Strain Name:
C57BL/6J-MtgxR8283Btlr/Mmmh
Stock Number:
067706-MU
Citation ID:
RRID:MMRRC_067706-MU
Other Names:
R8283 (G1)
Major Collection:

Strain Information

Aven
Name: apoptosis, caspase activation inhibitor
Synonyms: mAven-L, mAven-S, 1700013A01Rik, 1700056A21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74268
Homologene: 10683
Ubn2
Name: ubinuclein 2
Synonyms: D130059P03Rik, 2900060J04Rik, 6030408G03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320538
Homologene: 45564
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20321
Homologene: 40653
Phf14
Name: PHD finger protein 14
Synonyms: 1110001C23Rik, 5730446A07Rik, 4932409F11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75725
Homologene: 8775
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alphaII-spectrin, 2610027H02Rik, Spna-2, Spna2, alpha-fodrin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20740
Homologene: 2353
Srgap2
Name: SLIT-ROBO Rho GTPase activating protein 2
Synonyms: 9930124L22Rik, FBP2, Fnbp2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14270
Homologene: 52683
Suclg2
Name: succinate-Coenzyme A ligase, GDP-forming, beta subunit
Synonyms: D6Wsu120e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20917
Homologene: 2854
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Drosha
Name: drosha, ribonuclease type III
Synonyms: Etohi2, Rnasen, 1110013A17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14000
Homologene: 8293
Esrrb
Name: estrogen related receptor, beta
Synonyms: ERR2, Err2, ERRb, Estrrb
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26380
HGNC: HGNC:3473
Homologene: 69108
Fnbp4
Name: formin binding protein 4
Synonyms: FBP30
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 55935
Homologene: 9087
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: Sh3d5, Ponsin, c-Cbl-associated protein, CAP, 9530001P15Rik, 2310065E01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Xpo6
Name: exportin 6
Synonyms: 2610005L19Rik, Ranbp20, C230091E20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74204
Homologene: 12544
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: 6720464I07Rik, Solo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Ntm
Name: neurotrimin
Synonyms: 6230410L23Rik, Hnt, B230210G24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235106
Homologene: 41139
Iars2
Name: isoleucine-tRNA synthetase 2, mitochondrial
Synonyms: 2010002H18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381314
Homologene: 7118
Cdhr1
Name: cadherin-related family member 1
Synonyms: Prcad, Pcdh21
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 170677
VEGA: 14
Homologene: 13215
Hnrnpl
Name: heterogeneous nuclear ribonucleoprotein L
Synonyms: Hnrpl, D830027H13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15388
HGNC: HGNC:5045
Homologene: 1174
Boc
Name: BOC cell adhesion associated, oncogene regulated
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 117606
Homologene: 32819
Nup88
Name: nucleoporin 88
Synonyms: Prei2, Nup84
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19069
HGNC: HGNC:8067
Homologene: 1901
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: Sorla, LR11, mSorLA, 2900010L19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20660
Homologene: 2336
Thyn1
Name: thymocyte nuclear protein 1
Synonyms: D730042P09Rik, Thy28
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77862
VEGA: 9
Homologene: 8575
Arl6ip6
Name: ADP-ribosylation factor-like 6 interacting protein 6
Synonyms: 2310057C01Rik, Aip-6, 2610529A11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65103
Homologene: 11302
Pnpla7
Name: patatin-like phospholipase domain containing 7
Synonyms: NRE, E430013P11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241274
Homologene: 62431
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Wif1
Name: Wnt inhibitory factor 1
Synonyms: WIF-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 24117
Homologene: 31430
Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Synonyms: Pca, Pca-1, E-NPP1, CD203c, NPP1, twy, 4833416E15Rik, PC-1, Ly-41, Npps, Pdnp1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18605
HGNC: HGNC:3356
Homologene: 38151
Prkcb
Name: protein kinase C, beta
Synonyms: Prkcb2, PKC-Beta, A130082F03Rik, Prkcb1, Pkcb
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18751
HGNC: HGNC:9395
Homologene: 56424
Pcyt2
Name: phosphate cytidylyltransferase 2, ethanolamine
Synonyms: 1110033E03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68671
HGNC: HGNC:8756
Homologene: 2143
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: EGFL2, mfmi1, Adgrc2, flamingo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Adcy3
Name: adenylate cyclase 3
Synonyms: AC3, ACIII
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104111
HGNC: HGNC:234
Homologene: 2978
Or8b54
Name: olfactory receptor family 8 subfamily B member 54
Synonyms: MOR165-8, Olfr921, GA_x6K02T2PVTD-32478047-32478988
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258778
VEGA: 9
Homologene: 128138
Pgm2l1
Name: phosphoglucomutase 2-like 1
Synonyms: BM32A, 4931406N15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70974
Homologene: 12374
Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
Synonyms: mdr, Mdr1b, Mdr1, Pgy-1, Abcb1, Pgy1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18669
HGNC: HGNC:40
Homologene: 69084
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: Birc1a, D13Lsd1, Naip
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Sema3a
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: semaphorin III, Semad, collapsin-1, SemD, sema III
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20346
Homologene: 31358
Morc2b
Name: microrchidia 2B
Synonyms: 4932411A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240069
Homologene: 18615
Dsg1b
Name: desmoglein 1 beta
Synonyms: Dsg5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225256
HGNC: HGNC:3048
Homologene: 1463
Cts6
Name: cathepsin 6
Synonyms: 1600022N02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 58518
Homologene: 75165
Axl
Name: AXL receptor tyrosine kinase
Synonyms: Ufo, Ark, Tyro7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26362
HGNC: HGNC:905
Homologene: 7583
Snx19
Name: sorting nexin 19
Synonyms: 3526401K03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102607
VEGA: 9
Homologene: 8846
Ccndbp1
Name: cyclin D-type binding-protein 1
Synonyms: stage specific embryonic cDNA-8, Maid, DIP1, GCIP, SSEC-8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17151
HGNC: HGNC:1587
Homologene: 7826
Tex14
Name: testis expressed gene 14 intercellular bridge forming factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83560
Homologene: 12838
Ccr9
Name: C-C motif chemokine receptor 9
Synonyms: GPR-9-6, Cmkbr10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12769
HGNC: HGNC:1610
Homologene: 22546
Mcmdc2
Name: minichromosome maintenance domain containing 2
Synonyms: 6030422M02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240697
Homologene: 18309
Fbxl12
Name: F-box and leucine-rich repeat protein 12
Synonyms: 3110048D16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30843
Homologene: 32198
Setd7
Name: SET domain containing (lysine methyltransferase) 7
Synonyms: Set7/9, 1600028F23Rik, Set7, KMT7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73251
Homologene: 12741
Vmn2r101
Name: vomeronasal 2, receptor 101
Synonyms: EG627576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627576
Homologene: 115024
Foxj1
Name: forkhead box J1
Synonyms: HFH-4, Hfh4, FKHL-13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15223
HGNC: HGNC:3816
Homologene: 1117
Or10ag52
Name: olfactory receptor family 10 subfamily AG member 52
Synonyms: MOR264-25, GA_x6K02T2Q125-48697747-48698727, Olfr1113
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404327
Homologene: 27114
Mrgpra2b
Name: MAS-related GPR, member A2B
Synonyms: Mrgpra2, MrgA2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 235712
Homologene: 79615
Men1
Name: multiple endocrine neoplasia 1
Synonyms: menin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17283
HGNC: HGNC:7010
Homologene: 7418
Oscp1
Name: organic solute carrier partner 1
Synonyms: 1810007P19Rik, 6030436A01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230751
Homologene: 71010
Ccdc183
Name: coiled-coil domain containing 183
Synonyms: 4921530D09Rik, Cccd183
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77058
Homologene: 50023
Tbc1d12
Name: TBC1D12: TBC1 domain family, member 12
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 209478
VEGA: 19
Homologene: 50835
Calml3
Name: calmodulin-like 3
Synonyms: 2310068O22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70405
VEGA: 13
HGNC: HGNC:1452
Homologene: 133078
Gm10110
Name: predicted gene 10110
Type: Gene
Species: Mouse
Chromosome: 14
Sgms1
Name: sphingomyelin synthase 1
Synonyms: 9530058O11Rik, SMS1gamma, SMS1alpha2, SMS1, SMS1beta, Tmem23, SMS1alpha1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 208449
Homologene: 27040
Or51l4
Name: olfactory receptor family 51 subfamily L member 4
Synonyms: MOR17-1, GA_x6K02T2PBJ9-6483085-6482126, Olfr630
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259102
Homologene: 133674
Dcpp2
Name: demilune cell and parotid protein 2
Synonyms: EG630537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 630537
VEGA: 17
Homologene: 103921
Rnf187
Name: ring finger protein 187
Synonyms: 2410016F01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108660
Homologene: 23360
Pcdhgc3
Name: protocadherin gamma subfamily C, 3
Synonyms: Pcdh2, PC43
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93706
HGNC: HGNC:8716
Homologene: 31099
Arl14
Name: ADP-ribosylation factor-like 14
Synonyms: 9130014L17Rik, Arf7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71619
Homologene: 11812
RP24-77E13.10
Name:
Type: Gene
Species: Mouse
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 9,934,038 bp
  • T to C, chromosome 1 at 131,364,033 bp
  • T to A, chromosome 1 at 185,288,091 bp
  • A to G, chromosome 2 at 25,050,923 bp
  • G to A, chromosome 2 at 25,612,148 bp
  • C to T, chromosome 2 at 29,980,200 bp
  • A to G, chromosome 2 at 53,192,238 bp
  • T to C, chromosome 2 at 87,213,339 bp
  • C to A, chromosome 2 at 90,746,771 bp
  • C to T, chromosome 2 at 112,559,775 bp
  • A to G, chromosome 2 at 121,008,584 bp
  • T to G, chromosome 3 at 51,521,375 bp
  • A to T, chromosome 3 at 69,222,535 bp
  • C to T, chromosome 3 at 108,396,455 bp
  • A to G, chromosome 3 at 116,878,303 bp
  • A to G, chromosome 4 at 126,086,600 bp
  • C to T, chromosome 5 at 8,806,086 bp
  • T to C, chromosome 5 at 13,400,063 bp
  • T to G, chromosome 6 at 11,987,637 bp
  • T to A, chromosome 6 at 38,498,728 bp
  • T to A, chromosome 6 at 95,497,719 bp
  • T to C, chromosome 7 at 7,241,902 bp
  • C to T, chromosome 7 at 25,763,954 bp
  • T to C, chromosome 7 at 28,814,272 bp
  • A to G, chromosome 7 at 47,464,717 bp
  • C to G, chromosome 7 at 100,253,253 bp
  • T to A, chromosome 7 at 103,754,812 bp
  • T to C, chromosome 7 at 104,840,806 bp
  • T to A, chromosome 7 at 122,600,725 bp
  • T to G, chromosome 7 at 126,128,249 bp
  • T to C, chromosome 7 at 130,625,304 bp
  • T to C, chromosome 9 at 20,638,721 bp
  • C to T, chromosome 9 at 27,006,859 bp
  • T to C, chromosome 9 at 29,012,212 bp
  • T to C, chromosome 9 at 30,463,226 bp
  • G to A, chromosome 9 at 38,775,281 bp
  • T to C, chromosome 9 at 42,030,998 bp
  • A to G, chromosome 9 at 123,779,631 bp
  • T to A, chromosome 10 at 24,674,656 bp
  • G to A, chromosome 10 at 121,096,047 bp
  • T to A, chromosome 11 at 58,938,415 bp
  • A to T, chromosome 11 at 70,958,340 bp
  • G to A, chromosome 11 at 87,474,415 bp
  • A to T, chromosome 11 at 116,334,067 bp
  • A to T, chromosome 11 at 120,610,722 bp
  • A to T, chromosome 12 at 4,200,935 bp
  • A to G, chromosome 12 at 86,421,958 bp
  • A to G, chromosome 13 at 3,804,097 bp
  • T to C, chromosome 13 at 61,201,643 bp
  • T to C, chromosome 13 at 70,604,430 bp
  • C to T, chromosome 13 at 100,427,187 bp
  • A to G, chromosome 13 at 102,758,669 bp
  • T to C, chromosome 14 at 37,082,780 bp
  • C to T, chromosome 14 at 89,898,241 bp
  • A to G, chromosome 15 at 12,890,501 bp
  • T to A, chromosome 15 at 27,756,542 bp
  • A to T, chromosome 16 at 44,520,437 bp
  • T to A, chromosome 17 at 19,611,991 bp
  • T to C, chromosome 17 at 23,899,410 bp
  • T to G, chromosome 17 at 33,136,701 bp
  • A to G, chromosome 18 at 20,391,906 bp
  • C to A, chromosome 18 at 37,807,641 bp
  • A to T, chromosome 19 at 6,336,818 bp
  • T to C, chromosome 19 at 32,159,635 bp
  • C to T, chromosome 19 at 38,836,909 bp
  • G to C, chromosome 19 at 40,376,800 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8283 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067706-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.