Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8385Btlr/Mmmh
Stock Number:
067751-MU
Citation ID:
RRID:MMRRC_067751-MU
Other Names:
R8385 (G1)
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Dnmbp
Name: dynamin binding protein
Synonyms: 2410003M15Rik, Tuba, 2410003L07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71972
Homologene: 9061
Fbxo22
Name: F-box protein 22
Synonyms: 1600016C16Rik, 0610033L19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71999
Homologene: 12433
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Ese1, EHSH1, Sh3p17, Eh domain, SH3 domain regulator of endocytosis 1, Intersectin-L
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Ppfibp2
Name: PTPRF interacting protein, binding protein 2 (liprin beta 2)
Synonyms: liprin beta 2, Cclp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19024
HGNC: HGNC:9250
Homologene: 7486
Mark3
Name: MAP/microtubule affinity regulating kinase 3
Synonyms: ETK-1, 1600015G02Rik, A430080F22Rik, C-TAK1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17169
VEGA: 12
HGNC: HGNC:6897
Homologene: 55653
Lfng
Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: lunatic fringe
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16848
HGNC: HGNC:6560
Homologene: 22475
Brap
Name: BRCA1 associated protein
Synonyms: 3010002G07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72399
HGNC: HGNC:1099
Homologene: 4926
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
Gfm2
Name: G elongation factor, mitochondrial 2
Synonyms: MST027, EFG2, A930009M04Rik, 6530419G12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 320806
Homologene: 6238
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: C730024G01Rik, 2700017A04Rik, Brctx, Brctd1, Ankrd32
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105377
Homologene: 13000
Zdhhc13
Name: zinc finger, DHHC domain containing 13
Synonyms: kojak, 2410004E01Rik, Hip14l, skc4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243983
Homologene: 75106
Peg3
Name: paternally expressed 3
Synonyms: Pw1, Zfp102, End4, Gcap4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18616
HGNC: HGNC:8826
Homologene: 31363
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: C530005A01Rik, 6030465E24Rik, spastic paraplegia 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214585
Homologene: 41614
Naca
Name: nascent polypeptide-associated complex alpha polypeptide
Synonyms: skNAC, LOC380777
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17938
VEGA: 10
HGNC: HGNC:7629
Homologene: 136025
Thra
Name: thyroid hormone receptor alpha
Synonyms: T3Ralpha, T3R[a], Nr1a1, TR alpha 1, c-erbAalpha, Erba, TR alpha 2, 6430529J03Rik, Rvr, Thra2, Thra1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21833
Homologene: 37747
Gosr1
Name: golgi SNAP receptor complex member 1
Synonyms: Cis-Golgi SNARE, GS28, GOS-28
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53334
HGNC: HGNC:4430
Homologene: 37977
Ddhd2
Name: DDHD domain containing 2
Synonyms: SAMWD1, 2010305K11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72108
Homologene: 66646
Mphosph9
Name: M-phase phosphoprotein 9
Synonyms: 4930548D04Rik, MPP-9, MPP9, B930097C17Rik, 9630025B04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269702
HGNC: HGNC:7215
Homologene: 11256
Ythdc1
Name: YTH domain containing 1
Synonyms: A730098D12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231386
Homologene: 15796
Vit
Name: vitrin
Synonyms: 1700110E08Rik, 1700052E02Rik, 2810429K11Rik, AKH, akhirin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74199
VEGA: 17
Homologene: 24942
Mgat4f
Name: MGAT4 family, member F
Synonyms: 4933406M09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240755
Homologene: 128441
Rab19
Name: RAB19, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19331
Homologene: 22623
Dnai7
Name: dynein axonemal intermediate chain 7
Synonyms: A230084G12Rik, Las1, Casc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320662
Homologene: 41242
Slc38a4
Name: solute carrier family 38, member 4
Synonyms: Ata3, 1700012A18Rik, 1110012E16Rik, SNAT4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69354
VEGA: 15
Homologene: 75077
Mob3b
Name: MOB kinase activator 3B
Synonyms: MOB3B, A430018A01Rik, 8430436F23Rik, Mobkl2b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214944
Homologene: 69385
Zfp282
Name: zinc finger protein 282
Synonyms: HUB1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101095
Homologene: 2647
Dbt
Name: dihydrolipoamide branched chain transacylase E2
Synonyms: BCKAD E2, D3Wsu60e, dihydrolipoyl transacylase, dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13171
HGNC: HGNC:2698
Homologene: 1444
Vmn2r102
Name: vomeronasal 2, receptor 102
Synonyms: EG224572
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224572
Homologene: 115024
Or2w4
Name: olfactory receptor family 2 subfamily W member 4
Synonyms: GA_x6K02T2QHY8-11628399-11628868, GA_x6K02T2QHY8-11617756-11618682, MOR256-8, Olfr1363-ps1, Olfr1362
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258739
Homologene: 105885
Disp2
Name: dispatched RND transporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cav2.3, Cchra1, alpha1E
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Pla2g4c
Name: phospholipase A2, group IVC (cytosolic, calcium-independent)
Synonyms: CPLA2-gamma
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232889
HGNC: HGNC:9037
Homologene: 115256
Ttpa
Name: tocopherol (alpha) transfer protein
Synonyms: alpha TTP, alpha-TTP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50500
Homologene: 37295
Zfp872
Name: zinc finger protein 872
Synonyms: 9530015I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 619310
Or5e1
Name: olfactory receptor family 5 subfamily E member 1
Synonyms: GA_x6K02T2PBJ9-11084889-11085818, MOR195-1, Olfr513
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258718
Homologene: 64908
Raet1d
Name: retinoic acid early transcript delta
Synonyms: RAE-1delta
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56554
Homologene: 134115
Mterf1a
Name: mitochondrial transcription termination factor 1a
Synonyms: 9230106K09Rik, 4931431L11Rik, Mterf1, Mterf
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 545725
Homologene: 5073
Spata31f1a
Name: spermatogenesis associated 31 subfamily F member 1A
Synonyms: Gm12429, Fam205a1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433698
Homologene: 79022
Vps52
Name: VPS52 GARP complex subunit
Synonyms: ARE1, tcl-w5, D430041K17Rik, Sacm2l, tclw5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224705
Homologene: 5756
Dvl1
Name: dishevelled segment polarity protein 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13542
Homologene: 20926
Catsper2
Name: cation channel, sperm associated 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 212670
Homologene: 77423
Tmem181a
Name: transmembrane protein 181A
Synonyms: 5930418K15Rik, Gpr178, C76977, Tmem181
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77106
Homologene: 44787
Popdc2
Name: popeye domain containing 2
Synonyms: Pop2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 64082
Homologene: 11147
Pcdhga1
Name: protocadherin gamma subfamily A, 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93709
HGNC: HGNC:8696
Homologene: 56824
Speer4c2
Name: spermatogenesis associated glutamate (E)-rich protein 4C2
Synonyms: 4930572O03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381715
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 134,390,638 bp
  • T to A, chromosome 1 at 154,443,941 bp
  • T to A, chromosome 2 at 118,790,410 bp
  • A to G, chromosome 2 at 121,410,140 bp
  • A to T, chromosome 2 at 122,097,321 bp
  • T to C, chromosome 2 at 142,712,338 bp
  • A to T, chromosome 3 at 116,523,390 bp
  • G to A, chromosome 4 at 20,028,483 bp
  • T to C, chromosome 4 at 34,985,980 bp
  • C to T, chromosome 4 at 42,850,509 bp
  • A to G, chromosome 4 at 155,855,580 bp
  • A to T, chromosome 5 at 3,891,384 bp
  • A to T, chromosome 5 at 15,652,671 bp
  • T to A, chromosome 5 at 63,930,518 bp
  • C to A, chromosome 5 at 86,828,102 bp
  • C to T, chromosome 5 at 121,685,134 bp
  • T to C, chromosome 5 at 124,312,722 bp
  • G to A, chromosome 5 at 140,613,226 bp
  • T to A, chromosome 6 at 39,383,958 bp
  • A to T, chromosome 6 at 47,905,089 bp
  • T to C, chromosome 6 at 82,729,546 bp
  • C to T, chromosome 6 at 145,175,192 bp
  • T to C, chromosome 7 at 6,708,083 bp
  • C to T, chromosome 7 at 13,329,664 bp
  • T to C, chromosome 7 at 48,805,696 bp
  • C to T, chromosome 7 at 104,840,623 bp
  • A to G, chromosome 7 at 107,697,687 bp
  • T to G, chromosome 7 at 108,755,304 bp
  • T to C, chromosome 8 at 25,735,014 bp
  • A to T, chromosome 9 at 22,200,111 bp
  • A to G, chromosome 9 at 55,213,949 bp
  • T to A, chromosome 10 at 22,370,918 bp
  • A to G, chromosome 10 at 128,042,438 bp
  • T to C, chromosome 11 at 48,889,520 bp
  • T to A, chromosome 11 at 76,730,141 bp
  • C to G, chromosome 11 at 98,768,351 bp
  • A to G, chromosome 12 at 111,655,374 bp
  • A to T, chromosome 12 at 113,131,465 bp
  • T to C, chromosome 13 at 21,611,352 bp
  • T to C, chromosome 13 at 77,105,990 bp
  • A to G, chromosome 13 at 97,165,011 bp
  • T to A, chromosome 15 at 25,804,398 bp
  • A to G, chromosome 15 at 96,999,512 bp
  • G to A, chromosome 16 at 38,362,900 bp
  • A to C, chromosome 16 at 91,893,811 bp
  • T to C, chromosome 17 at 6,288,999 bp
  • A to G, chromosome 17 at 19,693,826 bp
  • G to A, chromosome 17 at 24,575,728 bp
  • T to C, chromosome 17 at 33,962,817 bp
  • A to T, chromosome 17 at 78,619,637 bp
  • A to T, chromosome 18 at 37,662,096 bp
  • T to C, chromosome 19 at 43,889,651 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8385 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067751-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.