Strain Name:
C57BL/6J-MtgxR8378Btlr/Mmmh
Stock Number:
067746-MU
Citation ID:
RRID:MMRRC_067746-MU
Other Names:
R8378 (G1)
Major Collection:

Strain Information

Ippk
Name: inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Synonyms: 1810043M15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75678
VEGA: 13
Homologene: 41495
Crhr2
Name: corticotropin releasing hormone receptor 2
Synonyms: Crfr2, CRF-R2, CRFR2beta, CRFR2alpha, CRF 2 receptor, CRH-R2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12922
HGNC: HGNC:2358
Homologene: 55612
Efemp1
Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216616
HGNC: HGNC:3218
Homologene: 3028
Rilpl1
Name: Rab interacting lysosomal protein-like 1
Synonyms: 6330559I19Rik, 2900002H16Rik, GOSPEL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75695
Homologene: 15619
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Diaph1
Name: diaphanous related formin 1
Synonyms: p140mDia, Drf1, Dia1, D18Wsu154e, mDia1, Diap1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13367
HGNC: HGNC:2876
Homologene: 129567
Zwilch
Name: zwilch kinetochore protein
Synonyms: 2310031L18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68014
Homologene: 32381
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: CRP-[b], CRP-[a], ebnerin, hensin, vomeroglandin, Crpd, MUCLIN, gp300
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Itgb3
Name: integrin beta 3
Synonyms: platelet glycoprotein IIIa (GP3A), CD61
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16416
HGNC: HGNC:6156
Homologene: 55444
Crebrf
Name: CREB3 regulatory factor
Synonyms: A930001N09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77128
Homologene: 12672
Ndufaf2
Name: NADH:ubiquinone oxidoreductase complex assembly factor 2
Synonyms: 1810058I14Rik, mimitin, Ndufa12l
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75597
VEGA: 13
Homologene: 18372
Car9
Name: carbonic anhydrase 9
Synonyms: CAIX, MN/CA9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230099
HGNC: HGNC:1383
Homologene: 20325
Yy1
Name: YY1 transcription factor
Synonyms: UCRBP transcription factor, delta transcription factor, NF-E1, Yin Yang 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22632
Homologene: 2556
Ccdc171
Name: coiled-coil domain containing 171
Synonyms: 4930418J05Rik, A330015D16Rik, 4930473A06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320226
Homologene: 27942
Tbk1
Name: TANK-binding kinase 1
Synonyms: 1200008B05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56480
VEGA: 10
Homologene: 22742
Dhtkd1
Name: dehydrogenase E1 and transketolase domain containing 1
Synonyms: C330018I04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209692
Homologene: 10278
Kif18b
Name: kinesin family member 18B
Synonyms: N-8 kinesin, 3000004C01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70218
Homologene: 15214
Rfx8
Name: regulatory factor X 8
Synonyms: 4933400N17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 619289
Homologene: 82436
Cdc42bpa
Name: CDC42 binding protein kinase alpha
Synonyms: DMPK-like, A930014J19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226751
HGNC: HGNC:1737
Homologene: 55765
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 637515
Homologene: 19080
Pcyt2
Name: phosphate cytidylyltransferase 2, ethanolamine
Synonyms: 1110033E03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68671
HGNC: HGNC:8756
Homologene: 2143
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320664
Homologene: 75128
Phf8l
Name: PHD finger protein 8 like
Synonyms: 4921501E09Rik, Phf8-ps
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74042
VEGA: 17
Homologene: 66275
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: slo2, Slack, C030030G16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227632
Homologene: 11055
Or2h15
Name: olfactory receptor family 2 subfamily H member 15
Synonyms: GA_x6K02T2PSCP-2579687-2578746, MOR256-49, Olfr132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 257889
Homologene: 46430
Kif2b
Name: kinesin family member 2B
Synonyms: 1700063D03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73470
Homologene: 23775
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, E030018G17Rik, 1110018I21Rik, Tns, E030037J05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21961
Homologene: 11219
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Hirip3
Name: HIRA interacting protein 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233876
HGNC: HGNC:4917
Homologene: 18218
Bmp3
Name: bone morphogenetic protein 3
Synonyms: 9530029I04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 110075
HGNC: HGNC:1070
Homologene: 927
Vmn2r68
Name: vomeronasal 2, receptor 68
Synonyms: EG620697, Vmn2r68-ps
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620697
Homologene: 115466
Sgce
Name: sarcoglycan, epsilon
Synonyms: e-SG
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20392
Homologene: 31205
Aadacl4fm4
Name: AADACL4 family member 4
Synonyms: LOC230890, Gm436
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230890
Homologene: 135765
Klhl30
Name: kelch-like 30
Synonyms: 4631423F02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70788
Homologene: 18891
4933412E24Rik
Name: RIKEN cDNA 4933412E24 gene
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71088
VEGA: 15
Homologene: 129990
Ankrd40
Name: ankyrin repeat domain 40
Synonyms: 5530600A18Rik, Gcap15, 1110011C06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71452
Homologene: 12393
Vmn1r192
Name: vomeronasal 1 receptor 192
Synonyms: V1ri1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 252907
Homologene: 110880
Lrfn1
Name: leucine rich repeat and fibronectin type III domain containing 1
Synonyms: SALM2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80749
Homologene: 12729
Or12e10
Name: olfactory receptor family 12 subfamily E member 10
Synonyms: GA_x6K02T2Q125-49311440-49312384, MOR264-19, Olfr1145
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258317
Homologene: 27123
Gm11444
Name: predicted gene 11444
Type: Gene
Species: Mouse
Chromosome: 11
Ap1s3
Name: adaptor-related protein complex AP-1, sigma 3
Synonyms: [s]3A, Jr2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 252903
Homologene: 65622
Alkal2
Name: ALK and LTK ligand 2
Synonyms: 6230419C23Rik, Fam150b, Augalpha, Augmentor alpha
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100294583
VEGA: 12
Homologene: 87330
Igkv1-135
Name: immunoglobulin kappa variable 1-135
Synonyms: Igkv1-135
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243420
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 39,670,421 bp
  • T to A, chromosome 1 at 73,937,246 bp
  • T to C, chromosome 1 at 79,623,728 bp
  • A to T, chromosome 1 at 91,357,772 bp
  • A to G, chromosome 1 at 180,162,144 bp
  • T to C, chromosome 2 at 5,917,888 bp
  • A to G, chromosome 2 at 25,907,271 bp
  • T to A, chromosome 2 at 87,810,050 bp
  • T to C, chromosome 2 at 172,427,794 bp
  • C to T, chromosome 4 at 43,509,021 bp
  • A to G, chromosome 4 at 83,864,253 bp
  • C to G, chromosome 4 at 144,670,599 bp
  • A to G, chromosome 5 at 98,855,389 bp
  • T to C, chromosome 5 at 124,530,901 bp
  • G to C, chromosome 6 at 4,689,760 bp
  • T to A, chromosome 6 at 4,691,525 bp
  • A to G, chromosome 6 at 55,092,956 bp
  • T to A, chromosome 6 at 67,610,394 bp
  • G to A, chromosome 7 at 25,518,172 bp
  • A to G, chromosome 7 at 28,459,732 bp
  • A to T, chromosome 7 at 85,221,900 bp
  • A to G, chromosome 7 at 126,863,585 bp
  • T to C, chromosome 7 at 131,106,465 bp
  • G to A, chromosome 8 at 125,760,910 bp
  • A to T, chromosome 9 at 64,152,958 bp
  • A to G, chromosome 9 at 118,558,322 bp
  • A to G, chromosome 10 at 121,578,692 bp
  • C to T, chromosome 11 at 28,921,765 bp
  • A to G, chromosome 11 at 71,161,719 bp
  • C to A, chromosome 11 at 85,850,249 bp
  • C to A, chromosome 11 at 91,576,375 bp
  • G to T, chromosome 11 at 94,334,836 bp
  • A to T, chromosome 11 at 102,916,473 bp
  • A to G, chromosome 11 at 104,642,316 bp
  • A to G, chromosome 11 at 120,613,408 bp
  • G to T, chromosome 12 at 30,884,851 bp
  • A to T, chromosome 12 at 108,793,636 bp
  • T to A, chromosome 13 at 22,187,859 bp
  • T to A, chromosome 13 at 49,435,579 bp
  • A to C, chromosome 13 at 100,161,782 bp
  • C to A, chromosome 13 at 108,052,853 bp
  • A to G, chromosome 15 at 60,015,118 bp
  • G to T, chromosome 17 at 26,762,289 bp
  • C to A, chromosome 17 at 33,067,064 bp
  • A to G, chromosome 17 at 38,130,787 bp
  • G to A, chromosome 18 at 37,891,953 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8378 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067746-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.