Strain Name:
C57BL/6J-MtgxR8299Btlr/Mmmh
Stock Number:
067787-MU
Citation ID:
RRID:MMRRC_067787-MU
Other Names:
R8299 (G1)
Major Collection:

Strain Information

Ednrb
Name: endothelin receptor type B
Synonyms: ETb, ETR-b, Sox10m1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13618
VEGA: 14
HGNC: HGNC:3180
Homologene: 89
Cep70
Name: centrosomal protein 70
Synonyms: 6720484E09Rik, C030018L16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68121
Homologene: 11387
Morc3
Name: microrchidia 3
Synonyms: D16Jhu32e, 1110051N18Rik, 1110051N18Rik, Zcwcc3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 338467
Homologene: 32257
Aspscr1
Name: ASPSCR1 tether for SLC2A4, UBX domain containing
Synonyms: TUG, 1190006K01Rik, RCC17, ASPL, ASPC, ASPCR1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68938
Homologene: 41550
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, Skt, E330027G05Rik, 9430077C05Rik, Sickle tail, 6620402G01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, Ki67, D630048A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Epha8
Name: Eph receptor A8
Synonyms: Eek, EphA8, Hek3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ankyrin-G, Ank-3, Ankyrin-3, 2900054D09Rik, AnkG
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Dctn4
Name: dynactin 4
Synonyms: p62, C130039E17Rik, 1110001K06Rik, 4930547K17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67665
VEGA: 18
Homologene: 9430
Bora
Name: bora, aurora kinase A activator
Synonyms: 6720463M24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 77744
VEGA: 14
Homologene: 11728
Strn3
Name: striatin, calmodulin binding protein 3
Synonyms: SG2NA
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 94186
VEGA: 12
Homologene: 82078
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: 2400004E04Rik, NMHC II-C
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71960
Homologene: 23480
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, LOC381026, 9330188B09Rik, D630001M17Rik, 4921513O20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66725
Homologene: 18982
Atp13a3
Name: ATPase type 13A3
Synonyms: LOC385637, LOC224088, LOC224087
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224088
Homologene: 23455
Klhl12
Name: kelch-like 12
Synonyms: C3ip1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240756
Homologene: 23317
Susd1
Name: sushi domain containing 1
Synonyms: Gm12528
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 634731
Homologene: 11204
Cdh19
Name: cadherin 19, type 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227485
HGNC: HGNC:1758
Homologene: 23286
Stk11
Name: serine/threonine kinase 11
Synonyms: Par-4, Lkb1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20869
Homologene: 393
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 2610202E01Rik, 8030475K17Rik, A330041G23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Mtcl2
Name: microtubule crosslinking factor 2
Synonyms: 9830001H06Rik, Soga1, D430036N24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320706
Homologene: 52382
Sf3a1
Name: splicing factor 3a, subunit 1
Synonyms: 5930416L09Rik, 1200014H24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67465
Homologene: 4294
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Or51a6
Name: olfactory receptor family 51 subfamily A member 6
Synonyms: GA_x6K02T2PBJ9-5666843-5665908, Olfr575, MOR8-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259118
Homologene: 122786
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: fibrocystin L, PKHDL1, D86 mRNA
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Plcb1
Name: phospholipase C, beta 1
Synonyms: 3110043I21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18795
Homologene: 22876
Cntnap4
Name: contactin associated protein-like 4
Synonyms: Caspr4, E130114F09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170571
Homologene: 24912
Clstn3
Name: calsyntenin 3
Synonyms: Cst-3, CSTN3, alcadein-beta, Clstn3b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232370
Homologene: 22836
Hltf
Name: helicase-like transcription factor
Synonyms: Smarca3, P113, Snf2l3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20585
Homologene: 30136
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
St18
Name: suppression of tumorigenicity 18
Synonyms: Myt3, Nzf3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240690
Homologene: 8792
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21974
Homologene: 134711
Or10al5
Name: olfactory receptor family 10 subfamily AL member 5
Synonyms: MOR263-4, Olfr121, GA_x6K02T2PSCP-2211113-2212078
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258622
Homologene: 17195
Speg
Name: SPEG complex locus
Synonyms: SPEGalpha, SPEG, D1Bwg1450e, Apeg1, SPEGbeta, BPEG
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Csf2rb
Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Synonyms: AIC2B, Il3rb1, beta c, Bc, CDw131, Csf2rb1, Il3r, common beta chain, Il5rb
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12983
VEGA: 15
HGNC: HGNC:2436
Homologene: 339
Rims3
Name: regulating synaptic membrane exocytosis 3
Synonyms: A730060M23Rik, Rim3, Nim3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242662
Homologene: 8837
Plxnc1
Name: plexin C1
Synonyms: vespr, CD232, 2510048K12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Synonyms: Park2, PRKN, Parkin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50873
HGNC: HGNC:8607
Homologene: 3355
Pcdhb17
Name: protocadherin beta 17
Synonyms: Pcdhb16, PcdhbQ
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93888
Homologene: 81881
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: EG629699, 2610204M08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
S1pr4
Name: sphingosine-1-phosphate receptor 4
Synonyms: lpC1, S1P4, Edg6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13611
VEGA: 10
HGNC: HGNC:3170
Homologene: 2799
Slc30a9
Name: solute carrier family 30 (zinc transporter), member 9
Synonyms: GAC63, 2310024J23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109108
HGNC: HGNC:1329
Homologene: 4627
Elovl2
Name: ELOVL fatty acid elongase 2
Synonyms: Ssc2, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 54326
Homologene: 23042
Or55b4
Name: olfactory receptor family 55 subfamily B member 4
Synonyms: Olfr544, GA_x6K02T2PBJ9-5206624-5205620, MOR42-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257926
Homologene: 133590
Or6c66
Name: olfactory receptor family 6 subfamily C member 66
Synonyms: GA_x6K02T2PULF-11304679-11303744, MOR108-1, Olfr798
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258549
Homologene: 133881
Tmem115
Name: transmembrane protein 115
Synonyms: Pl6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56395
Homologene: 135207
Gadd45a
Name: growth arrest and DNA-damage-inducible 45 alpha
Synonyms: Ddit1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13197
HGNC: HGNC:4095
Homologene: 1449
Slc35a4
Name: solute carrier family 35, member A4
Synonyms: 2610030J16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67843
Homologene: 12195
Wfikkn2
Name: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Synonyms: 2610304F08Rik, Gasp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 278507
Homologene: 35284
Mcee
Name: methylmalonyl CoA epimerase
Synonyms: 1110007A04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73724
Homologene: 13078
Gfod2
Name: glucose-fructose oxidoreductase domain containing 2
Synonyms: 5730466C23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70575
Homologene: 10361
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 6,802,992 bp
  • A to C, chromosome 1 at 75,387,836 bp
  • A to G, chromosome 1 at 110,919,548 bp
  • G to A, chromosome 1 at 134,488,940 bp
  • T to A, chromosome 2 at 20,744,063 bp
  • T to C, chromosome 2 at 135,335,476 bp
  • T to G, chromosome 2 at 157,020,731 bp
  • A to G, chromosome 3 at 20,082,822 bp
  • T to C, chromosome 3 at 97,205,536 bp
  • C to T, chromosome 4 at 59,315,773 bp
  • T to C, chromosome 4 at 120,889,372 bp
  • G to T, chromosome 4 at 136,938,586 bp
  • T to C, chromosome 4 at 143,950,757 bp
  • T to A, chromosome 5 at 67,326,905 bp
  • A to G, chromosome 6 at 67,037,199 bp
  • A to G, chromosome 6 at 124,437,373 bp
  • T to A, chromosome 7 at 44,627,048 bp
  • G to A, chromosome 7 at 64,411,873 bp
  • T to C, chromosome 7 at 102,484,202 bp
  • T to C, chromosome 7 at 102,955,532 bp
  • A to T, chromosome 7 at 135,704,620 bp
  • T to C, chromosome 8 at 105,728,162 bp
  • G to A, chromosome 8 at 112,773,692 bp
  • A to T, chromosome 9 at 99,262,861 bp
  • T to C, chromosome 9 at 107,534,546 bp
  • C to T, chromosome 10 at 39,821,541 bp
  • C to A, chromosome 10 at 69,976,151 bp
  • G to T, chromosome 10 at 80,128,033 bp
  • A to G, chromosome 10 at 81,499,433 bp
  • T to A, chromosome 10 at 94,827,179 bp
  • T to C, chromosome 10 at 129,625,960 bp
  • T to C, chromosome 11 at 4,179,420 bp
  • C to T, chromosome 11 at 94,239,064 bp
  • T to C, chromosome 11 at 120,709,074 bp
  • A to G, chromosome 12 at 51,648,107 bp
  • A to G, chromosome 12 at 112,604,112 bp
  • T to C, chromosome 13 at 41,191,920 bp
  • A to G, chromosome 14 at 16,386,123 bp
  • T to C, chromosome 14 at 50,868,045 bp
  • G to A, chromosome 14 at 99,068,134 bp
  • A to G, chromosome 14 at 103,823,500 bp
  • T to C, chromosome 15 at 44,581,934 bp
  • T to A, chromosome 15 at 78,346,469 bp
  • A to T, chromosome 15 at 91,673,240 bp
  • A to C, chromosome 16 at 30,333,801 bp
  • A to G, chromosome 16 at 32,755,897 bp
  • T to C, chromosome 16 at 93,853,200 bp
  • T to G, chromosome 17 at 11,237,521 bp
  • G to T, chromosome 17 at 37,752,000 bp
  • T to C, chromosome 18 at 36,682,927 bp
  • T to C, chromosome 18 at 37,485,355 bp
  • T to A, chromosome 18 at 60,545,800 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8299 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067787-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.