Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR8415Btlr/Mmmh
Stock Number:
067769-MU
Citation ID:
RRID:MMRRC_067769-MU
Other Names:
R8415 (G1)
Major Collection:

Strain Information

Hdgfl2
Name: HDGF like 2
Synonyms: HRP-2, Hdgfrp2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15193
VEGA: 17
Homologene: 7355
Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: CalDAG-GEFI, Caldaggef1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Dpagt1
Name: dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
Synonyms: GPT, Dpagt2, Gnpta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13478
VEGA: 9
HGNC: HGNC:2995
Homologene: 1058
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50492
Homologene: 55726
Utp20
Name: UTP20 small subunit processome component
Synonyms: mDRIM, DRIM, 3830408P06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Phf20
Name: PHD finger protein 20
Synonyms: 6820402O20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228829
Homologene: 9507
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Zc3hc1
Name: zinc finger, C3HC type 1
Synonyms: 1110054L24Rik, HSPC216, Nipa
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232679
Homologene: 32315
Tead1
Name: TEA domain family member 1
Synonyms: mTEF-1, TEF-1, TEAD-1, Tcf13, Gtrgeo5, B230114H05Rik, 2610024B07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21676
Homologene: 2418
Mettl25
Name: methyltransferase like 25
Synonyms: BC067068
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216292
Homologene: 32774
Git2
Name: GIT ArfGAP 2
Synonyms: Cool associated tyrosine phosphorylated-2, Cat-2, ARF GTPase activating protein 2, 5830420E16Rik, B230104M05Rik, 1500036H07Rik, 9630056M03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26431
HGNC: HGNC:4273
Homologene: 41336
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Sh3d19
Name: SH3 domain protein D19
Synonyms: Kryn
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 27059
Homologene: 19064
Glyr1
Name: glyoxylate reductase 1 homolog (Arabidopsis)
Synonyms: Npac, 2810419J22Rik, 3930401K13Rik, NDF
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74022
VEGA: 16
Homologene: 12525
St7
Name: suppression of tumorigenicity 7
Synonyms: RAY1, HELG, SEN4, TSG7, Fam4a2, 9430001H04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64213
Homologene: 10185
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, heb, QBRICK, crf11, eyes2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Rnd2
Name: Rho family GTPase 2
Synonyms: Arhn, Rohn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11858
Homologene: 21123
Nup85
Name: nucleoporin 85
Synonyms: frount, Pcnt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 445007
HGNC: HGNC:8734
Homologene: 11755
Twf1
Name: twinfilin actin binding protein 1
Synonyms: A6, actin monomer-binding protein, twinfilin, Twinfilin-1, Ptk9
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19230
HGNC: HGNC:9620
Homologene: 48140
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Snx29
Name: sorting nexin 29
Synonyms: LOC381035, LOC385605, 4933437K13Rik, Gm11170, Rundc2a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74478
Homologene: 32706
Cnot3
Name: CCR4-NOT transcription complex, subunit 3
Synonyms: A930039N10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232791
HGNC: HGNC:7879
Homologene: 133900
Map1s
Name: microtubule-associated protein 1S
Synonyms: VCY2IP1, 6430517J16Rik, Bpy2ip1, Map8, Mtap1s
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270058
Homologene: 10047
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239102
Homologene: 52657
Peg10
Name: paternally expressed 10
Synonyms: MEF3L, HB-1, MyEF-3, MyEF-3 like, Edr, Mart2, Mar2, Rtl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
Pitpnm1
Name: phosphatidylinositol transfer protein, membrane-associated 1
Synonyms: RdgB, DRES9
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18739
HGNC: HGNC:9003
Homologene: 3608
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Bnip2
Name: BCL2/adenovirus E1B interacting protein 2
Synonyms: 5730523P12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12175
HGNC: HGNC:1083
Homologene: 3194
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alpha myosin, Myhc-a, alpha cardiac MHC, cardiomyopathy, hypertrophic 1, Myhca, A830009F23Rik, alpha-MHC, alphaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Slc7a2
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Synonyms: Tea, Atrc2, Cat2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11988
Homologene: 20659
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Nlrp9a
Name: NLR family, pyrin domain containing 9A
Synonyms: D7Ertd565e, Nalp9a, Nalp-theta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233001
Homologene: 116072
Pter
Name: phosphotriesterase related
Synonyms: Mpr56-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19212
HGNC: HGNC:9590
Homologene: 7495
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546071
Homologene: 66191
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-2, Aox-1, Aox2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Nat8f2
Name: N-acetyltransferase 8 (GCN5-related) family member 2
Synonyms: Cml2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93673
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: Cryabp1, alphaA-CRYBP1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Ift140
Name: intraflagellar transport 140
Synonyms: Wdtc2, Tce5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106633
Homologene: 40979
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: mDGK[z], E130307B02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Or7e170
Name: olfactory receptor family 7 subfamily E member 170
Synonyms: GA_x6K02T2PVTD-13624132-13623212, MOR146-1, Olfr862
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258555
Homologene: 115540
Ankrd24
Name: ankyrin repeat domain 24
Synonyms: 5730519E19Rik, 4631433D01Rik, D10Bur2e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70615
Homologene: 49885
Pcdhb2
Name: protocadherin beta 2
Synonyms: PcdhbB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93873
HGNC: HGNC:8687
Homologene: 69266
Zfp267
Name: zinc finger protein 267
Synonyms: D3Ertd254e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241944
Homologene: 117700
Muc17
Name: mucin 17, cell surface associated
Synonyms: Muc3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666339
Homologene: 141159
Or5p79
Name: olfactory receptor family 5 subfamily P member 79
Synonyms: GA_x6K02T2PBJ9-10951546-10952496, MOR204-7, Olfr507
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258738
Homologene: 27249
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG668547, Vmn2r119, EG383258
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 383258
Homologene: 129687
Cntnap3
Name: contactin associated protein-like 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238680
VEGA: 13
Homologene: 129602
Ctnna3
Name: catenin alpha 3
Synonyms: Vr22, Catna3, 4930429L08Rik, alphaT-catenin, catenin (cadherin associated protein), alpha 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216033
HGNC: HGNC:2511
Homologene: 56583
Lrtm2
Name: leucine-rich repeats and transmembrane domains 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211187
Homologene: 65244
Tas2r115
Name: taste receptor, type 2, member 115
Synonyms: Tas2r15, mGR15, mt2r49, T2R15
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353325
Uck1
Name: uridine-cytidine kinase 1
Synonyms: URK1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22245
Homologene: 7990
Krt28
Name: keratin 28
Synonyms: 4733401L19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70843
Homologene: 124711
Dnaaf6rt
Name: dynein axonemal assembly factor 6, retrotransposed
Synonyms: 4930521A18Rik, Pih1d3, Dnaaf6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74708
Homologene: 16553
Vmn2r30
Name: vomeronasal 2, receptor 30
Synonyms: V2r15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22306
Homologene: 113703
Wfdc15a
Name: WAP four-disulfide core domain 15A
Synonyms: Wfdcl1, 1700049M11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68221
Homologene: 77715
Or4c99
Name: olfactory receptor family 4 subfamily C member 99
Synonyms: GA_x6K02T2Q125-49986553-49987462, MOR230-11, MOR230-10P, Olfr1185
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258059
Eppk1
Name: epiplakin 1
Synonyms: EPIPL1, EPPK
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223650
VEGA: 15
Homologene: 20006
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 31,223,483 bp
  • A to T, chromosome 1 at 58,041,479 bp
  • A to G, chromosome 2 at 13,000,889 bp
  • C to A, chromosome 2 at 31,391,076 bp
  • C to A, chromosome 2 at 32,260,141 bp
  • T to A, chromosome 2 at 88,499,366 bp
  • A to T, chromosome 2 at 91,940,304 bp
  • C to T, chromosome 2 at 156,287,993 bp
  • C to T, chromosome 2 at 156,526,953 bp
  • A to T, chromosome 2 at 164,199,751 bp
  • G to A, chromosome 3 at 36,165,033 bp
  • T to A, chromosome 3 at 86,085,056 bp
  • T to G, chromosome 4 at 83,000,262 bp
  • A to T, chromosome 4 at 145,091,979 bp
  • T to A, chromosome 5 at 108,216,033 bp
  • T to C, chromosome 5 at 114,733,928 bp
  • A to G, chromosome 5 at 137,143,950 bp
  • T to TCCA, chromosome 6 at 4,756,451 bp
  • T to C, chromosome 6 at 17,848,081 bp
  • T to C, chromosome 6 at 30,375,952 bp
  • A to G, chromosome 6 at 85,868,042 bp
  • A to T, chromosome 6 at 119,317,497 bp
  • A to G, chromosome 6 at 132,737,835 bp
  • T to C, chromosome 7 at 3,658,688 bp
  • A to T, chromosome 7 at 7,312,360 bp
  • A to T, chromosome 7 at 26,557,500 bp
  • C to T, chromosome 7 at 108,621,956 bp
  • C to A, chromosome 7 at 112,856,928 bp
  • A to T, chromosome 8 at 40,916,359 bp
  • A to G, chromosome 8 at 70,781,222 bp
  • G to A, chromosome 8 at 70,913,266 bp
  • G to A, chromosome 8 at 110,451,994 bp
  • T to A, chromosome 9 at 19,884,113 bp
  • C to A, chromosome 9 at 44,327,185 bp
  • T to C, chromosome 9 at 70,003,685 bp
  • G to A, chromosome 9 at 108,111,452 bp
  • A to G, chromosome 10 at 63,504,130 bp
  • A to G, chromosome 10 at 81,078,551 bp
  • A to G, chromosome 10 at 81,640,113 bp
  • A to G, chromosome 10 at 88,826,604 bp
  • G to T, chromosome 10 at 105,826,141 bp
  • T to A, chromosome 11 at 99,374,800 bp
  • A to T, chromosome 11 at 101,471,185 bp
  • A to G, chromosome 11 at 115,566,642 bp
  • A to T, chromosome 12 at 85,269,080 bp
  • T to C, chromosome 13 at 42,155,429 bp
  • A to G, chromosome 13 at 64,738,665 bp
  • C to G, chromosome 14 at 54,944,378 bp
  • G to T, chromosome 14 at 55,070,622 bp
  • A to G, chromosome 15 at 76,111,631 bp
  • T to C, chromosome 15 at 94,579,821 bp
  • T to C, chromosome 16 at 5,036,465 bp
  • T to C, chromosome 16 at 11,447,427 bp
  • A to G, chromosome 17 at 25,092,915 bp
  • G to T, chromosome 17 at 55,608,057 bp
  • C to T, chromosome 17 at 56,093,712 bp
  • A to T, chromosome 18 at 20,523,708 bp
  • A to G, chromosome 18 at 37,296,057 bp
  • T to C, chromosome 19 at 4,105,454 bp
  • T to G, chromosome 19 at 6,404,751 bp
  • C to T, chromosome 19 at 37,995,424 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8415 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067769-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.