Strain Name:
C57BL/6J-MtgxR8289Btlr/Mmmh
Stock Number:
067711-MU
Citation ID:
RRID:MMRRC_067711-MU
Other Names:
R8289 (G1)
Major Collection:

Strain Information

Camkk2
Name: calcium/calmodulin-dependent protein kinase kinase 2, beta
Synonyms: 6330570N16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207565
HGNC: HGNC:1470
Homologene: 32756
Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Calb2
Name: calbindin 2
Synonyms: CR, calretinin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12308
HGNC: HGNC:1435
Homologene: 1318
Cuedc1
Name: CUE domain containing 1
Synonyms: C330016O16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103841
Homologene: 9933
Neurl4
Name: neuralized E3 ubiquitin protein ligase 4
Synonyms: 0610025P10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216860
Homologene: 13029
Sbno1
Name: strawberry notch 1
Synonyms: 9330180L10Rik, sno
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243272
Homologene: 10055
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22763
Homologene: 8009
Cux1
Name: cut-like homeobox 1
Synonyms: Cux-1, Cux, CDP, Cutl1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Epha8
Name: Eph receptor A8
Synonyms: Eek, EphA8, Hek3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Rad50
Name: RAD50 double strand break repair protein
Synonyms: Rad50l, Mrell
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19360
HGNC: HGNC:9816
Homologene: 38092
Dhx8
Name: DEAH-box helicase 8
Synonyms: RNA helicase, mDEAH6, Ddx8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217207
HGNC: HGNC:2749
Homologene: 3628
Atoh1
Name: atonal bHLH transcription factor 1
Synonyms: Hath1, bHLHa14, Math1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11921
HGNC: HGNC:797
Homologene: 31297
Cecr2
Name: CECR2, histone acetyl-lysine reader
Synonyms: 2610101O16Rik, cat eye syndrome chromosome region, candidate 2, 2810409N01Rik, Gtl4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330409
HGNC: HGNC:1840
Homologene: 64662
Smc6
Name: structural maintenance of chromosomes 6
Synonyms: 2810489L22Rik, 3830418C19Rik, Smc6l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67241
VEGA: 12
Homologene: 41575
Zap70
Name: zeta-chain (TCR) associated protein kinase
Synonyms: TZK, Srk, ZAP-70
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22637
Homologene: 839
Prune2
Name: prune homolog 2
Synonyms: Olfaxin, A330102H22Rik, A230083H22Rik, 6330414G02Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Magel2
Name: MAGE family member L2
Synonyms: Mage-l2, ns7, nM15, NDNL1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27385
HGNC: HGNC:6814
Homologene: 8460
Atp1b3
Name: ATPase, Na+/K+ transporting, beta 3 polypeptide
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11933
HGNC: HGNC:806
Homologene: 37510
Stk11
Name: serine/threonine kinase 11
Synonyms: Par-4, Lkb1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20869
Homologene: 393
Osbpl7
Name: oxysterol binding protein-like 7
Synonyms: 4933437E18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71240
Homologene: 79672
Prkaa1
Name: protein kinase, AMP-activated, alpha 1 catalytic subunit
Synonyms: C130083N04Rik, AMPKalpha1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105787
VEGA: 15
HGNC: HGNC:9376
Homologene: 49590
Ssh1
Name: slingshot protein phosphatase 1
Synonyms: mSSH-1L, LOC384311
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231637
Homologene: 41299
Slc35f5
Name: solute carrier family 35, member F5
Synonyms: 1300003P13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74150
Homologene: 5745
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Apeh
Name: acylpeptide hydrolase
Synonyms: N-acylaminoacyl peptide hydrolase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235606
HGNC: HGNC:586
Homologene: 1240
Myo7a
Name: myosin VIIA
Synonyms: Myo7, polka, USH1B, nmf371, Hdb
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Cubn
Name: cubilin
Synonyms: intrinsic factor-cobalamin receptor, D2Wsu88e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, Adgrc1, crash
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Slc9c1
Name: solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Synonyms: LOC208169, Slc9a10, spermNHE
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208169
Homologene: 19505
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: Gm980, Dnahc14, LOC381311, A230079K17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Insrr
Name: insulin receptor-related receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23920
HGNC: HGNC:6093
Homologene: 56539
Or8b37
Name: olfactory receptor family 8 subfamily B member 37
Synonyms: MOR162-11P, MOR162-13, MOR162-11P, Olfr1550-ps1, MOR162-9P, GA_x6K02T2PVTD-31726544-31727473, Olfr884
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257996
Homologene: 79400
Slc26a6
Name: solute carrier family 26, member 6
Synonyms: Pat1, CFEX, B930010B04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 171429
Homologene: 99903
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20957
Homologene: 2389
Treml4
Name: triggering receptor expressed on myeloid cells-like 4
Synonyms: 5031403H21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224840
Adamts3
Name: ADAM metallopeptidase with thrombospondin type 1 motif 3
Synonyms: 6330442E02Rik, 1100001H14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330119
HGNC: HGNC:219
Homologene: 8596
Abca8a
Name: ATP-binding cassette, sub-family A member 8a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Dcaf17
Name: DDB1 and CUL4 associated factor 17
Synonyms: A930009G19Rik, A030004A10Rik, 4833418A01Rik, 2810055O12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75763
Homologene: 65979
Or1e29
Name: olfactory receptor family 1 subfamily E member 29
Synonyms: Olfr389, GA_x6K02T2P1NL-3932085-3931147, MOR135-6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259011
Homologene: 85925
Atp6v0a1
Name: ATPase, H+ transporting, lysosomal V0 subunit A1
Synonyms: Atp6n1a, Atp6n1, V-ATPase a1, Vpp1, Vpp-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11975
HGNC: HGNC:865
Homologene: 3795
F830016B08Rik
Name: RIKEN cDNA F830016B08 gene
Synonyms: Ifgga4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240328
VEGA: 18
Homologene: 129714
Or4d1
Name: olfactory receptor family 4 subfamily D member 1
Synonyms: Olfr464, MOR240-2, GA_x6K02T2PAEV-9555122-9554181
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258407
HGNC: HGNC:8293
Homologene: 44975
Mvb12a
Name: multivesicular body subunit 12A
Synonyms: 1110012M11Rik, Fam125a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73711
Homologene: 12509
Slc41a2
Name: solute carrier family 41, member 2
Synonyms: A230035L05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 338365
Homologene: 9870
Msln
Name: mesothelin
Synonyms: MPF, megakaryocyte potentiating factor
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56047
VEGA: 17
HGNC: HGNC:7371
Homologene: 4249
Wdr35
Name: WD repeat domain 35
Synonyms: 4930459M12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74682
Homologene: 10814
Ncoa5
Name: nuclear receptor coactivator 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228869
Homologene: 32496
Car15
Name: carbonic anhydrase 15
Synonyms: Cals2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 80733
Homologene: 113791
Lrrc23
Name: leucine rich repeat containing 23
Synonyms: Lrpb7, 4921537K05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16977
Homologene: 5082
Samsn1
Name: SAM domain, SH3 domain and nuclear localization signals, 1
Synonyms: Hacs1, 4930571B16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67742
Homologene: 11148
Arhgap24
Name: Rho GTPase activating protein 24
Synonyms: 0610025G21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231532
Homologene: 32754
Polr3gl
Name: polymerase (RNA) III (DNA directed) polypeptide G like
Synonyms: 2010003I19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69870
Homologene: 41712
Ap5s1
Name: adaptor-related protein 5 complex, sigma 1 subunit
Synonyms: 0610038L13Rik, 2310035K24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69596
Homologene: 23095
Mrgpra3
Name: MAS-related GPR, member A3
Synonyms: G protein-coupled receptor, MrgA3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233222
Homologene: 131159
Podnl1
Name: podocan-like 1
Synonyms: 5832418A03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244550
Homologene: 41590
Adra1b
Name: adrenergic receptor, alpha 1b
Synonyms: alpha1B-adrenergic receptor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11548
HGNC: HGNC:278
Homologene: 55477
Kcne2
Name: potassium voltage-gated channel, Isk-related subfamily, gene 2
Synonyms: MiRP1, 2200002I16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 246133
HGNC: HGNC:6242
Homologene: 71688
Gm15800
Name:
Type: Gene
Species: Mouse
Chromosome: 5
Gm4955
Name:
Type: Gene
Species: Mouse
Chromosome: 1
Or5p75-ps1
Name: olfactory receptor family 5 subfamily P member 75, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-10838051-10838996, Olfr501-ps1, MOR204-27P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258054
Cecr6
Name:
Type: Gene
Species: Mouse
Chromosome: 6
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,781,137 bp
  • T to G, chromosome 1 at 125,562,515 bp
  • T to C, chromosome 1 at 173,480,466 bp
  • T to A, chromosome 1 at 181,716,215 bp
  • C to T, chromosome 2 at 13,486,802 bp
  • T to A, chromosome 2 at 71,055,374 bp
  • A to C, chromosome 2 at 131,212,459 bp
  • C to T, chromosome 2 at 165,013,062 bp
  • A to G, chromosome 3 at 87,814,194 bp
  • G to T, chromosome 3 at 96,581,912 bp
  • A to G, chromosome 3 at 102,841,037 bp
  • G to A, chromosome 4 at 6,268,295 bp
  • T to A, chromosome 4 at 43,172,524 bp
  • G to T, chromosome 4 at 136,938,586 bp
  • C to A, chromosome 5 at 89,775,423 bp
  • T to C, chromosome 5 at 102,880,826 bp
  • T to C, chromosome 5 at 113,942,384 bp
  • A to G, chromosome 5 at 121,266,361 bp
  • A to C, chromosome 5 at 122,756,626 bp
  • T to G, chromosome 5 at 124,404,005 bp
  • T to A, chromosome 5 at 136,308,504 bp
  • A to G, chromosome 6 at 64,729,909 bp
  • A to T, chromosome 6 at 120,492,761 bp
  • A to G, chromosome 6 at 120,758,116 bp
  • A to T, chromosome 6 at 124,778,304 bp
  • G to A, chromosome 7 at 47,589,720 bp
  • A to C, chromosome 7 at 62,379,127 bp
  • T to G, chromosome 7 at 98,077,169 bp
  • T to A, chromosome 7 at 108,508,918 bp
  • T to A, chromosome 8 at 16,058,702 bp
  • T to C, chromosome 8 at 71,543,059 bp
  • T to C, chromosome 8 at 84,131,923 bp
  • T to C, chromosome 8 at 110,168,058 bp
  • T to A, chromosome 9 at 38,047,704 bp
  • G to A, chromosome 9 at 96,333,549 bp
  • A to G, chromosome 9 at 108,086,245 bp
  • G to A, chromosome 9 at 108,856,031 bp
  • G to T, chromosome 10 at 80,125,906 bp
  • T to C, chromosome 10 at 83,301,180 bp
  • G to A, chromosome 11 at 43,835,488 bp
  • A to T, chromosome 11 at 53,698,858 bp
  • T to A, chromosome 11 at 69,909,380 bp
  • T to A, chromosome 11 at 73,777,013 bp
  • T to C, chromosome 11 at 87,914,763 bp
  • G to A, chromosome 11 at 88,182,555 bp
  • T to A, chromosome 11 at 97,056,579 bp
  • A to G, chromosome 11 at 101,034,105 bp
  • T to A, chromosome 11 at 101,740,745 bp
  • G to C, chromosome 11 at 110,036,689 bp
  • A to G, chromosome 12 at 9,008,020 bp
  • T to A, chromosome 12 at 11,274,051 bp
  • A to G, chromosome 12 at 112,775,808 bp
  • G to T, chromosome 15 at 5,177,082 bp
  • G to T, chromosome 15 at 12,135,271 bp
  • G to T, chromosome 15 at 86,033,085 bp
  • A to G, chromosome 16 at 17,836,716 bp
  • A to G, chromosome 16 at 45,582,981 bp
  • C to A, chromosome 16 at 75,888,796 bp
  • A to G, chromosome 16 at 92,296,819 bp
  • A to G, chromosome 17 at 25,748,906 bp
  • A to C, chromosome 17 at 48,274,428 bp
  • G to A, chromosome 18 at 60,300,288 bp
  • A to T, chromosome 19 at 17,123,009 bp
  • A to G, chromosome 19 at 37,313,553 bp
  • G to C, chromosome 19 at 37,313,554 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8289 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067711-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.