Strain Name:
C57BL/6J-MtgxR8381Btlr/Mmmh
Stock Number:
067748-MU
Citation ID:
RRID:MMRRC_067748-MU
Other Names:
R8381 (G1)
Major Collection:

Strain Information

Fubp3
Name: far upstream element (FUSE) binding protein 3
Synonyms: FBP3, Marta2, A330051M14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320267
HGNC: HGNC:4005
Homologene: 45954
Top1
Name: topoisomerase (DNA) I
Synonyms: D130064I21Rik, Top-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21969
Homologene: 2467
Ttc17
Name: tetratricopeptide repeat domain 17
Synonyms: 9130020K17Rik, D2Bwg1005e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74569
Homologene: 10100
Hnrnpll
Name: heterogeneous nuclear ribonucleoprotein L-like
Synonyms: Hnrpll, 2810036L13Rik, 2510028H02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72692
Homologene: 26701
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Eif4enif1
Name: eukaryotic translation initiation factor 4E nuclear import factor 1
Synonyms: Clast4, D11Ertd166e, 2610509L04Rik, A930019J01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74203
Homologene: 10522
Smg6
Name: SMG6 nonsense mediated mRNA decay factor
Synonyms: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103677
Homologene: 23024
E2f8
Name: E2F transcription factor 8
Synonyms: 4432406C08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108961
Homologene: 11654
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox1, Xox-1, xanthine oxidase, Xor, XO
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Ice2
Name: interactor of little elongation complex ELL subunit 2
Synonyms: Narg2, B230343B06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93697
Homologene: 11618
Hey2
Name: hairy/enhancer-of-split related with YRPW motif 2
Synonyms: CHF1, bHLHb32, Hesr2, Hrt2, Herp1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15214
HGNC: HGNC:4881
Homologene: 22705
Robo3
Name: roundabout guidance receptor 3
Synonyms: Rig1, Rig-1, Robo3b, Rbig1, Robo3a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19649
Homologene: 32119
Bhlhe40
Name: basic helix-loop-helix family, member e40
Synonyms: cytokine response gene 8, Clast5, Stra13, Bhlhb2, C130042M06Rik, eip1 (E47 interaction protein 1), Stra14, Sharp2, DEC1, CR8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20893
HGNC: HGNC:1046
Homologene: 2722
Syk
Name: spleen tyrosine kinase
Synonyms: Sykb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20963
Homologene: 2390
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: C130041O22Rik, Zfh-4, Zfh4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Kif27
Name: kinesin family member 27
Synonyms: 4930517I18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75050
VEGA: 13
Homologene: 69235
4930579F01Rik
Name: RIKEN cDNA 4930579F01 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67741
Homologene: 12962
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: flamingo, mfmi1, EGFL2, Adgrc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Actrt3
Name: actin related protein T3
Synonyms: Arpm1, 1700119I24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76652
Homologene: 13038
Adam34
Name: a disintegrin and metallopeptidase domain 34
Synonyms: testase 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 252866
Homologene: 78104
Jkampl
Name: JNK1/MAPK8 associated membrane protein like
Synonyms: 4931417E11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66740
Homologene: 75225
Slc16a5
Name: solute carrier family 16 (monocarboxylic acid transporters), member 5
Synonyms: MCT5, A130015N09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217316
Homologene: 20985
Or8h10
Name: olfactory receptor family 8 subfamily H member 10
Synonyms: MOR206-4, Olfr1100, GA_x6K02T2Q125-48465387-48464422
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258587
Homologene: 34954
Mettl14
Name: methyltransferase 14, N6-adenosine-methyltransferase subunit
Synonyms: G430022H21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 210529
Homologene: 10865
Or5h22
Name: olfactory receptor family 5 subfamily H member 22
Synonyms: MOR183-4, GA_x54KRFPKG5P-55303207-55302284, Olfr190
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258392
Homologene: 131129
Obsl1
Name: obscurin-like 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98733
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329679
Homologene: 46417
Klk1b1
Name: kallikrein 1-related peptidase b1
Synonyms: tissue kallikrein, Klk1, mGK-1, mK1, TK
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16623
Homologene: 68141
Fbln5
Name: fibulin 5
Synonyms: EVEC
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23876
VEGA: 12
HGNC: HGNC:3602
Homologene: 38170
Stk36
Name: serine/threonine kinase 36
Synonyms: Fused, 1700112N14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269209
Homologene: 49432
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101613
Homologene: 15881
Or51b6
Name: olfactory receptor family 51 subfamily B member 6
Synonyms: 5'[b]3, MOR1-2, GA_x6K02T2PBJ9-6634906-6633983, Olfr65
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18365
Homologene: 66459
Pcbp4
Name: poly(rC) binding protein 4
Synonyms: 1200003L19Rik, AlphaCP-4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 59092
HGNC: HGNC:8652
Homologene: 56926
Pramel52-ps
Name: PRAME like 52, pseudogene
Synonyms: AA792892
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100554
Homologene: 133359
Gjb6
Name: gap junction protein, beta 6
Synonyms: D14Bwg0506e, Cx30, connexin 30
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14623
HGNC: HGNC:4288
Homologene: 4936
Gpr160
Name: G protein-coupled receptor 160
Synonyms: 1700025D19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71862
Homologene: 8659
Ighv5-2
Name: immunoglobulin heavy variable 5-2
Synonyms: Gm16969
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 777685
Ighv1-20
Name: immunoglobulin heavy variable V1-20
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668497
HGNC: HGNC:5553
Smok3c
Name: sperm motility kinase 3C
Synonyms: EG622486
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622486
Homologene: 128738
Zfp729b
Name: zinc finger protein 729b
Synonyms: AA987161
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100416706
Homologene: 133713
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,633,174 bp
  • G to T, chromosome 1 at 75,503,857 bp
  • G to A, chromosome 2 at 31,592,497 bp
  • T to C, chromosome 2 at 86,978,029 bp
  • A to G, chromosome 2 at 94,301,821 bp
  • A to G, chromosome 2 at 160,703,674 bp
  • A to C, chromosome 3 at 5,382,616 bp
  • A to G, chromosome 3 at 30,597,836 bp
  • A to G, chromosome 3 at 30,895,781 bp
  • T to A, chromosome 3 at 79,465,693 bp
  • T to C, chromosome 3 at 108,395,636 bp
  • A to G, chromosome 3 at 123,374,798 bp
  • C to T, chromosome 3 at 138,173,521 bp
  • C to T, chromosome 5 at 94,384,022 bp
  • C to T, chromosome 5 at 138,065,562 bp
  • A to T, chromosome 6 at 73,468,912 bp
  • TG to TGG, chromosome 6 at 108,664,857 bp
  • C to T, chromosome 7 at 43,970,343 bp
  • T to C, chromosome 7 at 48,877,962 bp
  • T to C, chromosome 7 at 103,906,939 bp
  • T to A, chromosome 7 at 130,624,242 bp
  • C to T, chromosome 7 at 140,923,841 bp
  • A to G, chromosome 8 at 43,651,810 bp
  • T to A, chromosome 9 at 37,429,760 bp
  • T to A, chromosome 9 at 69,410,171 bp
  • G to A, chromosome 9 at 106,461,289 bp
  • A to G, chromosome 10 at 30,833,990 bp
  • T to C, chromosome 11 at 3,227,470 bp
  • C to T, chromosome 11 at 74,931,740 bp
  • A to G, chromosome 11 at 115,469,890 bp
  • A to G, chromosome 12 at 101,761,855 bp
  • T to A, chromosome 12 at 113,578,705 bp
  • T to A, chromosome 12 at 114,723,881 bp
  • T to C, chromosome 13 at 52,633,049 bp
  • T to C, chromosome 13 at 58,291,177 bp
  • T to C, chromosome 13 at 67,591,498 bp
  • TG to T, chromosome 14 at 56,424,542 bp
  • T to C, chromosome 14 at 57,124,462 bp
  • A to G, chromosome 16 at 59,074,862 bp
  • T to G, chromosome 17 at 73,912,461 bp
  • A to T, chromosome 17 at 80,030,491 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8381 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067748-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.