Strain Name:
C57BL/6J-MtgxR8332Btlr/Mmmh
Stock Number:
067728-MU
Citation ID:
RRID:MMRRC_067728-MU
Other Names:
R8332 (G1)
Major Collection:

Strain Information

St3gal5
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Synonyms: ST3Gal V, mST3Gal V, GM3-specific sialytransferase, GM3 synthase, [a]2, 3S-T, Siat9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20454
Homologene: 2893
Ahdc1
Name: AT hook, DNA binding motif, containing 1
Synonyms: D030015G18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230793
Homologene: 17144
Taok1
Name: TAO kinase 1
Synonyms: D130018F14Rik, 2810468K05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216965
Homologene: 27041
Erp44
Name: endoplasmic reticulum protein 44
Synonyms: 1110001E24Rik, Txndc4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76299
Homologene: 12638
Cpne1
Name: copine I
Synonyms: 1810028N16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 266692
HGNC: HGNC:2314
Homologene: 36501
Cog5
Name: component of oligomeric golgi complex 5
Synonyms: GOLTC1, GTC90, 5430405C01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238123
VEGA: 12
Homologene: 42221
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, D7H15F37S1, rjs, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
T2
Name: brachyury 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21331
Homologene: 86977
Robo1
Name: roundabout guidance receptor 1
Synonyms: DUTT1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19876
Homologene: 2206
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Rrn3
Name: RRN3 RNA polymerase I transcription factor homolog (yeast)
Synonyms: E130302O19Rik, TIF-1A
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106298
VEGA: 16
Homologene: 39531
Angptl8
Name: angiopoietin-like 8
Synonyms: Lipasin, Rifl, Gm6484
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 624219
VEGA: 9
Homologene: 83285
Zfp59
Name: zinc finger protein 59
Synonyms: Mfg-2, Mfg2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22717
Homologene: 137243
Ikbkb
Name: inhibitor of kappaB kinase beta
Synonyms: IKK-beta, IKK-2, IKK2, IKK[b], IKKbeta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16150
HGNC: HGNC:5960
Homologene: 7782
Limd1
Name: LIM domains containing 1
Synonyms: D9Ertd192e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 29806
VEGA: 9
HGNC: HGNC:6612
Homologene: 8478
Cntrl
Name: centriolin
Synonyms: IB3/5, 6720467O09Rik, Ma2a8, Cep1, b2b1468Clo, Cep110
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Srek1ip1
Name: splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
Synonyms: 3110031B13Rik, Sfrs12ip1, Srsf12ip1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67288
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 8030475K17Rik, A330041G23Rik, 2610202E01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Crb1
Name: crumbs family member 1, photoreceptor morphogenesis associated
Synonyms: A930008G09Rik, 7530426H14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170788
HGNC: HGNC:2343
Homologene: 8092
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: 9430028L06Rik, 9030411M15Rik, Fam38b2, Piezo2, Fam38b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 667742
Homologene: 49695
Chsy3
Name: chondroitin sulfate synthase 3
Synonyms: 4833446K15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 78923
VEGA: 18
Homologene: 28624
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Vmn2r57
Name: vomeronasal 2, receptor 57
Synonyms: EG269902
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269902
Homologene: 104832
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Intu
Name: inturned planar cell polarity protein
Synonyms: 9430087H23Rik, 9230116I04Rik, Pdzk6, Pdzd6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 380614
Homologene: 41059
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Flad1
Name: flavin adenine dinucleotide synthetase 1
Synonyms: Pp591, A930017E24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319945
Homologene: 115598
Cstdc1
Name: cystatin domain containing 1
Synonyms: cystatin SC, 8030411F24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78609
Homologene: 128710
Thbs2
Name: thrombospondin 2
Synonyms: TSP2, Thbs-2, Thrombospondin-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Abca14
Name: ATP-binding cassette, sub-family A member 14
Synonyms: 1700110B15Rik, 4930539G24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67928
Homologene: 86128
Gli3
Name: GLI-Kruppel family member GLI3
Synonyms: Bph, brachyphalangy
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14634
HGNC: HGNC:4319
Homologene: 139
Crat
Name: carnitine acetyltransferase
Synonyms: CARAT
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12908
HGNC: HGNC:2342
Homologene: 598
Bscl2
Name: BSCL2 lipid droplet biogenesis associated, seipin
Synonyms: seipin, Gng3lg
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14705
Homologene: 32032
Xkr4
Name: X-linked Kx blood group related 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 497097
Homologene: 45848
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Prag1
Name: PEAK1 related kinase activating pseudokinase 1
Synonyms: NACK, D8Ertd82e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244418
Homologene: 18256
Ttll11
Name: tubulin tyrosine ligase-like family, member 11
Synonyms: 4932702F08Rik, D2Ertd624e, 4933424A20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74410
Homologene: 77534
Slc22a16
Name: solute carrier family 22 (organic cation transporter), member 16
Synonyms: FLIPT2, OKB1, OCT6, CT2, 4921504E14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70840
Homologene: 41957
Ccr8
Name: C-C motif chemokine receptor 8
Synonyms: Cmkbr8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12776
VEGA: 9
HGNC: HGNC:1609
Homologene: 21080
Zfp760
Name: zinc finger protein 760
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240034
VEGA: 17
Or2at1
Name: olfactory receptor family 2 subfamily AT member 1
Synonyms: GA_x6K02T2PBJ9-2443810-2444775, MOR101-2, Olfr521
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258353
Homologene: 128108
Or6c38
Name: olfactory receptor family 6 subfamily C member 38
Synonyms: GA_x6K02T2PULF-10779441-10778503, MOR114-4, Olfr768
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258863
Homologene: 17159
Rbm8a2
Name: RNA binding motif protein 8A2
Synonyms: Y14, B020018G12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545388
HGNC: HGNC:9905
Ccl28
Name: C-C motif chemokine ligand 28
Synonyms: Scya28, CCK1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56838
VEGA: 13
Homologene: 10649
4933428G20Rik
Name: RIKEN cDNA 4933428G20 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100141474
Krtap10-33
Name: keratin associated protein 10-33
Synonyms: Gm19402
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100502831
VEGA: 10
Homologene: 115744
Gata3os
Name: GATA binding protein 3 opposite strand
Synonyms: Gm10853, 4930412O13Rik, Gata3as
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381347
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 3,421,899 bp
  • T to A, chromosome 1 at 139,237,414 bp
  • T to C, chromosome 1 at 175,978,401 bp
  • G to A, chromosome 2 at 9,882,839 bp
  • T to A, chromosome 2 at 30,405,072 bp
  • A to G, chromosome 2 at 35,126,025 bp
  • T to A, chromosome 2 at 35,940,709 bp
  • A to G, chromosome 2 at 148,783,457 bp
  • T to C, chromosome 2 at 156,078,397 bp
  • A to G, chromosome 3 at 40,675,289 bp
  • G to T, chromosome 3 at 89,407,521 bp
  • C to T, chromosome 3 at 97,209,770 bp
  • A to G, chromosome 4 at 48,243,475 bp
  • A to G, chromosome 4 at 133,063,971 bp
  • A to T, chromosome 5 at 89,179,821 bp
  • T to A, chromosome 6 at 72,142,181 bp
  • G to A, chromosome 6 at 85,620,579 bp
  • A to G, chromosome 7 at 27,853,546 bp
  • C to T, chromosome 7 at 41,400,253 bp
  • T to C, chromosome 7 at 56,146,595 bp
  • T to C, chromosome 7 at 99,768,127 bp
  • A to G, chromosome 7 at 120,216,213 bp
  • A to T, chromosome 8 at 22,665,625 bp
  • T to C, chromosome 8 at 36,146,303 bp
  • A to T, chromosome 9 at 21,836,841 bp
  • C to T, chromosome 9 at 42,375,014 bp
  • A to T, chromosome 9 at 120,094,374 bp
  • A to G, chromosome 9 at 123,479,254 bp
  • G to A, chromosome 10 at 40,573,745 bp
  • A to T, chromosome 10 at 77,690,214 bp
  • G to A, chromosome 10 at 127,571,936 bp
  • A to G, chromosome 10 at 129,093,305 bp
  • A to G, chromosome 11 at 60,710,384 bp
  • A to T, chromosome 11 at 77,541,719 bp
  • A to T, chromosome 11 at 97,491,134 bp
  • A to C, chromosome 11 at 119,483,698 bp
  • A to T, chromosome 12 at 31,833,223 bp
  • G to T, chromosome 13 at 15,713,548 bp
  • C to T, chromosome 13 at 81,445,343 bp
  • A to T, chromosome 13 at 104,834,249 bp
  • C to A, chromosome 13 at 119,645,978 bp
  • T to A, chromosome 16 at 13,798,620 bp
  • T to C, chromosome 16 at 72,978,578 bp
  • A to G, chromosome 17 at 8,390,952 bp
  • G to A, chromosome 17 at 14,679,770 bp
  • A to G, chromosome 17 at 21,723,320 bp
  • T to A, chromosome 18 at 59,409,015 bp
  • A to T, chromosome 18 at 63,012,786 bp
  • A to G, chromosome 19 at 8,846,230 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8332 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067728-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.