Strain Name:
C57BL/6J-MtgxR8183Btlr/Mmmh
Stock Number:
067781-MU
Citation ID:
RRID:MMRRC_067781-MU
Other Names:
R8183 (G1)
Major Collection:

Strain Information

Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk2, Tsk-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Ifi203
Name: interferon activated gene 203
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15950
HGNC: HGNC:5395
Homologene: 115929
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Zmym1
Name: zinc finger, MYM domain containing 1
Synonyms: 5830412B09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68310
Homologene: 32904
Tnpo3
Name: transportin 3
Synonyms: D6Ertd313e, 5730544L10Rik, C430013M08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320938
Homologene: 40848
B3gnt2
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Synonyms: B3Galt6, B3gnt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53625
Homologene: 4797
Ints9
Name: integrator complex subunit 9
Synonyms: D14Ertd231e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 210925
VEGA: 14
Homologene: 10096
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Ago2
Name: argonaute RISC catalytic subunit 2
Synonyms: 2310051F07Rik, argonaute 2, Eif2c2, 1110029L17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239528
HGNC: HGNC:3263
Homologene: 81825
Gtf2ird1
Name: general transcription factor II I repeat domain-containing 1
Synonyms: binding factor for early enhancer, ESTM9, Cream1, MusTRD1, GTF3, WBSCR11, BEN
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57080
HGNC: HGNC:4661
Homologene: 4158
Sec23b
Name: SEC23 homolog B, COPII coat complex component
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27054
Homologene: 74571
Dcdc2a
Name: doublecortin domain containing 2a
Synonyms: RU2, Dcdc2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195208
Homologene: 9483
Krt33a
Name: keratin 33A
Synonyms: 2310015J09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71888
Homologene: 74433
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, D930005K06Rik, Zubr1, p600, 1810009A16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Cst9
Name: cystatin 9
Synonyms: cresp, testatin, M12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13013
Homologene: 49222
Metap1d
Name: methionyl aminopeptidase type 1D (mitochondrial)
Synonyms: Metapl1, 2310066F24Rik, 3110033D18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66559
Homologene: 11987
Cand2
Name: cullin associated and neddylation dissociated 2 (putative)
Synonyms: 2210404G23Rik, Tp120b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67088
Homologene: 41657
Ppil1
Name: peptidylprolyl isomerase (cyclophilin)-like 1
Synonyms: Cypl1, 1110060O10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68816
HGNC: HGNC:9260
Homologene: 9367
Cxxc1
Name: CXXC finger protein 1
Synonyms: 5830420C16Rik, Cgbp, Cfp1, 2410002I16Rik, PHF18, CXXC finger 1 (PHD domain)
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74322
VEGA: 18
Homologene: 32221
Lonrf1
Name: LON peptidase N-terminal domain and ring finger 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244421
Homologene: 34980
Hpse
Name: heparanase
Synonyms: Hpa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15442
HGNC: HGNC:5164
Homologene: 68528
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: Trrp6, mtrp6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Trappc11
Name: trafficking protein particle complex 11
Synonyms: D030016E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320714
Homologene: 11076
Snrpn
Name: small nuclear ribonucleoprotein N
Synonyms: Peg4, 2410045I01Rik, Pwcr1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20646
Homologene: 68297
Serpina3j
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J
Synonyms: alpha-1 antiproteinase, Gm4931
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238395
HGNC: HGNC:16
Homologene: 120222
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: IId, IId/x, Myhs-f2, A530084A17Rik, MyHC-IId/x, Myhs-f, Myhsf2, MYHC-IIX, myosin heavy chain 2X
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Urah
Name: urate (5-hydroxyiso-) hydrolase
Synonyms: HIU hydrolase, 2810420C16Rik, 1190003J15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76974
Homologene: 45975
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: Adlican2, CMF608, 6530405F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Osbpl6
Name: oxysterol binding protein-like 6
Synonyms: 1110062M20Rik, ORP-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99031
Homologene: 101447
Myo15b
Name: myosin XVB
Synonyms: LOC380737, E330039G21Rik, LOC217328
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217328
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: mDGK[z], E130307B02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: Prss7, enterokinase, A130097D21Rik, enteropeptidase
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Slc6a7
Name: solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
Synonyms: Prot
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240332
VEGA: 18
Homologene: 8592
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Kcnh7
Name: potassium voltage-gated channel, subfamily H (eag-related), member 7
Synonyms: Kv11.3, erg3, 9330137I11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170738
Homologene: 13249
Gzmc
Name: granzyme C
Synonyms: CCP2, Ctla5, Ctla-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14940
VEGA: 14
HGNC: HGNC:4709
Homologene: 105844
Dpy19l3
Name: dpy-19 like C-mannosyltransferase 3
Synonyms: 9330164H19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233115
Homologene: 18692
Mefv
Name: Mediterranean fever
Synonyms: marenostrin, FMF, pyrin, TRIM20
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 54483
VEGA: 16
HGNC: HGNC:6998
Homologene: 32441
Col20a1
Name: collagen, type XX, alpha 1
Synonyms: 1700051I12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73368
Homologene: 75138
Bpifa1
Name: BPI fold containing family A, member 1
Synonyms: Plunc, SPLUNC1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18843
Homologene: 7895
Osbpl3
Name: oxysterol binding protein-like 3
Synonyms: OSBP3, 6720421I08Rik, ORP3, 1200014M06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71720
Homologene: 49422
Clns1a
Name: chloride channel, nucleotide-sensitive, 1A
Synonyms: ICLN, 2610100O04Rik, Clci, Clcni, 2610036D06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12729
HGNC: HGNC:2080
Homologene: 990
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665255
Homologene: 129605
Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
Synonyms: Itih-3, Intin3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16426
HGNC: HGNC:6168
Homologene: 1669
Art1
Name: ADP-ribosyltransferase 1
Synonyms: Yac-1, ADPRT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11870
HGNC: HGNC:723
Homologene: 128621
Ftcd
Name: formiminotransferase cyclodeaminase
Synonyms: glutamate formiminotransferase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14317
HGNC: HGNC:3974
Homologene: 4848
Or10q12
Name: olfactory receptor family 10 subfamily Q member 12
Synonyms: Olfr1495, GA_x6K02T2RE5P-4101369-4102328, MOR266-9
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258341
Homologene: 73965
Plscr5
Name: phospholipid scramblase family, member 5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100504689
Homologene: 28688
Inadl
Name:
Type: Gene
Species: Mouse
Chromosome: 4
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to G, chromosome 1 at 45,334,810 bp
  • T to C, chromosome 1 at 97,834,474 bp
  • T to C, chromosome 1 at 172,289,351 bp
  • A to G, chromosome 1 at 173,928,700 bp
  • T to C, chromosome 2 at 62,702,977 bp
  • T to A, chromosome 2 at 71,506,863 bp
  • C to T, chromosome 2 at 76,585,060 bp
  • C to A, chromosome 2 at 91,939,592 bp
  • G to T, chromosome 2 at 144,559,269 bp
  • G to A, chromosome 2 at 148,836,714 bp
  • A to G, chromosome 2 at 154,146,119 bp
  • T to C, chromosome 2 at 180,998,414 bp
  • A to T, chromosome 3 at 59,330,615 bp
  • A to C, chromosome 4 at 98,674,229 bp
  • T to C, chromosome 4 at 127,058,856 bp
  • T to G, chromosome 4 at 139,482,471 bp
  • T to A, chromosome 5 at 100,685,118 bp
  • T to C, chromosome 5 at 134,357,835 bp
  • T to G, chromosome 5 at 144,828,533 bp
  • A to T, chromosome 6 at 29,558,759 bp
  • C to A, chromosome 6 at 50,303,109 bp
  • A to G, chromosome 6 at 115,791,918 bp
  • A to T, chromosome 7 at 5,488,148 bp
  • A to G, chromosome 7 at 35,695,389 bp
  • A to G, chromosome 7 at 59,985,082 bp
  • A to G, chromosome 7 at 97,705,681 bp
  • A to T, chromosome 7 at 102,107,426 bp
  • A to T, chromosome 7 at 140,836,794 bp
  • A to T, chromosome 8 at 36,222,665 bp
  • T to G, chromosome 8 at 47,529,356 bp
  • T to C, chromosome 9 at 8,653,149 bp
  • A to G, chromosome 9 at 92,198,602 bp
  • T to A, chromosome 10 at 76,575,707 bp
  • T to A, chromosome 11 at 22,836,373 bp
  • A to T, chromosome 11 at 67,202,006 bp
  • A to G, chromosome 11 at 100,014,749 bp
  • T to G, chromosome 11 at 115,883,017 bp
  • C to A, chromosome 12 at 104,318,495 bp
  • T to C, chromosome 13 at 25,107,650 bp
  • T to C, chromosome 13 at 55,312,373 bp
  • A to G, chromosome 14 at 30,909,476 bp
  • A to T, chromosome 14 at 56,232,707 bp
  • T to C, chromosome 14 at 65,036,453 bp
  • T to A, chromosome 15 at 73,119,488 bp
  • C to T, chromosome 16 at 3,708,582 bp
  • T to C, chromosome 16 at 79,087,512 bp
  • A to T, chromosome 17 at 29,262,079 bp
  • T to C, chromosome 18 at 61,007,376 bp
  • T to C, chromosome 18 at 74,220,357 bp
  • T to A, chromosome 19 at 13,768,722 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8183 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067781-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.