Strain Name:
C57BL/6J-MtgxR8304Btlr/Mmmh
Stock Number:
067791-MU
Citation ID:
RRID:MMRRC_067791-MU
Other Names:
R8304 (G1)
Major Collection:

Strain Information

Irx3
Name: Iroquois related homeobox 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16373
Homologene: 7385
Tfg
Name: Trk-fused gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21787
Homologene: 4426
Cltc
Name: clathrin heavy chain
Synonyms: CHC
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 2310022G15Rik, 5033407O22Rik, 4833414K03Rik, CHAK1, LTRPC7, CHAK, TRP-PLIK, Ltpr7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: 2900001A12Rik, ANCO-2, GAC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106585
Homologene: 9059
Hspbap1
Name: Hspb associated protein 1
Synonyms: 3830421G21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66667
VEGA: 16
Homologene: 11617
Ttc17
Name: tetratricopeptide repeat domain 17
Synonyms: D2Bwg1005e, 9130020K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74569
Homologene: 10100
Hmmr
Name: hyaluronan mediated motility receptor (RHAMM)
Synonyms: CD168, Rhamm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15366
HGNC: HGNC:5012
Homologene: 8271
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F37S1, D7H15F32S1, rjs, jdf2, D15F32S1h
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Caprin1
Name: cell cycle associated protein 1
Synonyms: RNG105, Gpiap1, caprin-1, MMGPIP137
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53872
HGNC: HGNC:6743
Homologene: 4310
Opa1
Name: OPA1, mitochondrial dynamin like GTPase
Synonyms: 1200011N24Rik, lilr3, optic atrophy 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74143
HGNC: HGNC:8140
Homologene: 14618
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, PX-RICS, 3426406O18Rik, Grit, GC-GAP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330914
Homologene: 8812
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Sh3bgrl3
Name: SH3 domain binding glutamic acid-rich protein-like 3
Synonyms: 1110004L05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73723
Homologene: 41824
Stim1
Name: stromal interaction molecule 1
Synonyms: SIM
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20866
Homologene: 20681
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: D14Ertd171e, CAST, ELKS2alpha
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 238988
Homologene: 69188
P3h1
Name: prolyl 3-hydroxylase 1
Synonyms: Leprecan, Gros1, 2410024C15Rik, Lepre1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56401
Homologene: 10509
Cul4a
Name: cullin 4A
Synonyms: 2810470J21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 99375
HGNC: HGNC:2554
Homologene: 81724
Eif5b
Name: eukaryotic translation initiation factor 5B
Synonyms: IF2, A030003E17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226982
Homologene: 134613
Akap11
Name: A kinase anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Tmtc1
Name: transmembrane and tetratricopeptide repeat containing 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387314
Homologene: 65299
Amigo2
Name: adhesion molecule with Ig like domain 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105827
VEGA: 15
Homologene: 18649
Ppp1r12b
Name: protein phosphatase 1, regulatory subunit 12B
Synonyms: 9530009M10Rik, 1810037O03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329251
HGNC: HGNC:7619
Homologene: 135710
Prkg1
Name: protein kinase, cGMP-dependent, type I
Synonyms: Prkgr1b, Prkg1b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19091
HGNC: HGNC:9414
Homologene: 55964
Slc25a47
Name: solute carrier family 25, member 47
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104910
VEGA: 12
Homologene: 64441
Nlgn1
Name: neuroligin 1
Synonyms: 6330415N05Rik, NL1, Nlg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192167
Homologene: 56690
Eral1
Name: Era like 12S mitochondrial rRNA chaperone 1
Synonyms: 9130407C09Rik, 2610524P08Rik, MERA-W, MERA-S
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57837
HGNC: HGNC:3424
Homologene: 4167
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77480
VEGA: 12
Homologene: 14254
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: Myhsp, Myhs-p, 4832426G23Rik, MyHC-pn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Kcns1
Name: K+ voltage-gated channel, subfamily S, 1
Synonyms: Kv9.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16538
HGNC: HGNC:6300
Homologene: 20517
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Taf5l
Name: TATA-box binding protein associated factor 5 like
Synonyms: 1110005N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102162
Homologene: 8676
Zfp282
Name: zinc finger protein 282
Synonyms: HUB1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101095
Homologene: 2647
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Pak5
Name: p21 (RAC1) activated kinase 5
Synonyms: Pak7, Pak5, 2900083L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241656
Homologene: 22211
Or8b57
Name: olfactory receptor family 8 subfamily B member 57
Synonyms: Olfr983, GA_x6K02T2PVTD-33790948-33790013, MOR162-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258824
VEGA: 9
Homologene: 121547
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: Gm1557, 4930503E15Rik, LOC380658
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74978
Homologene: 46007
Abca9
Name: ATP-binding cassette, sub-family A member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192187
Homologene: 9035
Zfp770
Name: zinc finger protein 770
Synonyms: 6430601A21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228491
Homologene: 82354
Or2r2
Name: olfactory receptor family 2 subfamily R member 2
Synonyms: MOR257-7P, Olfr456, GA_x6K02T2P3E9-5073878-5074816
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259144
Homologene: 79406
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Tesc
Name: tescalcin
Synonyms: TE-1, 1010001A17Rik, 2410011K10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57816
Homologene: 75158
Armc2
Name: armadillo repeat containing 2
Synonyms: 2610018I05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213402
Homologene: 41848
Asb15
Name: ankyrin repeat and SOCS box-containing 15
Synonyms: 4930400E23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78910
Homologene: 43797
Or51f5
Name: olfactory receptor family 51 subfamily F member 5
Synonyms: GA_x6K02T2PBJ9-5491151-5492095, MOR14-2, Olfr561
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259096
Homologene: 133029
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219140
Homologene: 19482
Cyp4a29
Name: cytochrome P450, family 4, subfamily a, polypeptide 29
Synonyms: Cyp4a29-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230639
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: D3F15S2h, D9H3F15S2, Hgfl, DNF15S2h
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15235
Homologene: 7360
Dapk2
Name: death-associated protein kinase 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13143
HGNC: HGNC:2675
Homologene: 74940
Mmp24
Name: matrix metallopeptidase 24
Synonyms: MT5-MMP, Membrane type 5-MMP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17391
HGNC: HGNC:7172
Homologene: 21331
Zfand1
Name: zinc finger, AN1-type domain 1
Synonyms: 2310008M20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66361
Homologene: 6779
Tbc1d12
Name: TBC1D12: TBC1 domain family, member 12
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 209478
VEGA: 19
Homologene: 50835
Galm
Name: galactose mutarotase
Synonyms: A530057M15Rik, aldose 1-epimerase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 319625
Homologene: 71795
Slfn9
Name: schlafen 9
Synonyms: 9830137M10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237886
Homologene: 45432
Or5v1
Name: olfactory receptor family 5 subfamily V member 1
Synonyms: GA_x6K02T2PSCP-1956307-1957260, MOR249-2, Olfr110
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258325
Homologene: 73968
Psmb3
Name: proteasome (prosome, macropain) subunit, beta type 3
Synonyms: C10-II
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26446
HGNC: HGNC:9540
Homologene: 2089
Ccnl2
Name: cyclin L2
Synonyms: Pcee, 1810019L15Rik, ania-6b, 2010319M22Rik, 1700010A01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56036
Homologene: 69477
Gm626
Name:
Type: Gene
Species: Mouse
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 38,045,693 bp
  • A to T, chromosome 1 at 134,896,363 bp
  • A to T, chromosome 2 at 94,369,181 bp
  • G to T, chromosome 2 at 103,769,517 bp
  • A to C, chromosome 2 at 114,197,410 bp
  • A to T, chromosome 2 at 126,797,877 bp
  • T to C, chromosome 2 at 136,098,283 bp
  • T to C, chromosome 2 at 155,799,839 bp
  • A to T, chromosome 2 at 164,168,102 bp
  • A to T, chromosome 2 at 181,230,157 bp
  • A to T, chromosome 3 at 10,348,555 bp
  • C to T, chromosome 3 at 26,133,385 bp
  • T to A, chromosome 4 at 115,254,456 bp
  • C to T, chromosome 4 at 119,247,205 bp
  • C to A, chromosome 4 at 134,128,001 bp
  • T to C, chromosome 4 at 155,813,222 bp
  • T to C, chromosome 5 at 118,056,430 bp
  • C to T, chromosome 6 at 24,559,297 bp
  • C to T, chromosome 6 at 42,486,738 bp
  • AGCGGCGGCGGCGGCGGC to AGCGGCGGCGGCGGC, chromosome 6 at 47,904,788 bp
  • T to C, chromosome 6 at 148,271,385 bp
  • A to G, chromosome 7 at 56,159,438 bp
  • G to A, chromosome 7 at 102,435,481 bp
  • A to G, chromosome 7 at 102,774,710 bp
  • G to A, chromosome 8 at 13,127,727 bp
  • T to C, chromosome 8 at 61,998,769 bp
  • T to A, chromosome 8 at 91,800,206 bp
  • A to T, chromosome 8 at 124,003,512 bp
  • T to A, chromosome 9 at 32,255,937 bp
  • A to T, chromosome 9 at 40,092,354 bp
  • C to T, chromosome 9 at 66,231,745 bp
  • A to G, chromosome 9 at 108,081,604 bp
  • T to C, chromosome 10 at 41,947,939 bp
  • T to C, chromosome 10 at 103,234,068 bp
  • G to A, chromosome 11 at 40,721,672 bp
  • C to A, chromosome 11 at 67,304,336 bp
  • A to T, chromosome 11 at 78,076,002 bp
  • A to C, chromosome 11 at 82,982,779 bp
  • C to T, chromosome 11 at 86,725,261 bp
  • T to A, chromosome 11 at 97,711,169 bp
  • A to G, chromosome 11 at 110,107,128 bp
  • A to G, chromosome 12 at 25,057,128 bp
  • T to C, chromosome 12 at 108,855,942 bp
  • T to G, chromosome 14 at 27,653,165 bp
  • C to A, chromosome 14 at 31,148,954 bp
  • A to G, chromosome 14 at 33,552,109 bp
  • A to T, chromosome 14 at 60,756,508 bp
  • T to C, chromosome 14 at 78,513,232 bp
  • T to C, chromosome 15 at 4,925,637 bp
  • T to A, chromosome 15 at 66,693,260 bp
  • A to T, chromosome 15 at 97,246,157 bp
  • C to T, chromosome 16 at 29,597,671 bp
  • T to A, chromosome 16 at 35,787,325 bp
  • T to C, chromosome 16 at 56,701,218 bp
  • A to T, chromosome 17 at 37,499,370 bp
  • A to G, chromosome 17 at 65,984,547 bp
  • A to G, chromosome 17 at 80,183,337 bp
  • A to G, chromosome 19 at 30,724,184 bp
  • A to T, chromosome 19 at 38,837,380 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8304 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067791-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.