Rik, 6720480F11Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69256
VEGA: 18
Homologene: 117445
1700019O17Rik
Name:
Type: Gene
Species: Mouse
Chromosome: 1
Fam132a
Name:
Type: Gene
Species: Mouse
Chromosome: 4
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 51,477,578 bp
  • A to G, chromosome 1 at 86,427,214 bp
  • G to T, chromosome 1 at 136,086,723 bp
  • A to G, chromosome 1 at 172,326,522 bp
  • A to C, chromosome 1 at 181,664,865 bp
  • C to T, chromosome 1 at 191,621,433 bp
  • T to C, chromosome 2 at 9,918,151 bp
  • T to C, chromosome 2 at 20,849,410 bp
  • A to C, chromosome 2 at 36,569,455 bp
  • A to T, chromosome 2 at 89,789,223 bp
  • C to A, chromosome 2 at 129,123,166 bp
  • A to G, chromosome 2 at 164,413,934 bp
  • C to T, chromosome 3 at 73,049,396 bp
  • C to T, chromosome 3 at 95,684,574 bp
  • T to A, chromosome 3 at 135,251,684 bp
  • A to G, chromosome 4 at 13,846,947 bp
  • T to C, chromosome 4 at 155,966,459 bp
  • G to A, chromosome 5 at 23,524,268 bp
  • T to A, chromosome 5 at 72,356,926 bp
  • T to C, chromosome 5 at 104,498,487 bp
  • A to T, chromosome 6 at 34,116,439 bp
  • A to G, chromosome 6 at 41,202,606 bp
  • T to A, chromosome 6 at 72,149,160 bp
  • A to T, chromosome 7 at 85,565,978 bp
  • T to C, chromosome 7 at 90,450,886 bp
  • A to G, chromosome 7 at 107,822,569 bp
  • T to A, chromosome 8 at 3,532,399 bp
  • A to G, chromosome 8 at 22,192,916 bp
  • C to A, chromosome 8 at 54,657,232 bp
  • G to A, chromosome 8 at 85,095,129 bp
  • T to A, chromosome 9 at 56,980,853 bp
  • A to T, chromosome 9 at 104,091,707 bp
  • A to T, chromosome 10 at 53,281,354 bp
  • T to C, chromosome 10 at 67,239,289 bp
  • C to A, chromosome 10 at 86,820,227 bp
  • A to G, chromosome 11 at 43,439,301 bp
  • A to G, chromosome 11 at 100,248,370 bp
  • A to G, chromosome 11 at 104,424,360 bp
  • A to G, chromosome 13 at 61,162,778 bp
  • T to C, chromosome 14 at 44,103,020 bp
  • T to C, chromosome 15 at 73,783,153 bp
  • A to G, chromosome 16 at 56,259,597 bp
  • A to T, chromosome 17 at 65,984,559 bp
  • T to G, chromosome 17 at 89,200,485 bp
  • G to A, chromosome 18 at 11,054,670 bp
  • C to A, chromosome 18 at 20,471,164 bp
  • T to C, chromosome 18 at 23,960,304 bp
  • T to A, chromosome 19 at 16,335,055 bp
  • T to C, chromosome 19 at 21,807,401 bp
  • T to C, chromosome 19 at 34,594,832 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8251 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067677-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.