Strain Name:
C57BL/6J-MtgxR8399Btlr/Mmmh
Stock Number:
067762-MU
Citation ID:
RRID:MMRRC_067762-MU
Other Names:
R8399 (G1)
Major Collection:

Strain Information

Chrnb4
Name: cholinergic receptor, nicotinic, beta polypeptide 4
Synonyms: Acrb4, Acrb-4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 108015
VEGA: 9
HGNC: HGNC:1964
Homologene: 20196
Htr1d
Name: 5-hydroxytryptamine (serotonin) receptor 1D
Synonyms: Gpcr14, Htr1db
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15552
HGNC: HGNC:5289
Homologene: 20240
Omd
Name: osteomodulin
Synonyms: SLRR2C, osteoadherin, OSAD
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27047
VEGA: 13
HGNC: HGNC:8134
Homologene: 3677
Dnm1l
Name: dynamin 1-like
Synonyms: Drp1, 6330417M19Rik, Dnmlp1, python
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74006
VEGA: 16
HGNC: HGNC:2973
Homologene: 6384
Plk4
Name: polo like kinase 4
Synonyms: Stk18, Sak
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20873
Homologene: 7962
Trappc9
Name: trafficking protein particle complex 9
Synonyms: 4632408O18Rik, 2900005P22Rik, Nibp, TRS130, 1810044A24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76510
VEGA: 15
Homologene: 81931
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: C130002K18Rik, 5430435M13Rik, 2610207I05Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Plcg2
Name: phospholipase C, gamma 2
Synonyms: Plcg-2, PLCgamma2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234779
HGNC: HGNC:9066
Homologene: 55671
Wdr62
Name: WD repeat domain 62
Synonyms: 2310038K02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233064
Homologene: 15927
Bcl6
Name: B cell leukemia/lymphoma 6
Synonyms: Bcl5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12053
HGNC: HGNC:1001
Homologene: 7640
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: MUCLIN, hensin, ebnerin, CRP-[b], gp300, Crpd, vomeroglandin, CRP-[a]
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Mtmr2
Name: myotubularin related protein 2
Synonyms: 6030445P13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77116
HGNC: HGNC:7450
Homologene: 22951
Zfp68
Name: zinc finger protein 68
Synonyms: KRAZ2, Zfp68, KRAB3, Zfp70
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 24135
Homologene: 56605
Chpf
Name: chondroitin polymerizing factor
Synonyms: 1700028N03Rik, D1Bwg1363e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74241
Homologene: 11574
Pms1
Name: PMS1 homolog 1, mismatch repair system component
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227099
HGNC: HGNC:9121
Homologene: 449
Def8
Name: differentially expressed in FDCP 8
Synonyms: D8Ertd713e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23854
Homologene: 14279
Apba3
Name: amyloid beta precursor protein binding family A member 3
Synonyms: Mint 3, neuron-specific X11L2 protein, X11gamma, lin-10, Mint-3, neuronal munc18-1-interacting protein 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57267
VEGA: 10
HGNC: HGNC:580
Homologene: 3591
Trmt10b
Name: tRNA methyltransferase 10B
Synonyms: 2610042J10Rik, Rg9mtd3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69934
Homologene: 12340
Raph1
Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Synonyms: Lpd, 9430025M21Rik, C730009O10Rik, lamellipodin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77300
Homologene: 71030
Skor1
Name: SKI family transcriptional corepressor 1
Synonyms: C230094B15Rik, Corl1, Lbxcor1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 207667
Homologene: 18175
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, 1500031A17Rik, C530008O15Rik, C630040K21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 665113
Homologene: 77943
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Shn-2, MIBP1, Gm20114, Schnurri-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Pcnx4
Name: pecanex homolog 4
Synonyms: 1810048J11Rik, Pcnxl4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67708
VEGA: 12
Homologene: 23366
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, VLGR1, Gpr98
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Eml1
Name: echinoderm microtubule associated protein like 1
Synonyms: ELP79, heco, A930030P13Rik, 1110008N23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68519
HGNC: HGNC:3330
Homologene: 20931
Ifi207
Name: interferon activated gene 207
Synonyms: AI607873, Pyhin-A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226691
HGNC: HGNC:5395
Homologene: 115929
Rtp4
Name: receptor transporter protein 4
Synonyms: 5830458K16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67775
Homologene: 56944
Frmd4a
Name: FERM domain containing 4A
Synonyms: C230040M21Rik, Gm13190, 2700017I06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209630
Homologene: 9971
Mppe1
Name: metallophosphoesterase 1
Synonyms: Pgap5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225651
VEGA: 18
Homologene: 41512
C1s1
Name: complement component 1, s subcomponent 1
Synonyms: C1s
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50908
HGNC: HGNC:1247
Homologene: 1314
Klra17
Name: killer cell lectin-like receptor, subfamily A, member 17
Synonyms: Ly49q1, Ly-49Q, Ly49Q
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170733
Hck
Name: hemopoietic cell kinase
Synonyms: Bmk, Hck-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15162
HGNC: HGNC:4840
Homologene: 20489
Maf
Name: MAF bZIP transcription factor
Synonyms: A230108G15Rik, c-maf, 2810401A20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17132
HGNC: HGNC:6776
Homologene: 74552
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: B830014K08Rik, very-kind, VKIND, 2410012C07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Tcp11l1
Name: t-complex 11 like 1
Synonyms: C130096D04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320554
Homologene: 41260
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: Gm6976, Gm29096, 5033413D22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Or4a39
Name: olfactory receptor family 4subfamily A member 39
Synonyms: Olfr1238, GA_x6K02T2Q125-50849945-50848998, MOR231-11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258786
Homologene: 128093
Vmn1r49
Name: vomeronasal 1, receptor 49
Synonyms: VRi2, V1r5, V1rb2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 24112
Homologene: 113975
Cers6
Name: ceramide synthase 6
Synonyms: CerS6, similar to TRH1, Lass6, T1L, 4732462C07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241447
Homologene: 72228
Bco2
Name: beta-carotene oxygenase 2
Synonyms: CMO2, beta-diox-II, Bcmo2, B-diox-II, Bcdo2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 170752
Homologene: 12912
Hexim2
Name: hexamethylene bis-acetamide inducible 2
Synonyms: 4933402L21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71059
Homologene: 16946
Nedd9
Name: neural precursor cell expressed, developmentally down-regulated gene 9
Synonyms: E230025G09Rik, Cas-L, HEF1, CasL
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18003
VEGA: 13
HGNC: HGNC:7733
Homologene: 4669
Dnaaf3
Name: dynein, axonemal assembly factor 3
Synonyms: 6030429G01Rik, b2b1739Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 436022
Homologene: 16205
Or12e10
Name: olfactory receptor family 12 subfamily E member 10
Synonyms: GA_x6K02T2Q125-49311440-49312384, MOR264-19, Olfr1145
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258317
Homologene: 27123
Pecr
Name: peroxisomal trans-2-enoyl-CoA reductase
Synonyms: 2400003B18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 111175
Homologene: 69255
Vmn1r224
Name: vomeronasal 1 receptor 224
Synonyms: Gm7673
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665525
Homologene: 85978
Kctd14
Name: potassium channel tetramerisation domain containing 14
Synonyms: D7Ertd760e, AI449310
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233529
Homologene: 11396
Vmn2r35
Name: vomeronasal 2, receptor 35
Synonyms: EG625353
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 625353
Homologene: 113703
Cox6a1
Name: cytochrome c oxidase subunit 6A1
Synonyms: VIaL, subunit VIaL (liver-type)
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12861
HGNC: HGNC:2277
Homologene: 3219
Ighv7-1
Name: immunoglobulin heavy variable 7-1
Synonyms: Gm16698
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 780799
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 53,267,932 bp
  • C to T, chromosome 1 at 60,489,318 bp
  • G to A, chromosome 1 at 72,267,465 bp
  • T to C, chromosome 1 at 75,476,220 bp
  • G to A, chromosome 1 at 173,730,278 bp
  • T to C, chromosome 2 at 4,572,433 bp
  • T to C, chromosome 2 at 68,861,771 bp
  • A to C, chromosome 2 at 87,810,224 bp
  • T to C, chromosome 2 at 89,406,684 bp
  • T to C, chromosome 2 at 104,685,375 bp
  • A to C, chromosome 2 at 153,138,317 bp
  • T to A, chromosome 3 at 28,494,010 bp
  • C to T, chromosome 3 at 40,808,830 bp
  • A to T, chromosome 4 at 45,305,870 bp
  • G to A, chromosome 4 at 136,443,375 bp
  • T to C, chromosome 5 at 115,345,899 bp
  • A to T, chromosome 5 at 138,607,820 bp
  • A to T, chromosome 6 at 90,072,707 bp
  • C to T, chromosome 6 at 124,535,293 bp
  • T to C, chromosome 6 at 129,874,937 bp
  • C to T, chromosome 7 at 4,523,937 bp
  • A to C, chromosome 7 at 7,816,898 bp
  • T to C, chromosome 7 at 30,258,061 bp
  • T to C, chromosome 7 at 97,457,604 bp
  • T to C, chromosome 7 at 118,190,571 bp
  • C to G, chromosome 7 at 131,082,587 bp
  • C to T, chromosome 7 at 139,913,518 bp
  • C to T, chromosome 8 at 109,623,888 bp
  • T to A, chromosome 8 at 115,706,512 bp
  • T to C, chromosome 8 at 117,596,362 bp
  • T to A, chromosome 8 at 123,455,499 bp
  • T to A, chromosome 9 at 13,792,067 bp
  • T to A, chromosome 9 at 50,541,118 bp
  • A to C, chromosome 9 at 55,043,823 bp
  • C to T, chromosome 9 at 63,145,158 bp
  • T to C, chromosome 10 at 14,132,434 bp
  • T to A, chromosome 10 at 41,539,521 bp
  • C to A, chromosome 10 at 81,268,998 bp
  • G to T, chromosome 11 at 103,138,503 bp
  • T to A, chromosome 12 at 72,574,211 bp
  • G to A, chromosome 12 at 108,538,131 bp
  • G to A, chromosome 12 at 113,896,912 bp
  • A to G, chromosome 12 at 114,612,427 bp
  • G to T, chromosome 13 at 41,318,474 bp
  • A to G, chromosome 13 at 49,589,869 bp
  • A to T, chromosome 13 at 81,489,170 bp
  • G to A, chromosome 15 at 73,052,282 bp
  • T to A, chromosome 16 at 16,321,672 bp
  • G to T, chromosome 16 at 23,520,414 bp
  • T to C, chromosome 16 at 23,972,948 bp
  • T to A, chromosome 17 at 20,419,749 bp
  • T to C, chromosome 18 at 67,225,875 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8399 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067762-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.