Strain Name:
C57BL/6J-MtgxR8269Btlr/Mmmh
Stock Number:
067693-MU
Citation ID:
RRID:MMRRC_067693-MU
Other Names:
R8269 (G1)
Major Collection:

Strain Information

Arhgap39
Name: Rho GTPase activating protein 39
Synonyms: D15Wsu169e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223666
Homologene: 27825
Mgll
Name: monoglyceride lipase
Synonyms: Magl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23945
Homologene: 38298
Ago3
Name: argonaute RISC catalytic subunit 3
Synonyms: C130014L07Rik, eIF2C3, argonaute 3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214150
Homologene: 49799
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Dmtf1
Name: cyclin D binding myb like transcription factor 1
Synonyms: Dmp1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23857
Homologene: 8017
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: BUB2-like protein 1, HBLP1, AD3, GRAM domain
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54610
Homologene: 31421
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Epha8
Name: Eph receptor A8
Synonyms: Eek, EphA8, Hek3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: 2810429C13Rik, 1110031N14Rik, D430026L04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235559
Homologene: 38262
Exosc4
Name: exosome component 4
Synonyms: 1110039I09Rik, 1500001N04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109075
Homologene: 6017
Lipc
Name: lipase, hepatic
Synonyms: Hpl, HL
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15450
VEGA: 9
HGNC: HGNC:6619
Homologene: 199
Arfgap3
Name: ADP-ribosylation factor GTPase activating protein 3
Synonyms: 1810035F16Rik, 0610009H19Rik, 1810004P07Rik, 9130416J18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66251
VEGA: 15
HGNC: HGNC:661
Homologene: 134103
Emc10
Name: ER membrane protein complex subunit 10
Synonyms: 2310044H10Rik, 5430410O10Rik, Mirta22
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69683
Homologene: 18036
Adgra3
Name: adhesion G protein-coupled receptor A3
Synonyms: Gpr125, Tem5-like, 3830613O22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70693
Homologene: 19235
Zcrb1
Name: zinc finger CCHC-type and RNA binding motif 1
Synonyms: 2700088M22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67197
Homologene: 12095
Cyb5r1
Name: cytochrome b5 reductase 1
Synonyms: 1500005G05Rik, Nqo3a2, B5R.1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72017
Homologene: 96059
Gin1
Name: gypsy retrotransposon integrase 1
Synonyms: 4930429M06, 4930429M06Rik, Zh2c2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 252876
Homologene: 69238
Akap11
Name: A kinase anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Amigo2
Name: adhesion molecule with Ig like domain 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105827
VEGA: 15
Homologene: 18649
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, Itpr-3, tf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Pld1
Name: phospholipase D1
Synonyms: Pld1b, Pld1a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, Fath2, mKIAA0811, LOC245827
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Pcdhb10
Name: protocadherin beta 10
Synonyms: PcdhbJ, Pcdhb5D
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93881
HGNC: HGNC:8690
Homologene: 88834
Slc3a1
Name: solute carrier family 3, member 1
Synonyms: D2H, NTAA
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20532
VEGA: 17
Homologene: 37289
Mapk4
Name: mitogen-activated protein kinase 4
Synonyms: Erk3-related, p63Mapk, A330097D03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225724
HGNC: HGNC:6878
Homologene: 2058
Atp1a4
Name: ATPase, Na+/K+ transporting, alpha 4 polypeptide
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27222
Homologene: 113769
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235505
Homologene: 25183
Pls1
Name: plastin 1 (I-isoform)
Synonyms: I-fimbrin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102502
HGNC: HGNC:9090
Homologene: 68270
Slc28a2b
Name: solute carrier family 28 member 2b
Synonyms: Gm14085
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381417
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Or4p18
Name: olfactory receptor family 4 subfamily P member 18
Synonyms: GA_x6K02T2Q125-49890854-49889931, Olfr1179, MOR225-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258919
Homologene: 74070
Vmn2r55
Name: vomeronasal 2, receptor 55
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042499
Homologene: 104040
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209683
Homologene: 41023
Zfp781a
Name: zinc finger protein 781A
Synonyms: D130040H23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211135
Homologene: 138403
Ncan
Name: neurocan
Synonyms: Cspg3-rs, Tgfbit, Cspg3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13004
HGNC: HGNC:2465
Homologene: 3229
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328643
Homologene: 28056
Mrrf
Name: mitochondrial ribosome recycling factor
Synonyms: 2400002D02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67871
HGNC: HGNC:7234
Homologene: 12203
Nox4
Name: NADPH oxidase 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50490
HGNC: HGNC:7891
Homologene: 41065
Gm57858
Name: gene model 57858
Synonyms: Ccdc144b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241943
Homologene: 87263
Acox2
Name: acyl-Coenzyme A oxidase 2, branched chain
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93732
HGNC: HGNC:120
Homologene: 74473
Gnal
Name: guanine nucleotide binding protein, alpha stimulating, olfactory type
Synonyms: Gna10, Golf, G alpha 10, Galphaolf, 9630020G10Rik, 2610011C15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14680
VEGA: 18
HGNC: HGNC:4388
Homologene: 68222
Tmem161a
Name: transmembrane protein 161A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234371
Homologene: 9853
Plscr1
Name: phospholipid scramblase 1
Synonyms: Tras2, MuPLSCR2, Tras1, TRA1, NOR1, MmTRA1a, MmTRA1b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22038
HGNC: HGNC:9092
Homologene: 41418
Ccpg1
Name: cell cycle progression 1
Synonyms: 9430028F23Rik, 1700030B06Rik, 1810073J13Rik, D9Ertd392e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72278
Homologene: 3487
Bckdhb
Name: branched chain ketoacid dehydrogenase E1, beta polypeptide
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12040
HGNC: HGNC:987
Homologene: 39
Zfp128
Name: zinc finger protein 128
Synonyms: mZnf8, 9630016P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243833
Homologene: 10889
Lsm14b
Name: LSM family member 14B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241846
Homologene: 100207
Or5p67
Name: olfactory receptor family 5 subfamily P member 67
Synonyms: GA_x6K02T2PBJ9-10653693-10652749, Olfr492, MOR204-18
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258490
Homologene: 133673
Suv39h1
Name: suppressor of variegation 3-9 1
Synonyms: DXHXS7466e, KMT1A, mIS6, Suv39h histone methyltransferase
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 20937
Homologene: 2388
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 39,426,088 bp
  • T to A, chromosome 1 at 97,783,204 bp
  • T to A, chromosome 1 at 134,407,065 bp
  • T to C, chromosome 1 at 172,232,325 bp
  • T to A, chromosome 2 at 36,147,961 bp
  • A to T, chromosome 2 at 88,402,037 bp
  • C to T, chromosome 2 at 122,521,688 bp
  • T to C, chromosome 2 at 180,032,614 bp
  • A to G, chromosome 3 at 28,025,239 bp
  • A to T, chromosome 3 at 36,046,713 bp
  • A to T, chromosome 3 at 93,201,880 bp
  • T to A, chromosome 4 at 126,376,928 bp
  • G to T, chromosome 4 at 136,938,586 bp
  • A to T, chromosome 5 at 9,132,500 bp
  • A to T, chromosome 5 at 49,963,737 bp
  • G to A, chromosome 5 at 111,277,459 bp
  • A to G, chromosome 6 at 73,168,827 bp
  • T to A, chromosome 6 at 88,813,948 bp
  • T to A, chromosome 7 at 12,670,658 bp
  • G to A, chromosome 7 at 12,890,736 bp
  • G to T, chromosome 7 at 44,491,984 bp
  • T to G, chromosome 7 at 87,306,722 bp
  • A to T, chromosome 7 at 108,323,569 bp
  • T to A, chromosome 8 at 69,303,148 bp
  • T to A, chromosome 8 at 70,107,680 bp
  • T to A, chromosome 8 at 70,181,958 bp
  • A to G, chromosome 8 at 86,029,582 bp
  • A to G, chromosome 8 at 95,751,761 bp
  • A to G, chromosome 9 at 70,820,373 bp
  • G to A, chromosome 9 at 73,005,719 bp
  • A to G, chromosome 9 at 78,665,682 bp
  • T to C, chromosome 9 at 84,122,364 bp
  • A to G, chromosome 9 at 92,263,042 bp
  • G to T, chromosome 9 at 95,761,970 bp
  • C to A, chromosome 9 at 103,328,593 bp
  • T to C, chromosome 11 at 55,282,709 bp
  • A to G, chromosome 11 at 103,497,898 bp
  • T to C, chromosome 14 at 8,246,325 bp
  • G to A, chromosome 14 at 78,513,378 bp
  • A to T, chromosome 15 at 76,327,532 bp
  • G to T, chromosome 15 at 76,751,742 bp
  • A to C, chromosome 15 at 83,310,341 bp
  • A to G, chromosome 15 at 93,397,175 bp
  • G to T, chromosome 15 at 97,246,231 bp
  • A to G, chromosome 16 at 20,604,438 bp
  • G to T, chromosome 17 at 27,093,284 bp
  • A to G, chromosome 17 at 85,032,554 bp
  • A to G, chromosome 18 at 37,414,009 bp
  • A to G, chromosome 18 at 67,135,622 bp
  • G to C, chromosome 18 at 73,930,551 bp
  • G to T, chromosome X at 8,071,031 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8269 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067693-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.